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The map label for this gene is oadA [H]

Identifier: 209694230

GI number: 209694230

Start: 709599

End: 711386

Strand: Direct

Name: oadA [H]

Synonym: VSAL_I0639

Alternate gene names: 209694230

Gene position: 709599-711386 (Clockwise)

Preceding gene: 209694229

Following gene: 209694231

Centisome position: 21.34

GC content: 41.5

Gene sequence:

>1788_bases
ATGTCTAAACCACTTTCTATCACTGATGTGGTACTTCGTGACGCCCACCAATCACTCTTCGCAACTCGTATGCGTGTTGA
AGATATGCTTCCAATTGCAGAGCAGTTGGATAAAATCGGTTATTGGTCATTAGAAACTTGGGGTGGGGCAACATTTGATG
CCTGTATTCGTTATTTAGGTGAAGACCCATGGGAACGTTTACGATTACTTAAAAAAGCGATGCCAAATACACCAATGCAA
ATGTTACTTCGTGGCCAAAACTTATTAGGTTACCGCCATTATGCTGATGACGTTGTTGAAAAATTTGTAGAGCGAGCTCA
TTGTAACGGTATGGATGTATTCCGTATTTTTGATGCAATGAATGACGTTAGAAATTTTCAAACAGCAGTAAAAGCAACAA
TTGATGTTGGTGCTCATGCTCAGGGCACTCTTTCTTACACAACAAGTCCTGTTCATAATTCAGATACATGGGTTGATTTA
GCAAAACGTCTTGAAGATTTAGGCTGTCATTCTCTTTGTATTAAAGACATGTCTGGTCTACTTAAACCTTATGAAGCTGA
AGAACTTATTACTCGTATTAAATCGTCTTGTGATGTACCACTTGCTTTGCATAGTCACGCGACAACAGGATTATCTACCG
CCACAGCCTTAAAAGCGGCAGAGGCTGGCATTGATATTTTAGATACGGCTATTTCATCCATGAGCCAAACTTATGGTCAT
ACTCCAACTGAAACGGTTGTTGCTATGCTAGAAGGGACAGGGCGCGATACAAATCTTAACCTTGAGCAACTTGAACCAAT
TGCTACCTATTTCCGTGAAGTTCGTAAAAAATACGCAAAGTTTGAAGGACAAATGAAAGGCGTCGATTCTCGAATTCTCA
TCGCTCAAGTTCCGGGTGGGATGTTGACGAATATGGAAAGTCAGTTAAAAGAGCAAGGTGCAGCTGACAGATTAGATGAA
GTGCTAATTGAGATCCCTAAAGTTCGTAAAGATCTAGGTTATATCCCATTAGTTACTCCAACGTCACAAATTGTAGGCAC
TCAAGCAGTAATTAATATCCTTACTGGAGAGCGTTATAAGAGTATTACAAAAGAAACGGCAGGTGTCCTAAAGGGAGAGT
ATGGCTCAGCGCCTGCTGCCGTTAATGCAGAGCTACAGGCTCGTGTTTTAGAAGGTGCGGAGCCGATTACCTGTCGTCCT
GCCGATTTATTAGCGGCCGAGTTACATACTTTAACGGATGAACTGATTGCTAAAGCAAAAGAAGATAATATCGCTTTAGC
GGAAGAGCAAATTGATGATGTACTTACTTATGCTCTATTTCCTCAAGTGGGTCTTAAATTTCTTAAAAATCGTAATAATC
CAGATGCCTTTGAACCTGCTCCTGGAACTGAAGTTGAATCAGCGGCTAATGTTGTAAAAGCAAACACGGCTAAAGGTGGT
GTTGAGGCTTATAGCGTTAAAGTTGATGGTCAAATCTATAATGTAGAAGTGGGGCCGCAAGGCGTTATTTCGTCTGTTGA
ACCAATATCAGCACAAGCAGCACCGGTTCAATCTCCTCAACTTTCGGCAGTTGACGCGGAATCTGTTGATGCGCCATTAG
CAGGAACTATCTTTAAGGTACTTGTACAAGCTGGTGCTGAAGTTGCTGAAGGTGATGTGTTACTTATACTTGAAGCGATG
AAAATGGAGACAGAGATCAGAGCATCACGTAATGGTACCGTTCAAGATATTTTAACTAAAGAGGGCGATGCAGTAGCAGT
TGGTACACCATTGCTTTCTCTAGCCTAA

Upstream 100 bases:

>100_bases
CAGCCTCAAATTATAGCTGCTATTTCTGCTGCGGTTAAATTATACCGCCAAAAGAATCGATAAACTGTTTTAGGAAAATC
ATTACAAGGAGTTTGTAAGT

Downstream 100 bases:

>100_bases
GGTAAGTAAACATGGATGGTTTATTAATATTATGGAATGAAACGGCGATTGCTAATTTTAAGTTTGAACAACTTATTATG
ATTTTAGTCGGTTGTGGGCT

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDACIRYLGEDPWERLRLLKKAMPNTPMQ
MLLRGQNLLGYRHYADDVVEKFVERAHCNGMDVFRIFDAMNDVRNFQTAVKATIDVGAHAQGTLSYTTSPVHNSDTWVDL
AKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKSSCDVPLALHSHATTGLSTATALKAAEAGIDILDTAISSMSQTYGH
TPTETVVAMLEGTGRDTNLNLEQLEPIATYFREVRKKYAKFEGQMKGVDSRILIAQVPGGMLTNMESQLKEQGAADRLDE
VLIEIPKVRKDLGYIPLVTPTSQIVGTQAVINILTGERYKSITKETAGVLKGEYGSAPAAVNAELQARVLEGAEPITCRP
ADLLAAELHTLTDELIAKAKEDNIALAEEQIDDVLTYALFPQVGLKFLKNRNNPDAFEPAPGTEVESAANVVKANTAKGG
VEAYSVKVDGQIYNVEVGPQGVISSVEPISAQAAPVQSPQLSAVDAESVDAPLAGTIFKVLVQAGAEVAEGDVLLILEAM
KMETEIRASRNGTVQDILTKEGDAVAVGTPLLSLA

Sequences:

>Translated_595_residues
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDACIRYLGEDPWERLRLLKKAMPNTPMQ
MLLRGQNLLGYRHYADDVVEKFVERAHCNGMDVFRIFDAMNDVRNFQTAVKATIDVGAHAQGTLSYTTSPVHNSDTWVDL
AKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKSSCDVPLALHSHATTGLSTATALKAAEAGIDILDTAISSMSQTYGH
TPTETVVAMLEGTGRDTNLNLEQLEPIATYFREVRKKYAKFEGQMKGVDSRILIAQVPGGMLTNMESQLKEQGAADRLDE
VLIEIPKVRKDLGYIPLVTPTSQIVGTQAVINILTGERYKSITKETAGVLKGEYGSAPAAVNAELQARVLEGAEPITCRP
ADLLAAELHTLTDELIAKAKEDNIALAEEQIDDVLTYALFPQVGLKFLKNRNNPDAFEPAPGTEVESAANVVKANTAKGG
VEAYSVKVDGQIYNVEVGPQGVISSVEPISAQAAPVQSPQLSAVDAESVDAPLAGTIFKVLVQAGAEVAEGDVLLILEAM
KMETEIRASRNGTVQDILTKEGDAVAVGTPLLSLA
>Mature_594_residues
SKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDACIRYLGEDPWERLRLLKKAMPNTPMQM
LLRGQNLLGYRHYADDVVEKFVERAHCNGMDVFRIFDAMNDVRNFQTAVKATIDVGAHAQGTLSYTTSPVHNSDTWVDLA
KRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKSSCDVPLALHSHATTGLSTATALKAAEAGIDILDTAISSMSQTYGHT
PTETVVAMLEGTGRDTNLNLEQLEPIATYFREVRKKYAKFEGQMKGVDSRILIAQVPGGMLTNMESQLKEQGAADRLDEV
LIEIPKVRKDLGYIPLVTPTSQIVGTQAVINILTGERYKSITKETAGVLKGEYGSAPAAVNAELQARVLEGAEPITCRPA
DLLAAELHTLTDELIAKAKEDNIALAEEQIDDVLTYALFPQVGLKFLKNRNNPDAFEPAPGTEVESAANVVKANTAKGGV
EAYSVKVDGQIYNVEVGPQGVISSVEPISAQAAPVQSPQLSAVDAESVDAPLAGTIFKVLVQAGAEVAEGDVLLILEAMK
METEIRASRNGTVQDILTKEGDAVAVGTPLLSLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=626, Percent_Identity=32.1086261980831, Blast_Score=283, Evalue=5e-76,
Organism=Homo sapiens, GI106049295, Length=626, Percent_Identity=32.1086261980831, Blast_Score=283, Evalue=5e-76,
Organism=Homo sapiens, GI106049292, Length=626, Percent_Identity=32.1086261980831, Blast_Score=283, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17562816, Length=616, Percent_Identity=33.6038961038961, Blast_Score=295, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6319695, Length=621, Percent_Identity=32.0450885668277, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321376, Length=621, Percent_Identity=31.2399355877617, Blast_Score=289, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24652212, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24652210, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24652214, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI19921944, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24652216, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI281363050, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652224, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652222, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652220, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652218, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 64448; Mature: 64317

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDACIRYLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EDPWERLRLLKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHCNGMDVFRIFDAM
CCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NDVRNFQTAVKATIDVGAHAQGTLSYTTSPVHNSDTWVDLAKRLEDLGCHSLCIKDMSGL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LKPYEAEELITRIKSSCDVPLALHSHATTGLSTATALKAAEAGIDILDTAISSMSQTYGH
CCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TPTETVVAMLEGTGRDTNLNLEQLEPIATYFREVRKKYAKFEGQMKGVDSRILIAQVPGG
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCC
MLTNMESQLKEQGAADRLDEVLIEIPKVRKDLGYIPLVTPTSQIVGTQAVINILTGERYK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCHHHH
SITKETAGVLKGEYGSAPAAVNAELQARVLEGAEPITCRPADLLAAELHTLTDELIAKAK
HHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
EDNIALAEEQIDDVLTYALFPQVGLKFLKNRNNPDAFEPAPGTEVESAANVVKANTAKGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
VEAYSVKVDGQIYNVEVGPQGVISSVEPISAQAAPVQSPQLSAVDAESVDAPLAGTIFKV
CEEEEEEECCEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHH
LVQAGAEVAEGDVLLILEAMKMETEIRASRNGTVQDILTKEGDAVAVGTPLLSLA
HHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCHHHCC
>Mature Secondary Structure 
SKPLSITDVVLRDAHQSLFATRMRVEDMLPIAEQLDKIGYWSLETWGGATFDACIRYLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EDPWERLRLLKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHCNGMDVFRIFDAM
CCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NDVRNFQTAVKATIDVGAHAQGTLSYTTSPVHNSDTWVDLAKRLEDLGCHSLCIKDMSGL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
LKPYEAEELITRIKSSCDVPLALHSHATTGLSTATALKAAEAGIDILDTAISSMSQTYGH
CCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TPTETVVAMLEGTGRDTNLNLEQLEPIATYFREVRKKYAKFEGQMKGVDSRILIAQVPGG
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCC
MLTNMESQLKEQGAADRLDEVLIEIPKVRKDLGYIPLVTPTSQIVGTQAVINILTGERYK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCHHHH
SITKETAGVLKGEYGSAPAAVNAELQARVLEGAEPITCRPADLLAAELHTLTDELIAKAK
HHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
EDNIALAEEQIDDVLTYALFPQVGLKFLKNRNNPDAFEPAPGTEVESAANVVKANTAKGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
VEAYSVKVDGQIYNVEVGPQGVISSVEPISAQAAPVQSPQLSAVDAESVDAPLAGTIFKV
CEEEEEEECCEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHH
LVQAGAEVAEGDVLLILEAMKMETEIRASRNGTVQDILTKEGDAVAVGTPLLSLA
HHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]