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The map label for this gene is PyrD [H]

Identifier: 20094001

GI number: 20094001

Start: 525882

End: 526838

Strand: Direct

Name: PyrD [H]

Synonym: MK0563

Alternate gene names: 20094001

Gene position: 525882-526838 (Clockwise)

Preceding gene: 20094000

Following gene: 20094002

Centisome position: 31.03

GC content: 64.68

Gene sequence:

>957_bases
GTGAGACCGGTGGAGGTCCTAGGGAAGCGCTGGGCCCACCCGATCGCCTGCGCTTCCGGGGCTCTCGCCGCCCATCGGCC
GGGCATGGAAAATGCCGTTCTACGCGGTGCGGCGGCTATTTTCACGAAGACGGTCACTGAATCACCGCGCGAGGGCCATC
CAGGACCGGTATTCGTGGATTACCTCGACGAGGGATACGCGCTCAACGCTATGGGTTTACCGAACCCCGGCCCGGACAGG
ATGGTGGTGGAAATCGAAGAGTTCCGGGACGAATTCGACGTACCGGTATACGCGAGCGTGGCGGCCGACGGTCCGGAGGG
TTTCAAGAGGTTGGCACGCGCGTTCTCCGGCGTAGCGGACGGATTGGAACTGAACGTCTCGTGCCCTCACGCGGGCAAGG
GGTACGGGGCGGAACTAGGCTCCGATCCGGAGGCCGTGGCCGAAATCACCGAGGCCGCCGTCCGGGCGTTCGACGGACCG
GTGTCCGTGAAATTGACTCCCAACGTGGACCGCGAAACCTTGCTCGAGGTGGCTGCGGCGGCCATCGATGCGGGAGCGGA
GGCACTCACCGCCGTGAACACGCTGGGACCTGGCCTTAGGATCGACCTGAGGACCGCCAGCCCCGTCCTAGGAGCCGGGG
TAGGTGGACTGTCGGGCCCCGCGCTCAAACCCATCGCGCTCCGCGTCGTGGCGGACTTAGCGCTGGAGTTCGGGGAGGAA
GTGGAGATCATAGGAGTCGGTGGGATCCGGAACGGGGAAGACGTCGTCGAGTTCCTGTTCGCCGGTGCCAAGGCGGTGCA
GGTCGCCACGGCGGCTCGAGAGAAAGACTTCGGAGATATCGCGATGGAAACCTCCCACATTCTCAAGGAACTCGGATACG
ATGGACCCGAAGAGGCGATCGGAGCTGCCCTTCCTGAGTACCGGGAGAGGCTGCGCCGATTGGGGTGGTGTCAGTGA

Upstream 100 bases:

>100_bases
ACGGGCGTCTAGCACCGATCGTCCTGGAAATCGAACGGGCGCTCGAAGACATGGACCGAGCCCTTGACGGGGTGAACAGG
ATTAAAGTGAGGTTCCTCGG

Downstream 100 bases:

>100_bases
AGCCAATACCGGCGGAGGTCGTGGAGAACAGGGAAGAATGTGAGCGGACGATCGTGCTCAGGCTACGGCCGGAGAGGCCG
ATACGTTGGGAACCCGGACA

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDYLDEGYALNAMGLPNPGPDR
MVVEIEEFRDEFDVPVYASVAADGPEGFKRLARAFSGVADGLELNVSCPHAGKGYGAELGSDPEAVAEITEAAVRAFDGP
VSVKLTPNVDRETLLEVAAAAIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVADLALEFGEE
VEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELGYDGPEEAIGAALPEYRERLRRLGWCQ

Sequences:

>Translated_318_residues
MRPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDYLDEGYALNAMGLPNPGPDR
MVVEIEEFRDEFDVPVYASVAADGPEGFKRLARAFSGVADGLELNVSCPHAGKGYGAELGSDPEAVAEITEAAVRAFDGP
VSVKLTPNVDRETLLEVAAAAIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVADLALEFGEE
VEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELGYDGPEEAIGAALPEYRERLRRLGWCQ
>Mature_318_residues
MRPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDYLDEGYALNAMGLPNPGPDR
MVVEIEEFRDEFDVPVYASVAADGPEGFKRLARAFSGVADGLELNVSCPHAGKGYGAELGSDPEAVAEITEAAVRAFDGP
VSVKLTPNVDRETLLEVAAAAIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVADLALEFGEE
VEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELGYDGPEEAIGAALPEYRERLRRLGWCQ

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=167, Percent_Identity=40.1197604790419, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI45006951, Length=326, Percent_Identity=26.6871165644172, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082059, Length=221, Percent_Identity=33.4841628959276, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787177, Length=281, Percent_Identity=24.5551601423488, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71984108, Length=295, Percent_Identity=31.1864406779661, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17509475, Length=329, Percent_Identity=24.3161094224924, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=311, Percent_Identity=29.2604501607717, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24640763, Length=298, Percent_Identity=31.2080536912752, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18858217, Length=298, Percent_Identity=31.2080536912752, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=25.3125, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=25.3125, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33274; Mature: 33274

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVD
CCCHHHHHHHCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
YLDEGYALNAMGLPNPGPDRMVVEIEEFRDEFDVPVYASVAADGPEGFKRLARAFSGVAD
ECCCCEEEEECCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCC
GLELNVSCPHAGKGYGAELGSDPEAVAEITEAAVRAFDGPVSVKLTPNVDRETLLEVAAA
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
AIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVADLALEFGEE
HHHCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELGYDGPEEAI
EEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
GAALPEYRERLRRLGWCQ
HHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MRPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVD
CCCHHHHHHHCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
YLDEGYALNAMGLPNPGPDRMVVEIEEFRDEFDVPVYASVAADGPEGFKRLARAFSGVAD
ECCCCEEEEECCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCC
GLELNVSCPHAGKGYGAELGSDPEAVAEITEAAVRAFDGPVSVKLTPNVDRETLLEVAAA
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
AIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVADLALEFGEE
HHHCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELGYDGPEEAI
EEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
GAALPEYRERLRRLGWCQ
HHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]