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The map label for this gene is yeaE [H]

Identifier: 194734501

GI number: 194734501

Start: 1333206

End: 1334054

Strand: Direct

Name: yeaE [H]

Synonym: SeSA_A1382

Alternate gene names: 194734501

Gene position: 1333206-1334054 (Clockwise)

Preceding gene: 194736621

Following gene: 194733920

Centisome position: 28.31

GC content: 55.71

Gene sequence:

>849_bases
GTGAAAAACGTAACGTTTTGCGGGCAGGTGACGCTTCCTGCCATCGGACAGGGAACATGGTATATGGGCGAGCGCGCGGA
TCAACGTCAGCGCGAGGTTTCGGCGCTGCGCGTGGGGCTGGATTTGGGGTTACGCCTTATTGATACGGCGGAAATGTATG
CCGACGGCGGGGCGGAAAAGGTCGTGGGCGAGGCGCTGGCAGGGCGACGCGATGAGGCATTTCTGGTGTCAAAAGTGTAC
CCGTGGAACGCTGGCGGCCAGAAGATAGTTGCCGCCTGTGAGGAAAGCCTGCGTCGTCTGAAAACAGATTATCTCGATCT
CTATCTATTGCACTGGGCCGGAAACTTTTCATTCGAAGAGACCGTTGAAGGTATGGAGCGGCTAATCGCGCAGGGAAAAA
TTCGCCGTTGGGGAGTCTCTAATCTTGCTTATGACGATATGCAGGCGCTGTGGCGCATCCCTGGGGGACAGCAATGCGCG
ACAAATCAGGTGCTCTATCATCTGGCGTCACGCGGTATTGAGTATGATTTATTGCCGTGGTGTCAACAACAGCGAATGCC
AGTGATGGCCTATAGCCCGCTGGCGCAGGCTGGCCGATTACGTAGCGGTTTACTGAATCATCCGGTGGTGAATGAAATTG
CGCAAGCGCATAACGCTACGGCGGCGCAAATCTTACTGACGTGGGTGATTGCGCATCCGAGCGTGATGGCGATCCCGAAA
GCCGGAAGTACAGAACACGTGAAGCAAAATGCGGCGGCGCTTGAGATCGCCTTGTCAGCAAACGAACTTGCCTTACTGGA
CAACGCCTGGCCTGCGCCAAAAGGGAAAACCGCGTTGGATATGGTGTGA

Upstream 100 bases:

>100_bases
AAATCGCCCCCTTGCGCGGTATGATGCCGGACATTACCGTAGGGTCTAAGAGTCCTGTATTGTTTTACCGTCGAGTGACA
TTGAAAAGGAAATGAAATCA

Downstream 100 bases:

>100_bases
CGCCGGATAAAATGCGTAAGCGCCGCCATCCGGCAGGTCATGCCTGATGGCGGCTGACGCCTTCCAGAGCCTATAGCAAC
GCCGTTATCCATTCACTTTT

Product: oxidoreductase, aldo/keto reductase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKNVTFCGQVTLPAIGQGTWYMGERADQRQREVSALRVGLDLGLRLIDTAEMYADGGAEKVVGEALAGRRDEAFLVSKVY
PWNAGGQKIVAACEESLRRLKTDYLDLYLLHWAGNFSFEETVEGMERLIAQGKIRRWGVSNLAYDDMQALWRIPGGQQCA
TNQVLYHLASRGIEYDLLPWCQQQRMPVMAYSPLAQAGRLRSGLLNHPVVNEIAQAHNATAAQILLTWVIAHPSVMAIPK
AGSTEHVKQNAAALEIALSANELALLDNAWPAPKGKTALDMV

Sequences:

>Translated_282_residues
MKNVTFCGQVTLPAIGQGTWYMGERADQRQREVSALRVGLDLGLRLIDTAEMYADGGAEKVVGEALAGRRDEAFLVSKVY
PWNAGGQKIVAACEESLRRLKTDYLDLYLLHWAGNFSFEETVEGMERLIAQGKIRRWGVSNLAYDDMQALWRIPGGQQCA
TNQVLYHLASRGIEYDLLPWCQQQRMPVMAYSPLAQAGRLRSGLLNHPVVNEIAQAHNATAAQILLTWVIAHPSVMAIPK
AGSTEHVKQNAAALEIALSANELALLDNAWPAPKGKTALDMV
>Mature_282_residues
MKNVTFCGQVTLPAIGQGTWYMGERADQRQREVSALRVGLDLGLRLIDTAEMYADGGAEKVVGEALAGRRDEAFLVSKVY
PWNAGGQKIVAACEESLRRLKTDYLDLYLLHWAGNFSFEETVEGMERLIAQGKIRRWGVSNLAYDDMQALWRIPGGQQCA
TNQVLYHLASRGIEYDLLPWCQQQRMPVMAYSPLAQAGRLRSGLLNHPVVNEIAQAHNATAAQILLTWVIAHPSVMAIPK
AGSTEHVKQNAAALEIALSANELALLDNAWPAPKGKTALDMV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=298, Percent_Identity=30.2013422818792, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=30.5660377358491, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI93277124, Length=299, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI24497577, Length=299, Percent_Identity=28.4280936454849, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI5174391, Length=299, Percent_Identity=28.4280936454849, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI5174695, Length=287, Percent_Identity=27.1777003484321, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI300116273, Length=274, Percent_Identity=27.7372262773723, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI310109922, Length=273, Percent_Identity=27.1062271062271, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=28.9655172413793, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24497585, Length=290, Percent_Identity=26.8965517241379, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310109920, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5453543, Length=290, Percent_Identity=25.1724137931034, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=26.4604810996564, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=76.8683274021352, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=29.7297297297297, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081735, Length=306, Percent_Identity=27.1241830065359, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082198, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=26.8370607028754, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789375, Length=334, Percent_Identity=25.748502994012, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789199, Length=339, Percent_Identity=27.1386430678466, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI48994888, Length=268, Percent_Identity=27.6119402985075, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787674, Length=257, Percent_Identity=24.5136186770428, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17564128, Length=295, Percent_Identity=29.4915254237288, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17552492, Length=270, Percent_Identity=30.3703703703704, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17561298, Length=279, Percent_Identity=30.1075268817204, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71998625, Length=272, Percent_Identity=30.8823529411765, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537077, Length=291, Percent_Identity=28.5223367697594, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17566692, Length=297, Percent_Identity=26.9360269360269, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=28.5223367697594, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=257, Percent_Identity=27.2373540856031, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=295, Percent_Identity=24.406779661017, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=22.6973684210526, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320576, Length=303, Percent_Identity=26.7326732673267, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320079, Length=268, Percent_Identity=27.6119402985075, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322556, Length=270, Percent_Identity=23.3333333333333, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323998, Length=310, Percent_Identity=22.9032258064516, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644950, Length=309, Percent_Identity=32.6860841423948, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI221378297, Length=329, Percent_Identity=31.0030395136778, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24663317, Length=289, Percent_Identity=25.2595155709343, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=25.531914893617, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=25.5172413793103, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24662789, Length=276, Percent_Identity=26.8115942028986, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=25.7936507936508, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129731, Length=282, Percent_Identity=26.241134751773, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356425, Length=261, Percent_Identity=21.8390804597701, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24662781, Length=291, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31055; Mature: 31055

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVTFCGQVTLPAIGQGTWYMGERADQRQREVSALRVGLDLGLRLIDTAEMYADGGAEK
CCCCEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VVGEALAGRRDEAFLVSKVYPWNAGGQKIVAACEESLRRLKTDYLDLYLLHWAGNFSFEE
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHH
TVEGMERLIAQGKIRRWGVSNLAYDDMQALWRIPGGQQCATNQVLYHLASRGIEYDLLPW
HHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
CQQQRMPVMAYSPLAQAGRLRSGLLNHPVVNEIAQAHNATAAQILLTWVIAHPSVMAIPK
HHHCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECC
AGSTEHVKQNAAALEIALSANELALLDNAWPAPKGKTALDMV
CCCHHHHHHHHHHEEEEECCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNVTFCGQVTLPAIGQGTWYMGERADQRQREVSALRVGLDLGLRLIDTAEMYADGGAEK
CCCCEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VVGEALAGRRDEAFLVSKVYPWNAGGQKIVAACEESLRRLKTDYLDLYLLHWAGNFSFEE
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHH
TVEGMERLIAQGKIRRWGVSNLAYDDMQALWRIPGGQQCATNQVLYHLASRGIEYDLLPW
HHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
CQQQRMPVMAYSPLAQAGRLRSGLLNHPVVNEIAQAHNATAAQILLTWVIAHPSVMAIPK
HHHCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECC
AGSTEHVKQNAAALEIALSANELALLDNAWPAPKGKTALDMV
CCCHHHHHHHHHHEEEEECCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]