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The map label for this gene is panC

Identifier: 194333350

GI number: 194333350

Start: 549499

End: 550365

Strand: Reverse

Name: panC

Synonym: Paes_0507

Alternate gene names: 194333350

Gene position: 550365-549499 (Counterclockwise)

Preceding gene: 194333351

Following gene: 194333349

Centisome position: 21.9

GC content: 49.25

Gene sequence:

>867_bases
ATGCAGATCATCACTAATCCCCGCGAGATGCAGAATATCGCGGAAAATCTGAGAATGAAGCATCAGCTGATCGCTGTCGT
CATGACCATGGGCGCATTGCATGAAGGCCATCTCAGCCTGATTAAACTGGCAAAACAGCAAGCAGGAACAGTCATTCTCA
CCATATTTGTCAATCCTGCACAGTTCGGAGAAAACGAGGATTTTCACTGTTACCCGAGACCATTTGAAAAAGACTCTTCT
ATGGCAAGGGCTGCAGAGGTCGATTATCTTTTTGCGCCGGACGCATCTATGATGTACCCCGAAGGGTTTCAGACCGGTAT
TCACAACGGTCCTGTCGCGGCAATACTCGAAGGGGAACACCGGCCCGATCACTTCAACGGGGTCTCGACAGTGGTTCTGA
AGCTCATGATGATCTGCAAAGCCCATATTGCCGTCTTCGGTGAGAAGGACGCCCAGCAGCTTGCGGTCATCAAACGTATG
ACGAACGATCTGAACATCGATATCAGGATTCTCGAAGCACCCCTGCTGCGCGACGATGACGGGGTCGCTATCAGTTCAAG
AAACATTTACCTCTCCTCCGAAGAAAGAAAACAGGCTGCCGTTCTTTTCAGAGCCCTGTCATTGGCCGATAAACGAATAC
AGGAAGGATGCACTGCCGCAGAGAAGCTTATCGATGAGGCCATAAGCCTGATCGAACAGGAACCCGATGCAAAGATTGAT
TATGTCTCGATTGTGGAAGCCGAATCATTCACCCAATCTGCACTCCTGGAACCGGGAAAAGAGTACCGGATGGTGCTTGC
AATATGGATCGGAACAACGAGACTTATAGATAACCGTAAGTATCGTGTACCCTTGATAAGCGCATAA

Upstream 100 bases:

>100_bases
GAGCTCGCCCGTCATTTCTCGGAGAAAAAAATCCGCGGCGAATTTGTCGTGGTGGTCTACCCTGCCTCACTGAACCATCA
ATCACACAGAAACAACGAAG

Downstream 100 bases:

>100_bases
TTAGCAATTATCGAATCTCTCAAATAATCGTATATTGCTTAATTACGTAAAAAGGTATTTTCATACCCGTCCGTCACCTT
CAGATCCAGCGGCAGACTGT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MQIITNPREMQNIAENLRMKHQLIAVVMTMGALHEGHLSLIKLAKQQAGTVILTIFVNPAQFGENEDFHCYPRPFEKDSS
MARAAEVDYLFAPDASMMYPEGFQTGIHNGPVAAILEGEHRPDHFNGVSTVVLKLMMICKAHIAVFGEKDAQQLAVIKRM
TNDLNIDIRILEAPLLRDDDGVAISSRNIYLSSEERKQAAVLFRALSLADKRIQEGCTAAEKLIDEAISLIEQEPDAKID
YVSIVEAESFTQSALLEPGKEYRMVLAIWIGTTRLIDNRKYRVPLISA

Sequences:

>Translated_288_residues
MQIITNPREMQNIAENLRMKHQLIAVVMTMGALHEGHLSLIKLAKQQAGTVILTIFVNPAQFGENEDFHCYPRPFEKDSS
MARAAEVDYLFAPDASMMYPEGFQTGIHNGPVAAILEGEHRPDHFNGVSTVVLKLMMICKAHIAVFGEKDAQQLAVIKRM
TNDLNIDIRILEAPLLRDDDGVAISSRNIYLSSEERKQAAVLFRALSLADKRIQEGCTAAEKLIDEAISLIEQEPDAKID
YVSIVEAESFTQSALLEPGKEYRMVLAIWIGTTRLIDNRKYRVPLISA
>Mature_288_residues
MQIITNPREMQNIAENLRMKHQLIAVVMTMGALHEGHLSLIKLAKQQAGTVILTIFVNPAQFGENEDFHCYPRPFEKDSS
MARAAEVDYLFAPDASMMYPEGFQTGIHNGPVAAILEGEHRPDHFNGVSTVVLKLMMICKAHIAVFGEKDAQQLAVIKRM
TNDLNIDIRILEAPLLRDDDGVAISSRNIYLSSEERKQAAVLFRALSLADKRIQEGCTAAEKLIDEAISLIEQEPDAKID
YVSIVEAESFTQSALLEPGKEYRMVLAIWIGTTRLIDNRKYRVPLISA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=269, Percent_Identity=42.0074349442379, Blast_Score=203, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322046, Length=282, Percent_Identity=35.4609929078014, Blast_Score=169, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_PROA2 (B4S5G6)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015210.1
- ProteinModelPortal:   B4S5G6
- SMR:   B4S5G6
- GeneID:   6460140
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0507
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32207; Mature: 32207

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIITNPREMQNIAENLRMKHQLIAVVMTMGALHEGHLSLIKLAKQQAGTVILTIFVNPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECHH
QFGENEDFHCYPRPFEKDSSMARAAEVDYLFAPDASMMYPEGFQTGIHNGPVAAILEGEH
HCCCCCCCEECCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCHHCCCCCCCEEEEEECCC
RPDHFNGVSTVVLKLMMICKAHIAVFGEKDAQQLAVIKRMTNDLNIDIRILEAPLLRDDD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEECCC
GVAISSRNIYLSSEERKQAAVLFRALSLADKRIQEGCTAAEKLIDEAISLIEQEPDAKID
CCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YVSIVEAESFTQSALLEPGKEYRMVLAIWIGTTRLIDNRKYRVPLISA
EEEEEEHHHHHHHHHHCCCCHHEEEEEEEECHHHEECCCCEEEEEECC
>Mature Secondary Structure
MQIITNPREMQNIAENLRMKHQLIAVVMTMGALHEGHLSLIKLAKQQAGTVILTIFVNPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECHH
QFGENEDFHCYPRPFEKDSSMARAAEVDYLFAPDASMMYPEGFQTGIHNGPVAAILEGEH
HCCCCCCCEECCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCHHCCCCCCCEEEEEECCC
RPDHFNGVSTVVLKLMMICKAHIAVFGEKDAQQLAVIKRMTNDLNIDIRILEAPLLRDDD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEECCC
GVAISSRNIYLSSEERKQAAVLFRALSLADKRIQEGCTAAEKLIDEAISLIEQEPDAKID
CCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YVSIVEAESFTQSALLEPGKEYRMVLAIWIGTTRLIDNRKYRVPLISA
EEEEEEHHHHHHHHHHCCCCHHEEEEEEEECHHHEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA