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The map label for this gene is galR [H]

Identifier: 209695109

GI number: 209695109

Start: 1714289

End: 1715311

Strand: Direct

Name: galR [H]

Synonym: VSAL_I1608

Alternate gene names: 209695109

Gene position: 1714289-1715311 (Clockwise)

Preceding gene: 209695107

Following gene: 209695110

Centisome position: 51.56

GC content: 42.62

Gene sequence:

>1023_bases
ATGGCAACCATTAATGATGTAGCAAAGCTAGCTGGTGTATCCACTGCCACCGTATCTCGTGTCATCAACAACTCAGCTTA
TGTTGAGCCTGTGACTCTTGAACGAGTACAAACCGCTGTCCGAGAACTGAACTATCAACGAGACGCCAGAGCAAGTGCAT
TAGCAAGAAAAACAAATAATACGCTTGGGTTATTAACGGGTAATCTCGCCGATCCTTTTTTTGCTCTTATCGCTAAACAT
GTAGAGGAGGTAGCACGTAAAAACAAGTGCCAGCTAGTCGTGGTTAGTGGCGGTCATGATGCTCAAAGAGAAAAAGAAGG
ATTAGATTTTTTAATCAGCCAAGGATGTGAAGCCATGGTGGTTCACGCCAAAATGTTAGATGACGCCACCCTACTTAGAT
ACAGTGCCCAATTGCCTTCGATGGTATTGCTTAATCGCACCATTCCGCAAATATCAAACCGCTCTGTCTATATTGATAAT
AGAGCCGGTGCTAAAAAATCCGTCATTCATTTAATTGAACAAGGTCACCGTAAGATCGCCTGTGTCACCAGTGATCTCCC
TATTGAAGACAGAACAGAGCGACTTAACGGTTATCGTGATGCGATGAAAGAAGCTAATATCACCATTGAGCCTAACTGGG
TAATAAATCAGAACTTTAGTGAACAAGGCGGAGAGCTTGCGGGCGAACAATTATTATCTCAATGCCCAGAAGTATCAGCC
GTTGTCACCTTTAATGATGTGATGGCCGCAGGATTAATGGCAAACCTGCATGAAAACAATATCAACGTACCTAACGATAT
TTCTATTGTCGGGTTTGACGATGTATTACTTGCTCGATACCTCTATCCGCGCTTAACCACCATGCACAATCCAATAGATG
AAATGTCGAGCTATGCTGCTGATTTAGCATTAAAAATCAAAAACACAGGATACATCCCCCCATCAAATCATCGCTTTCAT
GCGACCTTGGTTGAGCGACAAACAGTCATACAATATTCAGATAAACAAGCAGTAAAAGTGTGA

Upstream 100 bases:

>100_bases
ATAATATTATTAATTGTTAATCGGTTTGATAGCCCTAACATCTTTCTTGAAAAAATCACGCTACACTCTTGTCCAATGTT
AATCACCCTATATTGTAATC

Downstream 100 bases:

>100_bases
TGAACCTCTTAGGTAACAACCCCATGTAAGCGCTTACATGAGGGTGTTACTTATCTCTTACATTCTAATTAATAGAACTC
TTACTATGGCCTCATAAAAA

Product: GalR family transcriptional regulator

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MATINDVAKLAGVSTATVSRVINNSAYVEPVTLERVQTAVRELNYQRDARASALARKTNNTLGLLTGNLADPFFALIAKH
VEEVARKNKCQLVVVSGGHDAQREKEGLDFLISQGCEAMVVHAKMLDDATLLRYSAQLPSMVLLNRTIPQISNRSVYIDN
RAGAKKSVIHLIEQGHRKIACVTSDLPIEDRTERLNGYRDAMKEANITIEPNWVINQNFSEQGGELAGEQLLSQCPEVSA
VVTFNDVMAAGLMANLHENNINVPNDISIVGFDDVLLARYLYPRLTTMHNPIDEMSSYAADLALKIKNTGYIPPSNHRFH
ATLVERQTVIQYSDKQAVKV

Sequences:

>Translated_340_residues
MATINDVAKLAGVSTATVSRVINNSAYVEPVTLERVQTAVRELNYQRDARASALARKTNNTLGLLTGNLADPFFALIAKH
VEEVARKNKCQLVVVSGGHDAQREKEGLDFLISQGCEAMVVHAKMLDDATLLRYSAQLPSMVLLNRTIPQISNRSVYIDN
RAGAKKSVIHLIEQGHRKIACVTSDLPIEDRTERLNGYRDAMKEANITIEPNWVINQNFSEQGGELAGEQLLSQCPEVSA
VVTFNDVMAAGLMANLHENNINVPNDISIVGFDDVLLARYLYPRLTTMHNPIDEMSSYAADLALKIKNTGYIPPSNHRFH
ATLVERQTVIQYSDKQAVKV
>Mature_339_residues
ATINDVAKLAGVSTATVSRVINNSAYVEPVTLERVQTAVRELNYQRDARASALARKTNNTLGLLTGNLADPFFALIAKHV
EEVARKNKCQLVVVSGGHDAQREKEGLDFLISQGCEAMVVHAKMLDDATLLRYSAQLPSMVLLNRTIPQISNRSVYIDNR
AGAKKSVIHLIEQGHRKIACVTSDLPIEDRTERLNGYRDAMKEANITIEPNWVINQNFSEQGGELAGEQLLSQCPEVSAV
VTFNDVMAAGLMANLHENNINVPNDISIVGFDDVLLARYLYPRLTTMHNPIDEMSSYAADLALKIKNTGYIPPSNHRFHA
TLVERQTVIQYSDKQAVKV

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=329, Percent_Identity=44.6808510638298, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI1788474, Length=338, Percent_Identity=38.7573964497041, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1789068, Length=335, Percent_Identity=32.8358208955224, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790194, Length=313, Percent_Identity=34.5047923322684, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1790369, Length=303, Percent_Identity=32.013201320132, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=31.3253012048193, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=25.8358662613982, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787906, Length=263, Percent_Identity=28.8973384030418, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=29.073482428115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=27.7611940298507, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994940, Length=313, Percent_Identity=25.5591054313099, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786268, Length=287, Percent_Identity=25.0871080139373, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37581; Mature: 37450

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATINDVAKLAGVSTATVSRVINNSAYVEPVTLERVQTAVRELNYQRDARASALARKTNN
CCCHHHHHHHHCCHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
TLGLLTGNLADPFFALIAKHVEEVARKNKCQLVVVSGGHDAQREKEGLDFLISQGCEAMV
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
VHAKMLDDATLLRYSAQLPSMVLLNRTIPQISNRSVYIDNRAGAKKSVIHLIEQGHRKIA
HHHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEE
CVTSDLPIEDRTERLNGYRDAMKEANITIEPNWVINQNFSEQGGELAGEQLLSQCPEVSA
EEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCCHHCCHHHHHHHHHHHCCCCEE
VVTFNDVMAAGLMANLHENNINVPNDISIVGFDDVLLARYLYPRLTTMHNPIDEMSSYAA
EEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLALKIKNTGYIPPSNHRFHATLVERQTVIQYSDKQAVKV
HEEEEECCCCCCCCCCCEEEEEEHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
ATINDVAKLAGVSTATVSRVINNSAYVEPVTLERVQTAVRELNYQRDARASALARKTNN
CCHHHHHHHHCCHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
TLGLLTGNLADPFFALIAKHVEEVARKNKCQLVVVSGGHDAQREKEGLDFLISQGCEAMV
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
VHAKMLDDATLLRYSAQLPSMVLLNRTIPQISNRSVYIDNRAGAKKSVIHLIEQGHRKIA
HHHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEE
CVTSDLPIEDRTERLNGYRDAMKEANITIEPNWVINQNFSEQGGELAGEQLLSQCPEVSA
EEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCCHHCCHHHHHHHHHHHCCCCEE
VVTFNDVMAAGLMANLHENNINVPNDISIVGFDDVLLARYLYPRLTTMHNPIDEMSSYAA
EEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLALKIKNTGYIPPSNHRFHATLVERQTVIQYSDKQAVKV
HEEEEECCCCCCCCCCCEEEEEEHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6283521; 9278503; 6350601; 8188660; 8982002 [H]