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The map label for this gene is ppdK [H]

Identifier: 194333322

GI number: 194333322

Start: 516178

End: 518925

Strand: Reverse

Name: ppdK [H]

Synonym: Paes_0479

Alternate gene names: 194333322

Gene position: 518925-516178 (Counterclockwise)

Preceding gene: 194333324

Following gene: 194333317

Centisome position: 20.65

GC content: 53.89

Gene sequence:

>2748_bases
ATGCCAACGTCTCGACTCAACATTCAGGCAACATCAGGAAAACAGTACATCTACAGTTTTACAGAAGGCGGCGCCGAGGG
TGATGCCACGATGAAAAATCTCCTTGGAGGAAAAGGCGCAAACCTGGCTGAAATGGCAAATATCGGACTGCCTGTACCTC
CGGGATTCACCCTTTCGACAGAAGTCTGTACCTACTACTATGACCATAGTCAAACCTATCCTGAAGGACTTTTCGAACAG
GATATCCCCGATGCCCTGGAAAAAATCGAAACAGCACTGGGCAAAAAATTCGGCGACCCCGAGGATCCCCTTCTTGTATC
GGTGCGTTCCGGAGCCAGAGCGTCAATGCCGGGAATGATGGATACCATTCTCAACCTCGGACTTAACGATACCACCGTTG
AAGGACTTGCCCACAGATCCGGAAATCCGCGATTCGCCTGGGACTGCTACCGCCGTTTCGTGCAGATGTACGGTGATGTG
GTCATGGACCTCAAGCCTCAGGATTCAAAGCATAGCGACCCTTTTGAATCTATTCTCGACGAACACAAAAAGAAAAAAGG
CTGCTCACTCGACACCCAGCTCGATACCGATGATCTCAAAGCTATCGTCAGTGCATTCAAAGCAGCCATTCTTGAACGGA
CAGGACAGGAATTCCCCGAAGACCCCCACGTCCAGCTCCAGGGAGCTATAGGAGCAGTGTTCGGCAGCTGGAACAACGAA
CGCGCTATTGTCTACAGAAAACTGAACCACATTCCCGGTTACTGGGGAACTGCCTGTAACGTCCAGGCAATGGTCTTCGG
TAATATGGGCGACCGCTCCGGAACCGGTGTGGCATTCACCCGTGACGCCGCAACCGGAGAAAATATCTTTTATGGTGAAT
ACCTGATGAACGCACAGGGTGAAGATGTTGTAGCAGGAACCCGGACACCCCTCAAAATCCGACATCTCCAGGAGGAAAAA
CCCGATATCTACCAACAACTCGACTGCATCCGCACACGGCTCGAACAGCACTACCGCGACATGATGGATATCGAGTTCAC
CATTGAAAACGACCGATTGTTCATGCTCCAGTGCCGTGTTGGAAAACGAACCGGCCTGGCTGCCATCCGCATTGCCTACG
ATATGTGCAAAGAAGGTCTTATCGACGAAAAGGAAGCCCTTCTGCGCATTGAACCCGACCAGCTCAACCAGCTGCTTCGC
CCTGTTTTCGACCAGAAGGAGAAGGATAGAGCCATCAGCGAAGGAAGGCTCCTGGCAACAGGCCTCAACGCAGGTCCCGG
AGCGGCGACAGGAAGCATCTGTTTCAGCGCCCGGCAAGCTCAGGAGGTAAAAGAACGCGGCCAGCTGGCTATCCTCGTCA
GGATAGAGACCTCTCCCGAAGATATCGAGGGCATGTCCCTTGCAGAAGGCATTCTGACCGAGCGGGGCGGCATGACCTCT
CATGCGGCCCTGGTAGCCCGTCAGATGGGAAAAGTCTGTGTTGCCGGATGCGGAGAACTCGACATTGATTACCAAAAAGG
CGAAATGCGGATCGAAGGCACCGATATCGTCCTCAAAGAAGGGGACTCCATATCGCTTGACGGGACCACCGGCGAAGTCA
TCCAGGGAGAGATCAAAACCAGAAACCCGGAAGTTATCGAAGTTCTCGCCGACAAGACGCTCAAACCGGAAGATGCCCCG
ACATGGCAGATTTTCGATCAGGTCATGCAATGGGCCGATCACTACAGAACACTCAAGGTCCGTACCAATGCCGATCAGCC
CGAACAGGCAGAGCTCGCCGTCACATTCGGCGCTGAAGGAATCGGACTCTGCAGGACCGAACATATGTTCTTCGGCGGCC
AACGCATCGATGCCATGCGCGAAATGATCCTTGCCGATGACATCGGGGACCGCCAGAAAGCCCTTGAAAAGCTGCTGCCG
TATCAGCGCGATGATTTCTACGGGCTTTTCAAGGCAATGGGATCACGACCGGTGACCATCAGGCTGCTCGACCCGCCACT
CCATGAGTTCCTTCCGCAGGAAGATGCAGAGATAGAGGCGCTCGCCAAAAAAATCGGTATGGCGTTTCACGATGTCAAAA
CCCGTATCGACAATCTCCACGAATTCAACCCGATGCTTGGACTGCGCGGATGCCGCCTTGGTATTCTCCATCCTGAAATC
CCGGCCATGCAGGTCCGGGCAATTATCGAGGCAGCCTGCATCATCAAAAAAGAGGGTCATGACATTATCCCCGAGATCAT
GGTCCCGCTCGTCAGTACAGTCCGGGAACTCGAACTGACGAGTGAAATTATCCACAAGGTCGCCCGAAGAGTGATGGCAG
AGCAGGAAATCGGGGTCACATACCTTGTCGGCACGATGATCGAAGTCCCCAGGGCAGCCCTGACATCCGGCGACATAGCC
AAAGCCGCAGACTTTTTCAGTTACGGAACCAATGACCTTACCCAGATGGGGCTCGGTATGAGCCGCGATGATTCAGGACA
ATTCCTGCCCGTCTACCAGAACTACGATATCTTCCCGCACAATCCGTTCGAATCTCTCGACCAGGAAGGCATAGGAAGGC
TTATCAAGCTTTCAGCCAAGGAAGGAAGAAGCGTCAAATCAGATCTCAAACTCGGCATCTGCGGGGAACACGGCGGAGAC
CCCGCGACCATTGAATTCTGCCACACCACAGGAATCAACTACGTCTCCTGCAGCCCGTTCAGAATCCCCATCGCCCGCCT
CGCTGCCGCCAGGGCCGCCATCGGATAA

Upstream 100 bases:

>100_bases
TTTTTTATTACATTATTTTTGATAAAGTAGCCATCTCATTCTGCTTTTCACAAGCACTTTCGATTTTTTCCGGATTAACA
ATCTATCATCCATCTCAACC

Downstream 100 bases:

>100_bases
GAAAACGGCCCCACGTTTCCATACGTGGGGCCTTTTTCTATTGCAAATCTACTGGCATTGCTCAGGAACTACAATATCGA
TGCCGAACAGAAAATCGTCG

Product: pyruvate phosphate dikinase

Products: NA

Alternate protein names: Pyruvate, orthophosphate dikinase [H]

Number of amino acids: Translated: 915; Mature: 914

Protein sequence:

>915_residues
MPTSRLNIQATSGKQYIYSFTEGGAEGDATMKNLLGGKGANLAEMANIGLPVPPGFTLSTEVCTYYYDHSQTYPEGLFEQ
DIPDALEKIETALGKKFGDPEDPLLVSVRSGARASMPGMMDTILNLGLNDTTVEGLAHRSGNPRFAWDCYRRFVQMYGDV
VMDLKPQDSKHSDPFESILDEHKKKKGCSLDTQLDTDDLKAIVSAFKAAILERTGQEFPEDPHVQLQGAIGAVFGSWNNE
RAIVYRKLNHIPGYWGTACNVQAMVFGNMGDRSGTGVAFTRDAATGENIFYGEYLMNAQGEDVVAGTRTPLKIRHLQEEK
PDIYQQLDCIRTRLEQHYRDMMDIEFTIENDRLFMLQCRVGKRTGLAAIRIAYDMCKEGLIDEKEALLRIEPDQLNQLLR
PVFDQKEKDRAISEGRLLATGLNAGPGAATGSICFSARQAQEVKERGQLAILVRIETSPEDIEGMSLAEGILTERGGMTS
HAALVARQMGKVCVAGCGELDIDYQKGEMRIEGTDIVLKEGDSISLDGTTGEVIQGEIKTRNPEVIEVLADKTLKPEDAP
TWQIFDQVMQWADHYRTLKVRTNADQPEQAELAVTFGAEGIGLCRTEHMFFGGQRIDAMREMILADDIGDRQKALEKLLP
YQRDDFYGLFKAMGSRPVTIRLLDPPLHEFLPQEDAEIEALAKKIGMAFHDVKTRIDNLHEFNPMLGLRGCRLGILHPEI
PAMQVRAIIEAACIIKKEGHDIIPEIMVPLVSTVRELELTSEIIHKVARRVMAEQEIGVTYLVGTMIEVPRAALTSGDIA
KAADFFSYGTNDLTQMGLGMSRDDSGQFLPVYQNYDIFPHNPFESLDQEGIGRLIKLSAKEGRSVKSDLKLGICGEHGGD
PATIEFCHTTGINYVSCSPFRIPIARLAAARAAIG

Sequences:

>Translated_915_residues
MPTSRLNIQATSGKQYIYSFTEGGAEGDATMKNLLGGKGANLAEMANIGLPVPPGFTLSTEVCTYYYDHSQTYPEGLFEQ
DIPDALEKIETALGKKFGDPEDPLLVSVRSGARASMPGMMDTILNLGLNDTTVEGLAHRSGNPRFAWDCYRRFVQMYGDV
VMDLKPQDSKHSDPFESILDEHKKKKGCSLDTQLDTDDLKAIVSAFKAAILERTGQEFPEDPHVQLQGAIGAVFGSWNNE
