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The map label for this gene is thrC [H]

Identifier: 194333104

GI number: 194333104

Start: 269510

End: 270826

Strand: Reverse

Name: thrC [H]

Synonym: Paes_0260

Alternate gene names: 194333104

Gene position: 270826-269510 (Counterclockwise)

Preceding gene: 194333105

Following gene: 194333103

Centisome position: 10.78

GC content: 50.42

Gene sequence:

>1317_bases
ATGATTTACTACAGTACCAATAAATCTTCGACACCGGCAAGCCTCAAAAGAGCGACGCTTGAGGGTCTAGCCCCCGATGG
CGGCCTCTATGTCCCGTCTGCCATACCGGTTTTCTCTCCCTCGGAGATCGAACTGCTCAAAGAAGCTCCGTTTAAGGATA
TTGCCTTTGCCATAGCAAAAAAATATACCGGAAGTGAAATTCCCCCTGACCGTCTCTACGAGATCATTGAAGAGTGCTTC
AATTTCCCAACCCCACTGGTACCTCTCGACAACAACACGTTTATCGAGGAACTCTTCCATGGCCCCACACTTGCGTTCAA
AGACTACGGTGCACGTTTTCTGGCCAGAATGACCGGTTATTTCGCAGAGGAAGATCATACACTCATTACCATCCTCGTAG
CGACTTCCGGAGACACGGGTAGCGCTGTAGCCTACGGATTTCAGGGTATTCCCAATACACGGGTCGTCCTGCTCTATCCA
TCCGGAAAAGTCAGCCGCCTTCAGGAACAGCAGCTGACAACCGCAGGAGGAAACGTCACAGCACTTGAGGTCAAAGGTGA
TTTTGATGATTGTCAAAGGCTTGTCAAACAAGCATTTATGGACGGATCGATCAAGCAGAATCTCACCCTGACATCGGCAA
ACTCCATCAATATATCGCGTCTCATCCCCCAGTCGTTCTACTATGCATGGGCAGCGCTGCAACTCGACAGAAAGTATCCG
GGGAAAAAAGCTGTCTTCTCGGTTCCGAGCGGAAACTACGGCAACCTTACCGCTGGCGTACTGGCAAAAATGATGGGATT
CCCGATCGATCACTTTATTGCAGCCTCCAATGCAAACGACAGCGTTACACGCTATATTGAAGAGGGACGCTATGAGCCTC
ATCCGACAATCCGTACACTGTCGACGGCAATGGATGTCGGCGATCCAAGCAATTTCGCCCGCCTGCGCCACATCTATGCC
AATGATCACACGAAAATGGCTGCAGATATTACAGGCTACTCGATCTCGGACAACGAAACGCTCGAAACCATCAGAAGCGT
CTACGACCGTTTCGGCTATATCATGGATCCGCATACCGCTGTCGGCAGCAGGGCTCTTGAACTCTGGAGAGAGCAGATGA
CGCAAGCCGATTCCAACCCGGCTGTCGTACTGTCGACAGCGCATCCGGCAAAATTCCTTGAATCGATCCGTGAAGCGCTC
GATATGGAGATATCCATCCCTGACAGATTGCAGACCGTTCTGGATAAACAGAAAATAGCAACCCTGATCGGTTCCGACTA
CAATGAACTCTCAGCGTTTCTTTCTGCACTCGATTAA

Upstream 100 bases:

>100_bases
CGACATTGATGAACACCTTGAAGCCGACATATGGGTTTCTCCCGTCTGCCGCGAAGGGGCAAGGATTCTGTAACGAACTG
ACCATTACCCGACAACAGCC

Downstream 100 bases:

>100_bases
CAAGTAATCAACATGGCCAACAGACCCTCACCAGTTGCAGGCCAAGCGGTGAGAGTCTGTCTCCACCCCTTATTGACTTT
TTTTACCTTTGTCCACTTCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIYYSTNKSSTPASLKRATLEGLAPDGGLYVPSAIPVFSPSEIELLKEAPFKDIAFAIAKKYTGSEIPPDRLYEIIEECF
NFPTPLVPLDNNTFIEELFHGPTLAFKDYGARFLARMTGYFAEEDHTLITILVATSGDTGSAVAYGFQGIPNTRVVLLYP
SGKVSRLQEQQLTTAGGNVTALEVKGDFDDCQRLVKQAFMDGSIKQNLTLTSANSINISRLIPQSFYYAWAALQLDRKYP
GKKAVFSVPSGNYGNLTAGVLAKMMGFPIDHFIAASNANDSVTRYIEEGRYEPHPTIRTLSTAMDVGDPSNFARLRHIYA
NDHTKMAADITGYSISDNETLETIRSVYDRFGYIMDPHTAVGSRALELWREQMTQADSNPAVVLSTAHPAKFLESIREAL
DMEISIPDRLQTVLDKQKIATLIGSDYNELSAFLSALD

Sequences:

>Translated_438_residues
MIYYSTNKSSTPASLKRATLEGLAPDGGLYVPSAIPVFSPSEIELLKEAPFKDIAFAIAKKYTGSEIPPDRLYEIIEECF
NFPTPLVPLDNNTFIEELFHGPTLAFKDYGARFLARMTGYFAEEDHTLITILVATSGDTGSAVAYGFQGIPNTRVVLLYP
SGKVSRLQEQQLTTAGGNVTALEVKGDFDDCQRLVKQAFMDGSIKQNLTLTSANSINISRLIPQSFYYAWAALQLDRKYP
GKKAVFSVPSGNYGNLTAGVLAKMMGFPIDHFIAASNANDSVTRYIEEGRYEPHPTIRTLSTAMDVGDPSNFARLRHIYA
NDHTKMAADITGYSISDNETLETIRSVYDRFGYIMDPHTAVGSRALELWREQMTQADSNPAVVLSTAHPAKFLESIREAL
DMEISIPDRLQTVLDKQKIATLIGSDYNELSAFLSALD
>Mature_438_residues
MIYYSTNKSSTPASLKRATLEGLAPDGGLYVPSAIPVFSPSEIELLKEAPFKDIAFAIAKKYTGSEIPPDRLYEIIEECF
NFPTPLVPLDNNTFIEELFHGPTLAFKDYGARFLARMTGYFAEEDHTLITILVATSGDTGSAVAYGFQGIPNTRVVLLYP
SGKVSRLQEQQLTTAGGNVTALEVKGDFDDCQRLVKQAFMDGSIKQNLTLTSANSINISRLIPQSFYYAWAALQLDRKYP
GKKAVFSVPSGNYGNLTAGVLAKMMGFPIDHFIAASNANDSVTRYIEEGRYEPHPTIRTLSTAMDVGDPSNFARLRHIYA
NDHTKMAADITGYSISDNETLETIRSVYDRFGYIMDPHTAVGSRALELWREQMTQADSNPAVVLSTAHPAKFLESIREAL
DMEISIPDRLQTVLDKQKIATLIGSDYNELSAFLSALD

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=35.4022988505747, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI149193323, Length=436, Percent_Identity=30.045871559633, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1786185, Length=434, Percent_Identity=41.2442396313364, Blast_Score=313, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319901, Length=460, Percent_Identity=36.9565217391304, Blast_Score=251, Evalue=1e-67,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48311; Mature: 48311

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYYSTNKSSTPASLKRATLEGLAPDGGLYVPSAIPVFSPSEIELLKEAPFKDIAFAIAK
CEEECCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
KYTGSEIPPDRLYEIIEECFNFPTPLVPLDNNTFIEELFHGPTLAFKDYGARFLARMTGY
HCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHH
FAEEDHTLITILVATSGDTGSAVAYGFQGIPNTRVVLLYPSGKVSRLQEQQLTTAGGNVT
HCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFMDGSIKQNLTLTSANSINISRLIPQSFYYAWAALQLDRKYP
EEEEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCC
GKKAVFSVPSGNYGNLTAGVLAKMMGFPIDHFIAASNANDSVTRYIEEGRYEPHPTIRTL
CCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHHCCCCCCCHHHHH
STAMDVGDPSNFARLRHIYANDHTKMAADITGYSISDNETLETIRSVYDRFGYIMDPHTA
HHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEECCCHH
VGSRALELWREQMTQADSNPAVVLSTAHPAKFLESIREALDMEISIPDRLQTVLDKQKIA
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLIGSDYNELSAFLSALD
HHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIYYSTNKSSTPASLKRATLEGLAPDGGLYVPSAIPVFSPSEIELLKEAPFKDIAFAIAK
CEEECCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
KYTGSEIPPDRLYEIIEECFNFPTPLVPLDNNTFIEELFHGPTLAFKDYGARFLARMTGY
HCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHH
FAEEDHTLITILVATSGDTGSAVAYGFQGIPNTRVVLLYPSGKVSRLQEQQLTTAGGNVT
HCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFMDGSIKQNLTLTSANSINISRLIPQSFYYAWAALQLDRKYP
EEEEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCC
GKKAVFSVPSGNYGNLTAGVLAKMMGFPIDHFIAASNANDSVTRYIEEGRYEPHPTIRTL
CCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHHCCCCCCCHHHHH
STAMDVGDPSNFARLRHIYANDHTKMAADITGYSISDNETLETIRSVYDRFGYIMDPHTA
HHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEECCCHH
VGSRALELWREQMTQADSNPAVVLSTAHPAKFLESIREALDMEISIPDRLQTVLDKQKIA
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLIGSDYNELSAFLSALD
HHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]