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The map label for this gene is glmU [H]

Identifier: 194333222

GI number: 194333222

Start: 410981

End: 411718

Strand: Reverse

Name: glmU [H]

Synonym: Paes_0378

Alternate gene names: 194333222

Gene position: 411718-410981 (Counterclockwise)

Preceding gene: 194333223

Following gene: 194333202

Centisome position: 16.38

GC content: 50.27

Gene sequence:

>738_bases
ATGTCTCTCTCAATAATCGTCATGGCTGCGGGTAAAGGCACTCGAATGAAATCGGATCTGCCTAAAGTACTGCATCCAGC
TCATGGAAAACCCATTATCGAATATGTCGTCGAAACATCGAAACAGCTCTCGCCTGAAACGATCGTCCTGATCGTAGGCC
ATATGGCTGACGAGGTCAGAAAAGCCACAGAGCGATTCGGTGTTTCCTGCGCCCTGCAGCAGCCACAGCTTGGCACAGGC
CATGCGGTCATGCAGGCCGAACTGCCGCTCGCCTCATTTAAAGGCGATATTCTGATCCTGTCGGGAGACGCGCCACTGAT
CACCAGGGAAACCCTTTCAAAGCTTCTGGACTATCACAGGAAAGAAAATGCGACAGCAACGGTTCTGACCGCCGAACTTG
ACGATCCAACCGGTTACGGCCGAATCATCCGTGATCAGAAAAGCAATGATGTGCAGAGAATTGTTGAGCAGAAGGATGCC
CTGCCCGAGGAACAAAGGATCAGAGAGATCAACTCGGGAATCTACGTCTTTGATTCGACAACGCTGTTTTCAGCCTTGAA
GGCGATTGACAACAAAAATGCCCAGCAGGAATATTACCTGACCGACGTTTTTGCAATCTGCATGCAGCAGGGGAAAAAAA
TCTCTGCATTCAGAACAGAAGATCCCGATGAAATCAGGGGGATCAATACCCCCGAACAGCTCAGCGAAGCCGAAAGCATT
CTTTCCGGCAGGCAATAA

Upstream 100 bases:

>100_bases
GGTAGGCGAGGAAGACACCCCCCTGCCGCACTGACAATACAATAGTTCGTTGAGGCGGCCCGCTGCCTCAACAGTTCAAC
AACTCAACAATCTCCCCCCT

Downstream 100 bases:

>100_bases
CCGCCGCTATGCGAGCGGGCTGATCGAAGAAGGAGAAAAGTCGTCGCTGTCCTCATCGACGTCAAGCGAACGGTCGATGC
AGCGATCAAGCTGTGCCGAA

Product: Nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSLSIIVMAAGKGTRMKSDLPKVLHPAHGKPIIEYVVETSKQLSPETIVLIVGHMADEVRKATERFGVSCALQQPQLGTG
HAVMQAELPLASFKGDILILSGDAPLITRETLSKLLDYHRKENATATVLTAELDDPTGYGRIIRDQKSNDVQRIVEQKDA
LPEEQRIREINSGIYVFDSTTLFSALKAIDNKNAQQEYYLTDVFAICMQQGKKISAFRTEDPDEIRGINTPEQLSEAESI
LSGRQ

Sequences:

>Translated_245_residues
MSLSIIVMAAGKGTRMKSDLPKVLHPAHGKPIIEYVVETSKQLSPETIVLIVGHMADEVRKATERFGVSCALQQPQLGTG
HAVMQAELPLASFKGDILILSGDAPLITRETLSKLLDYHRKENATATVLTAELDDPTGYGRIIRDQKSNDVQRIVEQKDA
LPEEQRIREINSGIYVFDSTTLFSALKAIDNKNAQQEYYLTDVFAICMQQGKKISAFRTEDPDEIRGINTPEQLSEAESI
LSGRQ
>Mature_244_residues
SLSIIVMAAGKGTRMKSDLPKVLHPAHGKPIIEYVVETSKQLSPETIVLIVGHMADEVRKATERFGVSCALQQPQLGTGH
AVMQAELPLASFKGDILILSGDAPLITRETLSKLLDYHRKENATATVLTAELDDPTGYGRIIRDQKSNDVQRIVEQKDAL
PEEQRIREINSGIYVFDSTTLFSALKAIDNKNAQQEYYLTDVFAICMQQGKKISAFRTEDPDEIRGINTPEQLSEAESIL
SGRQ

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=244, Percent_Identity=42.2131147540984, Blast_Score=194, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI133931050, Length=186, Percent_Identity=23.6559139784946, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 27109; Mature: 26978

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSIIVMAAGKGTRMKSDLPKVLHPAHGKPIIEYVVETSKQLSPETIVLIVGHMADEVR
CCEEEEEEECCCCCCCHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
KATERFGVSCALQQPQLGTGHAVMQAELPLASFKGDILILSGDAPLITRETLSKLLDYHR
HHHHHHCCEEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCEEEHHHHHHHHHHHH
KENATATVLTAELDDPTGYGRIIRDQKSNDVQRIVEQKDALPEEQRIREINSGIYVFDST
CCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECH
TLFSALKAIDNKNAQQEYYLTDVFAICMQQGKKISAFRTEDPDEIRGINTPEQLSEAESI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCHHHHHHHHHH
LSGRQ
HCCCC
>Mature Secondary Structure 
SLSIIVMAAGKGTRMKSDLPKVLHPAHGKPIIEYVVETSKQLSPETIVLIVGHMADEVR
CEEEEEEECCCCCCCHHCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
KATERFGVSCALQQPQLGTGHAVMQAELPLASFKGDILILSGDAPLITRETLSKLLDYHR
HHHHHHCCEEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCEEEHHHHHHHHHHHH
KENATATVLTAELDDPTGYGRIIRDQKSNDVQRIVEQKDALPEEQRIREINSGIYVFDST
CCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECH
TLFSALKAIDNKNAQQEYYLTDVFAICMQQGKKISAFRTEDPDEIRGINTPEQLSEAESI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCHHHHHHHHHH
LSGRQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA