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The map label for this gene is pepB [H]

Identifier: 209694313

GI number: 209694313

Start: 807699

End: 808985

Strand: Direct

Name: pepB [H]

Synonym: VSAL_I0724

Alternate gene names: 209694313

Gene position: 807699-808985 (Clockwise)

Preceding gene: 209694312

Following gene: 209694314

Centisome position: 24.29

GC content: 42.19

Gene sequence:

>1287_bases
ATGTCACAGAAGATGACAGTACAACTTTCAAATACAAAAGCTCTTGCTCATTGGGGGAATAACGCACTGCTTTCATTTAC
CACAGAAGGCGCCGTCATTCATAATACTGACAATGATGTATACAGTACGGTTCAACGTGCTGCACGAAAGTTAAATACTC
AAGGTATTGTTGATGTAGCTTTGGATGGCGCGTCATGGGATCTCGAATCTATTTGGTCTTTTATTCAAGGCTTCCGTGGT
TCGAAAAGTAATAATGATATCGCTTGGAACTCACTCTCAGATCATGACGAAAAAGAATTAAATGCACGTATTTTAACGAC
CAACTGGACCCGTGACATTATTAATAAAACGGCAGAAGAAGTTGCCCCACGCCAGTTGGCGAGTATGGCTGCCGAATTCA
TTAAATCAGTTGCTCCGGAAGGAACGGTAAAAGCTAAAATTGTAAAAGATAAAGATCTTTTAACGGAAGGATGGACGGGA
ACATATGCCGTTGGTCGTGGTTCAGAACGTACGTCTGCGATGCTGCAATTAGACTACAACCCAACGGGTGATGAAAATAC
GCCTGTATACGCTTGTCTTGTAGGTAAAGGCATTACGTTTGATTCTGGTGGTTACAGCATTAAACCTTCAGGTGGCATGG
CATCAATGAAGGCTGACATGGGCGGAGCTGCGCTTGTTACTGCAGGTCTTGCAATGTCGATTCTTCGTGGTTTAGATAAG
CGCGTTAAGCTAATTCTATGTTGTGCTGAAAATATGATTTCAGGCCGAGCTTTAAAACTGGGTGATATCATTACCTATAA
AAATGGCAAAACAGTTGAGATTTTGAATACAGATGCAGAAGGACGTTTAGTCTTAGCGGATGGCCTTCAATTTGCTTCTG
AGCAAACCCCCGAATTAATTATCGATTGTGCAACGCTAACGGGATCCGCTAAAATGGCGGTTGGTAATGATTTTCATTCA
TTATTGAGTTTTGATGAAAAGTTAAGCCAGCAAGCATTAATTTCAGCTCAAGAAGAGAACGAAGGTTTATGGCGTTTGCC
GTTAATGGAATTTCATCGTGAGATGTTGCCTTCTAATTTTGCTGATTTAGCGAATATTGGTTCTGGAGCCTATTCACCAG
GCGCAAGTACGGCCGCGGGTTTTCTTTCTTATTTTGTTGATGATTATAAGAAAGGCTGGTTGCATATGGATTGCTCTGCA
ACTTACCGAACCGCTCCCTCAGACAAGTGGTCTGCAGGGGCAACGGGTGTCGGTGTAAGAACATTAGCGAACATTCTTAC
AAAATAA

Upstream 100 bases:

>100_bases
TAACCGAATACAAAAATGCAATAAAAATCAATGGCAAGTTGAATTGGTATGATCATGACTTATTGTTGAGTGGTGTTGCG
TTTTATAAAGGAGATACATG

Downstream 100 bases:

>100_bases
ATAAGAAAAGATCGGGCAATAGACTCGGTCTTTTTTCTAATAATTATAATAGCTTTTAAGAAGTAAAAGAAACTTGAAGG
AAAGTAGAATGACAATAGAA

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSQKMTVQLSNTKALAHWGNNALLSFTTEGAVIHNTDNDVYSTVQRAARKLNTQGIVDVALDGASWDLESIWSFIQGFRG
SKSNNDIAWNSLSDHDEKELNARILTTNWTRDIINKTAEEVAPRQLASMAAEFIKSVAPEGTVKAKIVKDKDLLTEGWTG
TYAVGRGSERTSAMLQLDYNPTGDENTPVYACLVGKGITFDSGGYSIKPSGGMASMKADMGGAALVTAGLAMSILRGLDK
RVKLILCCAENMISGRALKLGDIITYKNGKTVEILNTDAEGRLVLADGLQFASEQTPELIIDCATLTGSAKMAVGNDFHS
LLSFDEKLSQQALISAQEENEGLWRLPLMEFHREMLPSNFADLANIGSGAYSPGASTAAGFLSYFVDDYKKGWLHMDCSA
TYRTAPSDKWSAGATGVGVRTLANILTK

Sequences:

>Translated_428_residues
MSQKMTVQLSNTKALAHWGNNALLSFTTEGAVIHNTDNDVYSTVQRAARKLNTQGIVDVALDGASWDLESIWSFIQGFRG
SKSNNDIAWNSLSDHDEKELNARILTTNWTRDIINKTAEEVAPRQLASMAAEFIKSVAPEGTVKAKIVKDKDLLTEGWTG
TYAVGRGSERTSAMLQLDYNPTGDENTPVYACLVGKGITFDSGGYSIKPSGGMASMKADMGGAALVTAGLAMSILRGLDK
RVKLILCCAENMISGRALKLGDIITYKNGKTVEILNTDAEGRLVLADGLQFASEQTPELIIDCATLTGSAKMAVGNDFHS
LLSFDEKLSQQALISAQEENEGLWRLPLMEFHREMLPSNFADLANIGSGAYSPGASTAAGFLSYFVDDYKKGWLHMDCSA
TYRTAPSDKWSAGATGVGVRTLANILTK
>Mature_427_residues
SQKMTVQLSNTKALAHWGNNALLSFTTEGAVIHNTDNDVYSTVQRAARKLNTQGIVDVALDGASWDLESIWSFIQGFRGS
KSNNDIAWNSLSDHDEKELNARILTTNWTRDIINKTAEEVAPRQLASMAAEFIKSVAPEGTVKAKIVKDKDLLTEGWTGT
YAVGRGSERTSAMLQLDYNPTGDENTPVYACLVGKGITFDSGGYSIKPSGGMASMKADMGGAALVTAGLAMSILRGLDKR
VKLILCCAENMISGRALKLGDIITYKNGKTVEILNTDAEGRLVLADGLQFASEQTPELIIDCATLTGSAKMAVGNDFHSL
LSFDEKLSQQALISAQEENEGLWRLPLMEFHREMLPSNFADLANIGSGAYSPGASTAAGFLSYFVDDYKKGWLHMDCSAT
YRTAPSDKWSAGATGVGVRTLANILTK

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=324, Percent_Identity=35.1851851851852, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI47155554, Length=296, Percent_Identity=34.4594594594595, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=58.3138173302108, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1790710, Length=304, Percent_Identity=40.7894736842105, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=359, Percent_Identity=30.9192200557103, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=229, Percent_Identity=30.1310043668122, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357381, Length=345, Percent_Identity=30.7246376811594, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379063, Length=345, Percent_Identity=30.7246376811594, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379062, Length=345, Percent_Identity=30.7246376811594, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355725, Length=334, Percent_Identity=30.2395209580838, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24661038, Length=334, Percent_Identity=29.6407185628743, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20129969, Length=372, Percent_Identity=28.2258064516129, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662227, Length=406, Percent_Identity=26.6009852216749, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077148, Length=371, Percent_Identity=26.6846361185984, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130057, Length=371, Percent_Identity=26.6846361185984, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922386, Length=403, Percent_Identity=26.302729528536, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129963, Length=367, Percent_Identity=26.4305177111717, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21355645, Length=404, Percent_Identity=24.5049504950495, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24662223, Length=404, Percent_Identity=24.5049504950495, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646701, Length=218, Percent_Identity=32.1100917431193, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646703, Length=218, Percent_Identity=32.1100917431193, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358201, Length=218, Percent_Identity=32.1100917431193, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46149; Mature: 46017

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKMTVQLSNTKALAHWGNNALLSFTTEGAVIHNTDNDVYSTVQRAARKLNTQGIVDVA
CCCEEEEEECCCEEEEECCCCEEEEEEECCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
LDGASWDLESIWSFIQGFRGSKSNNDIAWNSLSDHDEKELNARILTTNWTRDIINKTAEE
ECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHH
VAPRQLASMAAEFIKSVAPEGTVKAKIVKDKDLLTEGWTGTYAVGRGSERTSAMLQLDYN
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCEEEECCCCCCCEEEEEEECC
PTGDENTPVYACLVGKGITFDSGGYSIKPSGGMASMKADMGGAALVTAGLAMSILRGLDK
CCCCCCCCEEEEEECCCEEECCCCCEECCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHH
RVKLILCCAENMISGRALKLGDIITYKNGKTVEILNTDAEGRLVLADGLQFASEQTPELI
HHEEEEEEHHHHHCCCEEEECCEEEECCCCEEEEEECCCCCCEEEECCCHHHCCCCCEEE
IDCATLTGSAKMAVGNDFHSLLSFDEKLSQQALISAQEENEGLWRLPLMEFHREMLPSNF
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHCCCCH
ADLANIGSGAYSPGASTAAGFLSYFVDDYKKGWLHMDCSATYRTAPSDKWSAGATGVGVR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHH
TLANILTK
HHHHHHCC
>Mature Secondary Structure 
SQKMTVQLSNTKALAHWGNNALLSFTTEGAVIHNTDNDVYSTVQRAARKLNTQGIVDVA
CCEEEEEECCCEEEEECCCCEEEEEEECCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
LDGASWDLESIWSFIQGFRGSKSNNDIAWNSLSDHDEKELNARILTTNWTRDIINKTAEE
ECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHH
VAPRQLASMAAEFIKSVAPEGTVKAKIVKDKDLLTEGWTGTYAVGRGSERTSAMLQLDYN
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCEEEECCCCCCCEEEEEEECC
PTGDENTPVYACLVGKGITFDSGGYSIKPSGGMASMKADMGGAALVTAGLAMSILRGLDK
CCCCCCCCEEEEEECCCEEECCCCCEECCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHH
RVKLILCCAENMISGRALKLGDIITYKNGKTVEILNTDAEGRLVLADGLQFASEQTPELI
HHEEEEEEHHHHHCCCEEEECCEEEECCCCEEEEEECCCCCCEEEECCCHHHCCCCCEEE
IDCATLTGSAKMAVGNDFHSLLSFDEKLSQQALISAQEENEGLWRLPLMEFHREMLPSNF
EEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHCCCCH
ADLANIGSGAYSPGASTAAGFLSYFVDDYKKGWLHMDCSATYRTAPSDKWSAGATGVGVR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHH
TLANILTK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA