Click here to switch to the map view.

The map label for this gene is NOP1

Identifier: 20093998

GI number: 20093998

Start: 523355

End: 524053

Strand: Direct

Name: NOP1

Synonym: MK0560

Alternate gene names: 20093998

Gene position: 523355-524053 (Clockwise)

Preceding gene: 20093997

Following gene: 20093999

Centisome position: 30.88

GC content: 60.23

Gene sequence:

>699_bases
ATGGTGGAGATCGAGATCGAACCGCATGAGGAGTTTGAGGGTGTGTACTGGGCGATCTTCGAGGACGGTCGGAAGAAGCC
CGCGACCGAGAACCTCGTGCCCGGACATCAGGTTTACGGTGAGAGGTTGGTAGAGTACGACGGGAAGGAGTACCGCGTAT
GGGAGCCACGGAGGAGCAAGCTCGCCGCCATGATCATGAACGGCATGGAGTACTTCCCGTTCGAGGAGGGTTCGAAGGTA
CTTTACCTGGGTGCGGCGGCCGGAACGACACCGTCACACGTGTCGGACATCATCAAGGAGTCGGGCGTGGAGTACTGCGT
CGAGTTCGCCTCGAGGATGATGCAGGAGCTGATCCCGGTGTGTGAGAAGCGCCCGAACATGATACCCATCCTGGGCGACG
CTACGAAGCCGCACGGGTACGCTCCGCTCGTCGAGCAAGTAGACGTAATCTACCAGGACATCGCTCAGCCGAAACAGGCG
GAGGTCGTCGCGGACAACGCCGAGGCGTTCCTGCGTCCCGGAGGGTACGTGATCGTCGCTATTAAGGCGCGCTCTATCGA
CGTAACTAAGGAGCCGGAAGAGGTCTTCGAGGACGAGGAGCGCAAGCTCGAGGAGCGTGGCTTCGAGGTGCTAGAAGTCA
TCGATCTGGAGCCGTACGAGCGTGATCACGTGGGGATCGTCGCGGAGTACCACGGGTAA

Upstream 100 bases:

>100_bases
CACCCCGGAGATCTCGTAGGGATCGCCGGCGCCGCTCACGTCGAAGGCGGTGACTTCATTTCCCCTGAACACAGCAGTTT
TTTCGGGGGTGAGTGGGAAA

Downstream 100 bases:

>100_bases
CCGTGATGAGCGTTTCGCTAGCCGACGCGCGGATGACGAGTTACTCCCGCTCTGAGCTCTTCTCCCGATGACTGCATTCA
CCCCTCCTGAATAAGTGATG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MVEIEIEPHEEFEGVYWAIFEDGRKKPATENLVPGHQVYGERLVEYDGKEYRVWEPRRSKLAAMIMNGMEYFPFEEGSKV
LYLGAAAGTTPSHVSDIIKESGVEYCVEFASRMMQELIPVCEKRPNMIPILGDATKPHGYAPLVEQVDVIYQDIAQPKQA
EVVADNAEAFLRPGGYVIVAIKARSIDVTKEPEEVFEDEERKLEERGFEVLEVIDLEPYERDHVGIVAEYHG

Sequences:

>Translated_232_residues
MVEIEIEPHEEFEGVYWAIFEDGRKKPATENLVPGHQVYGERLVEYDGKEYRVWEPRRSKLAAMIMNGMEYFPFEEGSKV
LYLGAAAGTTPSHVSDIIKESGVEYCVEFASRMMQELIPVCEKRPNMIPILGDATKPHGYAPLVEQVDVIYQDIAQPKQA
EVVADNAEAFLRPGGYVIVAIKARSIDVTKEPEEVFEDEERKLEERGFEVLEVIDLEPYERDHVGIVAEYHG
>Mature_232_residues
MVEIEIEPHEEFEGVYWAIFEDGRKKPATENLVPGHQVYGERLVEYDGKEYRVWEPRRSKLAAMIMNGMEYFPFEEGSKV
LYLGAAAGTTPSHVSDIIKESGVEYCVEFASRMMQELIPVCEKRPNMIPILGDATKPHGYAPLVEQVDVIYQDIAQPKQA
EVVADNAEAFLRPGGYVIVAIKARSIDVTKEPEEVFEDEERKLEERGFEVLEVIDLEPYERDHVGIVAEYHG

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family

Homologues:

Organism=Homo sapiens, GI12056465, Length=232, Percent_Identity=46.9827586206897, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17563672, Length=231, Percent_Identity=50.6493506493506, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320190, Length=239, Percent_Identity=46.0251046025105, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17647425, Length=232, Percent_Identity=49.1379310344828, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24646406, Length=230, Percent_Identity=34.7826086956522, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLPA_METKA (Q8TXU9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613845.1
- ProteinModelPortal:   Q8TXU9
- SMR:   Q8TXU9
- GeneID:   1476661
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0560
- NMPDR:   fig|190192.1.peg.558
- HOGENOM:   HBG297404
- OMA:   CAERENI
- ProtClustDB:   PRK04266
- BioCyc:   MKAN190192:MK0560-MONOMER
- HAMAP:   MF_00351
- InterPro:   IPR000692
- InterPro:   IPR020813
- PANTHER:   PTHR10335
- PIRSF:   PIRSF006540
- PRINTS:   PR00052

Pfam domain/function: PF01269 Fibrillarin

EC number: NA

Molecular weight: Translated: 26394; Mature: 26394

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00566 FIBRILLARIN

Important sites: BINDING 60-60 BINDING 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIEIEPHEEFEGVYWAIFEDGRKKPATENLVPGHQVYGERLVEYDGKEYRVWEPRRSK
CEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
LAAMIMNGMEYFPFEEGSKVLYLGAAAGTTPSHVSDIIKESGVEYCVEFASRMMQELIPV
HHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
CEKRPNMIPILGDATKPHGYAPLVEQVDVIYQDIAQPKQAEVVADNAEAFLRPGGYVIVA
HHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCEEEEE
IKARSIDVTKEPEEVFEDEERKLEERGFEVLEVIDLEPYERDHVGIVAEYHG
EEECEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVEIEIEPHEEFEGVYWAIFEDGRKKPATENLVPGHQVYGERLVEYDGKEYRVWEPRRSK
CEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
LAAMIMNGMEYFPFEEGSKVLYLGAAAGTTPSHVSDIIKESGVEYCVEFASRMMQELIPV
HHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
CEKRPNMIPILGDATKPHGYAPLVEQVDVIYQDIAQPKQAEVVADNAEAFLRPGGYVIVA
HHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCEEEEE
IKARSIDVTKEPEEVFEDEERKLEERGFEVLEVIDLEPYERDHVGIVAEYHG
EEECEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014