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The map label for this gene is tdcB [H]

Identifier: 197120050

GI number: 197120050

Start: 4215249

End: 4216457

Strand: Direct

Name: tdcB [H]

Synonym: Gbem_3689

Alternate gene names: 197120050

Gene position: 4215249-4216457 (Clockwise)

Preceding gene: 197120049

Following gene: 197120076

Centisome position: 91.34

GC content: 63.28

Gene sequence:

>1209_bases
ATGCTTGATTACAACCTGATCGTCGACGCAGCCCAGAGACTCAAAAAAAGGGTGCGCCGGACGGAACTGATCCACGCTCA
ACATTTCAGCGAGCGGCTCGGCCTCCCCCTTTACTTCAAATGCGAGAACCTGCAGCGCACCGGCGCCTTCAAGATTCGCG
GCGCACTCAATTTCATGACCGCGCAGCCGCGCCAGGCACTGGCCGGCGGCGTCATTACCGCCTCCGCAGGAAACCACGCC
CAGGGAGTCGCCTTCTCCGCCGACCTCCTCGGGGTTAAAGCGGTGGTCTACATGCCGGAGAGCACCCCGCCGCAGAAGGT
ATTCGCCACCCGGGACTACGGGGCCGAAGTCGTCCTGGAGGGAAAAAATTTCGACGAGGCGTGCGCCGCCGCCCTGAGGC
AAGCCGAGGCTACCGGCGCGCTTTTCGTGCACCCATTCAACGACCCCCTGGTGATGGCGGGACAAGGGACCATCGGGCTT
GAGCTGCTGGAGGACCTCCCGGATCTCGCCAACGTGCTGATCCCCGTGGGAGGGGGAGGACTGATAGCCGGCATCGCCCG
CGCCATCAAGGAGACCCACCCGCAGGTGAGGATCATCGGGGTCGAAGCCGCCGCAGCCCCTTCGATGCGCCAGGCGCTGC
ACAAAGGAGAGGTAGTCACCGTGCCGATACGGGCGAGCCTCGCCGACGGCATCGCCGTCAAAACCGCCGGTACCAACACC
TTTCCCGTGGCAAAGGAATACGTGGACGAAATCGTCCTGGTGGATGAGGAGGAGATCGCCCTCGCCATCGTCTCGCTGAT
GGAACGGAACAAGCTGATGGTGGAGGGCGCCGGCGCGGTGGGGCTCGCGGCGCTTTTGAACGGCAAGATAAAGCGGATTT
CCGGAAAGACGGTGGCGTTGTTATCAGGCGGGAACATAGACGTGAAGACCATAGCCGTGGTCGTGGAGCGGGGGCTTTTG
GCCGCGGGGCGCTACCTGAAGCTGAAGATCGAGCTGGACGACGTCCCCGGCGCGCTGGCACGGCTCGCCACCGAGATCGC
CGAGGCGCGGGCCAACATATCCATCATCACCCATGACCGCCGCTCCGAGTCCCTTCCCATCGGGAAGACCGAGGTGCTGG
TCGAGTTGGAGACCAGGGGTGCCGAGCACATACAGGACGTCATCAGGCACCTGAGCAAACGGGAGTACCTGCTGGAAGTC
ATCAAATAA

Upstream 100 bases:

>100_bases
GGCCCATGCCCATGCCCATCCGCACCACCACCCCCATGGCACTTGCCAGGGGGGGCATCACCATCACGACCACACACCTT
AACCCCTCGGACGGTAGATA

Downstream 100 bases:

>100_bases
ACAAAAGCCATCGGCCACGGGGAAAACCTGAGGAAAGCAAAACTCAAGCTTTGGGTTTTGCTCCGCCTTTCTCAGATGTT
CTCCGTGGCCAACGGTTTTA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLDYNLIVDAAQRLKKRVRRTELIHAQHFSERLGLPLYFKCENLQRTGAFKIRGALNFMTAQPRQALAGGVITASAGNHA
QGVAFSADLLGVKAVVYMPESTPPQKVFATRDYGAEVVLEGKNFDEACAAALRQAEATGALFVHPFNDPLVMAGQGTIGL
ELLEDLPDLANVLIPVGGGGLIAGIARAIKETHPQVRIIGVEAAAAPSMRQALHKGEVVTVPIRASLADGIAVKTAGTNT
FPVAKEYVDEIVLVDEEEIALAIVSLMERNKLMVEGAGAVGLAALLNGKIKRISGKTVALLSGGNIDVKTIAVVVERGLL
AAGRYLKLKIELDDVPGALARLATEIAEARANISIITHDRRSESLPIGKTEVLVELETRGAEHIQDVIRHLSKREYLLEV
IK

Sequences:

>Translated_402_residues
MLDYNLIVDAAQRLKKRVRRTELIHAQHFSERLGLPLYFKCENLQRTGAFKIRGALNFMTAQPRQALAGGVITASAGNHA
QGVAFSADLLGVKAVVYMPESTPPQKVFATRDYGAEVVLEGKNFDEACAAALRQAEATGALFVHPFNDPLVMAGQGTIGL
ELLEDLPDLANVLIPVGGGGLIAGIARAIKETHPQVRIIGVEAAAAPSMRQALHKGEVVTVPIRASLADGIAVKTAGTNT
FPVAKEYVDEIVLVDEEEIALAIVSLMERNKLMVEGAGAVGLAALLNGKIKRISGKTVALLSGGNIDVKTIAVVVERGLL
AAGRYLKLKIELDDVPGALARLATEIAEARANISIITHDRRSESLPIGKTEVLVELETRGAEHIQDVIRHLSKREYLLEV
IK
>Mature_402_residues
MLDYNLIVDAAQRLKKRVRRTELIHAQHFSERLGLPLYFKCENLQRTGAFKIRGALNFMTAQPRQALAGGVITASAGNHA
QGVAFSADLLGVKAVVYMPESTPPQKVFATRDYGAEVVLEGKNFDEACAAALRQAEATGALFVHPFNDPLVMAGQGTIGL
ELLEDLPDLANVLIPVGGGGLIAGIARAIKETHPQVRIIGVEAAAAPSMRQALHKGEVVTVPIRASLADGIAVKTAGTNT
FPVAKEYVDEIVLVDEEEIALAIVSLMERNKLMVEGAGAVGLAALLNGKIKRISGKTVALLSGGNIDVKTIAVVVERGLL
AAGRYLKLKIELDDVPGALARLATEIAEARANISIITHDRRSESLPIGKTEVLVELETRGAEHIQDVIRHLSKREYLLEV
IK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=312, Percent_Identity=34.9358974358974, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI19923959, Length=296, Percent_Identity=31.0810810810811, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI33469958, Length=278, Percent_Identity=31.294964028777, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI295821202, Length=200, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI295821200, Length=200, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4557415, Length=200, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=47.0779220779221, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790207, Length=325, Percent_Identity=40.9230769230769, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71991565, Length=393, Percent_Identity=42.2391857506361, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=35.6770833333333, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17508781, Length=306, Percent_Identity=28.4313725490196, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=347, Percent_Identity=36.5994236311239, Blast_Score=195, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6322631, Length=312, Percent_Identity=37.1794871794872, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=23.859649122807, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21355833, Length=360, Percent_Identity=40.2777777777778, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24645328, Length=264, Percent_Identity=43.1818181818182, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43023; Mature: 43023

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYNLIVDAAQRLKKRVRRTELIHAQHFSERLGLPLYFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECC
AQPRQALAGGVITASAGNHAQGVAFSADLLGVKAVVYMPESTPPQKVFATRDYGAEVVLE
CCCHHHHCCCEEEECCCCCCCCEEEEHHHHCEEEEEECCCCCCCHHEEEECCCCCEEEEE
GKNFDEACAAALRQAEATGALFVHPFNDPLVMAGQGTIGLELLEDLPDLANVLIPVGGGG
CCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCHHHHHHCCHHHHHEEEECCCCH
LIAGIARAIKETHPQVRIIGVEAAAAPSMRQALHKGEVVTVPIRASLADGIAVKTAGTNT
HHHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCC
FPVAKEYVDEIVLVDEEEIALAIVSLMERNKLMVEGAGAVGLAALLNGKIKRISGKTVAL
CCHHHHHHCCEEEECCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCEEEECCCEEEE
LSGGNIDVKTIAVVVERGLLAAGRYLKLKIELDDVPGALARLATEIAEARANISIITHDR
EECCCCCHHHHHHHHHHCHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECC
RSESLPIGKTEVLVELETRGAEHIQDVIRHLSKREYLLEVIK
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDYNLIVDAAQRLKKRVRRTELIHAQHFSERLGLPLYFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECC
AQPRQALAGGVITASAGNHAQGVAFSADLLGVKAVVYMPESTPPQKVFATRDYGAEVVLE
CCCHHHHCCCEEEECCCCCCCCEEEEHHHHCEEEEEECCCCCCCHHEEEECCCCCEEEEE
GKNFDEACAAALRQAEATGALFVHPFNDPLVMAGQGTIGLELLEDLPDLANVLIPVGGGG
CCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCHHHHHHCCHHHHHEEEECCCCH
LIAGIARAIKETHPQVRIIGVEAAAAPSMRQALHKGEVVTVPIRASLADGIAVKTAGTNT
HHHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCC
FPVAKEYVDEIVLVDEEEIALAIVSLMERNKLMVEGAGAVGLAALLNGKIKRISGKTVAL
CCHHHHHHCCEEEECCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCEEEECCCEEEE
LSGGNIDVKTIAVVVERGLLAAGRYLKLKIELDDVPGALARLATEIAEARANISIITHDR
EECCCCCHHHHHHHHHHCHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEECC
RSESLPIGKTEVLVELETRGAEHIQDVIRHLSKREYLLEVIK
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA