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The map label for this gene is SIK1

Identifier: 20093997

GI number: 20093997

Start: 522045

End: 523307

Strand: Direct

Name: SIK1

Synonym: MK0559

Alternate gene names: NA

Gene position: 522045-523307 (Clockwise)

Preceding gene: 20093996

Following gene: 20093998

Centisome position: 30.8

GC content: 62.47

Gene sequence:

>1263_bases
TTGGGGGTGTACGTGGCCGAGAACTTCACCGGAGTTTACGCGTTCGATGAGGAGGGGAACCTGATAGACCACGAGCCGTT
CCCGAAGGACCCGGACGAGATAGTGGAACGTCTGCTGAAGCGGGAACGTGGTGAGGTGTTGGAAGAGGAAGAGGCGCTGC
TGTCGAGACTGGACGCGGACGTGATCAACTTCGAGGGTACGAAGGCGGACCGGGAGCGGCTCGAGGAGGTGTTCGACGGA
GAGCTGGTCGTCGAGTTCCCGAACGTGGCTGGGGAGGTCCTTCGAGAGCGAGCACGGGAGCTCGCCGTCGAGGTCGGTGT
GGTCGACTCCGAGGAGGAGTACTCGGAGCTCGTGTACGAGGTCGGCATGAAGCTGTCGAAGGAGAAGGTCCGGGCGACGG
TAGAGGAACGGGATCAGATGATCATTCAGGCTATCAACACTATCGACGATATCGACAGGATACTGAACATACTCACCGAC
CGCGTGCGAGAGTGGTACGGAATACACTTCCCCGAGATCAACAAGATCGTGAAGAAGCACGACGATTTCGTGACGTTGGT
GGCCGAGCTGGGGCACCGGAAGAACTTCACTTATGACAACATCAAGGAGGTGCTGCCCGAGTTCCCCGATCATCTGGCCG
AGAAGCTCGAGGAGGCCGCGAAGGACTCGATGGGTGCGGAGATGGACGAGAAGGACTTGGCGGCGGTGCAGCGGATCGCG
GAGGTCGCGCGGGAGCTCTACGAGATCAGGCGGAAGACTGCGGACTACATCGACGAGTCGATGGACGACGTGGCGCCGAA
CGTGAAGGCTCTGGTGGGTCCACTGATCGGTGCGAGGTTGATCGCGCTGGCCGGCGGCTTGAAGGAGATGGCGAAGTTAC
CCGCGAGCACGATCCAGCTGTTGGGAGCGGAGAAGGCGCTGTTCAGGCACCTGACCAAGGGTACGAAGCCGCCGAAGCAC
GGTGTGATCTTCCAGCACCCGCTCATCCACCGGAGCCCGTGGTGGCAGCGCGGTAAGATCGCGAGGGCGCTGGCCGGTAA
GCTGGCCATCGCGGCGCGTATCGACGCTTACTCCGGTGAGTACCGGGGCGACGAGCTGAGGCGACAGCTGGAGCAGCGGG
TGAAAGAGATCAAGGAGAAGTACCCGAAGCCCCCGAAGCGCAAGCGTGGTGGTCGGCCGCCTCGCGGTCGTCGACCGCGT
CGGAGGCGTTCACCCCGGAGATCTCGTAGGGATCGCCGGCGCCGCTCACGTCGAAGGCGGTGA

Upstream 100 bases:

>100_bases
AGCTTGAAATGTATATGAGAGAGGAGGGTATCGGCGGGGAGGTAAGCGTTTCCGAACCGCGGAACGAGGGTTTCGAGGTG
ACGGGGTAGGGGGGTCACCT

Downstream 100 bases:

>100_bases
CTTCATTTCCCCTGAACACAGCAGTTTTTTCGGGGGTGAGTGGGAAAATGGTGGAGATCGAGATCGAACCGCATGAGGAG
TTTGAGGGTGTGTACTGGGC

Product: protein implicated in ribosomal biogenesis, Nop56p-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGVYVAENFTGVYAFDEEGNLIDHEPFPKDPDEIVERLLKRERGEVLEEEEALLSRLDADVINFEGTKADRERLEEVFDG
ELVVEFPNVAGEVLRERARELAVEVGVVDSEEEYSELVYEVGMKLSKEKVRATVEERDQMIIQAINTIDDIDRILNILTD
RVREWYGIHFPEINKIVKKHDDFVTLVAELGHRKNFTYDNIKEVLPEFPDHLAEKLEEAAKDSMGAEMDEKDLAAVQRIA
EVARELYEIRRKTADYIDESMDDVAPNVKALVGPLIGARLIALAGGLKEMAKLPASTIQLLGAEKALFRHLTKGTKPPKH
GVIFQHPLIHRSPWWQRGKIARALAGKLAIAARIDAYSGEYRGDELRRQLEQRVKEIKEKYPKPPKRKRGGRPPRGRRPR
RRRSPRRSRRDRRRRSRRRR

Sequences:

