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The map label for this gene is hexR [H]

Identifier: 194736565

GI number: 194736565

Start: 1960047

End: 1960916

Strand: Direct

Name: hexR [H]

Synonym: SeSA_A2041

Alternate gene names: 194736565

Gene position: 1960047-1960916 (Clockwise)

Preceding gene: 194736750

Following gene: 194735271

Centisome position: 41.62

GC content: 51.38

Gene sequence:

>870_bases
ATGAATATGCTGGAAAAAGTCCAGTCTCAACTGGAACATTTAAGCAAATCTGAACGAAAAGTCGCCGATGTTATTCTGGC
CGCCCCAGGCAGATCGATTCACTTAAGCATTGCCATGCTGGCCCAGGAAGCTAACGTTAGCGAGCCAACGGTGAACCGTT
TCTGTCGCAGCATGAATACCCGCGGCTTTCCTGATTTTAAACTGCATCTGGCGCAAAGTCTGGCAAATGGCACCCCCTAT
GTTAATCGCAATGTGGATGAAGATGACAGCGTTGAGGCCTATACAGGAAAAATCTTCGAGTCCGCCATGGCCAGTCTCGA
CCATGTTCGTCAGTCGCTGGATAAATCGGCCGTCAACCGCGCCGTCGATTTACTGACCCAGGCAAAAAAAATCGCCTTTT
TTGGCCTTGGTTCCTCCGCCGCGGTCGCGCATGACGCCATGAATAAGTTTTTTCGCTTCAATGTGCCGGTGATTTACTCC
GACGATATCGTGCTGCAACGGATGAGCTGTATGAATTGTAACGATGATGACGTCGTCGTGCTCATTTCGCATACTGGCAG
AACCAAGAGCCTGGTGGAACTGGCGCAGTTGGCGCGGGAAAACGATGCGATGGTGATCGCCCTGACCTCCGCTGGAACGC
CGCTGGCGCGCGAAGCCACGCTGGCCATTACCCTCGACGTACCGGAAGATACAGACATTTATATGCCCATGGTCTCTCGA
CTTGCTCAGCTGACCGTGATAGATGTGCTGGCAACGGGATTTACTTTGCGTCGCGGGGCAAAATTCAGAGATAACTTGAA
GCGTGTCAAGGAAGCGCTCAAGGAATCGCGTTTTGATAAAGAATTACTCATCAGGAGTGATGACCGCTAA

Upstream 100 bases:

>100_bases
CATTTTGCCCCCTTTGACAGCCGCCAGGAGTAATATCTAACAAAACGCGCTCGGTTTCGCGCATCATTGAAATCGCTAAT
ACCCATGAGCCTTGCTAATC

Downstream 100 bases:

>100_bases
AAGCAATAACAATGTTCTACCCTTTTCGTCATCCGGGGACGTTCATTTTATACCGTTAAGGTTTCAGAACGACCGGATCA
ATGTTCACGCAACACCAAGT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNMLEKVQSQLEHLSKSERKVADVILAAPGRSIHLSIAMLAQEANVSEPTVNRFCRSMNTRGFPDFKLHLAQSLANGTPY
VNRNVDEDDSVEAYTGKIFESAMASLDHVRQSLDKSAVNRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKSLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKELLIRSDDR

Sequences:

>Translated_289_residues
MNMLEKVQSQLEHLSKSERKVADVILAAPGRSIHLSIAMLAQEANVSEPTVNRFCRSMNTRGFPDFKLHLAQSLANGTPY
VNRNVDEDDSVEAYTGKIFESAMASLDHVRQSLDKSAVNRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKSLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKELLIRSDDR
>Mature_289_residues
MNMLEKVQSQLEHLSKSERKVADVILAAPGRSIHLSIAMLAQEANVSEPTVNRFCRSMNTRGFPDFKLHLAQSLANGTPY
VNRNVDEDDSVEAYTGKIFESAMASLDHVRQSLDKSAVNRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKSLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKELLIRSDDR

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=289, Percent_Identity=92.0415224913495, Blast_Score=549, Evalue=1e-158,
Organism=Escherichia coli, GI1788767, Length=264, Percent_Identity=26.8939393939394, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082130, Length=195, Percent_Identity=27.1794871794872, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=23.3333333333333, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32077; Mature: 32077

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLEKVQSQLEHLSKSERKVADVILAAPGRSIHLSIAMLAQEANVSEPTVNRFCRSMNT
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHEEEHHHCCCCCHHHHHHHHHCCC
RGFPDFKLHLAQSLANGTPYVNRNVDEDDSVEAYTGKIFESAMASLDHVRQSLDKSAVNR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYSDDIVLQRMSCMNCNDDDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKELLIRSDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure
MNMLEKVQSQLEHLSKSERKVADVILAAPGRSIHLSIAMLAQEANVSEPTVNRFCRSMNT
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHEEEHHHCCCCCHHHHHHHHHCCC
RGFPDFKLHLAQSLANGTPYVNRNVDEDDSVEAYTGKIFESAMASLDHVRQSLDKSAVNR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYSDDIVLQRMSCMNCNDDDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKSLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKELLIRSDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]