Click here to switch to the map view.

The map label for this gene is hemX [H]

Identifier: 209693830

GI number: 209693830

Start: 258472

End: 259686

Strand: Reverse

Name: hemX [H]

Synonym: VSAL_I0218

Alternate gene names: 209693830

Gene position: 259686-258472 (Counterclockwise)

Preceding gene: 209693831

Following gene: 209693829

Centisome position: 7.81

GC content: 41.4

Gene sequence:

>1215_bases
ATGACAAAAGACAATAACAAACCACAATCAGCAGAAGAAAAATCATCAAATTCTGCAACGGCACCTTCTTCTCAAATCCC
AAAAAAAGAGACGGAGAAACATGTGCAGCCAACAACATCTAAAGCGCCTTCAAATAAAGAAGAGCCTATCGTAGACAAAA
AAAGCCGTCGCCTAGGTACGGTTGCTATCATCATTTCAATTCTGCTAAGTGGCGGTGCATTTTTAGCATCACAGCAACAG
GTCACTCAACAACAGCTTAAAATTGCTCAACTTCAACAGCAATTAAAAAATGCCGACAGCACCTTTAATGAAAAACTCGT
CACAGCAGAGCAACGTATCACGGACAAAGCTGACGATATTGTACGTAAAGCAACCGTTCTCATCCAACAGCAAGACAAAA
GCATAGCAAGTCTTCAATTGGCCATTGCTGACGTTAAAGGTCGCAGACCAAATGACTGGTTACTTGCAGAAGCCGATTAT
CTTGTAAAAATGGCGGGCCGAAAATTATGGCTAGAGCATGACGTCGTCAGTGCGACCCGTTTAATGGAAAATGCCGATCA
ACGTATTTCAGCATTGAACGATCCAAGTTTAATGCCACTTCGCAGAGCCATGGCCAGTGATATCTCAACACTGAAAGCCA
TCCCACTGATTGATCGTGATGGTTTAGTTCTGAAATTAAACAGCTTAGAACAACAAATTAATACCCTTCCATTAGCGAGT
GCCATTCTCCCTGAAGCGGGCGTTGTAGAACAAAAAGAAGTGTCTACCAATATCAATGATTGGCAATCAAACCTGATGCA
GTCATTGGATGATTTTGCCGGCCACTTTATTACTTATCGTGTTCGTGAGGGTAATGTCATTCCATTACTTAGCCCTGAGC
AGCATTTTTATCTAAAAGAAAACATCAAAGGTAAACTACTACTGGCGTCTAAAGCTCTGTATCGCGAACAAAGTGAAGTG
TATGTGACGTCATTAGAAAGTGCGAAGTTGTGGTCATCTCAATATTTCCAACAAGATGATCCCGCAGTGAAGAGCTTTAT
GGCACAGTTAGATTCTTTGACTAAATTTAAAGTCGATGTTCGTTATCCACAAAAAATGAAAACTCAAGCACTTCTGTCTG
ATTTCATTTCAGAACGTCTACGCCGCAATATCCAAGCGGTTGGTACAACAACGCCCGAGACTAAAACCGCAACAATAGAA
GGAGGTAAATCATGA

Upstream 100 bases:

>100_bases
TCAACAACTTGGTTATCAACATATAGAAACGGTTGGCGGAGCCTCTAATTCCGATGTGCTGCACTATCTCAGTGAGCATC
ATGCATGATGGGACTTTCAA

Downstream 100 bases:

>100_bases
TTCGATTGCTTCTTCTGGCCATTGTCTTAGTCGGTGGATTAATCGTTGGGACAACATTCGCAGACCAACAAGGCTATGTA
TTAATTTCCGTCGCTGAGAT

Product: uroporphyrin-III C-methyltransferase HemX

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTKDNNKPQSAEEKSSNSATAPSSQIPKKETEKHVQPTTSKAPSNKEEPIVDKKSRRLGTVAIIISILLSGGAFLASQQQ
VTQQQLKIAQLQQQLKNADSTFNEKLVTAEQRITDKADDIVRKATVLIQQQDKSIASLQLAIADVKGRRPNDWLLAEADY
LVKMAGRKLWLEHDVVSATRLMENADQRISALNDPSLMPLRRAMASDISTLKAIPLIDRDGLVLKLNSLEQQINTLPLAS
AILPEAGVVEQKEVSTNINDWQSNLMQSLDDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEV
YVTSLESAKLWSSQYFQQDDPAVKSFMAQLDSLTKFKVDVRYPQKMKTQALLSDFISERLRRNIQAVGTTTPETKTATIE
GGKS

Sequences:

>Translated_404_residues
MTKDNNKPQSAEEKSSNSATAPSSQIPKKETEKHVQPTTSKAPSNKEEPIVDKKSRRLGTVAIIISILLSGGAFLASQQQ
VTQQQLKIAQLQQQLKNADSTFNEKLVTAEQRITDKADDIVRKATVLIQQQDKSIASLQLAIADVKGRRPNDWLLAEADY
LVKMAGRKLWLEHDVVSATRLMENADQRISALNDPSLMPLRRAMASDISTLKAIPLIDRDGLVLKLNSLEQQINTLPLAS
AILPEAGVVEQKEVSTNINDWQSNLMQSLDDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEV
YVTSLESAKLWSSQYFQQDDPAVKSFMAQLDSLTKFKVDVRYPQKMKTQALLSDFISERLRRNIQAVGTTTPETKTATIE
GGKS
>Mature_403_residues
TKDNNKPQSAEEKSSNSATAPSSQIPKKETEKHVQPTTSKAPSNKEEPIVDKKSRRLGTVAIIISILLSGGAFLASQQQV
TQQQLKIAQLQQQLKNADSTFNEKLVTAEQRITDKADDIVRKATVLIQQQDKSIASLQLAIADVKGRRPNDWLLAEADYL
VKMAGRKLWLEHDVVSATRLMENADQRISALNDPSLMPLRRAMASDISTLKAIPLIDRDGLVLKLNSLEQQINTLPLASA
ILPEAGVVEQKEVSTNINDWQSNLMQSLDDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEVY
VTSLESAKLWSSQYFQQDDPAVKSFMAQLDSLTKFKVDVRYPQKMKTQALLSDFISERLRRNIQAVGTTTPETKTATIEG
GKS

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=266, Percent_Identity=37.593984962406, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 45085; Mature: 44954

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDNNKPQSAEEKSSNSATAPSSQIPKKETEKHVQPTTSKAPSNKEEPIVDKKSRRLGT
CCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VAIIISILLSGGAFLASQQQVTQQQLKIAQLQQQLKNADSTFNEKLVTAEQRITDKADDI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VRKATVLIQQQDKSIASLQLAIADVKGRRPNDWLLAEADYLVKMAGRKLWLEHDVVSATR
HHHHHHHHHHCCCHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHH
LMENADQRISALNDPSLMPLRRAMASDISTLKAIPLIDRDGLVLKLNSLEQQINTLPLAS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEECCCCEEEEEHHHHHHHHHCCHHH
AILPEAGVVEQKEVSTNINDWQSNLMQSLDDFAGHFITYRVREGNVIPLLSPEQHFYLKE
HHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEEECC
NIKGKLLLASKALYREQSEVYVTSLESAKLWSSQYFQQDDPAVKSFMAQLDSLTKFKVDV
CCCCEEEEHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEE
RYPQKMKTQALLSDFISERLRRNIQAVGTTTPETKTATIEGGKS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
TKDNNKPQSAEEKSSNSATAPSSQIPKKETEKHVQPTTSKAPSNKEEPIVDKKSRRLGT
CCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VAIIISILLSGGAFLASQQQVTQQQLKIAQLQQQLKNADSTFNEKLVTAEQRITDKADDI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VRKATVLIQQQDKSIASLQLAIADVKGRRPNDWLLAEADYLVKMAGRKLWLEHDVVSATR
HHHHHHHHHHCCCHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHH
LMENADQRISALNDPSLMPLRRAMASDISTLKAIPLIDRDGLVLKLNSLEQQINTLPLAS
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEECCCCEEEEEHHHHHHHHHCCHHH
AILPEAGVVEQKEVSTNINDWQSNLMQSLDDFAGHFITYRVREGNVIPLLSPEQHFYLKE
HHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEEECC
NIKGKLLLASKALYREQSEVYVTSLESAKLWSSQYFQQDDPAVKSFMAQLDSLTKFKVDV
CCCCEEEEHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEE
RYPQKMKTQALLSDFISERLRRNIQAVGTTTPETKTATIEGGKS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]