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The map label for this gene is hpmB [H]

Identifier: 209397617

GI number: 209397617

Start: 1296108

End: 1297727

Strand: Direct

Name: hpmB [H]

Synonym: ECH74115_1282

Alternate gene names: 209397617

Gene position: 1296108-1297727 (Clockwise)

Preceding gene: 209399804

Following gene: 209398176

Centisome position: 23.26

GC content: 42.47

Gene sequence:

>1620_bases
ATGCAATTACGATTTAATTTTGGTTTGCTGCTCATTCTTTGTTGTTTTCAGGTTGCAGCGAAAGACAGTCTTGATAATTT
GATCAAGCAGCAAAAAAATGCAGATGAAAGCACGTTGCGCGCGCATAAATTAGAAAAAAAAGATGTTTACTCAAATGCAC
AACGTAATGCGTTTACTCTGGGTGATCTGCCGCAGGAAAAGAATTGCTTTATCATTAATCGGATTGAACTGGAAGATAAC
TTTCTGGGTGGTCAGTTGATTTCTGAAGTGCAAAAAGCGATTGCCGGACGTTGTGTCGGTAGTGCTGGTGTGCAAAAAAT
TGCAGCTGCCTTGCAGGATTATTATATTAATGCGGGATATATCACAACGCGAATTAGTATCCCTTCGCAGGATATTTCTA
AAGGCAAGCTACGTTTCCAGGTTAATGCCGGGAAGATAGAAAAAACGATTGTCGAAGGTAATGATATCAGTGAATGGATG
TTACCTTTTCAGCGTAACGATATTCTCAATATTCGTGATATTGAACAGGGGCTGGAAAATCTTCAGCGAGTACCTGACGT
TGATGTGAAAATTAATATTGAACCGGGAACACGGGATGGTTACAGCATCGTTCATATTGATACACACCGGGGGAAAAACT
GGAGCGTTCGGGCAAGTTACAACAATTGGGGCGATGAAGAAACGGGCCGTTACCAGACAACCTCGGTGGGTTATCTGTTT
AATCCAGCGAAAATGGGGGATCTGTTTTATCTCGCCGGTACGCGTAGTACTACCGGACAGTATGAAAACGTCAGTAGTTA
TTATTCCATTCCGGTGGGGTACTGGGAGTACGGCTTTTTCTATAGCAAAAGTAAATCGCAGCAGGTGATTCCGCTTTCGT
ACATCTCGCTGGATTATGTTGGCATCAGCGAATACTTGAGCGCAAAAGCGACGCATACCGTTTATCGCGATAAAACAAAA
AAGTTCGCCGGTAGTGCAGAACTCATTCGACGAAAGTCGAATTACACGCTTAATGGTGAGGAGCTGACATTACAGGCGCG
GGATATGGGAAATATCAAGCTGGGGCTAAATTATAAGCAACAGTTACCCGGCGCGTTCTGGGATTCAACCCTCTCGTGGC
AACGCTTTTTAACCTGGTTCGGTGGTGAAAAAACGCCGGATATGCAATATGGCGACGTTAGCCCGGTAAGCAATATCTTT
AATTTTGAGGGTAACTATACCCGACAAATAGAGAATGGATATTACAATACCGCTTTTTTTGCCCAGTACGCACCGCGTGA
ACTGACTTTGCAAGATAAAATTACAGTTGGCGATCGTTGGAGTATTCGCGGGTTTGAAAATAGCGTAGGTTTGTCAGGGA
ATGATGGTTTTTATATAAAAAATACGCTGGCATTTCCTTTGCCTGGAATGAAAGCTAATTATTATGCCGGTCTTGATTTT
GGGCAAGTGTATCAGGACGCTTCTTATGGCGATGAATCACTGGTGGGCTCGGCAGTTGGTATTGATGGAAACATTAAAAG
TCTTGAGTATAACTTTTCCGTTTCTACCCCATTAAAGTATCCGGCGACATTAGATATTGATCGGGTGAATGTAAATTTTA
ATTTTTCGTACCAAATGTAA

Upstream 100 bases:

>100_bases
GTCGGCATGTAAGATGTAACCAAAGACAGCAGTGGCTTTTAATATTAATGCGTCATGTCACGCAGGGGTTGCTGCTGTCT
TTATTTAGTTTGAGAAGATA

Downstream 100 bases:

>100_bases
AGGATAACGAGACTCATGAGAATAGGGACAGATATTGTTGAAATTGCCAGAATAACCAAAGCCATTATTAATGGAGAGAT
GGCTTTTTATGAGCGTGTTT

Product: hemolysin activator-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTLGDLPQEKNCFIINRIELEDN
FLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGYITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWM
LPFQRNDILNIRDIEQGLENLQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYVGISEYLSAKATHTVYRDKTK
KFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQQLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIF
NFEGNYTRQIENGYYNTAFFAQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM

Sequences:

>Translated_539_residues
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTLGDLPQEKNCFIINRIELEDN
FLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGYITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWM
LPFQRNDILNIRDIEQGLENLQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYVGISEYLSAKATHTVYRDKTK
KFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQQLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIF
NFEGNYTRQIENGYYNTAFFAQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM
>Mature_539_residues
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTLGDLPQEKNCFIINRIELEDN
FLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGYITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWM
LPFQRNDILNIRDIEQGLENLQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYVGISEYLSAKATHTVYRDKTK
KFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQQLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIF
NFEGNYTRQIENGYYNTAFFAQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM

Specific function: Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 60958; Mature: 60958

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTL
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHCCCCCCEEEE
GDLPQEKNCFIINRIELEDNFLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGY
CCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCE
ITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWMLPFQRNDILNIRDIEQGLEN
EEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHH
LQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEE
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYV
CCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCEEECEEEECCCCCEEEEEEEEEEEEE
GISEYLSAKATHTVYRDKTKKFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQ
CHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCCEEEEEECCCCCEEEECCHHH
QLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIFNFEGNYTRQIENGYYNTAFF
HCCCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCEECEEEE
AQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
EECCCCEEEEECEEEECCEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCH
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM
HHHHCCCCCCCHHHCCEEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEEEEEECC
>Mature Secondary Structure
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTL
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHCCCCCCEEEE
GDLPQEKNCFIINRIELEDNFLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGY
CCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCE
ITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWMLPFQRNDILNIRDIEQGLEN
EEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHH
LQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEE
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYV
CCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCEEECEEEECCCCCEEEEEEEEEEEEE
GISEYLSAKATHTVYRDKTKKFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQ
CHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCCEEEEEECCCCCEEEECCHHH
QLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIFNFEGNYTRQIENGYYNTAFF
HCCCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCEECEEEE
AQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
EECCCCEEEEECEEEECCEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCH
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM
HHHHCCCCCCCHHHCCEEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2407716 [H]