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The map label for this gene is gcvT [H]

Identifier: 197116793

GI number: 197116793

Start: 470541

End: 471632

Strand: Direct

Name: gcvT [H]

Synonym: Gbem_0395

Alternate gene names: 197116793

Gene position: 470541-471632 (Clockwise)

Preceding gene: 197116786

Following gene: 197116794

Centisome position: 10.2

GC content: 63.28

Gene sequence:

>1092_bases
ATGGAAGATCTCAAGGCGACACCGCTGCAAGCCCACCACGAGGGGCTCAAGGCGCTGATGGCTCCCTTCGGGGGATGGCT
GATGCCGATCCAGTACGAGGGGATCATCGCCGAACACAGGTGGTGCCGCGAAAAAGCGGCGCTTTTCGACATCTGCCACA
TGGGAGAGTTCCGGTTCCGGGGGGACATCCAGGCCGGCGGCTTGGAAGACGTCTTCACCTTCTCGGTCAAGGGGATCCCG
ATCGGGCGCTCGCGCTACGGGTTCCTGCTGAACCCGTCGGGGGGGGTGATCGACGACCTGATCGTCTTTAGGCTGGCTGA
GGACGAGGTGATGATCGTAGTAAACGCGGCGACCGCGCCCAACGATTTCAAGGTCATCGCCTCGCGTCTGAAAGAGCCGG
CGCAACTGGTCGACATCTCCGTGCAGACCGGGAAGCTGGACCTCCAGGGGCCGCTCTCCCGCGAGGTGCTGGTGGAACAT
CTGGGGAGCGAACTCGGCGCGCTTCCCTTCTTCAAGTTCACCAGGACCCGCGTCCTCGGGGAGGACGCCATCGTGAGCCG
GACCGGATACACCGGCGAACTCGGCTACGAGATCTTCCTCCCCAGCGGCAAGACTGCGGAACTGTGGGAGCTCCTGCTCA
AGGACCCGAGGGTTGCCCCAGCCGGATTGGGCGCCCGCGACCTGTTGCGGCTGGAGATGGGGTACTCGTTGTACGGAAAC
GACATCGACGAAAAGATCTCTCCGATTGCAGCGGGACTCACCGCATTCGTTAACCTGGACAAGGATTTCGTCGGCAAGGA
TGCGCTCCTTAAGGAGCGGGAAACGGGGCCGGAAAACGTGAAGGTCGCCTTCCGCGTCGACTCCCGCCGCTCTCCGCGCC
ACTTTTACGAGATCCTGCATCAGGGAGCGCAGGTGGGGATGGTGACCAGCGGCGCCTTCTCCCCCATGCTTTCCTGCGGC
ATCGGGATGGGGTACGTGAAGCCGGAGGCAGCGGCCTTGGGGACCAGGCTCACCATCAAGCACGAGCGGGTAGAGATGGA
GGCCCAGGTGGTCGAGCTTCCCTTCTACACCGGAGGTTCGCTGAGGGCATAG

Upstream 100 bases:

>100_bases
TGATTTGGCAAGAAGTTAAAGCGGGTTGCCTCCCGGCCTAATCCTTACGTGATAACGGAGCGAACCGCCGGCCCGCTGCC
GGTAGAAAGGAGAAGCAGCT

Downstream 100 bases:

>100_bases
GCTCCCCCCCCCCACCCGGCCTCCCCCCTCTTGCCATTCCCAGATCAGGCGCGGACCGGCCTGGGCTGCCAATTAACTCT
TTATGCGAACGATACGAACC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MEDLKATPLQAHHEGLKALMAPFGGWLMPIQYEGIIAEHRWCREKAALFDICHMGEFRFRGDIQAGGLEDVFTFSVKGIP
IGRSRYGFLLNPSGGVIDDLIVFRLAEDEVMIVVNAATAPNDFKVIASRLKEPAQLVDISVQTGKLDLQGPLSREVLVEH
LGSELGALPFFKFTRTRVLGEDAIVSRTGYTGELGYEIFLPSGKTAELWELLLKDPRVAPAGLGARDLLRLEMGYSLYGN
DIDEKISPIAAGLTAFVNLDKDFVGKDALLKERETGPENVKVAFRVDSRRSPRHFYEILHQGAQVGMVTSGAFSPMLSCG
IGMGYVKPEAAALGTRLTIKHERVEMEAQVVELPFYTGGSLRA

Sequences:

>Translated_363_residues
MEDLKATPLQAHHEGLKALMAPFGGWLMPIQYEGIIAEHRWCREKAALFDICHMGEFRFRGDIQAGGLEDVFTFSVKGIP
IGRSRYGFLLNPSGGVIDDLIVFRLAEDEVMIVVNAATAPNDFKVIASRLKEPAQLVDISVQTGKLDLQGPLSREVLVEH
LGSELGALPFFKFTRTRVLGEDAIVSRTGYTGELGYEIFLPSGKTAELWELLLKDPRVAPAGLGARDLLRLEMGYSLYGN
DIDEKISPIAAGLTAFVNLDKDFVGKDALLKERETGPENVKVAFRVDSRRSPRHFYEILHQGAQVGMVTSGAFSPMLSCG
IGMGYVKPEAAALGTRLTIKHERVEMEAQVVELPFYTGGSLRA
>Mature_363_residues
MEDLKATPLQAHHEGLKALMAPFGGWLMPIQYEGIIAEHRWCREKAALFDICHMGEFRFRGDIQAGGLEDVFTFSVKGIP
IGRSRYGFLLNPSGGVIDDLIVFRLAEDEVMIVVNAATAPNDFKVIASRLKEPAQLVDISVQTGKLDLQGPLSREVLVEH
LGSELGALPFFKFTRTRVLGEDAIVSRTGYTGELGYEIFLPSGKTAELWELLLKDPRVAPAGLGARDLLRLEMGYSLYGN
DIDEKISPIAAGLTAFVNLDKDFVGKDALLKERETGPENVKVAFRVDSRRSPRHFYEILHQGAQVGMVTSGAFSPMLSCG
IGMGYVKPEAAALGTRLTIKHERVEMEAQVVELPFYTGGSLRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=364, Percent_Identity=31.5934065934066, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI257796258, Length=349, Percent_Identity=31.5186246418338, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796256, Length=274, Percent_Identity=33.9416058394161, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI257796254, Length=361, Percent_Identity=29.6398891966759, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI197927446, Length=322, Percent_Identity=28.2608695652174, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI21361378, Length=322, Percent_Identity=28.2608695652174, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=24.702380952381, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI194306651, Length=321, Percent_Identity=23.6760124610592, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=36.0433604336043, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=32.2493224932249, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32563613, Length=316, Percent_Identity=27.8481012658228, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=346, Percent_Identity=24.2774566473988, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=346, Percent_Identity=24.2774566473988, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=379, Percent_Identity=32.9815303430079, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI20129441, Length=351, Percent_Identity=35.6125356125356, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28571104, Length=318, Percent_Identity=24.8427672955975, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI20130091, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39882; Mature: 39882

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLKATPLQAHHEGLKALMAPFGGWLMPIQYEGIIAEHRWCREKAALFDICHMGEFRFR
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHCCCEEEE
GDIQAGGLEDVFTFSVKGIPIGRSRYGFLLNPSGGVIDDLIVFRLAEDEVMIVVNAATAP
CCCCCCCCCCEEEEEEECEEECCCCCEEEECCCCCHHHHHHEEEECCCCEEEEEECCCCC
NDFKVIASRLKEPAQLVDISVQTGKLDLQGPLSREVLVEHLGSELGALPFFKFTRTRVLG
CHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
EDAIVSRTGYTGELGYEIFLPSGKTAELWELLLKDPRVAPAGLGARDLLRLEMGYSLYGN
CCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCC
DIDEKISPIAAGLTAFVNLDKDFVGKDALLKERETGPENVKVAFRVDSRRSPRHFYEILH
CHHHHHHHHHHHHHHEEECCHHHCCCHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHH
QGAQVGMVTSGAFSPMLSCGIGMGYVKPEAAALGTRLTIKHERVEMEAQVVELPFYTGGS
CCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHCCCEEEEEHHHHEEEEEEEEECEECCCC
LRA
CCC
>Mature Secondary Structure
MEDLKATPLQAHHEGLKALMAPFGGWLMPIQYEGIIAEHRWCREKAALFDICHMGEFRFR
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHCCCEEEE
GDIQAGGLEDVFTFSVKGIPIGRSRYGFLLNPSGGVIDDLIVFRLAEDEVMIVVNAATAP
CCCCCCCCCCEEEEEEECEEECCCCCEEEECCCCCHHHHHHEEEECCCCEEEEEECCCCC
NDFKVIASRLKEPAQLVDISVQTGKLDLQGPLSREVLVEHLGSELGALPFFKFTRTRVLG
CHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
EDAIVSRTGYTGELGYEIFLPSGKTAELWELLLKDPRVAPAGLGARDLLRLEMGYSLYGN
CCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCC
DIDEKISPIAAGLTAFVNLDKDFVGKDALLKERETGPENVKVAFRVDSRRSPRHFYEILH
CHHHHHHHHHHHHHHEEECCHHHCCCHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHH
QGAQVGMVTSGAFSPMLSCGIGMGYVKPEAAALGTRLTIKHERVEMEAQVVELPFYTGGS
CCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHCCCEEEEEHHHHEEEEEEEEECEECCCC
LRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA