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The map label for this gene is mcl1 [H]

Identifier: 194738068

GI number: 194738068

Start: 3178720

End: 3179562

Strand: Reverse

Name: mcl1 [H]

Synonym: SeSA_A3295

Alternate gene names: 194738068

Gene position: 3179562-3178720 (Counterclockwise)

Preceding gene: 194735305

Following gene: 194738180

Centisome position: 67.52

GC content: 49.47

Gene sequence:

>843_bases
ATGCCCGATATTTCTCATACACCGACACGTAGCTGGCTTTTTACCCCAGCAATTCGACCAGAACGTTTCATAAAAGCAGT
TGAAAGTGCGGCGGACATTTCTATTATCGATCTTGAAGATTCCGTCACCCCGAATGACAAGGCGCAGGCCCGGAAAATTG
CGATGCAGTTCCTTTCATCCCGACCAAACTCATCGCTGAAAATAGCATTAAGAATTAATGGAATGAATACTCATGCTGGC
ATTGAAGACCTGCATATGTTACTGGAATGCCGTTTTTTTCCTGATTACATTATTCTTCCAAAAACAGAGTCAGCCGCGCA
CCTGCAAATCGTGGATAGTCTTATCATGATGGCTGGTTCTGATACTCGCCTTATTGGCATTATTGAGTCAGTTGTCGGGC
TTAATGCCGTTGAGTCTATTGCGGACGCCACCCCCAGACTCTGCGGGTTGATGTTTGGCGCCGCAGATATGGCGGCTGAC
ATTGGCGCCACACCCGCCTGGGAGCCTCTTGCGCTGGCGCGGGCCAGAATAGTGGCTGCCTGCGCTATGAAAGGGCTTCT
TGCAATAGATGCTCCCTTCTTTGATATAGGCGATTTTTCAGGTCTGAAAGAGGAAACGCTGCAGGCGCTCAGTTTTGGTT
TTTCTGCAAAATCGGCTATTCACCCCGCTCAGATTAGTGTAATCAACACCGCATTTACTCCTACAACGGCAGAAATTAAT
CATGCTCGTGCAGTACTGACAGAGAATGCCAAAGGCGTCGGGATCGTTAGCGGCATGATGATAGATGCAGCCGTTGCCCG
TCAGGCCCGGAGATTACTCGCCCGGGCAGGGATCTTTTCCTGA

Upstream 100 bases:

>100_bases
CAGTTCCATCCTCATCTCCAAAAGCAATTAAGAATGGCACCATCATATATTGGAAGAATGAAACCAGCGAGCGCATAGTG
AGGTTAACAGGAGGTGCAAT

Downstream 100 bases:

>100_bases
TTTTATTAACAGAGGAATTGATTATGAACACGTTATTACCCGCTTATAAAACCATTAGCGAGGGGCGCTACCGAGAAATT
TCGGGTCTTTACTGGGAGGA

Product: HpcH/HpaI aldolase/citrate lyase family protein

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPDISHTPTRSWLFTPAIRPERFIKAVESAADISIIDLEDSVTPNDKAQARKIAMQFLSSRPNSSLKIALRINGMNTHAG
IEDLHMLLECRFFPDYIILPKTESAAHLQIVDSLIMMAGSDTRLIGIIESVVGLNAVESIADATPRLCGLMFGAADMAAD
IGATPAWEPLALARARIVAACAMKGLLAIDAPFFDIGDFSGLKEETLQALSFGFSAKSAIHPAQISVINTAFTPTTAEIN
HARAVLTENAKGVGIVSGMMIDAAVARQARRLLARAGIFS

Sequences:

>Translated_280_residues
MPDISHTPTRSWLFTPAIRPERFIKAVESAADISIIDLEDSVTPNDKAQARKIAMQFLSSRPNSSLKIALRINGMNTHAG
IEDLHMLLECRFFPDYIILPKTESAAHLQIVDSLIMMAGSDTRLIGIIESVVGLNAVESIADATPRLCGLMFGAADMAAD
IGATPAWEPLALARARIVAACAMKGLLAIDAPFFDIGDFSGLKEETLQALSFGFSAKSAIHPAQISVINTAFTPTTAEIN
HARAVLTENAKGVGIVSGMMIDAAVARQARRLLARAGIFS
>Mature_279_residues
PDISHTPTRSWLFTPAIRPERFIKAVESAADISIIDLEDSVTPNDKAQARKIAMQFLSSRPNSSLKIALRINGMNTHAGI
EDLHMLLECRFFPDYIILPKTESAAHLQIVDSLIMMAGSDTRLIGIIESVVGLNAVESIADATPRLCGLMFGAADMAADI
GATPAWEPLALARARIVAACAMKGLLAIDAPFFDIGDFSGLKEETLQALSFGFSAKSAIHPAQISVINTAFTPTTAEINH
ARAVLTENAKGVGIVSGMMIDAAVARQARRLLARAGIFS

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=289, Percent_Identity=29.757785467128, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI87081764, Length=282, Percent_Identity=29.7872340425532, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557458, Length=292, Percent_Identity=28.0821917808219, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 29942; Mature: 29811

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDISHTPTRSWLFTPAIRPERFIKAVESAADISIIDLEDSVTPNDKAQARKIAMQFLSS
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
RPNSSLKIALRINGMNTHAGIEDLHMLLECRFFPDYIILPKTESAAHLQIVDSLIMMAGS
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCC
DTRLIGIIESVVGLNAVESIADATPRLCGLMFGAADMAADIGATPAWEPLALARARIVAA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
CAMKGLLAIDAPFFDIGDFSGLKEETLQALSFGFSAKSAIHPAQISVINTAFTPTTAEIN
HHHHCHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHH
HARAVLTENAKGVGIVSGMMIDAAVARQARRLLARAGIFS
HHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PDISHTPTRSWLFTPAIRPERFIKAVESAADISIIDLEDSVTPNDKAQARKIAMQFLSS
CCCCCCCCCCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
RPNSSLKIALRINGMNTHAGIEDLHMLLECRFFPDYIILPKTESAAHLQIVDSLIMMAGS
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCC
DTRLIGIIESVVGLNAVESIADATPRLCGLMFGAADMAADIGATPAWEPLALARARIVAA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
CAMKGLLAIDAPFFDIGDFSGLKEETLQALSFGFSAKSAIHPAQISVINTAFTPTTAEIN
HHHHCHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHH
HARAVLTENAKGVGIVSGMMIDAAVARQARRLLARAGIFS
HHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA