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The map label for this gene is virB10 [H]

Identifier: 190571633

GI number: 190571633

Start: 1329507

End: 1331018

Strand: Direct

Name: virB10 [H]

Synonym: WPa_1257

Alternate gene names: 190571633

Gene position: 1329507-1331018 (Clockwise)

Preceding gene: 190571632

Following gene: 190571634

Centisome position: 89.68

GC content: 36.77

Gene sequence:

>1512_bases
ATGAGTAAAGAAAGGCATAATAGTGTAGAAGATGAATCAGAGATAGAAAGCAAGGTAGTAACAGTTGGCTCTAATCAAGG
TTATAAGGCATTGATGATAGTTATGGTAGCGCTCTTAGTTGGTGGAGTGTACTATCTTTATTTTAGTCCTTCTAATAAAG
AGGGTCCAGAGATTGTTAAAAAAGAGGAAACAAAGCAAAACATTCAAGAATTGAAAGGAAAGTTAGAACAAGTTCCAGAT
AATGTAGTAGTTTCCGAGAGGATAGCAACTGATCTCTTGCCACCCTTACCTCCTCTTCCTATCCCACAAGTCATACCAGA
AGTAAAACAAATCAAAAAAGAGGAAGTGACAAAAAAAGAAGAGCAACTAAAAGAAATTCCCTTGTCAAATATACCTGTTT
TACCAAAGCAAAATTTTCCTTCTGGTAATGTTATTAGCAATTTGCCTACTTCATTTCCTACAATAGGGGGTGGCGGTTAT
CCTAGAGACAGACGTAGTGCACAAATGTTAGCAATTTCAGGTAGTAGTGGGGAAGGTAAAGCTACAGATGCTGTTTTATC
CAATACCTCAGCACAGTCGAGCAAAGCTACCAAAGCTGGAAAGCTTGGTTTAATGATTATTCAAGGTAAAGTTATTGACG
CTATTCTTGAAACTGCAATAAGTTCTGACTTAAAAGGAATGCTCCGTGCTGTTGTTAGTAGAGACGTTTATGCAGAAACT
GGTGATACAATTTTAATACCAAAAGGTTCAAGGTTAATAGGTGGTTATTCATTCGACTCAAATGTTGCAAAAGCCCGCGT
GAACATAAATTGGAATAGGATCATTCTTCCTCATGGTATAGATGTTGCTATTGCATCATCTGGTACCGATGAGCTTGGAA
GGGCAGGGATAGCTGGAATAGTTGATAATAAAATAGCAAGTGCATTATTCTCTTCAGTGGCACTTGCTGGTGTTTCGATT
GGTTCAGCTGTTGTAGGACAAAAAGCCTCTAATCTTATCGATGCGCTAACTGCCATGGATGCAGTGAAGTCTATTACTGC
AACTGAAATAGATATTTCTTCTCTCAAAGGGGCTATTGTTGAGAGATTGGAGAATTCTATAAAAACTGAAGTTGGGAAGG
TAGGAGACGAAAAATGGAAATTGGGTATTAGGGCTATTGAAAAAATTCGAAATGCTAAAAGTGATCAGGATTTGCTGAGA
ATAATAAAGGAAGAAATAGTAAGTGTGATAAAAAGTTCTGGAGCTAGTGGAGTTGATACAATTACTAGTGACAATATCGG
TATAACTTTAGACGATGTACGTCAACTGTTGAGGCAAACTCAGAAAAGAAGCAAATCTGTTTATGATGAAGCAATCGGGA
AGTCAATCAATGATTTTTCCAAAGACATGCGAGATATAGTTGATAGGAGTGTAGATAAAAAACCAACTATTTATGTTAAT
CAAGGAACTGCATTGAAAGTATTTGTTAACCAAGATATAGTATTTCCTCCACAGTCAATATTAAATAACTGA

Upstream 100 bases:

>100_bases
TATGTTGTAATAAAAGGAGTACATAAAAAGCTATTAATGCGTTATGAAGGTAGTGAAGTTGAAGTTATAAATAGGTCACT
TTAGTTCTGGTACATATAAT

Downstream 100 bases:

>100_bases
AATGAACTATGCTGCACTTGATACATACTTGGAGCCATTACAAGGGATATTTCAAGAGGAAGGTGTAAATGAAATATCAA
TAAATAAACCGAAGGAAGTA

Product: type IV secretion system protein VirB10

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MSKERHNSVEDESEIESKVVTVGSNQGYKALMIVMVALLVGGVYYLYFSPSNKEGPEIVKKEETKQNIQELKGKLEQVPD
NVVVSERIATDLLPPLPPLPIPQVIPEVKQIKKEEVTKKEEQLKEIPLSNIPVLPKQNFPSGNVISNLPTSFPTIGGGGY
PRDRRSAQMLAISGSSGEGKATDAVLSNTSAQSSKATKAGKLGLMIIQGKVIDAILETAISSDLKGMLRAVVSRDVYAET
GDTILIPKGSRLIGGYSFDSNVAKARVNINWNRIILPHGIDVAIASSGTDELGRAGIAGIVDNKIASALFSSVALAGVSI
GSAVVGQKASNLIDALTAMDAVKSITATEIDISSLKGAIVERLENSIKTEVGKVGDEKWKLGIRAIEKIRNAKSDQDLLR
IIKEEIVSVIKSSGASGVDTITSDNIGITLDDVRQLLRQTQKRSKSVYDEAIGKSINDFSKDMRDIVDRSVDKKPTIYVN
QGTALKVFVNQDIVFPPQSILNN

Sequences:

>Translated_503_residues
MSKERHNSVEDESEIESKVVTVGSNQGYKALMIVMVALLVGGVYYLYFSPSNKEGPEIVKKEETKQNIQELKGKLEQVPD
NVVVSERIATDLLPPLPPLPIPQVIPEVKQIKKEEVTKKEEQLKEIPLSNIPVLPKQNFPSGNVISNLPTSFPTIGGGGY
PRDRRSAQMLAISGSSGEGKATDAVLSNTSAQSSKATKAGKLGLMIIQGKVIDAILETAISSDLKGMLRAVVSRDVYAET
GDTILIPKGSRLIGGYSFDSNVAKARVNINWNRIILPHGIDVAIASSGTDELGRAGIAGIVDNKIASALFSSVALAGVSI
GSAVVGQKASNLIDALTAMDAVKSITATEIDISSLKGAIVERLENSIKTEVGKVGDEKWKLGIRAIEKIRNAKSDQDLLR
IIKEEIVSVIKSSGASGVDTITSDNIGITLDDVRQLLRQTQKRSKSVYDEAIGKSINDFSKDMRDIVDRSVDKKPTIYVN
QGTALKVFVNQDIVFPPQSILNN
>Mature_502_residues
SKERHNSVEDESEIESKVVTVGSNQGYKALMIVMVALLVGGVYYLYFSPSNKEGPEIVKKEETKQNIQELKGKLEQVPDN
VVVSERIATDLLPPLPPLPIPQVIPEVKQIKKEEVTKKEEQLKEIPLSNIPVLPKQNFPSGNVISNLPTSFPTIGGGGYP
RDRRSAQMLAISGSSGEGKATDAVLSNTSAQSSKATKAGKLGLMIIQGKVIDAILETAISSDLKGMLRAVVSRDVYAETG
DTILIPKGSRLIGGYSFDSNVAKARVNINWNRIILPHGIDVAIASSGTDELGRAGIAGIVDNKIASALFSSVALAGVSIG
SAVVGQKASNLIDALTAMDAVKSITATEIDISSLKGAIVERLENSIKTEVGKVGDEKWKLGIRAIEKIRNAKSDQDLLRI
IKEEIVSVIKSSGASGVDTITSDNIGITLDDVRQLLRQTQKRSKSVYDEAIGKSINDFSKDMRDIVDRSVDKKPTIYVNQ
GTALKVFVNQDIVFPPQSILNN

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 54082; Mature: 53951

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKERHNSVEDESEIESKVVTVGSNQGYKALMIVMVALLVGGVYYLYFSPSNKEGPEIVK
CCCCCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHH
KEETKQNIQELKGKLEQVPDNVVVSERIATDLLPPLPPLPIPQVIPEVKQIKKEEVTKKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EQLKEIPLSNIPVLPKQNFPSGNVISNLPTSFPTIGGGGYPRDRRSAQMLAISGSSGEGK
HHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
ATDAVLSNTSAQSSKATKAGKLGLMIIQGKVIDAILETAISSDLKGMLRAVVSRDVYAET
HHHHHHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
GDTILIPKGSRLIGGYSFDSNVAKARVNINWNRIILPHGIDVAIASSGTDELGRAGIAGI
CCEEEEECCCEEEECCCCCCCCEEEEEEECCCEEEECCCCEEEEECCCCHHHHHCCHHHH
VDNKIASALFSSVALAGVSIGSAVVGQKASNLIDALTAMDAVKSITATEIDISSLKGAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERLENSIKTEVGKVGDEKWKLGIRAIEKIRNAKSDQDLLRIIKEEIVSVIKSSGASGVDT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ITSDNIGITLDDVRQLLRQTQKRSKSVYDEAIGKSINDFSKDMRDIVDRSVDKKPTIYVN
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEE
QGTALKVFVNQDIVFPPQSILNN
CCCEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure 
SKERHNSVEDESEIESKVVTVGSNQGYKALMIVMVALLVGGVYYLYFSPSNKEGPEIVK
CCCCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHH
KEETKQNIQELKGKLEQVPDNVVVSERIATDLLPPLPPLPIPQVIPEVKQIKKEEVTKKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EQLKEIPLSNIPVLPKQNFPSGNVISNLPTSFPTIGGGGYPRDRRSAQMLAISGSSGEGK
HHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
ATDAVLSNTSAQSSKATKAGKLGLMIIQGKVIDAILETAISSDLKGMLRAVVSRDVYAET
HHHHHHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
GDTILIPKGSRLIGGYSFDSNVAKARVNINWNRIILPHGIDVAIASSGTDELGRAGIAGI
CCEEEEECCCEEEECCCCCCCCEEEEEEECCCEEEECCCCEEEEECCCCHHHHHCCHHHH
VDNKIASALFSSVALAGVSIGSAVVGQKASNLIDALTAMDAVKSITATEIDISSLKGAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERLENSIKTEVGKVGDEKWKLGIRAIEKIRNAKSDQDLLRIIKEEIVSVIKSSGASGVDT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ITSDNIGITLDDVRQLLRQTQKRSKSVYDEAIGKSINDFSKDMRDIVDRSVDKKPTIYVN
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEE
QGTALKVFVNQDIVFPPQSILNN
CCCEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]