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The map label for this gene is uvrC

Identifier: 190571502

GI number: 190571502

Start: 1201078

End: 1202895

Strand: Reverse

Name: uvrC

Synonym: WPa_1120

Alternate gene names: 190571502

Gene position: 1202895-1201078 (Counterclockwise)

Preceding gene: 190571503

Following gene: 190571500

Centisome position: 81.14

GC content: 34.32

Gene sequence:

>1818_bases
ATGCTCAGGCAATATAAGGAACAAATCAAATCATCTCCACAATCCTGTGGCGTTTATAAGATGATTGGAGATAAGAGTAA
GGTTTTATACATTGGTAAAGCAAAAAACTTGAAGTCGAGATTATCTGACTACCTTCAATTCGAAAACCTTTCTGAACGAA
TCAGAGTAATGATCTCACAGGTTATTAAGGTTGAAATATTCATCACTGAGAATGAAATCGAAGCATTGCTTCTTGAAGCA
CAGTTAATAAAATCGTTAAAACCATCTTATAATATTTTGCTTAGGGATGGAAAATCTTATCCTTATATAACAATTTCTAA
GCATGATTATCCAAGAATAGCGAAATATAGAGGTAAGTTTAAGAAGAATGAGTTTCATTACTACGGCCCTTTTCCATCTG
CTGCTGCTGTTAAGAACACTATATTATCATTGCAAAAAGCTTTTCTCTTAAGAGTATGTTCAGATCAATATTTCTCTTCA
ACAAAAAGACCATGTCTTGAGTATCAAGTTAAGCGCTGTTCAGCACCATGCGTAGATAAAATTACAAAAGATGATTACTG
CAAATCAGTAAAACAAGCACAAGATACTCTGCTAGGAAGGAATAAAGAAGTGCAAAGACAGCTATTTTCTACAATGGAAA
AGTGCAGTAGGGAGATGAACTACGAGCTTGCTGCTGTCTATAGAGATCGATTGAAATTTCTTCAGCAAATTCAAATGCAG
CCAATGGATTTTTCTTTTGAAGAAGATGCAGATTTCTTTAGCGTTGTACGTGAGGCAGACTTAGCATGCATTGGTGTACT
ATCTTTCAGAGATAAAGGTAACTATGGAAGCATTCCTTACTTCATTGAGAATTGTAGTGATCATTCAAATGATGAAATTT
TATCCACCTTTTTGGTCAATTTGTATAATCCAGTTAACACACCACCAGCGCAAATTTACGTTCCCGATTTTATTAAGGAT
AAGGAAATTATAGAACAAGCACTTTATGCTCTTACTCAAAAATCAATAAAAGTTTTGCATGCGAAAAATAGTAAAGAACG
TGATTTGTTGAATTTTATTTACAATAATTCTCAGCATAGTCTAGAACAGAAGCTTACTGATTATAGAAATAACCTAGAAA
AGCTCGAAGAGCTTAGGAAGATTTTCTCGTTACCAAATATTCCAAAGCGTATCGAGGTTTATGATAATAGCCATATATCT
GGAAATCAACAAGTTGGTGTGATGATTGTTGCAGGGCAGGAAGGTTTTTTAAAAAGTGAATACAAAAAATTTACTATAAA
AGAAGAAATTTCAGGTGATGACTATAAAATGATGAGAGAAGTGCTGACTAGACGTTTCTCTGGCAATATAAAAGATATAA
TCCCTGATTTTTTACTGATTGATGGCGGTCCAGGACATGTTTCCATAGTGCAGAATGTGTTGGAAATATTGAATATAAAA
GTTCCTTTTGCTTGTATGGCAAAGGGTCATGATCGTAATGCAGGAAATGAAAGATTTTATGTGCCGGACAGAGAAGAATT
TACTCTAGCAAGTGACAGTAAGGTCATGCTTTATTTACAATTGCTGCGTAATGAAGCTCACCGTTTTGCGATAACTTCGC
ATAGAAAAAAACGCGATAAACAGTTTTTTGCTTCACAATTAAGTGAAATATCCGGTGTTGGCAGTAAAAGAAAGAAGGCA
CTCATGTCTCATTTTGGTTCTGTAGAAAATATAAGCAAAGCTTCTCTAGCTGAAATTCAAAACGTACCTGGAATTAGTAA
AGGTTTAGCAGAAATCATTCTTCAACACGTGAATTCTAAGAAAGGTACTCCTAAATAG

Upstream 100 bases:

>100_bases
AATGAGCTTAGAATAAACAGGTTATCTTTGCTTGCAAATGTTGTTTCTACCTTTCATTTAGTAGCAGAGTTTAACCTTAT
ACAGGTTAAACAATTGATAA

Downstream 100 bases:

>100_bases
GTACTCTAAAATTAACCTTTATTTCTTCTTAATAAGACATAAAAAGCTCCTTTGCCACCATGTTTTTTTATGGCTTGCTG
ATAGTATAAGATCATATTTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MLRQYKEQIKSSPQSCGVYKMIGDKSKVLYIGKAKNLKSRLSDYLQFENLSERIRVMISQVIKVEIFITENEIEALLLEA
QLIKSLKPSYNILLRDGKSYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFPSAAAVKNTILSLQKAFLLRVCSDQYFSS
TKRPCLEYQVKRCSAPCVDKITKDDYCKSVKQAQDTLLGRNKEVQRQLFSTMEKCSREMNYELAAVYRDRLKFLQQIQMQ
PMDFSFEEDADFFSVVREADLACIGVLSFRDKGNYGSIPYFIENCSDHSNDEILSTFLVNLYNPVNTPPAQIYVPDFIKD
KEIIEQALYALTQKSIKVLHAKNSKERDLLNFIYNNSQHSLEQKLTDYRNNLEKLEELRKIFSLPNIPKRIEVYDNSHIS
GNQQVGVMIVAGQEGFLKSEYKKFTIKEEISGDDYKMMREVLTRRFSGNIKDIIPDFLLIDGGPGHVSIVQNVLEILNIK
VPFACMAKGHDRNAGNERFYVPDREEFTLASDSKVMLYLQLLRNEAHRFAITSHRKKRDKQFFASQLSEISGVGSKRKKA
LMSHFGSVENISKASLAEIQNVPGISKGLAEIILQHVNSKKGTPK

Sequences:

>Translated_605_residues
MLRQYKEQIKSSPQSCGVYKMIGDKSKVLYIGKAKNLKSRLSDYLQFENLSERIRVMISQVIKVEIFITENEIEALLLEA
QLIKSLKPSYNILLRDGKSYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFPSAAAVKNTILSLQKAFLLRVCSDQYFSS
TKRPCLEYQVKRCSAPCVDKITKDDYCKSVKQAQDTLLGRNKEVQRQLFSTMEKCSREMNYELAAVYRDRLKFLQQIQMQ
PMDFSFEEDADFFSVVREADLACIGVLSFRDKGNYGSIPYFIENCSDHSNDEILSTFLVNLYNPVNTPPAQIYVPDFIKD
KEIIEQALYALTQKSIKVLHAKNSKERDLLNFIYNNSQHSLEQKLTDYRNNLEKLEELRKIFSLPNIPKRIEVYDNSHIS
GNQQVGVMIVAGQEGFLKSEYKKFTIKEEISGDDYKMMREVLTRRFSGNIKDIIPDFLLIDGGPGHVSIVQNVLEILNIK
VPFACMAKGHDRNAGNERFYVPDREEFTLASDSKVMLYLQLLRNEAHRFAITSHRKKRDKQFFASQLSEISGVGSKRKKA
LMSHFGSVENISKASLAEIQNVPGISKGLAEIILQHVNSKKGTPK
>Mature_605_residues
MLRQYKEQIKSSPQSCGVYKMIGDKSKVLYIGKAKNLKSRLSDYLQFENLSERIRVMISQVIKVEIFITENEIEALLLEA
QLIKSLKPSYNILLRDGKSYPYITISKHDYPRIAKYRGKFKKNEFHYYGPFPSAAAVKNTILSLQKAFLLRVCSDQYFSS
TKRPCLEYQVKRCSAPCVDKITKDDYCKSVKQAQDTLLGRNKEVQRQLFSTMEKCSREMNYELAAVYRDRLKFLQQIQMQ
PMDFSFEEDADFFSVVREADLACIGVLSFRDKGNYGSIPYFIENCSDHSNDEILSTFLVNLYNPVNTPPAQIYVPDFIKD
KEIIEQALYALTQKSIKVLHAKNSKERDLLNFIYNNSQHSLEQKLTDYRNNLEKLEELRKIFSLPNIPKRIEVYDNSHIS
GNQQVGVMIVAGQEGFLKSEYKKFTIKEEISGDDYKMMREVLTRRFSGNIKDIIPDFLLIDGGPGHVSIVQNVLEILNIK
VPFACMAKGHDRNAGNERFYVPDREEFTLASDSKVMLYLQLLRNEAHRFAITSHRKKRDKQFFASQLSEISGVGSKRKKA
LMSHFGSVENISKASLAEIQNVPGISKGLAEIILQHVNSKKGTPK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=598, Percent_Identity=35.9531772575251, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_WOLPP (B3CMV5)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975860.1
- EnsemblBacteria:   EBWOLT00000000321
- GeneID:   6385508
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_1120
- GeneTree:   EBGT00050000030917
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69596; Mature: 69596

