Click here to switch to the map view.

The map label for this gene is putP [H]

Identifier: 194733910

GI number: 194733910

Start: 1170655

End: 1172163

Strand: Direct

Name: putP [H]

Synonym: SeSA_A1190

Alternate gene names: 194733910

Gene position: 1170655-1172163 (Clockwise)

Preceding gene: 194737095

Following gene: 194734648

Centisome position: 24.86

GC content: 54.27

Gene sequence:

>1509_bases
ATGGCTATTAGCACACCGATGTTGGTGACATTCTGTGTCTATATTTTTGGCATGATATTGATTGGGTTTATCGCCTGGCG
CTCAACCAAAAACTTTGATGACTATATTCTTGGCGGTCGCAGCCTGGGGCCGTTTGTTACGGCTTTATCAGCCGGCGCGT
CGGATATGAGCGGCTGGCTGTTAATGGGGCTGCCTGGCGCTATCTTTCTGTCGGGGATCTCTGAAAGCTGGATCGCCATT
GGCCTGACGTTAGGCGCATGGATTAACTGGAAGCTGGTGGCCGGGCGCCTGCGCGTGCATACCGAATTTAACAATAACGC
GCTCACGTTGCCGGACTATTTTACCGGTCGGTTTGAGGATAAGAGCCGAGTCCTGCGTATTATTTCCGCGCTGGTCATTC
TGCTGTTTTTCACTATCTATTGCGCGTCAGGTATTGTCGCTGGAGCACGACTGTTCGAAAGCACCTTCGGTATGAGCTAT
GAAACCGCACTGTGGGCGGGGGCCGCGGCAACCATTATTTATACCTTTATCGGCGGGTTTCTTGCCGTTAGCTGGACGGA
TACCGTTCAGGCCAGCCTGATGATTTTTGCGTTAATCCTGACGCCGGTGATGGTTATTGTCGGCGTAGGCGGTTTTAGCG
AGTCGCTGGAGGTGATCAAGCAAAAGAGCATCGAGAATGTCGACATGCTCAAGGGGCTGAATTTTGTCGCCATTATTTCC
CTGATGGGCTGGGGACTGGGTTACTTCGGTCAGCCGCATATCCTGGCGCGCTTTATGGCGGCGGACTCCCATCACAGCAT
TGTTCATGCGCGTCGTATCAGTATGACCTGGATGATTCTGTGTCTGGCGGGCGCGGTGGCGGTGGGCTTCTTTGGCATTG
CGTACTTTAACAATAACCCCGCGCTGGCCGGGGCGGTGAACCAAAACTCAGAGCGCGTATTTATTGAACTGGCGCAGATC
CTGTTTAACCCGTGGATTGCCGGTGTTCTGCTGTCTGCTATCCTGGCGGCGGTGATGTCGACGTTGAGCTGTCAGTTGCT
GGTATGCTCCAGCGCGATTACGGAAGATTTATATAAGGCTTTTCTGCGTAAAAGCGCCAGCCAGCAAGAGCTGGTATGGG
TAGGGCGAGTGATGGTGCTGGTGGTAGCGCTGATCGCCATTGCGCTGGCGGCGAATCCCGATAACCGTGTGCTGGGGCTG
GTGAGCTACGCCTGGGCTGGATTCGGCGCGGCATTTGGACCTGTTGTCCTGTTTTCTGTGATGTGGTCGCGTATGACACG
TAACGGCGCGCTGGCGGGAATGATTATTGGCGCGGTGACGGTTATCGTCTGGAAACAATATGGCTGGCTGGATCTGTATG
AGATCATCCCTGGCTTCATTTTCGGCAGCCTGGGGATCGTAATCTTTAGCCTGCTTGGCAAAGCGCCGACAGCAGCGATG
CAGGAACGCTTTGCAAAAGCGGACGCGCATTATCATTCCGCGCCGCCGTCGAAGCTACAGGCGGAATAA

Upstream 100 bases:

>100_bases
GATACGGTCGCCCTGGTAAACATAACACCCTTGCCACGTTCCGGCAGGGTACAAAACGGCACGCTACGGTAGTGCCAATA
AATAAATTTGGAGAACCTTG

Downstream 100 bases:

>100_bases
CCGACATGTCCGATAGCATTATTGCCATCGGACATATTTTACCAGGCGGCGTTATACGCCCGCCTGGTCCTCTGATAAGT
CCCGGACCGATTGACTGAAG

Product: sodium/proline symporter

Products: NA

Alternate protein names: Proline permease; Propionate transporter [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAIFLSGISESWIAI
GLTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFEDKSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSY
ETALWAGAAATIIYTFIGGFLAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIIS
LMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNPALAGAVNQNSERVFIELAQI
LFNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGL
VSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAM
QERFAKADAHYHSAPPSKLQAE

Sequences:

>Translated_502_residues
MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAIFLSGISESWIAI
GLTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFEDKSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSY
ETALWAGAAATIIYTFIGGFLAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIIS
LMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNPALAGAVNQNSERVFIELAQI
LFNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGL
VSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAM
QERFAKADAHYHSAPPSKLQAE
>Mature_501_residues
AISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAIFLSGISESWIAIG
LTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFEDKSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYE
TALWAGAAATIIYTFIGGFLAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIISL
MGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNPALAGAVNQNSERVFIELAQIL
FNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGLV
SYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAMQ
ERFAKADAHYHSAPPSKLQAE

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=486, Percent_Identity=45.2674897119342, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI110835708, Length=510, Percent_Identity=24.1176470588235, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507035, Length=374, Percent_Identity=22.4598930481283, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787251, Length=500, Percent_Identity=94.8, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1790503, Length=455, Percent_Identity=27.2527472527473, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI87082237, Length=467, Percent_Identity=28.2655246252677, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI115533094, Length=379, Percent_Identity=26.6490765171504, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221459584, Length=387, Percent_Identity=23.7726098191214, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221459588, Length=374, Percent_Identity=25.9358288770053, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24645928, Length=357, Percent_Identity=25.2100840336134, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651741, Length=370, Percent_Identity=23.5135135135135, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221459582, Length=364, Percent_Identity=25.8241758241758, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650192, Length=400, Percent_Identity=22.75, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459586, Length=374, Percent_Identity=23.7967914438503, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651739, Length=471, Percent_Identity=21.4437367303609, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24640370, Length=356, Percent_Identity=24.1573033707865, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54319; Mature: 54188

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAIFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFED
EECCCHHHHHHCCCCCHHHHHHHHHHHEEEEEEEEEEEEEEEECCCEEECCCHHCCCCCC
KSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATIIYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIIS
HEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHH
LMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNP
HHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
ALAGAVNQNSERVFIELAQILFNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGLVSYAWAGFGAAFGPVVLFSV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
MWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAM
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QERFAKADAHYHSAPPSKLQAE
HHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAIFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFED
EECCCHHHHHHCCCCCHHHHHHHHHHHEEEEEEEEEEEEEEEECCCEEECCCHHCCCCCC
KSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATIIYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIIS
HEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHH
LMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNP
HHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
ALAGAVNQNSERVFIELAQILFNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGLVSYAWAGFGAAFGPVVLFSV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
MWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAM
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QERFAKADAHYHSAPPSKLQAE
HHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3302614; 8905232; 9278503; 1400239; 3325781; 3053687; 3053649; 1567896; 8119910 [H]