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Identifier: 197116861

GI number: 197116861

Start: 557183

End: 557812

Strand: Direct

Name: upp

Synonym: Gbem_0463

Alternate gene names: 197116861

Gene position: 557183-557812 (Clockwise)

Preceding gene: 308535165

Following gene: 197116862

Centisome position: 12.07

GC content: 60.79

Gene sequence:

>630_bases
ATGAGTGTCCACGAAGTAAACCATCCGTTGGTGAAGCACAAGATCGGCCTGATGCGCGAGGCCGGGATCAGCACCAAGAA
GTTCCGCGAACTCACCTCGGAGATCGCCTGCCTGCTAGCTTACGAGGCCAGCAGGGATTTCCAGATCGAGCCTAGAACCA
TCACCGGCTGGGACGGCAGCAAGGTAATGATCCAGCAGTTGAAAGGGAAGAAGGTGACGGTGGTCCCGATCCTGCGCGCC
GGCATCGGCATGCTGGACGGCGTACTGGACATGATCCCCAACGCCAAGGTGAGCGTGGTGGGGCTGGCCCGCAACGAAGA
GACGCTGGAGGCGCATACCTATTTCGAGAGGTTCGTCGGGAGCCTGGACGAGCGTCTTGCCCTCATCATCGACCCCATGC
TCGCTACCGGCGGGTCCATGGCCGCCACCATAGAGATGCTCAAGAAGAACGGCTGCCTCCAGATCCGCGTCCTTTGCCTC
GTCGCCGCTCCGGAAGGACTGGCGAAGATCACCGCTGCCTACCCGGAGATCGACATCTACGTCGCGGCGATCGACGAACG
GTTGAACGAGCAAGGGTACATCCTCCCTGGCTTGGGAGACGCCGGCGACAAGATCTTCGGCACCAAGTAA

Upstream 100 bases:

>100_bases
CTCCCGACTGTGCCCAATTGGTCGCGTCTAATGCGCAACTGCTTGTTTGTATGGATAAATTCCGGTATGGTTACATCAAA
ATTTTTGCCGGGAGATCCTG

Downstream 100 bases:

>100_bases
CGCACCCGGCTGCAACCAAAGCGGGGGCGTTCCCTCCCGTATCACTTTCCTAGCGAGGTCAACTGCATGTCACAAGCAAA
AGAACCGGTATGGCGCCAGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGSKVMIQQLKGKKVTVVPILRA
GIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVGSLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCL
VAAPEGLAKITAAYPEIDIYVAAIDERLNEQGYILPGLGDAGDKIFGTK

Sequences:

>Translated_209_residues
MSVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGSKVMIQQLKGKKVTVVPILRA
GIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVGSLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCL
VAAPEGLAKITAAYPEIDIYVAAIDERLNEQGYILPGLGDAGDKIFGTK
>Mature_208_residues
SVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGSKVMIQQLKGKKVTVVPILRAG
IGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVGSLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCLV
AAPEGLAKITAAYPEIDIYVAAIDERLNEQGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=27.4647887323944, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=27.4647887323944, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI87082118, Length=209, Percent_Identity=64.5933014354067, Blast_Score=287, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17539894, Length=152, Percent_Identity=23.6842105263158, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539892, Length=152, Percent_Identity=23.6842105263158, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=37.6811594202899, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=24.6305418719212, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=24.6305418719212, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=24.6305418719212, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=24.6305418719212, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_GEOBB (B5EBM3)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137288.1
- GeneID:   6783290
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0463
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22779; Mature: 22648

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGS
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCEECCCEEECCCCC
KVMIQQLKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVG
HHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
SLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCLVAAPEGLAKITAAYPEIDIY
HHHHHHHHEECHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHCCCCEEEE
VAAIDERLNEQGYILPGLGDAGDKIFGTK
EEEEHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SVHEVNHPLVKHKIGLMREAGISTKKFRELTSEIACLLAYEASRDFQIEPRTITGWDGS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCEECCCEEECCCCC
KVMIQQLKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYFERFVG
HHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
SLDERLALIIDPMLATGGSMAATIEMLKKNGCLQIRVLCLVAAPEGLAKITAAYPEIDIY
HHHHHHHHEECHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHCCCCEEEE
VAAIDERLNEQGYILPGLGDAGDKIFGTK
EEEEHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA