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The map label for this gene is tyv [H]

Identifier: 197117251

GI number: 197117251

Start: 1014695

End: 1015723

Strand: Direct

Name: tyv [H]

Synonym: Gbem_0859

Alternate gene names: 197117251

Gene position: 1014695-1015723 (Clockwise)

Preceding gene: 197117250

Following gene: 197117252

Centisome position: 21.99

GC content: 60.25

Gene sequence:

>1029_bases
ATGAAATTACTGATAACCGGCGGGTGCGGTTTTCTCGGAAGCAATTTGGCAGCACACGCGCTCAAGCGCGGGGACGAACT
CGTCGTCTTTGACAGCCTGTACCGGCAAGGGTCCGTGGCCAACCGGAAGTGGCTTGAAACACAGGGCCATTTTCATTTCA
TCCATGGTGACATCCGCAACCAAAATGATGTCACTCGGTTGATCCAGGAGTTCCAGCCTGACGCCATTTTCCATCTTGCT
GGACAGGTGGCGATGACAACCTCCATTGCCAATCCCCGCATGGATTTCGAGGTCAACGTAGTGGGTACGCACAACCTCCT
GGAGGCCGTCCGCCTGTTCGCGCCGGAGGCAAGCGTATTTTATTCTTCGACGAACAAGGTGTACGGAGACCTGGAGCAGT
ACAGCTATGCTGAGACCGAGACGCGCTTTGTCTGCAGCGACAGGCCGAACGGGTTCGACGAGTCGACTCCGCTTGAGTTC
CACTCGCCGTACGGCTGTTCCAAGGGGGGCGCCGACCAATACATGCTCGACTACGCCCGCATCTTCGGCCTGAAGACCAC
CGTATTTCGGCACTCCAGCATGTACGGGGGGCGCCAGTTTGCCACCTACGACCAGGGGTGGATCGGTTGGTTCTGCCAAA
AGGCGGCGGAGACCAGACTCGGTTTGCTTAAGGAGCCTTTCACGATCTCCGGGACCGGTAAGCAGGTGCGCGATGTTCTG
CACGCCGACGACATGATCACCCTTTATTTCGGGGCGCTGGAGCGCGCCGAGCTGCTACGCGGCCAGGTCTTCAACATCGG
GGGGGGGATCGAGAACAGCCTGTCGCTTCTGGAGCTGTTCGAGCTGCTGCAGGGGCACATCGGGGGGGCGCTTGACTACC
TGAAGCTCGCCCCCCGCGAGAGCGACCAGCGGGTCTTCGTGGCCGATATCGGCAAGGCCGCCGCTTTGATCGGCTGGCAG
CCACGGGTTTCCGCTTCCGAGGGCGTGGCCAGGATGCTGGAATGGACCAGCCGCGTGCTGGGCCATTGA

Upstream 100 bases:

>100_bases
GCTGGAAGGCAACTGTGGATCTCTCGGCAGGGCTTGCGCGCACCGTAGCCTACCAGCAACAGGAAGACAAAAACGGCAGT
GAAGCTGAAGGGAGCATGTC

Downstream 100 bases:

>100_bases
TCCGACCATCGCTTGGCTGAGCGGCTTAATCGGAGGCAGATCCGCTATGGCAACGCTGGCAGGTTGACTTGCATTTTGGT
GCCAACAGGATGGCTACCAT

Product: CDP-paratose 2-epimerase

Products: NA

Alternate protein names: CDP-tyvelose 2-epimerase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKLLITGGCGFLGSNLAAHALKRGDELVVFDSLYRQGSVANRKWLETQGHFHFIHGDIRNQNDVTRLIQEFQPDAIFHLA
GQVAMTTSIANPRMDFEVNVVGTHNLLEAVRLFAPEASVFYSSTNKVYGDLEQYSYAETETRFVCSDRPNGFDESTPLEF
HSPYGCSKGGADQYMLDYARIFGLKTTVFRHSSMYGGRQFATYDQGWIGWFCQKAAETRLGLLKEPFTISGTGKQVRDVL
HADDMITLYFGALERAELLRGQVFNIGGGIENSLSLLELFELLQGHIGGALDYLKLAPRESDQRVFVADIGKAAALIGWQ
PRVSASEGVARMLEWTSRVLGH

Sequences:

>Translated_342_residues
MKLLITGGCGFLGSNLAAHALKRGDELVVFDSLYRQGSVANRKWLETQGHFHFIHGDIRNQNDVTRLIQEFQPDAIFHLA
GQVAMTTSIANPRMDFEVNVVGTHNLLEAVRLFAPEASVFYSSTNKVYGDLEQYSYAETETRFVCSDRPNGFDESTPLEF
HSPYGCSKGGADQYMLDYARIFGLKTTVFRHSSMYGGRQFATYDQGWIGWFCQKAAETRLGLLKEPFTISGTGKQVRDVL
HADDMITLYFGALERAELLRGQVFNIGGGIENSLSLLELFELLQGHIGGALDYLKLAPRESDQRVFVADIGKAAALIGWQ
PRVSASEGVARMLEWTSRVLGH
>Mature_342_residues
MKLLITGGCGFLGSNLAAHALKRGDELVVFDSLYRQGSVANRKWLETQGHFHFIHGDIRNQNDVTRLIQEFQPDAIFHLA
GQVAMTTSIANPRMDFEVNVVGTHNLLEAVRLFAPEASVFYSSTNKVYGDLEQYSYAETETRFVCSDRPNGFDESTPLEF
HSPYGCSKGGADQYMLDYARIFGLKTTVFRHSSMYGGRQFATYDQGWIGWFCQKAAETRLGLLKEPFTISGTGKQVRDVL
HADDMITLYFGALERAELLRGQVFNIGGGIENSLSLLELFELLQGHIGGALDYLKLAPRESDQRVFVADIGKAAALIGWQ
PRVSASEGVARMLEWTSRVLGH

Specific function: Catalyzes the isomeration of CDP-paratose to CDP- tyvelose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=348, Percent_Identity=27.0114942528736, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI42516563, Length=339, Percent_Identity=25.3687315634218, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI56237023, Length=351, Percent_Identity=25.3561253561254, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI56118217, Length=351, Percent_Identity=25.3561253561254, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI189083684, Length=351, Percent_Identity=25.3561253561254, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4504031, Length=364, Percent_Identity=25.8241758241758, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788353, Length=350, Percent_Identity=28.8571428571429, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI48994969, Length=353, Percent_Identity=29.4617563739377, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1786974, Length=352, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788366, Length=378, Percent_Identity=23.8095238095238, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=348, Percent_Identity=24.1379310344828, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=335, Percent_Identity=24.1791044776119, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539532, Length=337, Percent_Identity=24.9258160237389, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI133901786, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=356, Percent_Identity=24.438202247191, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356223, Length=336, Percent_Identity=26.7857142857143, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19923002, Length=362, Percent_Identity=25.9668508287293, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.10 [H]

Molecular weight: Translated: 38092; Mature: 38092

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLITGGCGFLGSNLAAHALKRGDELVVFDSLYRQGSVANRKWLETQGHFHFIHGDIRN
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHEECCCCEEEEECCCCC
QNDVTRLIQEFQPDAIFHLAGQVAMTTSIANPRMDFEVNVVGTHNLLEAVRLFAPEASVF
CHHHHHHHHHHCCCHHHHHHCHHHEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCEE
YSSTNKVYGDLEQYSYAETETRFVCSDRPNGFDESTPLEFHSPYGCSKGGADQYMLDYAR
ECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IFGLKTTVFRHSSMYGGRQFATYDQGWIGWFCQKAAETRLGLLKEPFTISGTGKQVRDVL
HHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHH
HADDMITLYFGALERAELLRGQVFNIGGGIENSLSLLELFELLQGHIGGALDYLKLAPRE
HCCCEEEEHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
SDQRVFVADIGKAAALIGWQPRVSASEGVARMLEWTSRVLGH
CCCEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLLITGGCGFLGSNLAAHALKRGDELVVFDSLYRQGSVANRKWLETQGHFHFIHGDIRN
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHEECCCCEEEEECCCCC
QNDVTRLIQEFQPDAIFHLAGQVAMTTSIANPRMDFEVNVVGTHNLLEAVRLFAPEASVF
CHHHHHHHHHHCCCHHHHHHCHHHEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCCEE
YSSTNKVYGDLEQYSYAETETRFVCSDRPNGFDESTPLEFHSPYGCSKGGADQYMLDYAR
ECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IFGLKTTVFRHSSMYGGRQFATYDQGWIGWFCQKAAETRLGLLKEPFTISGTGKQVRDVL
HHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHH
HADDMITLYFGALERAELLRGQVFNIGGGIENSLSLLELFELLQGHIGGALDYLKLAPRE
HCCCEEEEHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
SDQRVFVADIGKAAALIGWQPRVSASEGVARMLEWTSRVLGH
CCCEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2793833; 11677608; 12644504; 12642575 [H]