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The map label for this gene is pyrK

Identifier: 20094002

GI number: 20094002

Start: 526826

End: 527614

Strand: Direct

Name: pyrK

Synonym: MK0564

Alternate gene names: 20094002

Gene position: 526826-527614 (Clockwise)

Preceding gene: 20094001

Following gene: 20094003

Centisome position: 31.08

GC content: 60.71

Gene sequence:

>789_bases
GTGGTGTCAGTGAAGCCAATACCGGCGGAGGTCGTGGAGAACAGGGAAGAATGTGAGCGGACGATCGTGCTCAGGCTACG
GCCGGAGAGGCCGATACGTTGGGAACCCGGACAATTCCTGATGCTCGGGATCTCCGGAGTCGACGAGAAGCCAATGGCGT
TCTCAGGAGGAGACGACCGGGAGTTCGAACTCACCATCGAGATCGTAGGCCCATTCACGGAGCGTTGCGCCGACCTCGAG
CCGGGGGACGTGGTCTGGGTACGGGGACCGTACGGGAAACCGTTCGAGGTGAGAGGTTCGAGGGCAGTGGTAGTTGCCGG
AGGAACCGGGGTAGCACCACTGGTTCCGCTCGTTGAAAGGCTACGTCGAGCGCGCGTCCACGTTACCTCGGTACTAGGAG
GCCCACACGCGGACCGCCTCCCTAGGAAGGATGATCTGGAAAAGTTGTCCGACGAGCTGTACGTCACCACGGAGGACGGT
AGCGAGGGGCGTAAAGGATTTCCTACGGACGTCCTTGAAGAACTCGTCGAAAAGGAATGTCCGGATGTAGTGTACGCGTG
CGGTCCCGAAGGGATGCTGGTCCGGGTTGCCGAGATAGCACGAGAGCACGATGTCCCTTGCCAGGTCAGCGTCGTCCGGT
ACGTGAAATGTGGCGAAGGAATCTGCGGCTCGTGCGCCTTAGGGAAGGGGCTACTAGTGTGCCGCGACGGTCCGGTGTTT
TGGACGGAGGAGTTGGAAGGTACGGAGTTCGGAGGGGTCAGACGTGACGTCACGGGAAAGCCTGAGTGA

Upstream 100 bases:

>100_bases
TGGAAACCTCCCACATTCTCAAGGAACTCGGATACGATGGACCCGAAGAGGCGATCGGAGCTGCCCTTCCTGAGTACCGG
GAGAGGCTGCGCCGATTGGG

Downstream 100 bases:

>100_bases
CGTCGCGTTCGTGCTACCGGCGCACAACGAGGAGGGAGCGGTGGGAAAAGTCGTACGCGAGATTCGGAGGATGTACCCCG
ATGCGCTGATAATAGTGGTG

Product: flavodoxin oxidoreductase related to 2-polyprenylphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVSVKPIPAEVVENREECERTIVLRLRPERPIRWEPGQFLMLGISGVDEKPMAFSGGDDREFELTIEIVGPFTERCADLE
PGDVVWVRGPYGKPFEVRGSRAVVVAGGTGVAPLVPLVERLRRARVHVTSVLGGPHADRLPRKDDLEKLSDELYVTTEDG
SEGRKGFPTDVLEELVEKECPDVVYACGPEGMLVRVAEIAREHDVPCQVSVVRYVKCGEGICGSCALGKGLLVCRDGPVF
WTEELEGTEFGGVRRDVTGKPE

Sequences:

>Translated_262_residues
MVSVKPIPAEVVENREECERTIVLRLRPERPIRWEPGQFLMLGISGVDEKPMAFSGGDDREFELTIEIVGPFTERCADLE
PGDVVWVRGPYGKPFEVRGSRAVVVAGGTGVAPLVPLVERLRRARVHVTSVLGGPHADRLPRKDDLEKLSDELYVTTEDG
SEGRKGFPTDVLEELVEKECPDVVYACGPEGMLVRVAEIAREHDVPCQVSVVRYVKCGEGICGSCALGKGLLVCRDGPVF
WTEELEGTEFGGVRRDVTGKPE
>Mature_262_residues
MVSVKPIPAEVVENREECERTIVLRLRPERPIRWEPGQFLMLGISGVDEKPMAFSGGDDREFELTIEIVGPFTERCADLE
PGDVVWVRGPYGKPFEVRGSRAVVVAGGTGVAPLVPLVERLRRARVHVTSVLGGPHADRLPRKDDLEKLSDELYVTTEDG
SEGRKGFPTDVLEELVEKECPDVVYACGPEGMLVRVAEIAREHDVPCQVSVVRYVKCGEGICGSCALGKGLLVCRDGPVF
WTEELEGTEFGGVRRDVTGKPE

Specific function: Is responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+)

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRK_METKA (P58887)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613849.1
- ProteinModelPortal:   P58887
- SMR:   P58887
- GeneID:   1476665
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0564
- NMPDR:   fig|190192.1.peg.562
- HOGENOM:   HBG730970
- OMA:   RYMKCGI
- BioCyc:   MKAN190192:MK0564-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01211_A
- InterPro:   IPR012165
- InterPro:   IPR019480
- InterPro:   IPR017927
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938
- PIRSF:   PIRSF006816
- PRINTS:   PR00409

Pfam domain/function: PF10418 DHODB_Fe-S_bind; PF00970 FAD_binding_6; PF00175 NAD_binding_1; SSF63380 Riboflavin_synthase_like_b-brl

EC number: NA

Molecular weight: Translated: 28783; Mature: 28783

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00197 2FE2S_FER_1; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVKPIPAEVVENREECERTIVLRLRPERPIRWEPGQFLMLGISGVDEKPMAFSGGDDR
CCCCCCCCHHHHCCHHHHCEEEEEEECCCCCCEECCCCEEEEEECCCCCCCCEECCCCCC
EFELTIEIVGPFTERCADLEPGDVVWVRGPYGKPFEVRGSRAVVVAGGTGVAPLVPLVER
EEEEEEEEECCHHHHHCCCCCCCEEEEECCCCCCEEECCCEEEEEECCCCCHHHHHHHHH
LRRARVHVTSVLGGPHADRLPRKDDLEKLSDELYVTTEDGSEGRKGFPTDVLEELVEKEC
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
PDVVYACGPEGMLVRVAEIAREHDVPCQVSVVRYVKCGEGICGSCALGKGLLVCRDGPVF
CCEEEEECCCCCEEHHHHHHHHCCCCCEEHEEEHHHCCCCCCCCHHCCCCEEEEECCCEE
WTEELEGTEFGGVRRDVTGKPE
EECCCCCCCCCCEECCCCCCCC
>Mature Secondary Structure
MVSVKPIPAEVVENREECERTIVLRLRPERPIRWEPGQFLMLGISGVDEKPMAFSGGDDR
CCCCCCCCHHHHCCHHHHCEEEEEEECCCCCCEECCCCEEEEEECCCCCCCCEECCCCCC
EFELTIEIVGPFTERCADLEPGDVVWVRGPYGKPFEVRGSRAVVVAGGTGVAPLVPLVER
EEEEEEEEECCHHHHHCCCCCCCEEEEECCCCCCEEECCCEEEEEECCCCCHHHHHHHHH
LRRARVHVTSVLGGPHADRLPRKDDLEKLSDELYVTTEDGSEGRKGFPTDVLEELVEKEC
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
PDVVYACGPEGMLVRVAEIAREHDVPCQVSVVRYVKCGEGICGSCALGKGLLVCRDGPVF
CCEEEEECCCCCEEHHHHHHHHCCCCCEEHEEEHHHCCCCCCCCHHCCCCEEEEECCCEE
WTEELEGTEFGGVRRDVTGKPE
EECCCCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014