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The map label for this gene is hpt [H]

Identifier: 197116939

GI number: 197116939

Start: 653824

End: 654375

Strand: Reverse

Name: hpt [H]

Synonym: Gbem_0541

Alternate gene names: 197116939

Gene position: 654375-653824 (Counterclockwise)

Preceding gene: 197116940

Following gene: 197116938

Centisome position: 14.18

GC content: 61.96

Gene sequence:

>552_bases
ATGTTACTGAAAGACATGGAGGACATCCGGCAGAAGGCCGATTGTCTGAAGTCCGCACAGGAAGTCGACGATGCGCTGTC
ACGGATGGCGCAGCAGATAACCGAGCGGCTGGCGGAGAGCAACCCGGTGGCGATTTGCATCATGAACGGCGGGCTGTTCG
TCACCGGCAAACTGGTGGACAAACTCCCCTTCGCGCTGGAACTCGACTATCTTCACGCCACCCGCTACGGCGCTGAGCTG
ACCGGCGGGAACCTGCTCTGGAAGGTAAAGCCGGAGCGCTCGCTCAAGGGGCGCACGGTGCTCTTGGTGGACGACATCCT
CGACGAAGGGGTGACTCTTGCGGAGATCGAGCGTTACTGCCGCGAGGAAGGCGCCGCTGCGGTCTACACCGCGGTCCTGG
TGGACAAGATCCACGACAGGAAGGCGCCCGGCGCCAAGGCCGATTTCGTCGGCCTAGAGGTAGAGGACCGCTTCCTCTTC
GGTTGCGGCATGGACATCGCAGGCTACTGGCGCAATCTCCCCGCGCTCTACGCAATGAAGGAGCAGAACTAG

Upstream 100 bases:

>100_bases
GGCCGATTCAAAGCAGATAATTAAAGCACAATTAATTGATTTCACGGCGAAAATTTGCTATGGTTCCGCCGCTTGAAACA
AAAGTTTCCAAGGAGCCTGA

Downstream 100 bases:

>100_bases
AAATGACCTCCCGCATAGCAGCATACTTCCAGTTCCAGCGCTACGGCACCGACATGAAGCGTGAGGTCATCGCAGGACTC
ACCACCTTCCTCACCATGGC

Product: hypoxanthine/guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLLKDMEDIRQKADCLKSAQEVDDALSRMAQQITERLAESNPVAICIMNGGLFVTGKLVDKLPFALELDYLHATRYGAEL
TGGNLLWKVKPERSLKGRTVLLVDDILDEGVTLAEIERYCREEGAAAVYTAVLVDKIHDRKAPGAKADFVGLEVEDRFLF
GCGMDIAGYWRNLPALYAMKEQN

Sequences:

>Translated_183_residues
MLLKDMEDIRQKADCLKSAQEVDDALSRMAQQITERLAESNPVAICIMNGGLFVTGKLVDKLPFALELDYLHATRYGAEL
TGGNLLWKVKPERSLKGRTVLLVDDILDEGVTLAEIERYCREEGAAAVYTAVLVDKIHDRKAPGAKADFVGLEVEDRFLF
GCGMDIAGYWRNLPALYAMKEQN
>Mature_183_residues
MLLKDMEDIRQKADCLKSAQEVDDALSRMAQQITERLAESNPVAICIMNGGLFVTGKLVDKLPFALELDYLHATRYGAEL
TGGNLLWKVKPERSLKGRTVLLVDDILDEGVTLAEIERYCREEGAAAVYTAVLVDKIHDRKAPGAKADFVGLEVEDRFLF
GCGMDIAGYWRNLPALYAMKEQN

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=168, Percent_Identity=26.1904761904762, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=26.0115606936416, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510817, Length=166, Percent_Identity=27.710843373494, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20382; Mature: 20382

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKDMEDIRQKADCLKSAQEVDDALSRMAQQITERLAESNPVAICIMNGGLFVTGKLVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEHHHH
KLPFALELDYLHATRYGAELTGGNLLWKVKPERSLKGRTVLLVDDILDEGVTLAEIERYC
HCCCEEEEHHHHHHHCCCEECCCEEEEEECCCCCCCCCEEEEEEHHHHCCCCHHHHHHHH
REEGAAAVYTAVLVDKIHDRKAPGAKADFVGLEVEDRFLFGCGMDIAGYWRNLPALYAMK
HHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEECCCCHHHHHHCCCCEEEEE
EQN
CCC
>Mature Secondary Structure
MLLKDMEDIRQKADCLKSAQEVDDALSRMAQQITERLAESNPVAICIMNGGLFVTGKLVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEHHHH
KLPFALELDYLHATRYGAELTGGNLLWKVKPERSLKGRTVLLVDDILDEGVTLAEIERYC
HCCCEEEEHHHHHHHCCCEECCCEEEEEECCCCCCCCCEEEEEEHHHHCCCCHHHHHHHH
REEGAAAVYTAVLVDKIHDRKAPGAKADFVGLEVEDRFLFGCGMDIAGYWRNLPALYAMK
HHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEECCCCHHHHHHCCCCEEEEE
EQN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]