RAIVYRKLNHIPGYWGTACNVQAMVFGNMGDRSGTGVAFTRDAATGENIFYGEYLMNAQGEDVVAGTRTPLKIRHLQEEK
PDIYQQLDCIRTRLEQHYRDMMDIEFTIENDRLFMLQCRVGKRTGLAAIRIAYDMCKEGLIDEKEALLRIEPDQLNQLLR
PVFDQKEKDRAISEGRLLATGLNAGPGAATGSICFSARQAQEVKERGQLAILVRIETSPEDIEGMSLAEGILTERGGMTS
HAALVARQMGKVCVAGCGELDIDYQKGEMRIEGTDIVLKEGDSISLDGTTGEVIQGEIKTRNPEVIEVLADKTLKPEDAP
TWQIFDQVMQWADHYRTLKVRTNADQPEQAELAVTFGAEGIGLCRTEHMFFGGQRIDAMREMILADDIGDRQKALEKLLP
YQRDDFYGLFKAMGSRPVTIRLLDPPLHEFLPQEDAEIEALAKKIGMAFHDVKTRIDNLHEFNPMLGLRGCRLGILHPEI
PAMQVRAIIEAACIIKKEGHDIIPEIMVPLVSTVRELELTSEIIHKVARRVMAEQEIGVTYLVGTMIEVPRAALTSGDIA
KAADFFSYGTNDLTQMGLGMSRDDSGQFLPVYQNYDIFPHNPFESLDQEGIGRLIKLSAKEGRSVKSDLKLGICGEHGGD
PATIEFCHTTGINYVSCSPFRIPIARLAAARAAIG
>Mature_914_residues
PTSRLNIQATSGKQYIYSFTEGGAEGDATMKNLLGGKGANLAEMANIGLPVPPGFTLSTEVCTYYYDHSQTYPEGLFEQD
IPDALEKIETALGKKFGDPEDPLLVSVRSGARASMPGMMDTILNLGLNDTTVEGLAHRSGNPRFAWDCYRRFVQMYGDVV
MDLKPQDSKHSDPFESILDEHKKKKGCSLDTQLDTDDLKAIVSAFKAAILERTGQEFPEDPHVQLQGAIGAVFGSWNNER
AIVYRKLNHIPGYWGTACNVQAMVFGNMGDRSGTGVAFTRDAATGENIFYGEYLMNAQGEDVVAGTRTPLKIRHLQEEKP
DIYQQLDCIRTRLEQHYRDMMDIEFTIENDRLFMLQCRVGKRTGLAAIRIAYDMCKEGLIDEKEALLRIEPDQLNQLLRP
VFDQKEKDRAISEGRLLATGLNAGPGAATGSICFSARQAQEVKERGQLAILVRIETSPEDIEGMSLAEGILTERGGMTSH
AALVARQMGKVCVAGCGELDIDYQKGEMRIEGTDIVLKEGDSISLDGTTGEVIQGEIKTRNPEVIEVLADKTLKPEDAPT
WQIFDQVMQWADHYRTLKVRTNADQPEQAELAVTFGAEGIGLCRTEHMFFGGQRIDAMREMILADDIGDRQKALEKLLPY
QRDDFYGLFKAMGSRPVTIRLLDPPLHEFLPQEDAEIEALAKKIGMAFHDVKTRIDNLHEFNPMLGLRGCRLGILHPEIP
AMQVRAIIEAACIIKKEGHDIIPEIMVPLVSTVRELELTSEIIHKVARRVMAEQEIGVTYLVGTMIEVPRAALTSGDIAK
AADFFSYGTNDLTQMGLGMSRDDSGQFLPVYQNYDIFPHNPFESLDQEGIGRLIKLSAKEGRSVKSDLKLGICGEHGGDP
ATIEFCHTTGINYVSCSPFRIPIARLAAARAAIG

Specific function: Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis [H]

COG id: COG0574

COG function: function code G; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PEP-utilizing enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1788756, Length=465, Percent_Identity=26.0215053763441, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1789193, Length=446, Percent_Identity=24.2152466367713, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI48994992, Length=452, Percent_Identity=23.0088495575221, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR008279
- InterPro:   IPR018274
- InterPro:   IPR023151
- InterPro:   IPR000121
- InterPro:   IPR002192
- InterPro:   IPR010121
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00391 PEP-utilizers; PF02896 PEP-utilizers_C; PF01326 PPDK_N [H]

EC number: =2.7.9.1 [H]

Molecular weight: Translated: 101242; Mature: 101111

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00370 PEP_ENZYMES_PHOS_SITE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSRLNIQATSGKQYIYSFTEGGAEGDATMKNLLGGKGANLAEMANIGLPVPPGFTLST
CCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEECH
EVCTYYYDHSQTYPEGLFEQDIPDALEKIETALGKKFGDPEDPLLVSVRSGARASMPGMM
HHEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHH
DTILNLGLNDTTVEGLAHRSGNPRFAWDCYRRFVQMYGDVVMDLKPQDSKHSDPFESILD
HHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHH
EHKKKKGCSLDTQLDTDDLKAIVSAFKAAILERTGQEFPEDPHVQLQGAIGAVFGSWNNE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCC
RAIVYRKLNHIPGYWGTACNVQAMVFGNMGDRSGTGVAFTRDAATGENIFYGEYLMNAQG
CEEEEEEHHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEEEEHHHCCCCC
EDVVAGTRTPLKIRHLQEEKPDIYQQLDCIRTRLEQHYRDMMDIEFTIENDRLFMLQCRV
CCEEECCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECC
GKRTGLAAIRIAYDMCKEGLIDEKEALLRIEPDQLNQLLRPVFDQKEKDRAISEGRLLAT
CCCCCHHHHHHHHHHHHCCCCCCCHHEEEECHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
GLNAGPGAATGSICFSARQAQEVKERGQLAILVRIETSPEDIEGMSLAEGILTERGGMTS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCHH
HAALVARQMGKVCVAGCGELDIDYQKGEMRIEGTDIVLKEGDSISLDGTTGEVIQGEIKT
HHHHHHHHHCHHHCCCCCCCCEEECCCCEEECCCEEEEECCCEEEECCCCCCEEECEECC
RNPEVIEVLADKTLKPEDAPTWQIFDQVMQWADHYRTLKVRTNADQPEQAELAVTFGAEG
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEECCCC
IGLCRTEHMFFGGQRIDAMREMILADDIGDRQKALEKLLPYQRDDFYGLFKAMGSRPVTI
CCEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEE
RLLDPPLHEFLPQEDAEIEALAKKIGMAFHDVKTRIDNLHEFNPMLGLRGCRLGILHPEI
EEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
PAMQVRAIIEAACIIKKEGHDIIPEIMVPLVSTVRELELTSEIIHKVARRVMAEQEIGVT
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLVGTMIEVPRAALTSGDIAKAADFFSYGTNDLTQMGLGMSRDDSGQFLPVYQNYDIFPH
HHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEECCCCCCCC
NPFESLDQEGIGRLIKLSAKEGRSVKSDLKLGICGEHGGDPATIEFCHTTGINYVSCSPF
CCHHHHCHHHCCCEEEEECCCCCCCHHCCEEEECCCCCCCCCEEEEEECCCCCEEECCCC
RIPIARLAAARAAIG
CCHHHHHHHHHHCCC
>Mature Secondary Structure 
PTSRLNIQATSGKQYIYSFTEGGAEGDATMKNLLGGKGANLAEMANIGLPVPPGFTLST
CCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEECH
EVCTYYYDHSQTYPEGLFEQDIPDALEKIETALGKKFGDPEDPLLVSVRSGARASMPGMM
HHEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHH
DTILNLGLNDTTVEGLAHRSGNPRFAWDCYRRFVQMYGDVVMDLKPQDSKHSDPFESILD
HHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHH
EHKKKKGCSLDTQLDTDDLKAIVSAFKAAILERTGQEFPEDPHVQLQGAIGAVFGSWNNE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCC
RAIVYRKLNHIPGYWGTACNVQAMVFGNMGDRSGTGVAFTRDAATGENIFYGEYLMNAQG
CEEEEEEHHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEEEEHHHCCCCC
EDVVAGTRTPLKIRHLQEEKPDIYQQLDCIRTRLEQHYRDMMDIEFTIENDRLFMLQCRV
CCEEECCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECC
GKRTGLAAIRIAYDMCKEGLIDEKEALLRIEPDQLNQLLRPVFDQKEKDRAISEGRLLAT
CCCCCHHHHHHHHHHHHCCCCCCCHHEEEECHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
GLNAGPGAATGSICFSARQAQEVKERGQLAILVRIETSPEDIEGMSLAEGILTERGGMTS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCHH
HAALVARQMGKVCVAGCGELDIDYQKGEMRIEGTDIVLKEGDSISLDGTTGEVIQGEIKT
HHHHHHHHHCHHHCCCCCCCCEEECCCCEEECCCEEEEECCCEEEECCCCCCEEECEECC
RNPEVIEVLADKTLKPEDAPTWQIFDQVMQWADHYRTLKVRTNADQPEQAELAVTFGAEG
CCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEECCCC
IGLCRTEHMFFGGQRIDAMREMILADDIGDRQKALEKLLPYQRDDFYGLFKAMGSRPVTI
CCEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEE
RLLDPPLHEFLPQEDAEIEALAKKIGMAFHDVKTRIDNLHEFNPMLGLRGCRLGILHPEI
EEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
PAMQVRAIIEAACIIKKEGHDIIPEIMVPLVSTVRELELTSEIIHKVARRVMAEQEIGVT
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLVGTMIEVPRAALTSGDIAKAADFFSYGTNDLTQMGLGMSRDDSGQFLPVYQNYDIFPH
HHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEECCCCCCCC
NPFESLDQEGIGRLIKLSAKEGRSVKSDLKLGICGEHGGDPATIEFCHTTGINYVSCSPF
CCHHHHCHHHCCCEEEEECCCCCCCHHCCEEEECCCCCCCCCEEEEEECCCCCEEECCCC
RIPIARLAAARAAIG
CCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2176881; 6257292; 11695893; 11468288; 8610096; 9753432 [H]