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The map label for this gene is adhC [H]

Identifier: 209694334

GI number: 209694334

Start: 832820

End: 833968

Strand: Reverse

Name: adhC [H]

Synonym: VSAL_I0746

Alternate gene names: 209694334

Gene position: 833968-832820 (Counterclockwise)

Preceding gene: 209694337

Following gene: 209694333

Centisome position: 25.08

GC content: 45.08

Gene sequence:

>1149_bases
ATGGCTCTTGATATTAAACCAGGTCAAACATCAATTAAATCTAAAGCAATGGTAGCTTGGGCTGCTGGCGAACCTCTTAA
AATGGAAGAAGTGGATGTTCAACTTCCTAAAGCGGGCGAAGTATTAGTTCGCATCGTGGCTACTGGCGTTTGTCACACTG
ACTTATTCACTCTTTCTGGTGATGATCCAGAAGGTATCTTCCCTTCAATCCTAGGCCATGAAGGCGGCGGTATTGTTGAA
ATGATCGGCGAAGGCGTGACAAGCGTTGAAGTTGGCGACCACGTTATCCCTCTTTACACTGCGGAATGTGGCGAATGTAA
GTTCTGTAAATCTGGTAAAACTAACCTTTGCCAAGCAGTTCGTGAAACTCAAGGTCAAGGCCTTATGCCTGATGGAACTA
GCCGTTTCTCTATTAATGGTGAAACTATCTTCCATTACATGGGTTGCTCTACGTTCTCTGAATTCACAGTTCTTCCTGAG
ATTTCACTAGCGAAAGTATCTAAAGAAGCACCACTTGAAGAAGTTTGTCTTTTAGGTTGTGGCGTAACTACGGGTATGGG
CGCGGTTCTTAACACGGCTAAAGTTGAAAAAGGCGACACAGTTGCTGTATTCGGTCTTGGCGGTATTGGTCTTTCAGCTA
TCATCGGCGCAAAAATGGCGGGTGCAAGTCGTATCATTGGTGTTGACTTGAACGAAAGCAAATACGAACTGGCTAAGAAA
TTAGGCGCAACTGATTGCATCAACCCAACAAAATTCGACAAGCCAATTCAAGAAGTGATTGTTGAAATGACTGACGGCGG
CGTTGATTACTCTTTTGAGTGTATCGGTAACGTACACGTTATGCGTGCTGCTCTTGAGTGTTGTCACAAAGGTTGGGGTG
AATCAATCATCATCGGTGTTGCTGGTGCTGGTCAAGAGATCTCAACTCGTCCGTTCCAACTTGTGACTGGTCGTGTATGG
CGTGGTTCTGCATTCGGTGGCGTTAAAGGCCGTACTGAGCTTCCAGGTATCGTTGACCGTTACATGCAAGGTGAGTTCGC
TCTTGATGATTTCATCACTCACACAATGGGTCTTGCTGATGTAAACGCAGCGTTCGACTTAATGCACGAAGGTAAATCTA
TCCGTACTGTTCTACACATGGATAAATAA

Upstream 100 bases:

>100_bases
GCACACAACAAGACGACGGACACAAAAAAAATAGCATTATGCTTAAAATGAAATAATCTATTAATATCGTCAATCTAATT
ATCCAAATAAGGAAAACCCA

Downstream 100 bases:

>100_bases
GAAATTCGATTCTAGCTCAAACCACTAGAACTTGATTTTATTTTGCTCCCATCTTCTATGCTGATGGGAGCAATTTATAA
ATGACTTTTTGATTTTAAAG

Product: alcohol dehydrogenase class 3

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MALDIKPGQTSIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDLFTLSGDDPEGIFPSILGHEGGGIVE
MIGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAVRETQGQGLMPDGTSRFSINGETIFHYMGCSTFSEFTVLPE
ISLAKVSKEAPLEEVCLLGCGVTTGMGAVLNTAKVEKGDTVAVFGLGGIGLSAIIGAKMAGASRIIGVDLNESKYELAKK
LGATDCINPTKFDKPIQEVIVEMTDGGVDYSFECIGNVHVMRAALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVW
RGSAFGGVKGRTELPGIVDRYMQGEFALDDFITHTMGLADVNAAFDLMHEGKSIRTVLHMDK

Sequences:

>Translated_382_residues
MALDIKPGQTSIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDLFTLSGDDPEGIFPSILGHEGGGIVE
MIGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAVRETQGQGLMPDGTSRFSINGETIFHYMGCSTFSEFTVLPE
ISLAKVSKEAPLEEVCLLGCGVTTGMGAVLNTAKVEKGDTVAVFGLGGIGLSAIIGAKMAGASRIIGVDLNESKYELAKK
LGATDCINPTKFDKPIQEVIVEMTDGGVDYSFECIGNVHVMRAALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVW
RGSAFGGVKGRTELPGIVDRYMQGEFALDDFITHTMGLADVNAAFDLMHEGKSIRTVLHMDK
>Mature_381_residues
ALDIKPGQTSIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDLFTLSGDDPEGIFPSILGHEGGGIVEM
IGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAVRETQGQGLMPDGTSRFSINGETIFHYMGCSTFSEFTVLPEI
SLAKVSKEAPLEEVCLLGCGVTTGMGAVLNTAKVEKGDTVAVFGLGGIGLSAIIGAKMAGASRIIGVDLNESKYELAKKL
GATDCINPTKFDKPIQEVIVEMTDGGVDYSFECIGNVHVMRAALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVWR
GSAFGGVKGRTELPGIVDRYMQGEFALDDFITHTMGLADVNAAFDLMHEGKSIRTVLHMDK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=64.769647696477, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=51.4986376021798, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=51.2261580381471, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=51.8817204301075, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=50.1362397820163, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=48.5094850948509, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=48.7534626038781, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=47.554347826087, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=47.554347826087, Blast_Score=357, Evalue=1e-98,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=68.6648501362398, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1790045, Length=372, Percent_Identity=28.494623655914, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=366, Percent_Identity=25.4098360655738, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=25.4285714285714, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=348, Percent_Identity=26.4367816091954, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=351, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=263, Percent_Identity=28.1368821292776, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=24.0997229916898, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=21.0958904109589, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786518, Length=250, Percent_Identity=27.6, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=61.0666666666667, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=60.7427055702918, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17565904, Length=377, Percent_Identity=56.763925729443, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=29.1105121293801, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=289, Percent_Identity=28.719723183391, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=258, Percent_Identity=29.0697674418605, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=257, Percent_Identity=29.9610894941634, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=59.4666666666667, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319621, Length=378, Percent_Identity=30.1587301587302, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=29.8630136986301, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=375, Percent_Identity=26.9333333333333, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=27.4725274725275, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=376, Percent_Identity=27.1276595744681, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=266, Percent_Identity=28.9473684210526, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=356, Percent_Identity=27.5280898876405, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=27.247191011236, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=278, Percent_Identity=26.2589928057554, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=61.2466124661247, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137530, Length=268, Percent_Identity=30.2238805970149, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17737897, Length=268, Percent_Identity=28.3582089552239, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40499; Mature: 40368

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDIKPGQTSIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDLFTLSG
CEECCCCCCCCCCCCEEEEEECCCCCEEECCEEECCCHHHHHHHHHHHCCHHHEEEEECC
DDPEGIFPSILGHEGGGIVEMIGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAV
CCCCCCCHHHHCCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCEECCCCCCHHHHHHH
RETQGQGLMPDGTSRFSINGETIFHYMGCSTFSEFTVLPEISLAKVSKEAPLEEVCLLGC
HHHCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHC
GVTTGMGAVLNTAKVEKGDTVAVFGLGGIGLSAIIGAKMAGASRIIGVDLNESKYELAKK
CHHHCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
LGATDCINPTKFDKPIQEVIVEMTDGGVDYSFECIGNVHVMRAALECCHKGWGESIIIGV
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEE
AGAGQEISTRPFQLVTGRVWRGSAFGGVKGRTELPGIVDRYMQGEFALDDFITHTMGLAD
ECCCCCCCCCCEEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCHHH
VNAAFDLMHEGKSIRTVLHMDK
HHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
ALDIKPGQTSIKSKAMVAWAAGEPLKMEEVDVQLPKAGEVLVRIVATGVCHTDLFTLSG
EECCCCCCCCCCCCEEEEEECCCCCEEECCEEECCCHHHHHHHHHHHCCHHHEEEEECC
DDPEGIFPSILGHEGGGIVEMIGEGVTSVEVGDHVIPLYTAECGECKFCKSGKTNLCQAV
CCCCCCCHHHHCCCCCCHHHHHCCCCCEEECCCEEEEEEECCCCCEECCCCCCHHHHHHH
RETQGQGLMPDGTSRFSINGETIFHYMGCSTFSEFTVLPEISLAKVSKEAPLEEVCLLGC
HHHCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHC
GVTTGMGAVLNTAKVEKGDTVAVFGLGGIGLSAIIGAKMAGASRIIGVDLNESKYELAKK
CHHHCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
LGATDCINPTKFDKPIQEVIVEMTDGGVDYSFECIGNVHVMRAALECCHKGWGESIIIGV
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEE
AGAGQEISTRPFQLVTGRVWRGSAFGGVKGRTELPGIVDRYMQGEFALDDFITHTMGLAD
ECCCCCCCCCCEEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCHHH
VNAAFDLMHEGKSIRTVLHMDK
HHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]