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The map label for this gene is ndk

Identifier: 209694314

GI number: 209694314

Start: 809074

End: 809508

Strand: Direct

Name: ndk

Synonym: VSAL_I0725

Alternate gene names: 209694314

Gene position: 809074-809508 (Clockwise)

Preceding gene: 209694313

Following gene: 209694315

Centisome position: 24.33

GC content: 42.3

Gene sequence:

>435_bases
ATGACAATAGAACGTACTTTTTCAATTGTAAAACCAGATGCGGTTAAGCGTAATTTAATCGGTGCTATTTACCGTCGTAT
TGAAAAAACGGGTATGCAAGTTGTAGCCGCTAAAATGCTCTCTCTAACAAAAGAACAGGCTCAAGGTTTTTATGCCGAGC
ATGAAGGCAAAGAATTTTTTGATGCACTCGTTGAGTACATGACATCAGGCCCTGTTATGGTTCAAGTGCTTGAAGGTGAA
AGTGTTATTACTCGCTACCGTGAATTGATGGGAAAAACAAATCCAGATGAAGCGGCCTGTGGTAGCTTGCGTTCTGATTA
TGCGATCAGCATGCGTTATAACTCTGTGCATGGTTCGGACAGTCCTGAATCAGCCGCTCGTGAGATTGCTTATTTCTTTG
TTGAAGATGAAATTTGCCCACGCCCTGCTGAGTAA

Upstream 100 bases:

>100_bases
CTTACAAAATAAATAAGAAAAGATCGGGCAATAGACTCGGTCTTTTTTCTAATAATTATAATAGCTTTTAAGAAGTAAAA
GAAACTTGAAGGAAAGTAGA

Downstream 100 bases:

>100_bases
ATTGAACTAAGAGTTTAGAATGTTTGCAGGCTCCCTGAAGATTCAGAGGAGCTTGTATTTACTGTAATATGAATACCCTA
GATAACAGAACGATAAATAC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQVVAAKMLSLTKEQAQGFYAEHEGKEFFDALVEYMTSGPVMVQVLEGE
SVITRYRELMGKTNPDEAACGSLRSDYAISMRYNSVHGSDSPESAAREIAYFFVEDEICPRPAE

Sequences:

>Translated_144_residues
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQVVAAKMLSLTKEQAQGFYAEHEGKEFFDALVEYMTSGPVMVQVLEGE
SVITRYRELMGKTNPDEAACGSLRSDYAISMRYNSVHGSDSPESAAREIAYFFVEDEICPRPAE
>Mature_143_residues
TIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQVVAAKMLSLTKEQAQGFYAEHEGKEFFDALVEYMTSGPVMVQVLEGES
VITRYRELMGKTNPDEAACGSLRSDYAISMRYNSVHGSDSPESAAREIAYFFVEDEICPRPAE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=46.6666666666667, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.8759124087591, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.8759124087591, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.8759124087591, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.8759124087591, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.8759124087591, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=39.568345323741, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=40, Blast_Score=96, Evalue=9e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI4505413, Length=143, Percent_Identity=35.6643356643357, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=31.6546762589928, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=36.2962962962963, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=31.3868613138686, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=63.8297872340426, Blast_Score=199, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=43.3823529411765, Blast_Score=124, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.1176470588235, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=34.5588235294118, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ALISL (B6EGY3)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262242.1
- GeneID:   6988958
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0725
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16171; Mature: 16039

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQVVAAKMLSLTKEQAQGFYAEHEGKEFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
DALVEYMTSGPVMVQVLEGESVITRYRELMGKTNPDEAACGSLRSDYAISMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEECCCCCCC
SPESAAREIAYFFVEDEICPRPAE
CHHHHHHHHHHHEECCCCCCCCCC
>Mature Secondary Structure 
TIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQVVAAKMLSLTKEQAQGFYAEHEGKEFF
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
DALVEYMTSGPVMVQVLEGESVITRYRELMGKTNPDEAACGSLRSDYAISMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEECCCCCCC
SPESAAREIAYFFVEDEICPRPAE
CHHHHHHHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA