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The map label for this gene is gpmA

Identifier: 197119863

GI number: 197119863

Start: 4011796

End: 4012500

Strand: Direct

Name: gpmA

Synonym: Gbem_3501

Alternate gene names: 197119863

Gene position: 4011796-4012500 (Clockwise)

Preceding gene: 197119862

Following gene: 197119871

Centisome position: 86.93

GC content: 65.25

Gene sequence:

>705_bases
ATGCATCAACTGGTGCTGCTGCGACATGGCGAAAGCGTCTGGAACAAGGAGAACCTCTTCACGGGGTGGACCGACGTGGA
GCTCTCCCCGCGGGGGGAGGAGGAGAGCCGCAACGCGGGGCTGCTCCTGAAGGAGCACGGCTTCGTCTTCGACCTGGCCT
TTACCTCCCTCTTGAAGCGGGCGATAAAGACGCTCTGGATCGTGCTGGAGCAGATGGACCTGATGTGGATTCCGGAGCAC
AAGGAGTGGCGCCTGAACGAGAGGCATTACGGCGCGCTGCAGGGGCTGAACAAGGCGCAGACCGCGCAAGAGTACGGGGA
CGAGCAGGTGAAACTCTGGAGGCGCAGCTATAAGGTGCGGCCGCCGGCGCTCGCGGAGGGAGACCAGCGGCACCCGTCGT
TCGACCCGCGCTACCACTCCCTCTCCAGGGATCTGCTCCCCGATACCGAGTGCCTGCAGGACACGGTCGAGCGCGTGCTT
CCCTTCTGGCAGCAGCAGGCGGTCCCGGCCCTGCAGCAAGGAAAGCGCATCCTGATCGCGGCGCACGGCAACAGCCTGCG
GGGGCTGATCAAGTACCTGGACCAGATCCCGGACGACGACATCGTGGGGCTGGAGATCCCCACCGGGAGCCCGCTGGTGT
ACGAACTGGACCGCGACCTGAAGCCCGTGCGCCGCTACTACCTGGAGACGGGGAAAGCCGGGTAA

Upstream 100 bases:

>100_bases
ACGGACAAGTTGAAAGACGCAAGGGAAGCCGCGGCTGCGGCCGCCGGGGCCGCGAAGTAGGGCGATGGATGGGGCGGCCG
GAAGACAGCGGAGGTAAAGG

Downstream 100 bases:

>100_bases
CACCGGCACCATGATGAAAAAACGGGGATAAGTCCTGAAGGGCTTATCCCCGTTTTTTATTGCAACGAGAGCGGGTCCGA
ATGCTACTCCTGGGGCGCGG

Product: phosphoglycerate mutase 1

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MHQLVLLRHGESVWNKENLFTGWTDVELSPRGEEESRNAGLLLKEHGFVFDLAFTSLLKRAIKTLWIVLEQMDLMWIPEH
KEWRLNERHYGALQGLNKAQTAQEYGDEQVKLWRRSYKVRPPALAEGDQRHPSFDPRYHSLSRDLLPDTECLQDTVERVL
PFWQQQAVPALQQGKRILIAAHGNSLRGLIKYLDQIPDDDIVGLEIPTGSPLVYELDRDLKPVRRYYLETGKAG

Sequences:

>Translated_234_residues
MHQLVLLRHGESVWNKENLFTGWTDVELSPRGEEESRNAGLLLKEHGFVFDLAFTSLLKRAIKTLWIVLEQMDLMWIPEH
KEWRLNERHYGALQGLNKAQTAQEYGDEQVKLWRRSYKVRPPALAEGDQRHPSFDPRYHSLSRDLLPDTECLQDTVERVL
PFWQQQAVPALQQGKRILIAAHGNSLRGLIKYLDQIPDDDIVGLEIPTGSPLVYELDRDLKPVRRYYLETGKAG
>Mature_234_residues
MHQLVLLRHGESVWNKENLFTGWTDVELSPRGEEESRNAGLLLKEHGFVFDLAFTSLLKRAIKTLWIVLEQMDLMWIPEH
KEWRLNERHYGALQGLNKAQTAQEYGDEQVKLWRRSYKVRPPALAEGDQRHPSFDPRYHSLSRDLLPDTECLQDTVERVL
PFWQQQAVPALQQGKRILIAAHGNSLRGLIKYLDQIPDDDIVGLEIPTGSPLVYELDRDLKPVRRYYLETGKAG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=225, Percent_Identity=53.3333333333333, Blast_Score=260, Evalue=8e-70,
Organism=Homo sapiens, GI50593010, Length=228, Percent_Identity=51.3157894736842, Blast_Score=259, Evalue=1e-69,
Organism=Homo sapiens, GI71274132, Length=225, Percent_Identity=50.6666666666667, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI4502445, Length=229, Percent_Identity=49.3449781659389, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI40353764, Length=229, Percent_Identity=49.3449781659389, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI310129614, Length=162, Percent_Identity=53.7037037037037, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786970, Length=226, Percent_Identity=59.7345132743363, Blast_Score=297, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6322697, Length=230, Percent_Identity=50.4347826086956, Blast_Score=235, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6320183, Length=284, Percent_Identity=32.3943661971831, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324516, Length=282, Percent_Identity=32.6241134751773, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646216, Length=225, Percent_Identity=48.8888888888889, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI85725270, Length=225, Percent_Identity=49.3333333333333, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI85725272, Length=225, Percent_Identity=49.3333333333333, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24650981, Length=225, Percent_Identity=49.3333333333333, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=36.0730593607306, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=36.0730593607306, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=36.0730593607306, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_GEOBB (B5EC38)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140290.1
- ProteinModelPortal:   B5EC38
- GeneID:   6780364
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3501
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   CLSK2544926
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27146; Mature: 27146

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQLVLLRHGESVWNKENLFTGWTDVELSPRGEEESRNAGLLLKEHGFVFDLAFTSLLKR
CCEEEEEECCCHHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
AIKTLWIVLEQMDLMWIPEHKEWRLNERHYGALQGLNKAQTAQEYGDEQVKLWRRSYKVR
HHHHHHHHHHHHCEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCC
PPALAEGDQRHPSFDPRYHSLSRDLLPDTECLQDTVERVLPFWQQQAVPALQQGKRILIA
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEE
AHGNSLRGLIKYLDQIPDDDIVGLEIPTGSPLVYELDRDLKPVRRYYLETGKAG
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHQLVLLRHGESVWNKENLFTGWTDVELSPRGEEESRNAGLLLKEHGFVFDLAFTSLLKR
CCEEEEEECCCHHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
AIKTLWIVLEQMDLMWIPEHKEWRLNERHYGALQGLNKAQTAQEYGDEQVKLWRRSYKVR
HHHHHHHHHHHHCEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCC
PPALAEGDQRHPSFDPRYHSLSRDLLPDTECLQDTVERVLPFWQQQAVPALQQGKRILIA
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEE
AHGNSLRGLIKYLDQIPDDDIVGLEIPTGSPLVYELDRDLKPVRRYYLETGKAG
ECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA