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The map label for this gene is acpS

Identifier: 209398176

GI number: 209398176

Start: 1297743

End: 1298111

Strand: Direct

Name: acpS

Synonym: ECH74115_1283

Alternate gene names: 209398176

Gene position: 1297743-1298111 (Clockwise)

Preceding gene: 209397617

Following gene: 209396825

Centisome position: 23.29

GC content: 42.28

Gene sequence:

>369_bases
ATGAGAATAGGGACAGATATTGTTGAAATTGCCAGAATAACCAAAGCCATTATTAATGGAGAGATGGCTTTTTATGAGCG
TGTTTATACTTCTCATGAGCGCTTACTCATTAACCCTGCAGAACCTGATTATGAACGGGCCTCTGGATTCTGGGCGGCGA
AAGAAGCGTTAGTTAAAGCGATTGGTTGTGGTTTTCGTGATGGCGTACGTTTCCAGGATATTGAAATAAAGCATGATGCA
GCCAAAGCACCTTATTTCGTTATTTCCGGAAGACTACAAGAAATTTTTATCGGGCAGGGGTTGCAAAATAACTCCCTGAG
TATTTCGCATTGCCGTACCCACGCCATTGCGACTGTCATCGTTTATTAA

Upstream 100 bases:

>100_bases
TTCCGTTTCTACCCCATTAAAGTATCCGGCGACATTAGATATTGATCGGGTGAATGTAAATTTTAATTTTTCGTACCAAA
TGTAAAGGATAACGAGACTC

Downstream 100 bases:

>100_bases
CTCAACATATGTGATGAATATGTACAAATATAATGATTTAAATGAAAAAACCGTACTGGTGACAGGAGCCAGTGGTGATA
TTGGACTGGGTATTTGCGAA

Product: holo-(acyl-carrier-protein) synthase

Products: NA

Alternate protein names: Holo-ACP synthase 2; 4'-phosphopantetheinyl transferase AcpS2

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MRIGTDIVEIARITKAIINGEMAFYERVYTSHERLLINPAEPDYERASGFWAAKEALVKAIGCGFRDGVRFQDIEIKHDA
AKAPYFVISGRLQEIFIGQGLQNNSLSISHCRTHAIATVIVY

Sequences:

>Translated_122_residues
MRIGTDIVEIARITKAIINGEMAFYERVYTSHERLLINPAEPDYERASGFWAAKEALVKAIGCGFRDGVRFQDIEIKHDA
AKAPYFVISGRLQEIFIGQGLQNNSLSISHCRTHAIATVIVY
>Mature_122_residues
MRIGTDIVEIARITKAIINGEMAFYERVYTSHERLLINPAEPDYERASGFWAAKEALVKAIGCGFRDGVRFQDIEIKHDA
AKAPYFVISGRLQEIFIGQGLQNNSLSISHCRTHAIATVIVY

Specific function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein. This isozyme may be involved into a specific lipid biosynthetic pathway that also includes Z1545, Z1546 and Z1547

COG id: COG0736

COG function: function code I; Phosphopantetheinyl transferase (holo-ACP synthase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. AcpS family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACPS2_ECO57 (Q8XAN7)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D90789
- PIR:   G85649
- RefSeq:   NP_287048.1
- RefSeq:   NP_309311.1
- ProteinModelPortal:   Q8XAN7
- SMR:   Q8XAN7
- EnsemblBacteria:   EBESCT00000026858
- EnsemblBacteria:   EBESCT00000056934
- GeneID:   912725
- GeneID:   959179
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1544
- KEGG:   ecs:ECs1284
- GeneTree:   EBGT00050000010978
- HOGENOM:   HBG734479
- OMA:   SEIVLCK
- ProtClustDB:   CLSK701257
- BioCyc:   ECOL83334:ECS1284-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00101
- InterPro:   IPR008278
- InterPro:   IPR002582
- InterPro:   IPR004568
- ProDom:   PD004282
- TIGRFAMs:   TIGR00516
- TIGRFAMs:   TIGR00556

Pfam domain/function: PF01648 ACPS; SSF56214 4-PPT_transf

EC number: =2.7.8.7

Molecular weight: Translated: 13685; Mature: 13685

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGTDIVEIARITKAIINGEMAFYERVYTSHERLLINPAEPDYERASGFWAAKEALVKA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCHHHHCCHHHHHHHHHHH
IGCGFRDGVRFQDIEIKHDAAKAPYFVISGRLQEIFIGQGLQNNSLSISHCRTHAIATVI
HCCCCCCCCEEEEEEECCCCCCCCEEEEECCHHHHEECCCCCCCCEEHHHHHHHHEEEEE
VY
EC
>Mature Secondary Structure
MRIGTDIVEIARITKAIINGEMAFYERVYTSHERLLINPAEPDYERASGFWAAKEALVKA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCHHHHCCHHHHHHHHHHH
IGCGFRDGVRFQDIEIKHDAAKAPYFVISGRLQEIFIGQGLQNNSLSISHCRTHAIATVI
HCCCCCCCCEEEEEEECCCCCCCCEEEEECCHHHHEECCCCCCCCEEHHHHHHHHEEEEE
VY
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796