Click here to switch to the map view.

The map label for this gene is MtlA [H]

Identifier: 20806856

GI number: 20806856

Start: 359186

End: 360619

Strand: Direct

Name: MtlA [H]

Synonym: TTE0339

Alternate gene names: 20806856

Gene position: 359186-360619 (Clockwise)

Preceding gene: 20806855

Following gene: 20806857

Centisome position: 13.36

GC content: 43.44

Gene sequence:

>1434_bases
ATGCAAAATGTGAATGCGATTACTACAAAAGGTGGAAGCCTAAGAGTAAAATTACAGAGACTGGGTGGCTTCTTGGCAGG
AATGGTAATACCTAATATTGGCGCATTTATAGCATGGGGACTTATCACTGCATTCTTTATACCGACAGGATGGGTTCCGA
ATGAACACTTAGCTAAGTTGGTCGGTCCCATGATAATGTACCTCTTGCCTATATTGATAGGTTATACAGGCGGTAAACTT
GTATATGATGTAAGAGGTGGAGTTGTTGGAGCCGTTGCCACGGCTGGTGTAGCTATAGGTTCTTCTGTTCCAATGTTCAT
CGGTGCTATGATAATGGGACCACTGGGTGGTTATGTAATCAAAAAATTTGACGAAGCGGTGGAAGGCAAAGTACCAGCCG
GATTTGAAATGCTTGTGAACAACTTCTCAGCAGGAATTTTAGGAGGAATTTTGGCAATTTTAGCATTTTTATTTGTAGAG
CCTGTTATGAACGCTATCTCACTTGGACTTGGAGCTGCAGCTCAGTGGGTTACGGACAAAGGATTACTTCCTTTGATAGC
ATTGTTTATTGAACCCGGAAAGGTTCTCTTCCTGAATAATGCCATAAACCATGGTATATTGGCTCCTCTTGGAGTAGCCC
AGGTAAAAGAATTTGGAAAGTCTATATTCTTCCTTCTTGAAACAAACCCAGGCCCAGGTTTGGGAGTGCTTTTGGCATAC
TGGCTCTTTGGAAAGGGAGACGCAAAACAGTCAGCTCCTGGCGCCATAATAATCCAGTTCTTTGGTGGAATACATGAAAT
ATACTTCCCGTATGTTTTAATGAACCCTGCATTGCTTCTCGCTGTCATAGGCGGCGGAATGGCTGCAGATGCAACATTTG
TTCTCACAAAAGCAGGACTTGTGGCAACTCCTTCACCTGGCAGCATATTTGCAGAAATAGCTATGGCTCCAAAAGGCGGA
TTACTTCCTGTACTTGCAGGTATAGCAGTAGGAGCTCTGGTTTCCTTCTTGATAGCTTCACCTATTGTAAAGAGGGCAAG
CGAAGAGAGCATGTCAGCTGAAAGCATGAGCTTTGCACGTTCAATAGTAAGTGGTCTCAAGGCCCAGAGCAAGGGCGAAA
AAGTTGAAATGCCAAAAGCAGAAGTGAAAATGGATACACTTCCCAAACTCATAGTTTTTGCCTGCGATGCAGGTATGGGT
TCTTCAGCTATGGGAGAAACTATCTTGAGAAAGAAGCTCAAAGAAGCCGGTTTTGACATACAGGTGAAGCACTCAGCTGT
AAATCAGATACCAAAAGAAGCGGATGTAGTATTCACACAGGAGAATCTGGCAGAAAGAGCAGCCCAGGTTGTGCCCCATG
CTAAGATTGTGACAGTGAAGAATTTCCTTGACAATACCGTGTATGACGAATTTGTAAAAAGCCTTAGAAAATAG

Upstream 100 bases:

>100_bases
AGAAAACGAATGACAAGACTGAGTTTCTTTTAATTGCATAAAAAAAGAAGGGGGATTACAATATAGTTAAAGAAGTTTTT
GAAAGAAGGAGGGAAAAGGT

Downstream 100 bases:

>100_bases
CTGATGGTGAAAGCCATGGAAGATTTGAGTGTAAGGCAGAAGTTTATCCTTAAAAATTTAATAGAAAAGGGACCATTTGA
AATAGCTGACCTTGCCAATC

Product: phosphotransferase system, mannitol-specific IIBC component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MQNVNAITTKGGSLRVKLQRLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWVPNEHLAKLVGPMIMYLLPILIGYTGGKL
VYDVRGGVVGAVATAGVAIGSSVPMFIGAMIMGPLGGYVIKKFDEAVEGKVPAGFEMLVNNFSAGILGGILAILAFLFVE
PVMNAISLGLGAAAQWVTDKGLLPLIALFIEPGKVLFLNNAINHGILAPLGVAQVKEFGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIQFFGGIHEIYFPYVLMNPALLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMAPKGG
LLPVLAGIAVGALVSFLIASPIVKRASEESMSAESMSFARSIVSGLKAQSKGEKVEMPKAEVKMDTLPKLIVFACDAGMG
SSAMGETILRKKLKEAGFDIQVKHSAVNQIPKEADVVFTQENLAERAAQVVPHAKIVTVKNFLDNTVYDEFVKSLRK

Sequences:

>Translated_477_residues
MQNVNAITTKGGSLRVKLQRLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWVPNEHLAKLVGPMIMYLLPILIGYTGGKL
VYDVRGGVVGAVATAGVAIGSSVPMFIGAMIMGPLGGYVIKKFDEAVEGKVPAGFEMLVNNFSAGILGGILAILAFLFVE
PVMNAISLGLGAAAQWVTDKGLLPLIALFIEPGKVLFLNNAINHGILAPLGVAQVKEFGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIQFFGGIHEIYFPYVLMNPALLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMAPKGG
LLPVLAGIAVGALVSFLIASPIVKRASEESMSAESMSFARSIVSGLKAQSKGEKVEMPKAEVKMDTLPKLIVFACDAGMG
SSAMGETILRKKLKEAGFDIQVKHSAVNQIPKEADVVFTQENLAERAAQVVPHAKIVTVKNFLDNTVYDEFVKSLRK
>Mature_477_residues
MQNVNAITTKGGSLRVKLQRLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWVPNEHLAKLVGPMIMYLLPILIGYTGGKL
VYDVRGGVVGAVATAGVAIGSSVPMFIGAMIMGPLGGYVIKKFDEAVEGKVPAGFEMLVNNFSAGILGGILAILAFLFVE
PVMNAISLGLGAAAQWVTDKGLLPLIALFIEPGKVLFLNNAINHGILAPLGVAQVKEFGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIQFFGGIHEIYFPYVLMNPALLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMAPKGG
LLPVLAGIAVGALVSFLIASPIVKRASEESMSAESMSFARSIVSGLKAQSKGEKVEMPKAEVKMDTLPKLIVFACDAGMG
SSAMGETILRKKLKEAGFDIQVKHSAVNQIPKEADVVFTQENLAERAAQVVPHAKIVTVKNFLDNTVYDEFVKSLRK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=465, Percent_Identity=55.0537634408602, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1789301, Length=464, Percent_Identity=51.2931034482759, Blast_Score=454, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 50055; Mature: 50055

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVNAITTKGGSLRVKLQRLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWVPNEHLAKL
CCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGPMIMYLLPILIGYTGGKLVYDVRGGVVGAVATAGVAIGSSVPMFIGAMIMGPLGGYVI
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KKFDEAVEGKVPAGFEMLVNNFSAGILGGILAILAFLFVEPVMNAISLGLGAAAQWVTDK
HHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
GLLPLIALFIEPGKVLFLNNAINHGILAPLGVAQVKEFGKSIFFLLETNPGPGLGVLLAY
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHH
WLFGKGDAKQSAPGAIIIQFFGGIHEIYFPYVLMNPALLLAVIGGGMAADATFVLTKAGL
HHHCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCE
VATPSPGSIFAEIAMAPKGGLLPVLAGIAVGALVSFLIASPIVKRASEESMSAESMSFAR
EECCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVSGLKAQSKGEKVEMPKAEVKMDTLPKLIVFACDAGMGSSAMGETILRKKLKEAGFDI
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCE
QVKHSAVNQIPKEADVVFTQENLAERAAQVVPHAKIVTVKNFLDNTVYDEFVKSLRK
EEEHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNVNAITTKGGSLRVKLQRLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWVPNEHLAKL
CCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGPMIMYLLPILIGYTGGKLVYDVRGGVVGAVATAGVAIGSSVPMFIGAMIMGPLGGYVI
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KKFDEAVEGKVPAGFEMLVNNFSAGILGGILAILAFLFVEPVMNAISLGLGAAAQWVTDK
HHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
GLLPLIALFIEPGKVLFLNNAINHGILAPLGVAQVKEFGKSIFFLLETNPGPGLGVLLAY
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHH
WLFGKGDAKQSAPGAIIIQFFGGIHEIYFPYVLMNPALLLAVIGGGMAADATFVLTKAGL
HHHCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCE
VATPSPGSIFAEIAMAPKGGLLPVLAGIAVGALVSFLIASPIVKRASEESMSAESMSFAR
EECCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVSGLKAQSKGEKVEMPKAEVKMDTLPKLIVFACDAGMGSSAMGETILRKKLKEAGFDI
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCE
QVKHSAVNQIPKEADVVFTQENLAERAAQVVPHAKIVTVKNFLDNTVYDEFVKSLRK
EEEHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160802; 11466286 [H]