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The map label for this gene is CdhA_1

Identifier: 20094156

GI number: 20094156

Start: 685725

End: 687623

Strand: Direct

Name: CdhA_1

Synonym: MK0719

Alternate gene names: 20094156

Gene position: 685725-687623 (Clockwise)

Preceding gene: 20094155

Following gene: 20094157

Centisome position: 40.46

GC content: 62.35

Gene sequence:

>1899_bases
TTGGGCATAGAATGGGAGGGAGTCAAAGTCGAGATAGGAGAGCTCGTGGTGGAAGGAGACTCCGAAAGTGAGATGGAGGG
GCCGACCCGCCGCGAGTTGCTCCCGTGGGATCGGACGTTGGCGTCGGTCTACGACCTGGCCGTGGTTCCCGGTGATTCGG
AAGAGGAGCGACGAGAGGTAGCTCGTACGATAGTAACGCTCTGTTGCGAGGGGACGGCAGGGCTCATCTCCACGGCCCGA
CTCGTGGTGGAACTGCTGCGTCAAACGGGGGAGAACCTGGACCCTGGATTCGACGCGGAGACGCCGCTCCCCCTCTACGA
GACGCTACTGGGGAGTTCCCCCGAGTGTGCAGATGACCTCGAGGCCGGATTATCCTACGCGGAGCGGGAACTAACGTCCT
CGGTTTCGGAGCTCCTGCGGTCGCATTCCCTAAAGGGTTACGAGTCCGTGGCCATGCACGCCGGTGCGATCGGTCTCCTC
GCGATGGAGATAGCCGATGCGACCCCCTCCACGCTGATGGAGGTCACGGAGTCGGAGGAAGTGTTTGAGATCGGGACGGA
TGATCTGCCGAGACGTCCCACGGTGTTACTGGTCGGTCATCTACCGCTCTTGGGGCACATCATCACCGAAGAGCTAGGAA
CGCTCGCGAGACAGGTGGAGCTCGTCGGACTAACACACACCGCGTGGCCTAACCGAGAGGACCACGTCAGGGTCGTAGGT
CCCCTGTCTATGTACCATGAATACCTCTCTTCCGGGTTCGCGGATGTGGTAGTGGTCGACGGGGCGTGTCCGGGAGAAGA
CGTGATCGAAGCGGCACGTGAGGGCGGATCCAAGCTCGTCGCCACCGTCGGGGCCCGCGTGGCGGACCTACTCGACGTCA
CCGACTACCCGGTTGAGGAGGCGGTCGAAGTCCTCGTCACCGAGGAGGACGCCGTTTACGTGGAGGAACCCATCAAGGCC
GTGGAAATCGCCGCGTGGGCGGCGCTTCGAGTCGAGGGATCGCGCGACCGAAGAGAACCTCCTCGGAGGGCTTTCCGGGT
CGGCCCGCCGACTCGCCTCACGGACGTAGTGATCCGAAACGTAGGTGTTCCGGTAGTAGCCGGCAACATTCCGGGAATCG
TCGTCTTGGTATCCTGCCCCGAGAAATCCGCGGACGTCGAAGAGCCCGCCAAGATCGCCGAAGTCCTCCTGGAGCGCGGG
TACCTCGTGCTGGTTCCGGGTTGTCTAGCCGTCGCGCTAGGTTCGTACCTGGACGACGATGGTAAAACTCTGTACGAACG
GTACCCCGACACGCTTCTCAACACCGGTCCCTGTACCTCCGCCGCGCACTTAGTCGGGGCTTGCATCCGTGTGGGGGTCA
TCTTCGGTAAGCTCCCTATCAGAGGGGAGTTCGTGCGGGTCGCCGATTACGTACTCAACCGGGTCGGGGCTTGCGTAATA
GCCTGGGGTGGCGAGTACTCGGAACACCTGGTTTCGGCCGCCTACGGGGTCACTCGATGGGGTATTCCGGTGGTACTGGG
TCCCGACCCGGAGGCTGGTTCGTTGTTGGTCGAGAAGAACCCGAAGGTTATCGACGCTTGCTCGGGAGAGGAGGTGGAGG
ATCCCACCCCGGAGCACCTGAGGTGCGTGGTTTCGGATTGGAAGGAGGCGGCGATCACAGCCGCGCGGCTTTGTATGCGT
CCCAACGATACCCCGGAAGGCCGCCAGAACAAGGTCGAGTCGTACGTCGAGCTGTACCGGGAGTTGTACGGAGAATTACC
CCCCGATCTTGACCTGCTCATCCGGGATGAGAGCGATATCCCGGTGACGCTCAGGTCCGAGATACGGGAGCTGCTGGAGG
AGACCGGGTGGACACCTAGATCGCGCGCATCCGATCCTACCCTACTACCCGAGGGGTGA

Upstream 100 bases:

>100_bases
CCCGAGTACTGTCCCAGCGCAGATTACTCGCTACCTACAGTGAAGAGGGATCAGTTCCTCCAAGAGTTGAAGGCTTTAGT
GGGAATCTAGGGGTGAGAAG

Downstream 100 bases:

>100_bases
ATGTAACATTGACGAGTCTTGCGGATCTACCCGTGGACGTGAGCCCGAGGCACGAGGGCGAGCGGATACGAAGCGGCGAC
ATGTACGTCGAGCTAGCGGG

Product: acetyl-CoA decarbonylase/synthase complex subunit alpha

Products: CO2; AH2

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MGIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREVARTIVTLCCEGTAGLISTAR
LVVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDLEAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLL
AMEIADATPSTLMEVTESEEVFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVG
PLSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEEAVEVLVTEEDAVYVEEPIKA
VEIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRNVGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERG
YLVLVPGCLAVALGSYLDDDGKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVI
AWGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHLRCVVSDWKEAAITAARLCMR
PNDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDIPVTLRSEIRELLEETGWTPRSRASDPTLLPEG

Sequences:

>Translated_632_residues
MGIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREVARTIVTLCCEGTAGLISTAR
LVVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDLEAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLL
AMEIADATPSTLMEVTESEEVFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVG
PLSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEEAVEVLVTEEDAVYVEEPIKA
VEIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRNVGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERG
YLVLVPGCLAVALGSYLDDDGKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVI
AWGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHLRCVVSDWKEAAITAARLCMR
PNDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDIPVTLRSEIRELLEETGWTPRSRASDPTLLPEG
>Mature_631_residues
GIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREVARTIVTLCCEGTAGLISTARL
VVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDLEAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLLA
MEIADATPSTLMEVTESEEVFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVGP
LSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEEAVEVLVTEEDAVYVEEPIKAV
EIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRNVGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERGY
LVLVPGCLAVALGSYLDDDGKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVIA
WGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHLRCVVSDWKEAAITAARLCMRP
NDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDIPVTLRSEIRELLEETGWTPRSRASDPTLLPEG

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2)

COG id: COG1152

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ni-containing carbon monoxide dehydrogenase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDA2_METKA (Q8TXF5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614003.1
- ProteinModelPortal:   Q8TXF5
- SMR:   Q8TXF5
- GeneID:   1476820
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0719
- NMPDR:   fig|190192.1.peg.716
- HOGENOM:   HBG539676
- BioCyc:   MKAN190192:MK0719-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01137
- InterPro:   IPR004137
- InterPro:   IPR011254
- InterPro:   IPR016099
- Gene3D:   G3DSA:3.40.50.2030

Pfam domain/function: PF03063 Prismane; SSF56821 Prismane_like

EC number: 1.2.99.2

Molecular weight: Translated: 68559; Mature: 68428

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREV
CCCCCCCCEEEEEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHEECCCCCHHHHHHH
ARTIVTLCCEGTAGLISTARLVVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
EAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLLAMEIADATPSTLMEVTESEE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHCCCH
VFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVG
HEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEC
PLSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEE
CHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
AVEVLVTEEDAVYVEEPIKAVEIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRN
HHHHHCCCCCCEEHHCCHHHHHHHHHHEEEECCCCCCCCCCHHHEECCCCHHHHHHHHHH
VGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERGYLVLVPGCLAVALGSYLDDD
CCCCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCC
GKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVI
CHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEE
AWGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHL
EECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHH
RCVVSDWKEAAITAARLCMRPNDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PVTLRSEIRELLEETGWTPRSRASDPTLLPEG
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GIEWEGVKVEIGELVVEGDSESEMEGPTRRELLPWDRTLASVYDLAVVPGDSEEERREV
CCCCCCCEEEEEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHEECCCCCHHHHHHH
ARTIVTLCCEGTAGLISTARLVVELLRQTGENLDPGFDAETPLPLYETLLGSSPECADDL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
EAGLSYAERELTSSVSELLRSHSLKGYESVAMHAGAIGLLAMEIADATPSTLMEVTESEE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHCCCH
VFEIGTDDLPRRPTVLLVGHLPLLGHIITEELGTLARQVELVGLTHTAWPNREDHVRVVG
HEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEC
PLSMYHEYLSSGFADVVVVDGACPGEDVIEAAREGGSKLVATVGARVADLLDVTDYPVEE
CHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
AVEVLVTEEDAVYVEEPIKAVEIAAWAALRVEGSRDRREPPRRAFRVGPPTRLTDVVIRN
HHHHHCCCCCCEEHHCCHHHHHHHHHHEEEECCCCCCCCCCHHHEECCCCHHHHHHHHHH
VGVPVVAGNIPGIVVLVSCPEKSADVEEPAKIAEVLLERGYLVLVPGCLAVALGSYLDDD
CCCCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCC
GKTLYERYPDTLLNTGPCTSAAHLVGACIRVGVIFGKLPIRGEFVRVADYVLNRVGACVI
CHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEE
AWGGEYSEHLVSAAYGVTRWGIPVVLGPDPEAGSLLVEKNPKVIDACSGEEVEDPTPEHL
EECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHH
RCVVSDWKEAAITAARLCMRPNDTPEGRQNKVESYVELYRELYGELPPDLDLLIRDESDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PVTLRSEIRELLEETGWTPRSRASDPTLLPEG
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014