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The map label for this gene is nuoE [H]

Identifier: 190570998

GI number: 190570998

Start: 635537

End: 636037

Strand: Direct

Name: nuoE [H]

Synonym: WPa_0588

Alternate gene names: 190570998

Gene position: 635537-636037 (Clockwise)

Preceding gene: 190570997

Following gene: 190570999

Centisome position: 42.87

GC content: 36.33

Gene sequence:

>501_bases
ATGAAAGAGAAAGAAGAGCAGTTTAGTTTTACATCAGACAACCTCAGAAAAGCGAAAAAGTCTATAGAGATGTATCCTAA
AGGTAGAGAAGGTAGTGCCGTCATGCCTTTACTATACCTGGTTCAAGAACAATGCGGATGGGTTCCTGAATCTGCCATGC
GCTACGTTGCTGACATGCTTCATATTCCACATATTCGCGTGTATGAAGTGGCAAATTTTTATACCATGTATAATTTAAAA
CCAGTAGGTAAATATCTCATACAAATTTGTAGAACAACTCCTTGCTGGTTGTGCAATAGCGAAGAAGTGTTAAATACCTT
TAAAAAGAAACTAGGAATCAATATCGGTGAAACTACTAAAGATAATCTATTTACTTTAAAGGAAGTTGAATGTCTTGGTG
CATGCGTTAATGCCCCTGTGGTGCAGATCAATAATGACTTTTATGAAAACCTCACTCCTGAAAAAGTGGAAAATATCATA
GCAGAACTTTCAAGTAAATAG

Upstream 100 bases:

>100_bases
CCCACTCTACAGATATAATATTGTAGAGCTCAAAAAACCAACAATTGCAATTGTTAACTCTTCAAGTATAATTTGTTGAG
ATTTACACGAACTTTATTAG

Downstream 100 bases:

>100_bases
ATGGAAAAGTTCTCGTTTAGGATAACTAAGCAATCAGGTTCTGCAAGAGTTGGAACGATCAAAACTCCAAATGGAAGTAT
AGAAACACCAGCATTTATAT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKEKEEQFSFTSDNLRKAKKSIEMYPKGREGSAVMPLLYLVQEQCGWVPESAMRYVADMLHIPHIRVYEVANFYTMYNLK
PVGKYLIQICRTTPCWLCNSEEVLNTFKKKLGINIGETTKDNLFTLKEVECLGACVNAPVVQINNDFYENLTPEKVENII
AELSSK

Sequences:

>Translated_166_residues
MKEKEEQFSFTSDNLRKAKKSIEMYPKGREGSAVMPLLYLVQEQCGWVPESAMRYVADMLHIPHIRVYEVANFYTMYNLK
PVGKYLIQICRTTPCWLCNSEEVLNTFKKKLGINIGETTKDNLFTLKEVECLGACVNAPVVQINNDFYENLTPEKVENII
AELSSK
>Mature_166_residues
MKEKEEQFSFTSDNLRKAKKSIEMYPKGREGSAVMPLLYLVQEQCGWVPESAMRYVADMLHIPHIRVYEVANFYTMYNLK
PVGKYLIQICRTTPCWLCNSEEVLNTFKKKLGINIGETTKDNLFTLKEVECLGACVNAPVVQINNDFYENLTPEKVENII
AELSSK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=161, Percent_Identity=57.1428571428571, Blast_Score=199, Evalue=9e-52,
Organism=Escherichia coli, GI1788621, Length=155, Percent_Identity=33.5483870967742, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561328, Length=159, Percent_Identity=55.3459119496855, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI18859877, Length=158, Percent_Identity=53.7974683544304, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21355353, Length=161, Percent_Identity=42.8571428571429, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19097; Mature: 19097

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKEEQFSFTSDNLRKAKKSIEMYPKGREGSAVMPLLYLVQEQCGWVPESAMRYVADML
CCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HIPHIRVYEVANFYTMYNLKPVGKYLIQICRTTPCWLCNSEEVLNTFKKKLGINIGETTK
HCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHCCCCCCCCC
DNLFTLKEVECLGACVNAPVVQINNDFYENLTPEKVENIIAELSSK
CCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEKEEQFSFTSDNLRKAKKSIEMYPKGREGSAVMPLLYLVQEQCGWVPESAMRYVADML
CCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HIPHIRVYEVANFYTMYNLKPVGKYLIQICRTTPCWLCNSEEVLNTFKKKLGINIGETTK
HCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHCCCCCCCCC
DNLFTLKEVECLGACVNAPVVQINNDFYENLTPEKVENIIAELSSK
CCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA