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The map label for this gene is thrB [H]

Identifier: 194333105

GI number: 194333105

Start: 270854

End: 271816

Strand: Reverse

Name: thrB [H]

Synonym: Paes_0261

Alternate gene names: 194333105

Gene position: 271816-270854 (Counterclockwise)

Preceding gene: 194333110

Following gene: 194333104

Centisome position: 10.82

GC content: 53.06

Gene sequence:

>963_bases
ATGAAAACTGTCACAGGATTTGCTTCGGCAACCATCGGGAATGTCGCCTGCGGTTTTGATGTTCTGGGATTTGCCATCAA
GGAACCCGGTGATGAAGTCATTCTGACGCTTCACGAAGAGAGCTCATCAGAATCACCCGTTTCCATCAAGACAATTCATG
GAGATGGCGGAGCACTCCCAAGAGATCCAAAAAAAAACACATCCAGCTTTGTCGTCCTGAAATTCCTTGAATATCTGAGA
AACCACAAAGGTATTGATTTCCAGGGTCATATAGATCTCGAACTAAAAAAAAATCTTCCACTCAGCAGCGGAATGGGAAG
CAGTGCAGCCAGTGCTGCTGCAGCCCTTATCGCAGCAAATGAACTCCTGGGCGGTCCATGCACCAAGATGGAACTCGTTC
ATTTCGCTATTGAAGGAGAACGCGTCGCCTGCGGCTCGGCCCATGCCGACAACGCTGCTCCGGCAATGCTGGGAAACTTC
ATCCTGATAAGAAGCTACAATCCCCTTGACCTGATCACGATACCTCCGCCCGATCAGCTCTACTGCACGCTGGCACACCC
CCACATCGAACTTCGAACCGCCTATGCCCGCTCAGTCCTGCCACGCAGCATATCACTGAAAACGGCGACCGAGCAATGGG
GAAATGTAGGCGCATTGATCTCTGGCCTCCTCACCTCAGACTATGAGCTCATCGGACGCGCCCTGGTCGATGTGATCGCC
GAGCCCAAACGAGCGACGCTGATACCGGGATTCTACCAGGTCAAAGAGGCTGCTCTTGGAGCCGGAGCGCTCGGCTGCAG
CATAGCCGGTTCCGGACCGTCGATCTTCGCATTCTCATCATCAGCCGCAACAGCCGAAAAGGCCGGTACAGCCATGAGAA
ACGCATTTCTCGACATTGATGAACACCTTGAAGCCGACATATGGGTTTCTCCCGTCTGCCGCGAAGGGGCAAGGATTCTG
TAA

Upstream 100 bases:

>100_bases
TTAGTTATTCAAATTCTGCCGTTAATTTGAGTCCAAAAGCACACAGGCTTTTCCCATCGAAATAGAGGAAACAGGAATCT
AGCTACCGATATAATTACAT

Downstream 100 bases:

>100_bases
CGAACTGACCATTACCCGACAACAGCCATGATTTACTACAGTACCAATAAATCTTCGACACCGGCAAGCCTCAAAAGAGC
GACGCTTGAGGGTCTAGCCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKTVTGFASATIGNVACGFDVLGFAIKEPGDEVILTLHEESSSESPVSIKTIHGDGGALPRDPKKNTSSFVVLKFLEYLR
NHKGIDFQGHIDLELKKNLPLSSGMGSSAASAAAALIAANELLGGPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYNPLDLITIPPPDQLYCTLAHPHIELRTAYARSVLPRSISLKTATEQWGNVGALISGLLTSDYELIGRALVDVIA
EPKRATLIPGFYQVKEAALGAGALGCSIAGSGPSIFAFSSSAATAEKAGTAMRNAFLDIDEHLEADIWVSPVCREGARIL

Sequences:

>Translated_320_residues
MKTVTGFASATIGNVACGFDVLGFAIKEPGDEVILTLHEESSSESPVSIKTIHGDGGALPRDPKKNTSSFVVLKFLEYLR
NHKGIDFQGHIDLELKKNLPLSSGMGSSAASAAAALIAANELLGGPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYNPLDLITIPPPDQLYCTLAHPHIELRTAYARSVLPRSISLKTATEQWGNVGALISGLLTSDYELIGRALVDVIA
EPKRATLIPGFYQVKEAALGAGALGCSIAGSGPSIFAFSSSAATAEKAGTAMRNAFLDIDEHLEADIWVSPVCREGARIL
>Mature_320_residues
MKTVTGFASATIGNVACGFDVLGFAIKEPGDEVILTLHEESSSESPVSIKTIHGDGGALPRDPKKNTSSFVVLKFLEYLR
NHKGIDFQGHIDLELKKNLPLSSGMGSSAASAAAALIAANELLGGPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYNPLDLITIPPPDQLYCTLAHPHIELRTAYARSVLPRSISLKTATEQWGNVGALISGLLTSDYELIGRALVDVIA
EPKRATLIPGFYQVKEAALGAGALGCSIAGSGPSIFAFSSSAATAEKAGTAMRNAFLDIDEHLEADIWVSPVCREGARIL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=317, Percent_Identity=31.5457413249211, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33683; Mature: 33683

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVTGFASATIGNVACGFDVLGFAIKEPGDEVILTLHEESSSESPVSIKTIHGDGGALP
CCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC
RDPKKNTSSFVVLKFLEYLRNHKGIDFQGHIDLELKKNLPLSSGMGSSAASAAAALIAAN
CCCCCCCCHHHHHHHHHHHHCCCCCCEECEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ELLGGPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNFILIRSYNPLDLITIPPPDQL
HHCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHCCEEEEEECCCEEEEEECCCCCE
YCTLAHPHIELRTAYARSVLPRSISLKTATEQWGNVGALISGLLTSDYELIGRALVDVIA
EEEEECCCEEEHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRATLIPGFYQVKEAALGAGALGCSIAGSGPSIFAFSSSAATAEKAGTAMRNAFLDID
CCCCCEECCCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCHH
EHLEADIWVSPVCREGARIL
HHCCCCEEECHHHCCCCCCC
>Mature Secondary Structure
MKTVTGFASATIGNVACGFDVLGFAIKEPGDEVILTLHEESSSESPVSIKTIHGDGGALP
CCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCC
RDPKKNTSSFVVLKFLEYLRNHKGIDFQGHIDLELKKNLPLSSGMGSSAASAAAALIAAN
CCCCCCCCHHHHHHHHHHHHCCCCCCEECEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ELLGGPCTKMELVHFAIEGERVACGSAHADNAAPAMLGNFILIRSYNPLDLITIPPPDQL
HHCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHCCEEEEEECCCEEEEEECCCCCE
YCTLAHPHIELRTAYARSVLPRSISLKTATEQWGNVGALISGLLTSDYELIGRALVDVIA
EEEEECCCEEEHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRATLIPGFYQVKEAALGAGALGCSIAGSGPSIFAFSSSAATAEKAGTAMRNAFLDID
CCCCCEECCCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCHH
EHLEADIWVSPVCREGARIL
HHCCCCEEECHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA