BacMap

Definition	Escherichia coli O157:H7 str. EC4115, complete genome.
Accession	NC_011353
Length	5,572,075

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The map label for this gene is fabG [H]

Identifier: 209396825

GI number: 209396825

Start: 1298131

End: 1298886

Strand: Direct

Name: fabG [H]

Synonym: ECH74115_1284

Alternate gene names: 209396825

Gene position: 1298131-1298886 (Clockwise)

Preceding gene: 209398176

Following gene: 209397474

Centisome position: 23.3

GC content: 51.32

Gene sequence:

>756_bases
ATGTACAAATATAATGATTTAAATGAAAAAACCGTACTGGTGACAGGAGCCAGTGGTGATATTGGACTGGGTATTTGCGA
AAAATATCTGGAGCAGAACTGCGATGTTTATGCGCTCTATAAATCCAACGACGTGCAATTAACGGCGCTGAAAGCAAGCC
ATCCTGCAGGCGATAAACTGCATATTGTGCAGTGCGATCTTGCCTGCCCCCAGAGCGTGAGCGCATTGTGCGAACAGATA
GAGCGCCAAGCTGGCAAGATTGATGTGCTGGTAAATAACGCGGGCATCGTTAAAGACAGCCTGTTTGCCTCGATGAGTTA
TGAGGATTTCACCCAGGTTATCGAAACCAACATGTTCAGCATTTTCCGTCTGACGAAAGACGCGCTGATGCTGCTTCGTG
CGGCAGAAAATCCCGCCATTATTAACGTTGCCTCTATTGCAGCGCTGATCCCAAGCGTCGGTCAGGCGAATTACAGCGCG
TCAAAAGGGGCGATCCTAGGCTTCACCCGCACGCTGGCAGCAGAAATGGCACCCTGGGGCGTGCGCGTCAACGCGGTCGC
ACCGGGAATGATTGAATCGAAAATGGTGAAAAAAGTATCCCGCGCAGTGGTCCGTGCGGTAACCAGTACCATCCCGTTAC
GCCGTCTGGGTAAATGTGAAGAAGTGGCGAACACCATCGTCTTCTTAAGTTCCTCTGCCTCCAGCTACATTGTCGGCCAG
ACCATCGTTATCGATGGCGGCCTGGTCATGCGGTGA

Upstream 100 bases:

>100_bases
ATCGGGCAGGGGTTGCAAAATAACTCCCTGAGTATTTCGCATTGCCGTACCCACGCCATTGCGACTGTCATCGTTTATTA
ACTCAACATATGTGATGAAT

Downstream 100 bases:

>100_bases
TTTATGTCTAAATACACGATTCCTTCGAAAATCTTCCTCGAAATGGGCGGCTGGCGTCAGCCGCTGCTGATGGTCGATAA
AATTGCAGATTATAAATACG

Product: oxidoreductase, short chain dehydrogenase/reductase family

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MYKYNDLNEKTVLVTGASGDIGLGICEKYLEQNCDVYALYKSNDVQLTALKASHPAGDKLHIVQCDLACPQSVSALCEQI
ERQAGKIDVLVNNAGIVKDSLFASMSYEDFTQVIETNMFSIFRLTKDALMLLRAAENPAIINVASIAALIPSVGQANYSA
SKGAILGFTRTLAAEMAPWGVRVNAVAPGMIESKMVKKVSRAVVRAVTSTIPLRRLGKCEEVANTIVFLSSSASSYIVGQ
TIVIDGGLVMR

Sequences:

>Translated_251_residues
MYKYNDLNEKTVLVTGASGDIGLGICEKYLEQNCDVYALYKSNDVQLTALKASHPAGDKLHIVQCDLACPQSVSALCEQI
ERQAGKIDVLVNNAGIVKDSLFASMSYEDFTQVIETNMFSIFRLTKDALMLLRAAENPAIINVASIAALIPSVGQANYSA
SKGAILGFTRTLAAEMAPWGVRVNAVAPGMIESKMVKKVSRAVVRAVTSTIPLRRLGKCEEVANTIVFLSSSASSYIVGQ
TIVIDGGLVMR
>Mature_251_residues
MYKYNDLNEKTVLVTGASGDIGLGICEKYLEQNCDVYALYKSNDVQLTALKASHPAGDKLHIVQCDLACPQSVSALCEQI
ERQAGKIDVLVNNAGIVKDSLFASMSYEDFTQVIETNMFSIFRLTKDALMLLRAAENPAIINVASIAALIPSVGQANYSA
SKGAILGFTRTLAAEMAPWGVRVNAVAPGMIESKMVKKVSRAVVRAVTSTIPLRRLGKCEEVANTIVFLSSSASSYIVGQ
TIVIDGGLVMR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=193, Percent_Identity=38.3419689119171, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=33.59375, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=28.90625, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI59889578, Length=196, Percent_Identity=33.1632653061224, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=27.8225806451613, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=27.734375, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=32.5, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=24.9027237354086, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=29.1497975708502, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=28.9795918367347, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503301, Length=221, Percent_Identity=28.5067873303167, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI66933014, Length=177, Percent_Identity=28.2485875706215, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40548397, Length=204, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI214010158, Length=204, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI214010156, Length=204, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI22758144, Length=204, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=24.6963562753036, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=26.6409266409266, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4504505, Length=206, Percent_Identity=28.6407766990291, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=32.9411764705882, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI119392083, Length=152, Percent_Identity=30.9210526315789, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7657478, Length=204, Percent_Identity=28.4313725490196, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4504503, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7706318, Length=211, Percent_Identity=27.4881516587678, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=26.7379679144385, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=35.6846473029046, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=32.8, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=30.9236947791165, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=30.4878048780488, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=34.1463414634146, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=26.8, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=26.7489711934156, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=29.5081967213115, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=29.9595141700405, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789057, Length=198, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI2367365, Length=238, Percent_Identity=26.890756302521, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=29.8342541436464, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=24.8062015503876, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788891, Length=271, Percent_Identity=26.5682656826568, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=36.7588932806324, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25147288, Length=191, Percent_Identity=37.17277486911, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=32.6530612244898, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=31.6793893129771, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=31.4285714285714, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=30.7116104868914, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=31.640625, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=255, Percent_Identity=30.5882352941176, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=31.9548872180451, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=31.0344827586207, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=193, Percent_Identity=31.6062176165803, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=30.9701492537313, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=29.811320754717, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=30.3846153846154, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508651, Length=199, Percent_Identity=30.1507537688442, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=26.2096774193548, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=257, Percent_Identity=30.3501945525292, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=183, Percent_Identity=31.6939890710383, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=27.6515151515151, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559962, Length=211, Percent_Identity=29.3838862559242, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=257, Percent_Identity=28.7937743190661, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=28.4046692607004, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=30.3370786516854, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559964, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32563809, Length=255, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17507613, Length=255, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=27.8350515463918, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=27.7486910994764, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=30.0380228136882, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72001658, Length=258, Percent_Identity=26.3565891472868, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=181, Percent_Identity=30.3867403314917, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=200, Percent_Identity=26.5, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=27.6679841897233, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=153, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323882, Length=249, Percent_Identity=28.1124497991968, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=36.6935483870968, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=33.6032388663968, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=31.3008130081301, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=31.4516129032258, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=33.2, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=32.8, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=32.3886639676113, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644337, Length=249, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=30.1960784313725, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI116007236, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641388, Length=233, Percent_Identity=29.1845493562232, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221331218, Length=218, Percent_Identity=27.5229357798165, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221331216, Length=219, Percent_Identity=27.3972602739726, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665243, Length=218, Percent_Identity=27.5229357798165, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665247, Length=219, Percent_Identity=27.3972602739726, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI116007238, Length=181, Percent_Identity=28.7292817679558, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584752, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355631, Length=182, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364892, Length=202, Percent_Identity=28.2178217821782, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665264, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571387, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26957; Mature: 26957

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKYNDLNEKTVLVTGASGDIGLGICEKYLEQNCDVYALYKSNDVQLTALKASHPAGDKL
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCEE
HIVQCDLACPQSVSALCEQIERQAGKIDVLVNNAGIVKDSLFASMSYEDFTQVIETNMFS
EEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHH
IFRLTKDALMLLRAAENPAIINVASIAALIPSVGQANYSASKGAILGFTRTLAAEMAPWG
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHCCCCC
VRVNAVAPGMIESKMVKKVSRAVVRAVTSTIPLRRLGKCEEVANTIVFLSSSASSYIVGQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHEEEEEECCCCCEEEEE
TIVIDGGLVMR
EEEEECCEECC
>Mature Secondary Structure
MYKYNDLNEKTVLVTGASGDIGLGICEKYLEQNCDVYALYKSNDVQLTALKASHPAGDKL
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCEE
HIVQCDLACPQSVSALCEQIERQAGKIDVLVNNAGIVKDSLFASMSYEDFTQVIETNMFS
EEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHH
IFRLTKDALMLLRAAENPAIINVASIAALIPSVGQANYSASKGAILGFTRTLAAEMAPWG
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHCCCCC
VRVNAVAPGMIESKMVKKVSRAVVRAVTSTIPLRRLGKCEEVANTIVFLSSSASSYIVGQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHEEEEEECCCCCEEEEE
TIVIDGGLVMR
EEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]