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The map label for this gene is nanM [H]

Identifier: 194734648

GI number: 194734648

Start: 1178136

End: 1179296

Strand: Direct

Name: nanM [H]

Synonym: SeSA_A1195

Alternate gene names: 194734648

Gene position: 1178136-1179296 (Clockwise)

Preceding gene: 194733910

Following gene: 194736391

Centisome position: 25.02

GC content: 40.91

Gene sequence:

>1161_bases
ATGGGGATGCAGATGAAAAACTTTAAGAAAATGATGACGCTAATGGCGCTATGTTTATCAGTCGCTATCACCACATCAGG
ATATGCAACGACGCTTCCTGATATACCAGAACCACTGAAAAATGGTACTGGCGCTATTGATAATAATGGCGTGATTTATG
TCGGCTTAGGTACCGCAGGGACATCCTGGTATAAAATTGATCTTAAAAAGCAACATAAAGACTGGGAGCGTATAAAGTCG
TTTCCTGGTGGAGCTCGTGAGCAATCCGTGTCGGTATTTTTAAATGATGAGCTTTATGTTTTTGGTGGCGTAGGGAAAAA
AAACAGTGAATCACCGTTGCAGGTTTATAGCGATGTGTACAAATACTCACCGGTGAAAAATACATGGCAAAAAGTTGACA
CTATATCTCCAGTTGGATTAACAGGGCATACGGGAGTAAAATTAAACGAAACGATGGTACTTATTACCGGAGGGGTTAAT
GAGCATATCTTTGATAAGTATTTTATTGATATAGCGGCTGCGGCTGCGGATGAAAGTGAAAAAAATAAAGTCATCTATAA
TTATTTTAATAAACCTGCCAAAGATTATTTTTTTAATAAAATCGTATTTATCTACAATGCTAAAGAGAACACATGGAAGA
ATGCCGGTGAGCTGCCAGGCGCGGGGACGGCAGGATCGTCATCGGTAATGGAAAATAATTTCCTGATGCTGATTAATGGT
GAGCTCAAACCGGGTTTACGTACCGATGTGATTTACCGCGCCATGTGGGATAACGACAAGCTAACATGGTTGAAGAACAG
CCAGTTACCGCCATCGCCTGGAGAACAACAGCAAGAAGGGTTGGCCGGAGCATTTTCGGGCTATAGTCACGGTGTCCTGC
TTGTCGGTGGTGGCGCGAATTTTCCGGGAGCAAAACAAAATTATACCAATGGAAAGTTTTATTCCCACGAAGGAATAAAT
AAAAAATGGCGAGATGAAGTCTATGGTTTGGTTAATGGCCATTGGCAATATATGGGTAAAATGAAACAACCTCTCGGCTA
TGGTGTATCAGTAAGTTATGGTGATGAAGTTTTCCTTATCGGTGGTGAAAATGCTAAAGGGAAACCTGTTTCGTCTGTAA
CCTCCTTTACCATGCGTGATGGTAATTTATTAATAAAATAA

Upstream 100 bases:

>100_bases
TTATTTTTAGCGCTTGGTCACATTTTGTCATTATCATTGTTGAAATTATGCGCCATAAGATCACTAATGATGAAGCTTTA
CTCCAATTGTATTTCTTCGC

Downstream 100 bases:

>100_bases
TTTTTAAATACAAAAATAAAGTTAATTGATAAGCGGAGTATTTTATGAAAATCAACAGATATCTTCTGGGTATGGTTTCG
TTTATAGAATTTTCATCATA

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGMQMKNFKKMMTLMALCLSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAGTSWYKIDLKKQHKDWERIKS
FPGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVYKYSPVKNTWQKVDTISPVGLTGHTGVKLNETMVLITGGVN
EHIFDKYFIDIAAAAADESEKNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGSSSVMENNFLMLING
ELKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGANFPGAKQNYTNGKFYSHEGIN
KKWRDEVYGLVNGHWQYMGKMKQPLGYGVSVSYGDEVFLIGGENAKGKPVSSVTSFTMRDGNLLIK

Sequences:

>Translated_386_residues
MGMQMKNFKKMMTLMALCLSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAGTSWYKIDLKKQHKDWERIKS
FPGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVYKYSPVKNTWQKVDTISPVGLTGHTGVKLNETMVLITGGVN
EHIFDKYFIDIAAAAADESEKNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGSSSVMENNFLMLING
ELKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGANFPGAKQNYTNGKFYSHEGIN
KKWRDEVYGLVNGHWQYMGKMKQPLGYGVSVSYGDEVFLIGGENAKGKPVSSVTSFTMRDGNLLIK
>Mature_385_residues
GMQMKNFKKMMTLMALCLSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAGTSWYKIDLKKQHKDWERIKSF
PGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVYKYSPVKNTWQKVDTISPVGLTGHTGVKLNETMVLITGGVNE
HIFDKYFIDIAAAAADESEKNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGSSSVMENNFLMLINGE
LKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGANFPGAKQNYTNGKFYSHEGINK
KWRDEVYGLVNGHWQYMGKMKQPLGYGVSVSYGDEVFLIGGENAKGKPVSSVTSFTMRDGNLLIK

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=374, Percent_Identity=40.9090909090909, Blast_Score=299, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936 [H]

Pfam domain/function: PF01344 Kelch_1 [H]

EC number: NA

Molecular weight: Translated: 42516; Mature: 42385

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMQMKNFKKMMTLMALCLSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHCCCCCCCCCCEEEEEECCCC
TSWYKIDLKKQHKDWERIKSFPGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVY
CEEEEEEEHHHCCHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHHHH
KYSPVKNTWQKVDTISPVGLTGHTGVKLNETMVLITGGVNEHIFDKYFIDIAAAAADESE
HCCCCHHHHHHHHCCCCCCCCCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
KNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGSSSVMENNFLMLING
CCCEEEECCCCCHHHHHCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
ELKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGAN
CCCCCCCHHEEEEEEECCCCEEEEECCCCCCCCCCHHHHCCHHHCCCCCCCEEEEECCCC
FPGAKQNYTNGKFYSHEGINKKWRDEVYGLVNGHWQYMGKMKQPLGYGVSVSYGDEVFLI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCEEEEE
GGENAKGKPVSSVTSFTMRDGNLLIK
ECCCCCCCCHHHHEEEEEECCCEEEC
>Mature Secondary Structure 
GMQMKNFKKMMTLMALCLSVAITTSGYATTLPDIPEPLKNGTGAIDNNGVIYVGLGTAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHCCCCCCCCCCEEEEEECCCC
TSWYKIDLKKQHKDWERIKSFPGGAREQSVSVFLNDELYVFGGVGKKNSESPLQVYSDVY
CEEEEEEEHHHCCHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHHHH
KYSPVKNTWQKVDTISPVGLTGHTGVKLNETMVLITGGVNEHIFDKYFIDIAAAAADESE
HCCCCHHHHHHHHCCCCCCCCCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
KNKVIYNYFNKPAKDYFFNKIVFIYNAKENTWKNAGELPGAGTAGSSSVMENNFLMLING
CCCEEEECCCCCHHHHHCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
ELKPGLRTDVIYRAMWDNDKLTWLKNSQLPPSPGEQQQEGLAGAFSGYSHGVLLVGGGAN
CCCCCCCHHEEEEEEECCCCEEEEECCCCCCCCCCHHHHCCHHHCCCCCCCEEEEECCCC
FPGAKQNYTNGKFYSHEGINKKWRDEVYGLVNGHWQYMGKMKQPLGYGVSVSYGDEVFLI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCEEEEE
GGENAKGKPVSSVTSFTMRDGNLLIK
ECCCCCCCCHHHHEEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA