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The map label for this gene is virB11 [H]

Identifier: 190571634

GI number: 190571634

Start: 1331020

End: 1332012

Strand: Direct

Name: virB11 [H]

Synonym: WPa_1258

Alternate gene names: 190571634

Gene position: 1331020-1332012 (Clockwise)

Preceding gene: 190571633

Following gene: 190571635

Centisome position: 89.78

GC content: 35.85

Gene sequence:

>993_bases
ATGAACTATGCTGCACTTGATACATACTTGGAGCCATTACAAGGGATATTTCAAGAGGAAGGTGTAAATGAAATATCAAT
AAATAAACCGAAGGAAGTATGGATTGAAAATCGCGGTGAAATAAGATGCGAAAAGTTAGAAATATTTGATCTTAATCATT
TAAAATCTCTTAGCAGGTTGATTGCTCAAGCTACAGAACAAAAACTGAGCGAAGAGACACCGCTGCTTTCAGCTACATTA
CCAAATGGTTATCGTATACAGATAGTGTTTCCTCCAGCATGTGAGCCTGATAAAGTAGTCATTTCAATTCGTAAACCTTC
TTCTATGCAATTGGCATTGGATGATTATGAAAAAATGGGGGCTTTTTCTGAAACTGTTATAGGAGTGACCGATAATCCAG
TAGATCGTCACCTAGATTTGCTACTGAAACAAAAAAAAATAAAAGAGTTTTTAGAATATGCTGTAATAAGTAAGAAAAAT
ATCATAATTAGTGGTGGAACTTCCACTGGTAAAACCACTTTTACTAATGCTACTTTGCGTGCTATTCCATCTGAAGAAAG
AATTATTACTGTTGAAGATGCAAGAGAGATAGTTTTGAATGATCATCCGAATAGAGTACATCTTATTGCTTCTAAAGGAG
GTCAGGGTAGGGCAAAAGTGACCACTCAAGATTTGATAGAGGCATGTTTACGTTTAAGACCAGATAGAATAATAGTTGGT
GAGCTGCGTGGAGCAGAAGCTTTTAGTTTTCTTAGAGCAATAAACACTGGCCACCCAGGGTCAATATCAACTCTTCATGC
GGATAGTCCGGCAATGGCTCTTGAGCAAATAAAACTTATGGTTATGCAAGCAAATCTTGGAATTCCCCCAGATCAGATCA
TACCATACATTAGAAATGTAATTGACATTGTTATTCAACTCAAAAGGACCAGTGGTGGAAAAAGAAGCATTTCTGAAATA
TTATTTACTAGATCTTCAAATGAAAATACTTAA

Upstream 100 bases:

>100_bases
GATAAAAAACCAACTATTTATGTTAATCAAGGAACTGCATTGAAAGTATTTGTTAACCAAGATATAGTATTTCCTCCACA
GTCAATATTAAATAACTGAA

Downstream 100 bases:

>100_bases
ATTTATACGTAAGTTAAGAAAAAGTAGTTTATGAGTAATGGAAATCACCTACGCAATATTCTCATAGGAGGTGTAGTATC
TTTTAGCATACTTGAATTTT

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLSRLIAQATEQKLSEETPLLSATL
PNGYRIQIVFPPACEPDKVVISIRKPSSMQLALDDYEKMGAFSETVIGVTDNPVDRHLDLLLKQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPSEERIITVEDAREIVLNDHPNRVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPAMALEQIKLMVMQANLGIPPDQIIPYIRNVIDIVIQLKRTSGGKRSISEI
LFTRSSNENT

Sequences:

>Translated_330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLSRLIAQATEQKLSEETPLLSATL
PNGYRIQIVFPPACEPDKVVISIRKPSSMQLALDDYEKMGAFSETVIGVTDNPVDRHLDLLLKQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPSEERIITVEDAREIVLNDHPNRVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPAMALEQIKLMVMQANLGIPPDQIIPYIRNVIDIVIQLKRTSGGKRSISEI
LFTRSSNENT
>Mature_330_residues
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLSRLIAQATEQKLSEETPLLSATL
PNGYRIQIVFPPACEPDKVVISIRKPSSMQLALDDYEKMGAFSETVIGVTDNPVDRHLDLLLKQKKIKEFLEYAVISKKN
IIISGGTSTGKTTFTNATLRAIPSEERIITVEDAREIVLNDHPNRVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ELRGAEAFSFLRAINTGHPGSISTLHADSPAMALEQIKLMVMQANLGIPPDQIIPYIRNVIDIVIQLKRTSGGKRSISEI
LFTRSSNENT

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36749; Mature: 36749

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLSRL
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHEEECCCCCEEEEEEEEECCHHHHHHHHH
IAQATEQKLSEETPLLSATLPNGYRIQIVFPPACEPDKVVISIRKPSSMQLALDDYEKMG
HHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEHHHHHHCC
AFSETVIGVTDNPVDRHLDLLLKQKKIKEFLEYAVISKKNIIISGGTSTGKTTFTNATLR
CHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCEEE
AIPSEERIITVEDAREIVLNDHPNRVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ECCCCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCEEECHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADSPAMALEQIKLMVMQANLGIPPDQIIPYIRNV
ECCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
IDIVIQLKRTSGGKRSISEILFTRSSNENT
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNYAALDTYLEPLQGIFQEEGVNEISINKPKEVWIENRGEIRCEKLEIFDLNHLKSLSRL
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHEEECCCCCEEEEEEEEECCHHHHHHHHH
IAQATEQKLSEETPLLSATLPNGYRIQIVFPPACEPDKVVISIRKPSSMQLALDDYEKMG
HHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEHHHHHHCC
AFSETVIGVTDNPVDRHLDLLLKQKKIKEFLEYAVISKKNIIISGGTSTGKTTFTNATLR
CHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCCEEE
AIPSEERIITVEDAREIVLNDHPNRVHLIASKGGQGRAKVTTQDLIEACLRLRPDRIIVG
ECCCCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCEEECHHHHHHHHHHCCCCEEEEE
ELRGAEAFSFLRAINTGHPGSISTLHADSPAMALEQIKLMVMQANLGIPPDQIIPYIRNV
ECCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
IDIVIQLKRTSGGKRSISEILFTRSSNENT
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]