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The map label for this gene is rnc [H]

Identifier: 189499162

GI number: 189499162

Start: 173499

End: 174314

Strand: Reverse

Name: rnc [H]

Synonym: Cphamn1_0177

Alternate gene names: 189499162

Gene position: 174314-173499 (Counterclockwise)

Preceding gene: 189499163

Following gene: 189499161

Centisome position: 6.37

GC content: 48.77

Gene sequence:

>816_bases
ATGGAGAAGCTCTGGCAAAAACTCAGCTCATTAGCCTTCAATCGCCCTCAAAGCCATGAGCAGTCTGAAACCGGACCTAC
CACAGATCGAAATGCACCGCCGATTCCGCAGAACACCTCAACATGGTTAGAAGACATTCTCGGCTTTTCGCCCATTGACG
AGAAGTTATACGTGATCGCCCTTACACACCGCTCGATCGTGCATGACCATCCGGAAGCGTCCGATTCAAACCAACGTCTT
GAATTTCTGGGAGACGCTGTTCTCGATCTGATCATTTCCGAGTTGCTCTATACCGTTTTCCCTGAAAGTGACGAAGGGAA
GCTGTCGAGCAATCGGGCGAAAATCGTTAACAGGAAGTCGCTCGCCGGTTTTGCCGGAAAAATATCTCTTGGAGAACACC
TGCTTATCGGTGAAACCGCTGACAAGATCAACATACAAACAAGCACTTCCTCTCTTGCAGATGCTTTTGAGGCCCTCATT
GGAGCACTCTATCTCGATAAAGGGCTGGAGGAAACTCGAAAGTTCATCATGCGGCATGTCGCAGGGCATGTCGATATAAA
AAAAATCGATACTGTCGAGAACAATTATAAAAGCCGCCTGATTGAATATACCCAGTCCTGCCAGATTGCGCCGCCTGTAT
ACACCGTCGTTTCAGAAGAAGGGGCAGAACATGAAAAACTGTTTACCATAGAAGTTTCCTGTGACAACAGACCTCTCGGA
AAAGGCTCTGCCAGAAGAAAGAAAGATGCGGAGCAAACCGCCGCCAGAGAAGCCCTCGAGGAGCTGGAAGCAAGAAAAAG
ATCGGAGAGCGACTGA

Upstream 100 bases:

>100_bases
AAAAATCGACTACGTTCTCAACAACGGCTTTGGCTTTGGCGGTCATAACGCTACGCTTATTTTCAAAAAAATATAGGTAT
CCGCAAAACATCTCCTGCAT

Downstream 100 bases:

>100_bases
TCCGGGGTATTCCAAACCTAAAAACCCCCTCTTTTTTTCTCTTTGTTTGAGCATTTCCTGTCAGTCATCTATATTCAAAA
TAGATAACATCTAACGCCTT

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MEKLWQKLSSLAFNRPQSHEQSETGPTTDRNAPPIPQNTSTWLEDILGFSPIDEKLYVIALTHRSIVHDHPEASDSNQRL
EFLGDAVLDLIISELLYTVFPESDEGKLSSNRAKIVNRKSLAGFAGKISLGEHLLIGETADKINIQTSTSSLADAFEALI
GALYLDKGLEETRKFIMRHVAGHVDIKKIDTVENNYKSRLIEYTQSCQIAPPVYTVVSEEGAEHEKLFTIEVSCDNRPLG
KGSARRKKDAEQTAAREALEELEARKRSESD

Sequences:

>Translated_271_residues
MEKLWQKLSSLAFNRPQSHEQSETGPTTDRNAPPIPQNTSTWLEDILGFSPIDEKLYVIALTHRSIVHDHPEASDSNQRL
EFLGDAVLDLIISELLYTVFPESDEGKLSSNRAKIVNRKSLAGFAGKISLGEHLLIGETADKINIQTSTSSLADAFEALI
GALYLDKGLEETRKFIMRHVAGHVDIKKIDTVENNYKSRLIEYTQSCQIAPPVYTVVSEEGAEHEKLFTIEVSCDNRPLG
KGSARRKKDAEQTAAREALEELEARKRSESD
>Mature_271_residues
MEKLWQKLSSLAFNRPQSHEQSETGPTTDRNAPPIPQNTSTWLEDILGFSPIDEKLYVIALTHRSIVHDHPEASDSNQRL
EFLGDAVLDLIISELLYTVFPESDEGKLSSNRAKIVNRKSLAGFAGKISLGEHLLIGETADKINIQTSTSSLADAFEALI
GALYLDKGLEETRKFIMRHVAGHVDIKKIDTVENNYKSRLIEYTQSCQIAPPVYTVVSEEGAEHEKLFTIEVSCDNRPLG
KGSARRKKDAEQTAAREALEELEARKRSESD

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=250, Percent_Identity=30, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI155030234, Length=250, Percent_Identity=30, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788920, Length=208, Percent_Identity=37.9807692307692, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17506883, Length=256, Percent_Identity=31.25, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=256, Percent_Identity=31.25, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323895, Length=226, Percent_Identity=28.3185840707965, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137682, Length=267, Percent_Identity=32.2097378277154, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 30247; Mature: 30247

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLWQKLSSLAFNRPQSHEQSETGPTTDRNAPPIPQNTSTWLEDILGFSPIDEKLYVIA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
LTHRSIVHDHPEASDSNQRLEFLGDAVLDLIISELLYTVFPESDEGKLSSNRAKIVNRKS
EECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LAGFAGKISLGEHLLIGETADKINIQTSTSSLADAFEALIGALYLDKGLEETRKFIMRHV
HHCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGHVDIKKIDTVENNYKSRLIEYTQSCQIAPPVYTVVSEEGAEHEKLFTIEVSCDNRPLG
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCEEEEEEEECCCCCCC
KGSARRKKDAEQTAAREALEELEARKRSESD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKLWQKLSSLAFNRPQSHEQSETGPTTDRNAPPIPQNTSTWLEDILGFSPIDEKLYVIA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
LTHRSIVHDHPEASDSNQRLEFLGDAVLDLIISELLYTVFPESDEGKLSSNRAKIVNRKS
EECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LAGFAGKISLGEHLLIGETADKINIQTSTSSLADAFEALIGALYLDKGLEETRKFIMRHV
HHCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGHVDIKKIDTVENNYKSRLIEYTQSCQIAPPVYTVVSEEGAEHEKLFTIEVSCDNRPLG
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCEEEEEEEECCCCCCC
KGSARRKKDAEQTAAREALEELEARKRSESD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]