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The map label for this gene is Cdd [H]

Identifier: 20806970

GI number: 20806970

Start: 475646

End: 476053

Strand: Direct

Name: Cdd [H]

Synonym: TTE0462

Alternate gene names: 20806970

Gene position: 475646-476053 (Clockwise)

Preceding gene: 20806969

Following gene: 20806971

Centisome position: 17.69

GC content: 41.42

Gene sequence:

>408_bases
ATGGAGTACAGGGACTATGAAAAACTAATAGAAATTGCAAAAGAAGCGAGGGAAAATGCTTACGCTCCTTACTCTAATTT
TAAAGTAGGAGCTTGTGTGCTTACGGAAGATGGAAATATATACAAAGGATGTAACATTGAAAATGCATCTTTTGGTCTTA
CTGTGTGCGCAGAAAGGGTTGCCATGTTTAACGCCTATAGCGGAGGGGAAAGGAAGCTTAAAGCTATTGCCGTTGTAGCC
GATACTGATGGACCTGTTTCGCCTTGTGGTGCTTGCAGGCAAGTTATGATGGAACTGGGCGGAGAAGATATGGTCGTTAT
ATTGAGCAATATGAAGGGTGACCATGCGATAATGACTGTAAGAGATTTATTGCCAGGAGCTTTCACATCTAAAGATATGG
AAAAGTAG

Upstream 100 bases:

>100_bases
AAAATAACACGCCAATTTTGTTTTCGTCAAATTATTTTAATGCCTCTAAATTTGACTTTTACATTGTCAGAAAAAGAACA
TTGTGAAAGTAGGTGTGTAA

Downstream 100 bases:

>100_bases
TAATTCTATACTAACAAAAGAGGTGGTAAAATGCTGCAAAGAGTTATACTTATAGTCCTGGATAGCGTCGGAGTAGGGGA
ACTTCCAGACGCGTACAAGT

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MEYRDYEKLIEIAKEARENAYAPYSNFKVGACVLTEDGNIYKGCNIENASFGLTVCAERVAMFNAYSGGERKLKAIAVVA
DTDGPVSPCGACRQVMMELGGEDMVVILSNMKGDHAIMTVRDLLPGAFTSKDMEK

Sequences:

>Translated_135_residues
MEYRDYEKLIEIAKEARENAYAPYSNFKVGACVLTEDGNIYKGCNIENASFGLTVCAERVAMFNAYSGGERKLKAIAVVA
DTDGPVSPCGACRQVMMELGGEDMVVILSNMKGDHAIMTVRDLLPGAFTSKDMEK
>Mature_135_residues
MEYRDYEKLIEIAKEARENAYAPYSNFKVGACVLTEDGNIYKGCNIENASFGLTVCAERVAMFNAYSGGERKLKAIAVVA
DTDGPVSPCGACRQVMMELGGEDMVVILSNMKGDHAIMTVRDLLPGAFTSKDMEK

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=130, Percent_Identity=46.9230769230769, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1788465, Length=115, Percent_Identity=41.7391304347826, Blast_Score=70, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551074, Length=129, Percent_Identity=48.8372093023256, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540514, Length=128, Percent_Identity=46.09375, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323274, Length=131, Percent_Identity=40.4580152671756, Blast_Score=97, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24582741, Length=128, Percent_Identity=44.53125, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24582744, Length=141, Percent_Identity=41.1347517730496, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920920, Length=138, Percent_Identity=35.5072463768116, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 14731; Mature: 14731

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
9.6 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
9.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRDYEKLIEIAKEARENAYAPYSNFKVGACVLTEDGNIYKGCNIENASFGLTVCAERV
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHH
AMFNAYSGGERKLKAIAVVADTDGPVSPCGACRQVMMELGGEDMVVILSNMKGDHAIMTV
HHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHEEEH
RDLLPGAFTSKDMEK
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MEYRDYEKLIEIAKEARENAYAPYSNFKVGACVLTEDGNIYKGCNIENASFGLTVCAERV
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHH
AMFNAYSGGERKLKAIAVVADTDGPVSPCGACRQVMMELGGEDMVVILSNMKGDHAIMTV
HHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHEEEH
RDLLPGAFTSKDMEK
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11739901 [H]