>Translated_420_residues
MGVYVAENFTGVYAFDEEGNLIDHEPFPKDPDEIVERLLKRERGEVLEEEEALLSRLDADVINFEGTKADRERLEEVFDG
ELVVEFPNVAGEVLRERARELAVEVGVVDSEEEYSELVYEVGMKLSKEKVRATVEERDQMIIQAINTIDDIDRILNILTD
RVREWYGIHFPEINKIVKKHDDFVTLVAELGHRKNFTYDNIKEVLPEFPDHLAEKLEEAAKDSMGAEMDEKDLAAVQRIA
EVARELYEIRRKTADYIDESMDDVAPNVKALVGPLIGARLIALAGGLKEMAKLPASTIQLLGAEKALFRHLTKGTKPPKH
GVIFQHPLIHRSPWWQRGKIARALAGKLAIAARIDAYSGEYRGDELRRQLEQRVKEIKEKYPKPPKRKRGGRPPRGRRPR
RRRSPRRSRRDRRRRSRRRR
>Mature_419_residues
GVYVAENFTGVYAFDEEGNLIDHEPFPKDPDEIVERLLKRERGEVLEEEEALLSRLDADVINFEGTKADRERLEEVFDGE
LVVEFPNVAGEVLRERARELAVEVGVVDSEEEYSELVYEVGMKLSKEKVRATVEERDQMIIQAINTIDDIDRILNILTDR
VREWYGIHFPEINKIVKKHDDFVTLVAELGHRKNFTYDNIKEVLPEFPDHLAEKLEEAAKDSMGAEMDEKDLAAVQRIAE
VARELYEIRRKTADYIDESMDDVAPNVKALVGPLIGARLIALAGGLKEMAKLPASTIQLLGAEKALFRHLTKGTKPPKHG
VIFQHPLIHRSPWWQRGKIARALAGKLAIAARIDAYSGEYRGDELRRQLEQRVKEIKEKYPKPPKRKRGGRPPRGRRPRR
RRSPRRSRRDRRRRSRRRR

Specific function: Unknown

COG id: COG1498

COG function: function code J; Protein implicated in ribosomal biogenesis, Nop56p homolog

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Nop domain [H]

Homologues:

Organism=Homo sapiens, GI7706254, Length=271, Percent_Identity=37.6383763837638, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI32483374, Length=259, Percent_Identity=38.996138996139, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI221136939, Length=255, Percent_Identity=27.843137254902, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17509449, Length=288, Percent_Identity=39.5833333333333, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17562296, Length=261, Percent_Identity=38.3141762452107, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17510923, Length=313, Percent_Identity=26.8370607028754, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6324886, Length=274, Percent_Identity=37.956204379562, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323226, Length=259, Percent_Identity=38.996138996139, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321528, Length=204, Percent_Identity=28.921568627451, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28572126, Length=259, Percent_Identity=40.1544401544402, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137636, Length=270, Percent_Identity=37.7777777777778, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21357435, Length=289, Percent_Identity=25.6055363321799, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012976
- InterPro:   IPR002687 [H]

Pfam domain/function: PF01798 Nop; PF08060 NOSIC [H]

EC number: NA

Molecular weight: Translated: 48516; Mature: 48385

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVYVAENFTGVYAFDEEGNLIDHEPFPKDPDEIVERLLKRERGEVLEEEEALLSRLDAD
CCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VINFEGTKADRERLEEVFDGELVVEFPNVAGEVLRERARELAVEVGVVDSEEEYSELVYE
HHCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VGMKLSKEKVRATVEERDQMIIQAINTIDDIDRILNILTDRVREWYGIHFPEINKIVKKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DDFVTLVAELGHRKNFTYDNIKEVLPEFPDHLAEKLEEAAKDSMGAEMDEKDLAAVQRIA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EVARELYEIRRKTADYIDESMDDVAPNVKALVGPLIGARLIALAGGLKEMAKLPASTIQL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHH
LGAEKALFRHLTKGTKPPKHGVIFQHPLIHRSPWWQRGKIARALAGKLAIAARIDAYSGE
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
YRGDELRRQLEQRVKEIKEKYPKPPKRKRGGRPPRGRRPRRRRSPRRSRRDRRRRSRRRR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVYVAENFTGVYAFDEEGNLIDHEPFPKDPDEIVERLLKRERGEVLEEEEALLSRLDAD
CEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VINFEGTKADRERLEEVFDGELVVEFPNVAGEVLRERARELAVEVGVVDSEEEYSELVYE
HHCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VGMKLSKEKVRATVEERDQMIIQAINTIDDIDRILNILTDRVREWYGIHFPEINKIVKKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DDFVTLVAELGHRKNFTYDNIKEVLPEFPDHLAEKLEEAAKDSMGAEMDEKDLAAVQRIA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EVARELYEIRRKTADYIDESMDDVAPNVKALVGPLIGARLIALAGGLKEMAKLPASTIQL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHH
LGAEKALFRHLTKGTKPPKHGVIFQHPLIHRSPWWQRGKIARALAGKLAIAARIDAYSGE
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
YRGDELRRQLEQRVKEIKEKYPKPPKRKRGGRPPRGRRPRRRRSPRRSRRDRRRRSRRRR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]