Click here to switch to the map view.

The map label for this gene is uge [H]

Identifier: 197117253

GI number: 197117253

Start: 1016924

End: 1017934

Strand: Direct

Name: uge [H]

Synonym: Gbem_0861

Alternate gene names: 197117253

Gene position: 1016924-1017934 (Clockwise)

Preceding gene: 197117252

Following gene: 197117254

Centisome position: 22.03

GC content: 61.13

Gene sequence:

>1011_bases
ATGACAAAGATACTTGTTACCGGCGCAGCGGGTTTCATAGGCTCGCACCTTTCCCACAGGCTCCTCGCCAAGGGGCACGA
GGTGGTTGGGCTCGATAACCTGAACGACTATTACGATGTCAGCCTGAAAGAGGGGAGGCTGGCGAGGCTGGAAGGGAAGC
CGGGCTTTCGCTTAGTGCGGATGAACCTTGAGGACCGGGAGGGGATAGCCCGCCTCTTTGCCGCAGAGAAGTTCGATTCC
GTGGTGAACCTGGCCGCCCAGGCCGGGGTCCGCTACTCGATCCAGAACCCCTACGCCTACATCGACAGCAACATCTCCGG
TTTCATCAACATCCTGGAGGGATGCCGCCACAACAAGGTGAAGCACCTGGTCTACGCCTCGTCCTCCTCGGTCTACGGCG
CCAACACCACGATGCCCTTCTCGGTGCACCACAACGTGGACCATCCGGTCTCGCTCTACGCCGCCACCAAGAAGGCGAAC
GAGCTGATGGCCCACACTTATTCCAGCCTTTACGGGCTCCCCACCACGGGGCTGCGCTTTTTCACCGTCTATGGACCGTG
GGGGCGTCCCGACATGGCGCTGTTCCTTTTCACCAAGGCGATCCTGGAGGGGAAGCCGATCGACGTCTTCAACTATGGGA
AGATGCAGCGCGACTTCACTTTCGTCGACGACATCGTGGAAGGCGTAAGCCGCGTGATCGACAGCGTTCCTCCCGGCGAA
GCCGGCTGGAGCGGGGCGACCCCGGATCCGGGGACGAGCTACGCCCCTTACAAGATCTACAACATCGGGAACAACAACCC
GGTGGAGCTCTTGCGCTTCATCGAGGTGCTGGAAAAGGCGCTGGGGAAAGAGGCGCAGAAGAACCTGCTTCCGATCCAGG
CCGGCGACGTCCCGGCGACCTACGCCGACGTGGACGATCTGATGCGGGACGTCGGCTTCAAGCCGGCCACCTCCATCGAG
GACGGAATAGCCCGCTTCGTCGCCTGGTACCGGGATTTCTACAAGGTCTAG

Upstream 100 bases:

>100_bases
GGTCAAGGAGATGCTGCTGCAGCCGTGCCGCACCAGCGGAAGCGTTTGCAAGTGACGATGATGTTTTATTCCCTTCAATA
TGGCAATTTCTGGAGGTCAG

Downstream 100 bases:

>100_bases
AAGGGGCATTCTCCCAGGGGCGCGTTCGGTGGCCAGCCGAAGTTCCGGAGTTGGCAGCCGGCGCTAAAATGCGAAAAGGA
TAGCTCGTGAAGAAATACCG

Product: UDP-galacturonate 4-epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTKILVTGAAGFIGSHLSHRLLAKGHEVVGLDNLNDYYDVSLKEGRLARLEGKPGFRLVRMNLEDREGIARLFAAEKFDS
VVNLAAQAGVRYSIQNPYAYIDSNISGFINILEGCRHNKVKHLVYASSSSVYGANTTMPFSVHHNVDHPVSLYAATKKAN
ELMAHTYSSLYGLPTTGLRFFTVYGPWGRPDMALFLFTKAILEGKPIDVFNYGKMQRDFTFVDDIVEGVSRVIDSVPPGE
AGWSGATPDPGTSYAPYKIYNIGNNNPVELLRFIEVLEKALGKEAQKNLLPIQAGDVPATYADVDDLMRDVGFKPATSIE
DGIARFVAWYRDFYKV

Sequences:

>Translated_336_residues
MTKILVTGAAGFIGSHLSHRLLAKGHEVVGLDNLNDYYDVSLKEGRLARLEGKPGFRLVRMNLEDREGIARLFAAEKFDS
VVNLAAQAGVRYSIQNPYAYIDSNISGFINILEGCRHNKVKHLVYASSSSVYGANTTMPFSVHHNVDHPVSLYAATKKAN
ELMAHTYSSLYGLPTTGLRFFTVYGPWGRPDMALFLFTKAILEGKPIDVFNYGKMQRDFTFVDDIVEGVSRVIDSVPPGE
AGWSGATPDPGTSYAPYKIYNIGNNNPVELLRFIEVLEKALGKEAQKNLLPIQAGDVPATYADVDDLMRDVGFKPATSIE
DGIARFVAWYRDFYKV
>Mature_335_residues
TKILVTGAAGFIGSHLSHRLLAKGHEVVGLDNLNDYYDVSLKEGRLARLEGKPGFRLVRMNLEDREGIARLFAAEKFDSV
VNLAAQAGVRYSIQNPYAYIDSNISGFINILEGCRHNKVKHLVYASSSSVYGANTTMPFSVHHNVDHPVSLYAATKKANE
LMAHTYSSLYGLPTTGLRFFTVYGPWGRPDMALFLFTKAILEGKPIDVFNYGKMQRDFTFVDDIVEGVSRVIDSVPPGEA
GWSGATPDPGTSYAPYKIYNIGNNNPVELLRFIEVLEKALGKEAQKNLLPIQAGDVPATYADVDDLMRDVGFKPATSIED
GIARFVAWYRDFYKV

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=338, Percent_Identity=26.0355029585799, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI56237023, Length=346, Percent_Identity=26.878612716763, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI56118217, Length=346, Percent_Identity=26.878612716763, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI189083684, Length=346, Percent_Identity=26.878612716763, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI42516563, Length=338, Percent_Identity=25.4437869822485, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788353, Length=356, Percent_Identity=28.3707865168539, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI48994969, Length=354, Percent_Identity=28.5310734463277, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=24.8520710059172, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788589, Length=313, Percent_Identity=27.1565495207668, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982038, Length=351, Percent_Identity=25.3561253561254, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71982035, Length=349, Percent_Identity=25.214899713467, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17539532, Length=339, Percent_Identity=26.2536873156342, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17568069, Length=346, Percent_Identity=26.5895953757225, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=343, Percent_Identity=25.0728862973761, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=26.9565217391304, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19923002, Length=349, Percent_Identity=26.9340974212034, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356223, Length=341, Percent_Identity=26.3929618768328, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 37201; Mature: 37070

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILVTGAAGFIGSHLSHRLLAKGHEVVGLDNLNDYYDVSLKEGRLARLEGKPGFRLVR
CCEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCEEEECCCCCEEEEE
MNLEDREGIARLFAAEKFDSVVNLAAQAGVRYSIQNPYAYIDSNISGFINILEGCRHNKV
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHCCCCE
KHLVYASSSSVYGANTTMPFSVHHNVDHPVSLYAATKKANELMAHTYSSLYGLPTTGLRF
EEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEE
FTVYGPWGRPDMALFLFTKAILEGKPIDVFNYGKMQRDFTFVDDIVEGVSRVIDSVPPGE
EEEECCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
AGWSGATPDPGTSYAPYKIYNIGNNNPVELLRFIEVLEKALGKEAQKNLLPIQAGDVPAT
CCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCCH
YADVDDLMRDVGFKPATSIEDGIARFVAWYRDFYKV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKILVTGAAGFIGSHLSHRLLAKGHEVVGLDNLNDYYDVSLKEGRLARLEGKPGFRLVR
CEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCEEEECCCCCEEEEE
MNLEDREGIARLFAAEKFDSVVNLAAQAGVRYSIQNPYAYIDSNISGFINILEGCRHNKV
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHCCCCE
KHLVYASSSSVYGANTTMPFSVHHNVDHPVSLYAATKKANELMAHTYSSLYGLPTTGLRF
EEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEE
FTVYGPWGRPDMALFLFTKAILEGKPIDVFNYGKMQRDFTFVDDIVEGVSRVIDSVPPGE
EEEECCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
AGWSGATPDPGTSYAPYKIYNIGNNNPVELLRFIEVLEKALGKEAQKNLLPIQAGDVPAT
CCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCCH
YADVDDLMRDVGFKPATSIEDGIARFVAWYRDFYKV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]