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQYKEQIKSSPQSCGVYKMIGDKSKVLYIGKAKNLKSRLSDYLQFENLSERIRVMISQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKVEIFITENEIEALLLEAQLIKSLKPSYNILLRDGKSYPYITISKHDYPRIAKYRGKF
HHEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHCCC
KKNEFHYYGPFPSAAAVKNTILSLQKAFLLRVCSDQYFSSTKRPCLEYQVKRCSAPCVDK
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
ITKDDYCKSVKQAQDTLLGRNKEVQRQLFSTMEKCSREMNYELAAVYRDRLKFLQQIQMQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PMDFSFEEDADFFSVVREADLACIGVLSFRDKGNYGSIPYFIENCSDHSNDEILSTFLVN
CCCCCCCCCHHHHHHHHHCCHHEEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHH
LYNPVNTPPAQIYVPDFIKDKEIIEQALYALTQKSIKVLHAKNSKERDLLNFIYNNSQHS
HHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LEQKLTDYRNNLEKLEELRKIFSLPNIPKRIEVYDNSHISGNQQVGVMIVAGQEGFLKSE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHH
YKKFTIKEEISGDDYKMMREVLTRRFSGNIKDIIPDFLLIDGGPGHVSIVQNVLEILNIK
HHHEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHCCC
VPFACMAKGHDRNAGNERFYVPDREEFTLASDSKVMLYLQLLRNEAHRFAITSHRKKRDK
CCHHHHCCCCCCCCCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFFASQLSEISGVGSKRKKALMSHFGSVENISKASLAEIQNVPGISKGLAEIILQHVNSK
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
KGTPK
CCCCC
>Mature Secondary Structure
MLRQYKEQIKSSPQSCGVYKMIGDKSKVLYIGKAKNLKSRLSDYLQFENLSERIRVMISQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIKVEIFITENEIEALLLEAQLIKSLKPSYNILLRDGKSYPYITISKHDYPRIAKYRGKF
HHEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHCCC
KKNEFHYYGPFPSAAAVKNTILSLQKAFLLRVCSDQYFSSTKRPCLEYQVKRCSAPCVDK
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
ITKDDYCKSVKQAQDTLLGRNKEVQRQLFSTMEKCSREMNYELAAVYRDRLKFLQQIQMQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PMDFSFEEDADFFSVVREADLACIGVLSFRDKGNYGSIPYFIENCSDHSNDEILSTFLVN
CCCCCCCCCHHHHHHHHHCCHHEEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHH
LYNPVNTPPAQIYVPDFIKDKEIIEQALYALTQKSIKVLHAKNSKERDLLNFIYNNSQHS
HHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LEQKLTDYRNNLEKLEELRKIFSLPNIPKRIEVYDNSHISGNQQVGVMIVAGQEGFLKSE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHHHH
YKKFTIKEEISGDDYKMMREVLTRRFSGNIKDIIPDFLLIDGGPGHVSIVQNVLEILNIK
HHHEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHCCC
VPFACMAKGHDRNAGNERFYVPDREEFTLASDSKVMLYLQLLRNEAHRFAITSHRKKRDK
CCHHHHCCCCCCCCCCCEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFFASQLSEISGVGSKRKKALMSHFGSVENISKASLAEIQNVPGISKGLAEIILQHVNSK
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
KGTPK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA