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The map label for this gene is dmsA [H]

Identifier: 209395905

GI number: 209395905

Start: 3467557

End: 3469938

Strand: Reverse

Name: dmsA [H]

Synonym: ECH74115_3747

Alternate gene names: 209395905

Gene position: 3469938-3467557 (Counterclockwise)

Preceding gene: 209396651

Following gene: 209397819

Centisome position: 62.27

GC content: 50.0

Gene sequence:

>2382_bases
ATGGATACGCCAGACGAAAAGGAACGCATTACATTTCCGCAAGTATCACGACGTAGTTTTTTACAAGCGACTTCCGCGCT
TATCACTTTGCCTTTTATTTCTTCTACCGCAAAGGCGCAATCCCCAGATGCGTCGCCAGAAGTTACAGCTCCAGTAGCTG
ATAAAGTCGTGCCCACCTGTAGCACATTTGACTGCGGTGGTAAGTGCGATATTCGGGCGCATATGCGCGACGGCGTGGTG
ACGCAAATTACCACGCTTCCCGATAACGAATTGGATCCACAAATGCCGATTATGCGCGCCTGTGTTCGTGGTCGCGGCTA
TCGTAAATTTGTTTATCATCCAGACCGTTTGAAATATCCGATGAAGCGGGTAGGTAAACGAGGCGAGGGTAAATTTGAGC
GTATCTCATGGGATGAGGCGACGACCTTAATTGCCGATAACCTGAAAAGGATCACGCAACAATATGGCCCAGCTTCACGT
TATGTCCATGTCGGGACGGCTGTTTCTGGTGGAACATTTTCTGGCGATGCGATGGCGCGTCGGCTGTTAAATTTAACCGG
TGGTTATCTTGAATATTATCACTCAGTTAGTCTGGGTAATACTGCGGCGGCCACGCCTTACACGTATGGCGTGGCCGCGA
GCGGTAACTCGATGGATACTCTTCTGGATACCAAACTGGTGATTCTCTGGGGGCATAACCCAACGGAAACCATATTCGGT
CACACCAATTACTATTTTCAAAAAATGAAGCAAAACGGTACACGTTTTATCGTGGTGGATCCGCGCTATTCCGACACCGT
ATCTTCACTTGCCGATCAGTGGATCCCGCTGTTGCCGACCACGGACAATGCGTTGATGGACGCGATGATGTACGTCATTA
TCAGCGAGAATCTCCACGATAAGACATTTATCGACACATATACTCTCGGTTTTGATGAAAACTCCATGCCGGAAGGCGTA
CCAGCCAACGAATCGTTGGTTGCCTACCTTTTTGGCGCAAAAGATGGGATACACAAAACGCCGGAATGGGCAGAAAAAAT
TACCCACGTTCCAGCACAATCCATTCGTCAACTGGCACGCGATTACGCCACTACAAAACCCGCAGCGTTGATTCAGGGAT
GGGGGCCACAGCGACATATTTGCGGCGAACGCACCGCCCGAGGTTCAACTTTACTGGCCTCGATTACCGGTAACGTCGGC
ATCAAAGGTGGCTGGGCGGCAGGTTACGGCGGTAGTTCTAATCGTAAATTCTGCGTTGGACCAGATATGCCAGAAAATCC
GGTACAAGCGAAAATCTCGATTATGAACTGGATGCAGGCGGCGGATGATGCTTCTAAAGTTACGCCGCAAGATGGGCTTA
AAGGTGTCGATAAACTCGACAGTAATATCCGCCTGCTGTTCTCACTGGCAGGTAATTATCTGGCGAACCAGAACCCGGAC
GTCCACCAGGCCGCGAAGCTCCTTGAAGACGAATCTAAAATAGAATTCATCGTACTCAGCGATCTGTTCATGACTCCGAG
CGCGAAATATGCCGATGTGTTGCTGCCGGAAACCAGCTTTATGGAACGCTGGAATATCGGCGAAACATGGGGAACTGCGA
GCTATCTTATTCTGTCAGAAAAACCGATTGAGCCGGATTTTGAACGTCGCACCGATTATGACTGGTTGCGTGACGTGGCG
AAAAAACTGGGTGTCGAAGCCGAGTTCAGTCAAGGACGTGATGAGAAGCAATGGATCGAGCATATCTGGGAGCAAACTCG
TCTGGCGATGCCGGATGAAAATTTGCCGGACTTCGCAACCCTGCAAAAAACACGTCGACATCTTTTCAAAAGCGCGCCGC
ACATCGCTTTCGAAGCAAATATTCGCGATCCGCAGAATAATCCTTTCCCGACGCCTTCCGGCAAAATTGAGATCTTCTCT
AAGCGTCTTTTTGATATGCAAGATCCAGAAATTCCCGCGCTTTCGCACTATGTCCCTGCCTTTGAAGGGCCAGAAGATAA
ACTGACGGCGAAATACCCGTTGCAGCTCATCACCTGGAAAGGGAAAAACCGTGCTAATTCCACCCAGTATGCTAACCCGT
GGCTGCAAGAAGTTCAGACGCAAAAACTCTGGCTGAATCCGCAAGATGCAAAACAGCGCGGGATTAGCGAAGGAGATAGC
GTAAAAATTTATAACGATCGTGGTGTGAGCATTATCCCGGTGGAAATAACCCCCCGTATCATCCCTGGCGTAGTTGCTAT
GCAGGCGGGGGCATGGTGGCAACCGGATGCACAAGGTATCGATCGCGGAGGCTGTGCCAATGTACTGAGTTCGACCCGCA
TTACGGCGCTGGCGAAAGGGAATTCGCATCAAACAATGCTGGTGGAGGTTGAGAAAGCATGA

Upstream 100 bases:

>100_bases
TAATCTCACGTTTTTTTAAACGACTAATTATTTGATTGTTATCAGCATTGTTCTCGAATAAATACGTGAATATTTATTTT
TTCATTTTCGGGAACGCAAG

Downstream 100 bases:

>100_bases
GCCAATTTAAAGAATTTGCATCTGTCAGCGACAAACAATTAGGGTTCTTTATTGACTCTTCGCGTTGTTCGGGCTGTAAA
GCGTGTCAGGTGGCCTGTAA

Product: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MDTPDEKERITFPQVSRRSFLQATSALITLPFISSTAKAQSPDASPEVTAPVADKVVPTCSTFDCGGKCDIRAHMRDGVV
TQITTLPDNELDPQMPIMRACVRGRGYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKRITQQYGPASR
YVHVGTAVSGGTFSGDAMARRLLNLTGGYLEYYHSVSLGNTAAATPYTYGVAASGNSMDTLLDTKLVILWGHNPTETIFG
HTNYYFQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDKTFIDTYTLGFDENSMPEGV
PANESLVAYLFGAKDGIHKTPEWAEKITHVPAQSIRQLARDYATTKPAALIQGWGPQRHICGERTARGSTLLASITGNVG
IKGGWAAGYGGSSNRKFCVGPDMPENPVQAKISIMNWMQAADDASKVTPQDGLKGVDKLDSNIRLLFSLAGNYLANQNPD
VHQAAKLLEDESKIEFIVLSDLFMTPSAKYADVLLPETSFMERWNIGETWGTASYLILSEKPIEPDFERRTDYDWLRDVA
KKLGVEAEFSQGRDEKQWIEHIWEQTRLAMPDENLPDFATLQKTRRHLFKSAPHIAFEANIRDPQNNPFPTPSGKIEIFS
KRLFDMQDPEIPALSHYVPAFEGPEDKLTAKYPLQLITWKGKNRANSTQYANPWLQEVQTQKLWLNPQDAKQRGISEGDS
VKIYNDRGVSIIPVEITPRIIPGVVAMQAGAWWQPDAQGIDRGGCANVLSSTRITALAKGNSHQTMLVEVEKA

Sequences:

>Translated_793_residues
MDTPDEKERITFPQVSRRSFLQATSALITLPFISSTAKAQSPDASPEVTAPVADKVVPTCSTFDCGGKCDIRAHMRDGVV
TQITTLPDNELDPQMPIMRACVRGRGYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKRITQQYGPASR
YVHVGTAVSGGTFSGDAMARRLLNLTGGYLEYYHSVSLGNTAAATPYTYGVAASGNSMDTLLDTKLVILWGHNPTETIFG
HTNYYFQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDKTFIDTYTLGFDENSMPEGV
PANESLVAYLFGAKDGIHKTPEWAEKITHVPAQSIRQLARDYATTKPAALIQGWGPQRHICGERTARGSTLLASITGNVG
IKGGWAAGYGGSSNRKFCVGPDMPENPVQAKISIMNWMQAADDASKVTPQDGLKGVDKLDSNIRLLFSLAGNYLANQNPD
VHQAAKLLEDESKIEFIVLSDLFMTPSAKYADVLLPETSFMERWNIGETWGTASYLILSEKPIEPDFERRTDYDWLRDVA
KKLGVEAEFSQGRDEKQWIEHIWEQTRLAMPDENLPDFATLQKTRRHLFKSAPHIAFEANIRDPQNNPFPTPSGKIEIFS
KRLFDMQDPEIPALSHYVPAFEGPEDKLTAKYPLQLITWKGKNRANSTQYANPWLQEVQTQKLWLNPQDAKQRGISEGDS
VKIYNDRGVSIIPVEITPRIIPGVVAMQAGAWWQPDAQGIDRGGCANVLSSTRITALAKGNSHQTMLVEVEKA
>Mature_793_residues
MDTPDEKERITFPQVSRRSFLQATSALITLPFISSTAKAQSPDASPEVTAPVADKVVPTCSTFDCGGKCDIRAHMRDGVV
TQITTLPDNELDPQMPIMRACVRGRGYRKFVYHPDRLKYPMKRVGKRGEGKFERISWDEATTLIADNLKRITQQYGPASR
YVHVGTAVSGGTFSGDAMARRLLNLTGGYLEYYHSVSLGNTAAATPYTYGVAASGNSMDTLLDTKLVILWGHNPTETIFG
HTNYYFQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHDKTFIDTYTLGFDENSMPEGV
PANESLVAYLFGAKDGIHKTPEWAEKITHVPAQSIRQLARDYATTKPAALIQGWGPQRHICGERTARGSTLLASITGNVG
IKGGWAAGYGGSSNRKFCVGPDMPENPVQAKISIMNWMQAADDASKVTPQDGLKGVDKLDSNIRLLFSLAGNYLANQNPD
VHQAAKLLEDESKIEFIVLSDLFMTPSAKYADVLLPETSFMERWNIGETWGTASYLILSEKPIEPDFERRTDYDWLRDVA
KKLGVEAEFSQGRDEKQWIEHIWEQTRLAMPDENLPDFATLQKTRRHLFKSAPHIAFEANIRDPQNNPFPTPSGKIEIFS
KRLFDMQDPEIPALSHYVPAFEGPEDKLTAKYPLQLITWKGKNRANSTQYANPWLQEVQTQKLWLNPQDAKQRGISEGDS
VKIYNDRGVSIIPVEITPRIIPGVVAMQAGAWWQPDAQGIDRGGCANVLSSTRITALAKGNSHQTMLVEVEKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=815, Percent_Identity=43.1901840490798, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=809, Percent_Identity=42.7688504326329, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1787870, Length=813, Percent_Identity=39.9753997539975, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI145693196, Length=741, Percent_Identity=29.4197031039136, Blast_Score=265, Evalue=1e-71,
Organism=Escherichia coli, GI1787231, Length=790, Percent_Identity=27.8481012658228, Blast_Score=249, Evalue=7e-67,
Organism=Escherichia coli, GI87081994, Length=737, Percent_Identity=29.4436906377205, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI3868721, Length=721, Percent_Identity=26.0748959778086, Blast_Score=173, Evalue=5e-44,
Organism=Escherichia coli, GI3868720, Length=459, Percent_Identity=23.7472766884532, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1787741, Length=281, Percent_Identity=27.7580071174377, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI3868719, Length=457, Percent_Identity=22.9759299781182, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 88323; Mature: 88323

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPDEKERITFPQVSRRSFLQATSALITLPFISSTAKAQSPDASPEVTAPVADKVVPTC
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCC
STFDCGGKCDIRAHMRDGVVTQITTLPDNELDPQMPIMRACVRGRGYRKFVYHPDRLKYP
CCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHCCH
MKRVGKRGEGKFERISWDEATTLIADNLKRITQQYGPASRYVHVGTAVSGGTFSGDAMAR
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHH
RLLNLTGGYLEYYHSVSLGNTAAATPYTYGVAASGNSMDTLLDTKLVILWGHNPTETIFG
HHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHEECCEEEEEECCCCCCCEEC
HTNYYFQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHD
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCCCC
KTFIDTYTLGFDENSMPEGVPANESLVAYLFGAKDGIHKTPEWAEKITHVPAQSIRQLAR
CEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHH
DYATTKPAALIQGWGPQRHICGERTARGSTLLASITGNVGIKGGWAAGYGGSSNRKFCVG
HHCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCEEEEC
PDMPENPVQAKISIMNWMQAADDASKVTPQDGLKGVDKLDSNIRLLFSLAGNYLANQNPD
CCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHCCCHHHHCCCCEEHHHHHCCHHCCCCCC
VHQAAKLLEDESKIEFIVLSDLFMTPSAKYADVLLPETSFMERWNIGETWGTASYLILSE
HHHHHHHHCCCCCEEEEEEECHHCCCCCCCCEEECCCHHHHHHCCCCCCCCCEEEEEEEC
KPIEPDFERRTDYDWLRDVAKKLGVEAEFSQGRDEKQWIEHIWEQTRLAMPDENLPDFAT
CCCCCCHHHCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHEECCCCCCCCCHHH
LQKTRRHLFKSAPHIAFEANIRDPQNNPFPTPSGKIEIFSKRLFDMQDPEIPALSHYVPA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCHHHCCCC
FEGPEDKLTAKYPLQLITWKGKNRANSTQYANPWLQEVQTQKLWLNPQDAKQRGISEGDS
CCCCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHCCCCCCCC
VKIYNDRGVSIIPVEITPRIIPGVVAMQAGAWWQPDAQGIDRGGCANVLSSTRITALAKG
EEEECCCCCEEEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHHCCEEEEEECC
NSHQTMLVEVEKA
CCCCEEEEEEECC
>Mature Secondary Structure
MDTPDEKERITFPQVSRRSFLQATSALITLPFISSTAKAQSPDASPEVTAPVADKVVPTC
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCC
STFDCGGKCDIRAHMRDGVVTQITTLPDNELDPQMPIMRACVRGRGYRKFVYHPDRLKYP
CCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHCCH
MKRVGKRGEGKFERISWDEATTLIADNLKRITQQYGPASRYVHVGTAVSGGTFSGDAMAR
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHH
RLLNLTGGYLEYYHSVSLGNTAAATPYTYGVAASGNSMDTLLDTKLVILWGHNPTETIFG
HHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHEECCEEEEEECCCCCCCEEC
HTNYYFQKMKQNGTRFIVVDPRYSDTVSSLADQWIPLLPTTDNALMDAMMYVIISENLHD
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCCCC
KTFIDTYTLGFDENSMPEGVPANESLVAYLFGAKDGIHKTPEWAEKITHVPAQSIRQLAR
CEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHH
DYATTKPAALIQGWGPQRHICGERTARGSTLLASITGNVGIKGGWAAGYGGSSNRKFCVG
HHCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCEEEEC
PDMPENPVQAKISIMNWMQAADDASKVTPQDGLKGVDKLDSNIRLLFSLAGNYLANQNPD
CCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHCCCHHHHCCCCEEHHHHHCCHHCCCCCC
VHQAAKLLEDESKIEFIVLSDLFMTPSAKYADVLLPETSFMERWNIGETWGTASYLILSE
HHHHHHHHCCCCCEEEEEEECHHCCCCCCCCEEECCCHHHHHHCCCCCCCCCEEEEEEEC
KPIEPDFERRTDYDWLRDVAKKLGVEAEFSQGRDEKQWIEHIWEQTRLAMPDENLPDFAT
CCCCCCHHHCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHEECCCCCCCCCHHH
LQKTRRHLFKSAPHIAFEANIRDPQNNPFPTPSGKIEIFSKRLFDMQDPEIPALSHYVPA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCHHHCCCC
FEGPEDKLTAKYPLQLITWKGKNRANSTQYANPWLQEVQTQKLWLNPQDAKQRGISEGDS
CCCCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHCCCCCCCC
VKIYNDRGVSIIPVEITPRIIPGVVAMQAGAWWQPDAQGIDRGGCANVLSSTRITALAKG
EEEECCCCCEEEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHHCCEEEEEECC
NSHQTMLVEVEKA
CCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]