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The map label for this gene is hemD [H]

Identifier: 209693831

GI number: 209693831

Start: 259699

End: 260445

Strand: Reverse

Name: hemD [H]

Synonym: VSAL_I0219

Alternate gene names: 209693831

Gene position: 260445-259699 (Counterclockwise)

Preceding gene: 209693832

Following gene: 209693830

Centisome position: 7.83

GC content: 42.84

Gene sequence:

>747_bases
ATGACCATATTGGTGACTCGCCCAGAGCAAGAGAGCCAAGCACTCTGTGATGCCCTACACCAAGCAGGGCACCTCGCCAT
TTCTCATCCTTTGTTAACCATACATCCAGGACGAGAACTTTCTCAACTGCCTTCTCTTTTTTCTTCTCTGTCTGATGGTG
ATTTTATCATCGCCGTAAGCCAACATGCTGTTGAACATGCGCAGAACAGCCTTCAAATGCAGCAAACGGAATGGAAAAAA
GGGGTAAATTATATTGCGGTTGGTCAAAAGAGCGCTCAACACCTCAAAAAGTATGTTGTAGATACAGTACACTTTCCAAC
ACACAGCGATAGCGAACATTTATTGGCTCTTCCTGTTTTAAAAAACACAAAAGGAAAGAAAGCCCTCATTTTACGAGGCA
ATGGCGGACGAGACTTAATATTTCAAGCGCTTGACAATTCGGGGGTAGAAGTCTCTTATTGTGAAACATATCAACGAAAA
AACACACCATTTAATGGCGCATTAAAAGCAGCAGAATGGCAAAAAGAGCACGTAGATACAATCATAGTGACCAGCGGAGA
ACAACTGTCCTTCTTCACTGAACAATTCACACTCATACATTTACACTGGGTACTGCACTGTCGTTTATTAGTACCGAGTG
AACGAATTAACCAACTTGCTCAACAACTTGGTTATCAACATATAGAAACGGTTGGCGGAGCCTCTAATTCCGATGTGCTG
CACTATCTCAGTGAGCATCATGCATGA

Upstream 100 bases:

>100_bases
CCAGTCTCTGATGCTGAAGAACTTGGCACAAAACTGGCTGAACAACTGCTTAATGACGGTGCAAAAGACATTTTAGACCG
CCTATACGCTGACGCTTAAC

Downstream 100 bases:

>100_bases
TGGGACTTTCAAATGACAAAAGACAATAACAAACCACAATCAGCAGAAGAAAAATCATCAAATTCTGCAACGGCACCTTC
TTCTCAAATCCCAAAAAAAG

Product: uroporphyrinogen III synthase HemD

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTILVTRPEQESQALCDALHQAGHLAISHPLLTIHPGRELSQLPSLFSSLSDGDFIIAVSQHAVEHAQNSLQMQQTEWKK
GVNYIAVGQKSAQHLKKYVVDTVHFPTHSDSEHLLALPVLKNTKGKKALILRGNGGRDLIFQALDNSGVEVSYCETYQRK
NTPFNGALKAAEWQKEHVDTIIVTSGEQLSFFTEQFTLIHLHWVLHCRLLVPSERINQLAQQLGYQHIETVGGASNSDVL
HYLSEHHA

Sequences:

>Translated_248_residues
MTILVTRPEQESQALCDALHQAGHLAISHPLLTIHPGRELSQLPSLFSSLSDGDFIIAVSQHAVEHAQNSLQMQQTEWKK
GVNYIAVGQKSAQHLKKYVVDTVHFPTHSDSEHLLALPVLKNTKGKKALILRGNGGRDLIFQALDNSGVEVSYCETYQRK
NTPFNGALKAAEWQKEHVDTIIVTSGEQLSFFTEQFTLIHLHWVLHCRLLVPSERINQLAQQLGYQHIETVGGASNSDVL
HYLSEHHA
>Mature_247_residues
TILVTRPEQESQALCDALHQAGHLAISHPLLTIHPGRELSQLPSLFSSLSDGDFIIAVSQHAVEHAQNSLQMQQTEWKKG
VNYIAVGQKSAQHLKKYVVDTVHFPTHSDSEHLLALPVLKNTKGKKALILRGNGGRDLIFQALDNSGVEVSYCETYQRKN
TPFNGALKAAEWQKEHVDTIIVTSGEQLSFFTEQFTLIHLHWVLHCRLLVPSERINQLAQQLGYQHIETVGGASNSDVLH
YLSEHHA

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=248, Percent_Identity=41.9354838709677, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27701; Mature: 27570

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTRPEQESQALCDALHQAGHLAISHPLLTIHPGRELSQLPSLFSSLSDGDFIIAVS
CEEEEECCCHHHHHHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEEEC
QHAVEHAQNSLQMQQTEWKKGVNYIAVGQKSAQHLKKYVVDTVHFPTHSDSEHLLALPVL
HHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHEECCCCCCCCCEEEEEEE
KNTKGKKALILRGNGGRDLIFQALDNSGVEVSYCETYQRKNTPFNGALKAAEWQKEHVDT
CCCCCCEEEEEECCCCHHHHHEECCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCE
IIVTSGEQLSFFTEQFTLIHLHWVLHCRLLVPSERINQLAQQLGYQHIETVGGASNSDVL
EEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCHHHHHHHCCCCCCHHH
HYLSEHHA
HHHHHCCC
>Mature Secondary Structure 
TILVTRPEQESQALCDALHQAGHLAISHPLLTIHPGRELSQLPSLFSSLSDGDFIIAVS
EEEEECCCHHHHHHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEEEC
QHAVEHAQNSLQMQQTEWKKGVNYIAVGQKSAQHLKKYVVDTVHFPTHSDSEHLLALPVL
HHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHEECCCCCCCCCEEEEEEE
KNTKGKKALILRGNGGRDLIFQALDNSGVEVSYCETYQRKNTPFNGALKAAEWQKEHVDT
CCCCCCEEEEEECCCCHHHHHEECCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHCCCE
IIVTSGEQLSFFTEQFTLIHLHWVLHCRLLVPSERINQLAQQLGYQHIETVGGASNSDVL
EEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCHHHHHHHCCCCCCHHH
HYLSEHHA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]