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The map label for this gene is atsA [H]

Identifier: 194735305

GI number: 194735305

Start: 3180580

End: 3182319

Strand: Reverse

Name: atsA [H]

Synonym: SeSA_A3297

Alternate gene names: 194735305

Gene position: 3182319-3180580 (Counterclockwise)

Preceding gene: 194735302

Following gene: 194738068

Centisome position: 67.58

GC content: 48.33

Gene sequence:

>1740_bases
GTGAAAAAACAAGTAACACTTGCCACACTCAGCATTATCTTCTCCGGTACGGCGCACAGTACGCAAAACGAACGTCCTGA
TATTATCGTGATTATCGCTGATGATATGGGATATTCTGATATCACTCCCTTCGGTGGGGAAATCCCAACGCCTAATTTGC
AGGCGATGGCTGAGAACGGCGTGCGGATGAGTCAATATTACACGTCTCCCATGTCTGCTCCCGCCCGTGCGATGCTATTA
ACCGGGAACACCAGTCAGCAAGCGGGTATAGGCGGTATGTGGTGGTATGAAAATACCATAGGTAAGGAAGGCTATGAATT
GCGCCTGACTGATCGGGTGACGACCATGGCTGAACGCTTTAAAGATGCTGGTTACAATACGCTGATGGCGGGTAAATGGC
ATCTTGGTTTTACGCCAGGCTCGACGCCAAAAGATCGGGGCTTTCGTCATTCTTTCGCCTTGATGGGGGGAGGCGCCAGT
CACTTTGATGATGCCGTGCCGCTGGGAACCGTGGAGATATTTCATACCTATTATACCCGTGACAATCAGCGCATTTCACT
GCCCTCCAGTTTTTACTCCAGCGAAGCCTATGCCAGCCAGATTAATCGCTGGATCAGCGAGACGCCACGGGAACAACCTA
TCTTCGCGTGGTTGGCCTTTACTGCGCCACATGATCCTCTGCAGGCACCGGATGAATGGATTAGTCGTTTTAAAAGTCAG
TATGAACAGGGCTATGCAGACGTCTATCGTCAGCGTATTGCTCGTTTGAAGAAACTGGGTTTCCTGCGTGATGACATACC
TCTGCCAGGACTGGAACTTGATAAAGAATGGCAGGCGATGACCCCGGAACAGCAGAAATATACGGCGAAGGTGATGCAGG
TTTACGCTGCTATGATCGCCAATATGGATGCACAGATTGGTACCGTTATTGAGACGTTAAAAAAGACCGGGCGCGATAAA
AACACGATTCTGGTCTTCTTAAGTGATAATGGGGTGAATCCGGCGGAGGGCTTTCACTATGAATCTGAACCGGATTTTTG
GAAGCAATTCGATAATCGTTACGAAAATATTGGTCGTAAAAATTCATTTATCTCTTATGGTCCCCACTGGGCTGATGTCA
GCAATGCGCCTTATGGTCGCTATCACAAAACGACCAGCGGTCAGGGGGGAATTAATACCAGTTTTATGATTTCCGGTCCT
GGTATCATCCATAATGGCGCCATAGATAACGCCACAATGGCGGCGTATGATGTCGCGCCCACGCTCTATGAATTTGCAGG
TATTGATGTCAGTAAATCATTATCTGAAAGACCGACACTGCCAATGATCGGCGTGAGTTTTAAACGCTATCTGACCGGTG
AAAGTCTGCACGCGCCTCGCACACAATATGGTGTTGAACTCCATAATCAGGCGGCCTGGATAGATGGGGAATGGAAATTG
CGTCGTCTTGTCACAGTATTCCCACAGGCGGGTAATGCGCCATGGGAATTATTCAACCTGCAACGTGACCCCCTGGAAAC
GCATAATCTCGCAGCAGATTATGTGGATAAAGTGAAAATACTGAGCAGTGCATATGAGGCATTTGCAAAACAGACAATGG
TGCTTTATGCCAAAGGCAAGCTTATCGATTATGTGGGTATCGACAGTAAAACCGGGCGTTATCTGGCTGTCGATCCACAG
ACATTGCAGCCAGTTCCTGCTCCGTTAGCGATTCCTTTAGACACAAAATCGGACCAATAA

Upstream 100 bases:

>100_bases
GTGCTGACGTTATGGGCAGATTTTCGGGCTGATGGTCCATCTTGCCGCATTTGCCCGCCGCTCTTGTACAACATCCGTAG
TCTGAAATGGAGAATAAGCC

Downstream 100 bases:

>100_bases
TTATTGGTTACGTTTCAAATGATTATTCAACGCTCACATAACCGCATTCAGCCAGTGACTTTCAGGATGAAGTTTCTCAG
CGTTGGCGATGTATCGCCGC

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MKKQVTLATLSIIFSGTAHSTQNERPDIIVIIADDMGYSDITPFGGEIPTPNLQAMAENGVRMSQYYTSPMSAPARAMLL
TGNTSQQAGIGGMWWYENTIGKEGYELRLTDRVTTMAERFKDAGYNTLMAGKWHLGFTPGSTPKDRGFRHSFALMGGGAS
HFDDAVPLGTVEIFHTYYTRDNQRISLPSSFYSSEAYASQINRWISETPREQPIFAWLAFTAPHDPLQAPDEWISRFKSQ
YEQGYADVYRQRIARLKKLGFLRDDIPLPGLELDKEWQAMTPEQQKYTAKVMQVYAAMIANMDAQIGTVIETLKKTGRDK
NTILVFLSDNGVNPAEGFHYESEPDFWKQFDNRYENIGRKNSFISYGPHWADVSNAPYGRYHKTTSGQGGINTSFMISGP
GIIHNGAIDNATMAAYDVAPTLYEFAGIDVSKSLSERPTLPMIGVSFKRYLTGESLHAPRTQYGVELHNQAAWIDGEWKL
RRLVTVFPQAGNAPWELFNLQRDPLETHNLAADYVDKVKILSSAYEAFAKQTMVLYAKGKLIDYVGIDSKTGRYLAVDPQ
TLQPVPAPLAIPLDTKSDQ

Sequences:

>Translated_579_residues
MKKQVTLATLSIIFSGTAHSTQNERPDIIVIIADDMGYSDITPFGGEIPTPNLQAMAENGVRMSQYYTSPMSAPARAMLL
TGNTSQQAGIGGMWWYENTIGKEGYELRLTDRVTTMAERFKDAGYNTLMAGKWHLGFTPGSTPKDRGFRHSFALMGGGAS
HFDDAVPLGTVEIFHTYYTRDNQRISLPSSFYSSEAYASQINRWISETPREQPIFAWLAFTAPHDPLQAPDEWISRFKSQ
YEQGYADVYRQRIARLKKLGFLRDDIPLPGLELDKEWQAMTPEQQKYTAKVMQVYAAMIANMDAQIGTVIETLKKTGRDK
NTILVFLSDNGVNPAEGFHYESEPDFWKQFDNRYENIGRKNSFISYGPHWADVSNAPYGRYHKTTSGQGGINTSFMISGP
GIIHNGAIDNATMAAYDVAPTLYEFAGIDVSKSLSERPTLPMIGVSFKRYLTGESLHAPRTQYGVELHNQAAWIDGEWKL
RRLVTVFPQAGNAPWELFNLQRDPLETHNLAADYVDKVKILSSAYEAFAKQTMVLYAKGKLIDYVGIDSKTGRYLAVDPQ
TLQPVPAPLAIPLDTKSDQ
>Mature_579_residues
MKKQVTLATLSIIFSGTAHSTQNERPDIIVIIADDMGYSDITPFGGEIPTPNLQAMAENGVRMSQYYTSPMSAPARAMLL
TGNTSQQAGIGGMWWYENTIGKEGYELRLTDRVTTMAERFKDAGYNTLMAGKWHLGFTPGSTPKDRGFRHSFALMGGGAS
HFDDAVPLGTVEIFHTYYTRDNQRISLPSSFYSSEAYASQINRWISETPREQPIFAWLAFTAPHDPLQAPDEWISRFKSQ
YEQGYADVYRQRIARLKKLGFLRDDIPLPGLELDKEWQAMTPEQQKYTAKVMQVYAAMIANMDAQIGTVIETLKKTGRDK
NTILVFLSDNGVNPAEGFHYESEPDFWKQFDNRYENIGRKNSFISYGPHWADVSNAPYGRYHKTTSGQGGINTSFMISGP
GIIHNGAIDNATMAAYDVAPTLYEFAGIDVSKSLSERPTLPMIGVSFKRYLTGESLHAPRTQYGVELHNQAAWIDGEWKL
RRLVTVFPQAGNAPWELFNLQRDPLETHNLAADYVDKVKILSSAYEAFAKQTMVLYAKGKLIDYVGIDSKTGRYLAVDPQ
TLQPVPAPLAIPLDTKSDQ

Specific function: Plays an important role in the mineralization of sulfates [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI38569405, Length=567, Percent_Identity=23.9858906525573, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI109389362, Length=319, Percent_Identity=26.6457680250784, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI38569407, Length=436, Percent_Identity=24.7706422018349, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI59797060, Length=543, Percent_Identity=25.0460405156538, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI58743319, Length=338, Percent_Identity=25.4437869822485, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI53831991, Length=472, Percent_Identity=22.6694915254237, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI4503899, Length=271, Percent_Identity=26.1992619926199, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI157266309, Length=165, Percent_Identity=32.7272727272727, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI45430057, Length=448, Percent_Identity=25.2232142857143, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31742482, Length=359, Percent_Identity=21.4484679665738, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI71852586, Length=138, Percent_Identity=32.6086956521739, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI71852584, Length=138, Percent_Identity=32.6086956521739, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI146229331, Length=131, Percent_Identity=36.6412213740458, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI146229329, Length=131, Percent_Identity=36.6412213740458, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI6005990, Length=131, Percent_Identity=36.6412213740458, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI146229324, Length=131, Percent_Identity=36.6412213740458, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1790112, Length=337, Percent_Identity=25.2225519287834, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790233, Length=325, Percent_Identity=24.3076923076923, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081924, Length=371, Percent_Identity=23.7196765498652, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=548, Percent_Identity=20.8029197080292, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17559078, Length=156, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666175, Length=475, Percent_Identity=27.7894736842105, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24666109, Length=474, Percent_Identity=27.8481012658228, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281366397, Length=353, Percent_Identity=28.328611898017, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281366395, Length=353, Percent_Identity=28.328611898017, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24666163, Length=353, Percent_Identity=28.328611898017, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281363223, Length=482, Percent_Identity=24.6887966804979, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 64828; Mature: 64828

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQVTLATLSIIFSGTAHSTQNERPDIIVIIADDMGYSDITPFGGEIPTPNLQAMAENG
CCCEEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCC
VRMSQYYTSPMSAPARAMLLTGNTSQQAGIGGMWWYENTIGKEGYELRLTDRVTTMAERF
CEEEHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHH
KDAGYNTLMAGKWHLGFTPGSTPKDRGFRHSFALMGGGASHFDDAVPLGTVEIFHTYYTR
HHCCCCEEEECCEEECCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCHHEEEEEEHCC
DNQRISLPSSFYSSEAYASQINRWISETPREQPIFAWLAFTAPHDPLQAPDEWISRFKSQ
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
YEQGYADVYRQRIARLKKLGFLRDDIPLPGLELDKEWQAMTPEQQKYTAKVMQVYAAMIA
HHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
NMDAQIGTVIETLKKTGRDKNTILVFLSDNGVNPAEGFHYESEPDFWKQFDNRYENIGRK
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NSFISYGPHWADVSNAPYGRYHKTTSGQGGINTSFMISGPGIIHNGAIDNATMAAYDVAP
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCCEEEHHHHHH
TLYEFAGIDVSKSLSERPTLPMIGVSFKRYLTGESLHAPRTQYGVELHNQAAWIDGEWKL
HHHHHHCCCHHHHHHCCCCCCEECCHHHHHHCCCCCCCCCHHHCEEECCCEEEECCCHHH
RRLVTVFPQAGNAPWELFNLQRDPLETHNLAADYVDKVKILSSAYEAFAKQTMVLYAKGK
EEEEEECCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCC
LIDYVGIDSKTGRYLAVDPQTLQPVPAPLAIPLDTKSDQ
EEEEECCCCCCCCEEEECCHHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKKQVTLATLSIIFSGTAHSTQNERPDIIVIIADDMGYSDITPFGGEIPTPNLQAMAENG
CCCEEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCC
VRMSQYYTSPMSAPARAMLLTGNTSQQAGIGGMWWYENTIGKEGYELRLTDRVTTMAERF
CEEEHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHH
KDAGYNTLMAGKWHLGFTPGSTPKDRGFRHSFALMGGGASHFDDAVPLGTVEIFHTYYTR
HHCCCCEEEECCEEECCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCHHEEEEEEHCC
DNQRISLPSSFYSSEAYASQINRWISETPREQPIFAWLAFTAPHDPLQAPDEWISRFKSQ
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
YEQGYADVYRQRIARLKKLGFLRDDIPLPGLELDKEWQAMTPEQQKYTAKVMQVYAAMIA
HHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
NMDAQIGTVIETLKKTGRDKNTILVFLSDNGVNPAEGFHYESEPDFWKQFDNRYENIGRK
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NSFISYGPHWADVSNAPYGRYHKTTSGQGGINTSFMISGPGIIHNGAIDNATMAAYDVAP
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCCEEEHHHHHH
TLYEFAGIDVSKSLSERPTLPMIGVSFKRYLTGESLHAPRTQYGVELHNQAAWIDGEWKL
HHHHHHCCCHHHHHHCCCCCCEECCHHHHHHCCCCCCCCCHHHCEEECCCEEEECCCHHH
RRLVTVFPQAGNAPWELFNLQRDPLETHNLAADYVDKVKILSSAYEAFAKQTMVLYAKGK
EEEEEECCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCC
LIDYVGIDSKTGRYLAVDPQTLQPVPAPLAIPLDTKSDQ
EEEEECCCCCCCCEEEECCHHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10336424 [H]