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The map label for this gene is 20094663

Identifier: 20094663

GI number: 20094663

Start: 1211864

End: 1213822

Strand: Reverse

Name: 20094663

Synonym: MK1227

Alternate gene names: NA

Gene position: 1213822-1211864 (Counterclockwise)

Preceding gene: 20094664

Following gene: 20094662

Centisome position: 71.61

GC content: 62.79

Gene sequence:

>1959_bases
TTGAGCGAGCGAAGAGGCGGCGAAAAGACGTTGGAAGAGGTCAAAAAGAAGGTCATGGAGAGAGTCGAGGAAGTGCTGCC
TTCGGACGTCGTCGTGACCGACGTAGACTTCGAAGGTCCCGAGGTCGTCCTGTACACCAACTCACCGCACTCCTTCGTCA
AGGACGATTCGGACCTGGTCACGAGATTGGCTAAAGCCCTGAGGAAACGTGTCAAGATAAGACCTAATCCCGCCGCGCTC
TCCCCGGCCAAGGAGGCCAAGAAGGTCATCCTGAAGATCATCCCGGAGGAGGCCGGGGTCAGCGAACGGGACCTGCTGTT
CCTGGACACCGGAGAGGTAGTGATCTTCTCGAAGAAACCCGGACTGGTGATCGGCAAGCGCGGGAAGAACGTGCACAGGA
TCTCCCGGGATACCGGCTGGGTACCGCGGATCTACAGGCAACCACCGATCCCGTCGAAGACCGTGAACACGACACGCCGA
CTGATACTCTCGGACGACTCGCGCCGCAAGTTCCTGAGGAACGTCAGCGCCCGGATCTTCTGCGGTCGAACGCGGAGCCG
CGGCACCGAGTCACGGTGGGCCCGGGTCAGCGCCTTGGGAGGCTTCCAGGAGGTCGGACGCTCCTCACTGTTCCTACACA
CCGAGGAGAGCCGCGTGCTCCTGGACTGCGGTGTGAACGTGGCCGCGAACGGTACGGACGCCTATCCGCACTTCAACGTC
CCGGAGTTCCGTATGGACGACCTCGACGCGATCGTGATCACGCACGCACACCTGGACCACTGCGGCTTCCTGCCGTACTT
CTACCGACACAAGGTCATCGAGAGCCGGGTCCCGGTCTACTGCACGCCGCCGACCCGCGACCTCATGTACCTGCTCTTGA
CGGACTACATCAAGGTCCTCGAGAAGCGCGGCCAGGAGCCCCCGTACACCGAGAAGGACGTCAAGAAGGTCATCAAGCGC
ACGATCACGATCGACTACCGGGAGCCCACCGACATCACGCCCGACATGAGCATCACCTTCTACAACGCCGGACACATCCT
GGGATCGGCCTCCGTGCACGTGTTCCTCCAGGACAAGGGCCACAACTTCGTGTACACGGGCGACATCAACCCGACCCCGT
CCCGGTTGCTCGAGGGCGCGGACAACCGGTTCAAGCGGGTCGACTCGATGGTCGTCGAGGCCACCTACGGTGACTCGCGA
CACGGGAGCCGTCGTAAGGAGGAGAACCGGTTCAGGAAGATCGTGCGGGACACGCTGAAGAAGGGCGGTAAGGTGCTCAT
ACCGTCCTTCGCCGTCGGACGCGCCCAGGAGGTCATGCTCGTCCTGGAGGACATGCACCGCAAGGACGAGCTCGAGGGCC
CGGTGTACTTGGACGGTATGATTTACGAGGCGACGGCCATCCACACGGCGTACCCGGAGTACCTCAACCGCCGCCTGCAG
CACAGGATCCTACACGAGGACGACGACCCGTTCACCTCGGAAGTCTTCGAGCCCGTGGAGGGCTCGGACCACCGCCAGGC
GATCATGGAGGACGACGAACCCGCGGTCATCCTCTCGACCTCGGGTATGCTCGAGGGGGGCCCGATCCTGGAGTACCTGC
GCGAGCTCTCCGACGATCCCAAGAACACGCTGATCTTCGTGGGTTACCAGGCCGAGGGCACGCTCGGAAGGCAGATCCAG
GAGGGTGCCAAGGAGGTCCCGCTGCCCACGCCCACGGGCAAGACGGAGACCCTACGGATCGAGCTCCGCGTCGAGACCGT
GAGCGGGTTCAGTGGACACGGCGACAAGATCGAGCTCACCAAATACGTGCGGTCGATACGTCCGTCGCCGCCGTCGAAGG
TCTTCACGAACCACGGCGAGCCGCGCGCGTGTAAGTACTTCTCCAACCACCTGCGCCGCACGGTCAGGAAGGTCTTTTCC
ATGGCGCCCGAGAACCTGGAGTGCTTCCGTCTCACTTAG

Upstream 100 bases:

>100_bases
TACCCGAGGAGGAGGTGGAGAAGCTCCTCTCGTGATCCCTCAGCCCCCTCCCCCGGACAATCGACCCCGGTGATCACCGG
TGAAGCCAGGGGCGGATGCG

Downstream 100 bases:

>100_bases
GGGGTACGACGAGTTGTCCGAGATGACCTACAAGGACGCCGGAGTGGACATCGACAAGGAGGCGTTCGCCGTCCGGGCGA
TCCGGGACGTGCTGGAGAAG

Product: metal-dependent RNase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSERRGGEKTLEEVKKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKDDSDLVTRLAKALRKRVKIRPNPAAL
SPAKEAKKVILKIIPEEAGVSERDLLFLDTGEVVIFSKKPGLVIGKRGKNVHRISRDTGWVPRIYRQPPIPSKTVNTTRR
LILSDDSRRKFLRNVSARIFCGRTRSRGTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCGVNVAANGTDAYPHFNV
PEFRMDDLDAIVITHAHLDHCGFLPYFYRHKVIESRVPVYCTPPTRDLMYLLLTDYIKVLEKRGQEPPYTEKDVKKVIKR
TITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKGHNFVYTGDINPTPSRLLEGADNRFKRVDSMVVEATYGDSR
HGSRRKEENRFRKIVRDTLKKGGKVLIPSFAVGRAQEVMLVLEDMHRKDELEGPVYLDGMIYEATAIHTAYPEYLNRRLQ
HRILHEDDDPFTSEVFEPVEGSDHRQAIMEDDEPAVILSTSGMLEGGPILEYLRELSDDPKNTLIFVGYQAEGTLGRQIQ
EGAKEVPLPTPTGKTETLRIELRVETVSGFSGHGDKIELTKYVRSIRPSPPSKVFTNHGEPRACKYFSNHLRRTVRKVFS
MAPENLECFRLT

Sequences:

>Translated_652_residues
MSERRGGEKTLEEVKKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKDDSDLVTRLAKALRKRVKIRPNPAAL
SPAKEAKKVILKIIPEEAGVSERDLLFLDTGEVVIFSKKPGLVIGKRGKNVHRISRDTGWVPRIYRQPPIPSKTVNTTRR
LILSDDSRRKFLRNVSARIFCGRTRSRGTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCGVNVAANGTDAYPHFNV
PEFRMDDLDAIVITHAHLDHCGFLPYFYRHKVIESRVPVYCTPPTRDLMYLLLTDYIKVLEKRGQEPPYTEKDVKKVIKR
TITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKGHNFVYTGDINPTPSRLLEGADNRFKRVDSMVVEATYGDSR
HGSRRKEENRFRKIVRDTLKKGGKVLIPSFAVGRAQEVMLVLEDMHRKDELEGPVYLDGMIYEATAIHTAYPEYLNRRLQ
HRILHEDDDPFTSEVFEPVEGSDHRQAIMEDDEPAVILSTSGMLEGGPILEYLRELSDDPKNTLIFVGYQAEGTLGRQIQ
EGAKEVPLPTPTGKTETLRIELRVETVSGFSGHGDKIELTKYVRSIRPSPPSKVFTNHGEPRACKYFSNHLRRTVRKVFS
MAPENLECFRLT
>Mature_651_residues
SERRGGEKTLEEVKKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKDDSDLVTRLAKALRKRVKIRPNPAALS
PAKEAKKVILKIIPEEAGVSERDLLFLDTGEVVIFSKKPGLVIGKRGKNVHRISRDTGWVPRIYRQPPIPSKTVNTTRRL
ILSDDSRRKFLRNVSARIFCGRTRSRGTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCGVNVAANGTDAYPHFNVP
EFRMDDLDAIVITHAHLDHCGFLPYFYRHKVIESRVPVYCTPPTRDLMYLLLTDYIKVLEKRGQEPPYTEKDVKKVIKRT
ITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKGHNFVYTGDINPTPSRLLEGADNRFKRVDSMVVEATYGDSRH
GSRRKEENRFRKIVRDTLKKGGKVLIPSFAVGRAQEVMLVLEDMHRKDELEGPVYLDGMIYEATAIHTAYPEYLNRRLQH
RILHEDDDPFTSEVFEPVEGSDHRQAIMEDDEPAVILSTSGMLEGGPILEYLRELSDDPKNTLIFVGYQAEGTLGRQIQE
GAKEVPLPTPTGKTETLRIELRVETVSGFSGHGDKIELTKYVRSIRPSPPSKVFTNHGEPRACKYFSNHLRRTVRKVFSM
APENLECFRLT

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33300633, Length=462, Percent_Identity=30.952380952381, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI7706427, Length=434, Percent_Identity=30.4147465437788, Blast_Score=215, Evalue=9e-56,
Organism=Homo sapiens, GI34101288, Length=376, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=32.9545454545455, Blast_Score=212, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI32564696, Length=460, Percent_Identity=30.4347826086957, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17559452, Length=380, Percent_Identity=23.4210526315789, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323307, Length=439, Percent_Identity=28.0182232346241, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24648013, Length=444, Percent_Identity=32.2072072072072, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21358523, Length=452, Percent_Identity=30.9734513274336, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21358013, Length=364, Percent_Identity=20.8791208791209, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 74082; Mature: 73950

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50084 KH_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERRGGEKTLEEVKKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKDDSDLV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHCCCHHHH
TRLAKALRKRVKIRPNPAALSPAKEAKKVILKIIPEEAGVSERDLLFLDTGEVVIFSKKP
HHHHHHHHHHCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCC
GLVIGKRGKNVHRISRDTGWVPRIYRQPPIPSKTVNTTRRLILSDDSRRKFLRNVSARIF
CEEEECCCCCCEEECCCCCCCCHHHCCCCCCCCHHCCHHEEEECCCHHHHHHHCCCCEEE
CGRTRSRGTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCGVNVAANGTDAYPHFNV
ECCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEECCCCEEEECCCEEECCCCCCCCCCCC
PEFRMDDLDAIVITHAHLDHCGFLPYFYRHKVIESRVPVYCTPPTRDLMYLLLTDYIKVL
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHH
EKRGQEPPYTEKDVKKVIKRTITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKG
HHCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCEECCCEEEEEEEECC
HNFVYTGDINPTPSRLLEGADNRFKRVDSMVVEATYGDSRHGSRRKEENRFRKIVRDTLK
CEEEEECCCCCCHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
KGGKVLIPSFAVGRAQEVMLVLEDMHRKDELEGPVYLDGMIYEATAIHTAYPEYLNRRLQ
CCCEEEECCHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEEEEHHHHHHHHHHHHHHHHH
HRILHEDDDPFTSEVFEPVEGSDHRQAIMEDDEPAVILSTSGMLEGGPILEYLRELSDDP
HHHCCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
KNTLIFVGYQAEGTLGRQIQEGAKEVPLPTPTGKTETLRIELRVETVSGFSGHGDKIELT
CCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCEEHHH
KYVRSIRPSPPSKVFTNHGEPRACKYFSNHLRRTVRKVFSMAPENLECFRLT
HHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SERRGGEKTLEEVKKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKDDSDLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHCCCHHHH
TRLAKALRKRVKIRPNPAALSPAKEAKKVILKIIPEEAGVSERDLLFLDTGEVVIFSKKP
HHHHHHHHHHCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCC
GLVIGKRGKNVHRISRDTGWVPRIYRQPPIPSKTVNTTRRLILSDDSRRKFLRNVSARIF
CEEEECCCCCCEEECCCCCCCCHHHCCCCCCCCHHCCHHEEEECCCHHHHHHHCCCCEEE
CGRTRSRGTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCGVNVAANGTDAYPHFNV
ECCCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEECCCCEEEECCCEEECCCCCCCCCCCC
PEFRMDDLDAIVITHAHLDHCGFLPYFYRHKVIESRVPVYCTPPTRDLMYLLLTDYIKVL
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHH
EKRGQEPPYTEKDVKKVIKRTITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKG
HHCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCEECCCEEEEEEEECC
HNFVYTGDINPTPSRLLEGADNRFKRVDSMVVEATYGDSRHGSRRKEENRFRKIVRDTLK
CEEEEECCCCCCHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
KGGKVLIPSFAVGRAQEVMLVLEDMHRKDELEGPVYLDGMIYEATAIHTAYPEYLNRRLQ
CCCEEEECCHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEEEEHHHHHHHHHHHHHHHHH
HRILHEDDDPFTSEVFEPVEGSDHRQAIMEDDEPAVILSTSGMLEGGPILEYLRELSDDP
HHHCCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
KNTLIFVGYQAEGTLGRQIQEGAKEVPLPTPTGKTETLRIELRVETVSGFSGHGDKIELT
CCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCEEHHH
KYVRSIRPSPPSKVFTNHGEPRACKYFSNHLRRTVRKVFSMAPENLECFRLT
HHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]