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The map label for this gene is plsC [H]

Identifier: 194333103

GI number: 194333103

Start: 268696

End: 269406

Strand: Reverse

Name: plsC [H]

Synonym: Paes_0259

Alternate gene names: 194333103

Gene position: 269406-268696 (Counterclockwise)

Preceding gene: 194333104

Following gene: 194333102

Centisome position: 10.72

GC content: 51.34

Gene sequence:

>711_bases
ATGAACCTTCAGACCCTCTTATTCTTTCTGGTTATTCTCCCGGTGACGTTTTTCGGTTTACTGATAGCACTGCTCGTCAA
CCTCATCGACCCATCCGGCGACGGATTTCACCGTATGGCCGCCTGGTGGGGACGATTCTGTGCAAAACTGCTGGGCATCA
GGATTGACGTCGTCGGCAGAGAGCACTACGACGCCACAAAAAACTATCTGGTCATAAGCAACCACGCAGGTATGGCCGAC
ATTCCGATCCTCCTTGGCACACTGCAACTGAACCTGCGTTTTGTCGCAAAGGAAGAGCTCGGGCGCATCCCTGTTTTTGG
CTGGGCTCTCAAAAAGGGCGGCTATGTGCTCATCAAACGCGGCCAGAACAAAGAAGCGCTCAAAAGCCTGTTCAAAGCGG
CAGAAGTCCTCAATAGCGGACGCTCTGTGCATATTTTCCCGGAAGGAACGCGCTCTGCGACCGGGGAACTGCTTCCGTTT
AAAAGAGGCGCGTTTCTGATTGCCCAGAAAGCACCAACACCGATTCTTCCCATAGCCATTATCGGAAGCAGCACCATCAC
TCCGAAAAAAAGCCTGAAAATCCGAAAAGGAACCATCAGGATTATCATCAATCCTCCAATAGAAACAAGCGGCAAAACAG
CCCTGCAGCTGCAAGAAGCTGCATTTCAGACAATCAGCAGCGCCATCGAACAGTCTGGAATTTCGGCTTAA

Upstream 100 bases:

>100_bases
GTAATCAACATGGCCAACAGACCCTCACCAGTTGCAGGCCAAGCGGTGAGAGTCTGTCTCCACCCCTTATTGACTTTTTT
TACCTTTGTCCACTTCGCTG

Downstream 100 bases:

>100_bases
AAAAACAGTATGAAGCTCATGATCAACGGCGTGAACGCCTATGCAGGTCTTACCGACCCAAAACGAATACTTTGAATAAC
CTGCATTTTTCTGATACCTT

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MNLQTLLFFLVILPVTFFGLLIALLVNLIDPSGDGFHRMAAWWGRFCAKLLGIRIDVVGREHYDATKNYLVISNHAGMAD
IPILLGTLQLNLRFVAKEELGRIPVFGWALKKGGYVLIKRGQNKEALKSLFKAAEVLNSGRSVHIFPEGTRSATGELLPF
KRGAFLIAQKAPTPILPIAIIGSSTITPKKSLKIRKGTIRIIINPPIETSGKTALQLQEAAFQTISSAIEQSGISA

Sequences:

>Translated_236_residues
MNLQTLLFFLVILPVTFFGLLIALLVNLIDPSGDGFHRMAAWWGRFCAKLLGIRIDVVGREHYDATKNYLVISNHAGMAD
IPILLGTLQLNLRFVAKEELGRIPVFGWALKKGGYVLIKRGQNKEALKSLFKAAEVLNSGRSVHIFPEGTRSATGELLPF
KRGAFLIAQKAPTPILPIAIIGSSTITPKKSLKIRKGTIRIIINPPIETSGKTALQLQEAAFQTISSAIEQSGISA
>Mature_236_residues
MNLQTLLFFLVILPVTFFGLLIALLVNLIDPSGDGFHRMAAWWGRFCAKLLGIRIDVVGREHYDATKNYLVISNHAGMAD
IPILLGTLQLNLRFVAKEELGRIPVFGWALKKGGYVLIKRGQNKEALKSLFKAAEVLNSGRSVHIFPEGTRSATGELLPF
KRGAFLIAQKAPTPILPIAIIGSSTITPKKSLKIRKGTIRIIINPPIETSGKTALQLQEAAFQTISSAIEQSGISA

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=165, Percent_Identity=33.9393939393939, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI15100175, Length=165, Percent_Identity=33.9393939393939, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI6041665, Length=196, Percent_Identity=30.1020408163265, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1789395, Length=194, Percent_Identity=32.4742268041237, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17568319, Length=179, Percent_Identity=28.4916201117318, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17564032, Length=230, Percent_Identity=27.3913043478261, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320151, Length=227, Percent_Identity=33.0396475770925, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24641614, Length=231, Percent_Identity=27.7056277056277, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641612, Length=231, Percent_Identity=27.7056277056277, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281364648, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582856, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582854, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 25756; Mature: 25756

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQTLLFFLVILPVTFFGLLIALLVNLIDPSGDGFHRMAAWWGRFCAKLLGIRIDVVGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECC
EHYDATKNYLVISNHAGMADIPILLGTLQLNLRFVAKEELGRIPVFGWALKKGGYVLIKR
CCCCCCCCEEEEECCCCCCHHHHHEEEEEEEEEEEEHHHCCCCCEEEEEECCCCEEEEEC
GQNKEALKSLFKAAEVLNSGRSVHIFPEGTRSATGELLPFKRGAFLIAQKAPTPILPIAI
CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEE
IGSSTITPKKSLKIRKGTIRIIINPPIETSGKTALQLQEAAFQTISSAIEQSGISA
ECCCCCCCCCCEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLQTLLFFLVILPVTFFGLLIALLVNLIDPSGDGFHRMAAWWGRFCAKLLGIRIDVVGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECC
EHYDATKNYLVISNHAGMADIPILLGTLQLNLRFVAKEELGRIPVFGWALKKGGYVLIKR
CCCCCCCCEEEEECCCCCCHHHHHEEEEEEEEEEEEHHHCCCCCEEEEEECCCCEEEEEC
GQNKEALKSLFKAAEVLNSGRSVHIFPEGTRSATGELLPFKRGAFLIAQKAPTPILPIAI
CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEE
IGSSTITPKKSLKIRKGTIRIIINPPIETSGKTALQLQEAAFQTISSAIEQSGISA
ECCCCCCCCCCEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]