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The map label for this gene is glmS [H]

Identifier: 189499096

GI number: 189499096

Start: 96005

End: 97852

Strand: Direct

Name: glmS [H]

Synonym: Cphamn1_0102

Alternate gene names: 189499096

Gene position: 96005-97852 (Clockwise)

Preceding gene: 189499095

Following gene: 189499097

Centisome position: 3.51

GC content: 50.92

Gene sequence:

>1848_bases
ATGTGTGGAATAGTTGGATATATCGGCCATCGTGATGCGGCGGGGTTGCTCTTGAACGGACTTCGGCGTCTGGAATACCG
GGGCTACGATTCTGCGGGAATTGCTGTTCTGAACGGCGGTTTGAAGATGTTCAAGCAAAAAGGAAGCGTCGATGAGCTGA
GAAGATCATTGCATGATGCAGGAAATCCTCTCAACGGGGCTACGATAGGTATCGGTCATACCCGGTGGGCGACGCACGGC
GACCCCAGCGACCGGAATGCACACCCTCATGTGAGCAGTGACGGCCGGATAGCGCTTATACATAACGGGATCATTGAGAA
CTATCCGGCTATTAAAAAAGAGCTGATTTCAAAAGGGGTTCATTTCAGCAGCGATACCGATTCAGAAGTGCTTGTTCATC
TTATAGAAAGCATCTGGTCGGATAATCCCGGGATGGCCCTGGAAGCTGCGGTCCGTTCTGCGCTCTATCATGTGGAAGGA
GCATACGGGCTGTGTGTTATCTCAGAGCGGGAGCCGGACAGCATTGTTGTCGCCCGTAAGGGAAGCCCGCTGGTTATAGG
TATCGGTGAAGGCGAGTACTATATAGCATCTGATGCCGCTCCCATTGTCGAACATACCAAAAAGGTTGTCTACCTCGCTG
ATGGAGAAATGGCTGTTGTTACAAGAAATGACGGTTTTGCTATCAAGACAATAGAGAACATAGCCCGTGAAAAGCATGTA
AGTGAGCTTGAATTCGAACTCGCCGAGATTGAAAAAGGGGGGTTTGAGCATTTTATGCTCAAGGAGATTTTTGAGCAGCC
AAAGGTGCTTCAGGATGTTATGCGGGGACGGGTCAGGCTTGATGAGGGTCAGGTTCGCCTGGGAGGTATAGAGGATTATC
TCGATCGCCTGAAGCTATCCAGCAGGGTGATTATCTGCGCATGCGGGACAAGCTGGCATGCGGGGTTGATCGGGGAGTAC
CTGATTGAAGAGTTTGCCCGGATTCCCGTTGAAGTTGATTATGCCTCGGAGTTTCGTTACCGCAATCCGGTGATTACCAG
GGATGATGTGGTAATCGTTATTTCGCAGTCGGGCGAGACCGCCGATACGCTTGCCGCATTGCGCCTTGCAAGGGAGAAGG
GGGCGTTGGTTATGGGGATCTGTAATGTAGTTGGTTCAACCATAGCCCGTGAAACACTCTGCGGGATTTACACTCACGCC
GGTCCGGAGGTCGGTGTTGCGTCGACCAAGGCGTTCACCGCCCAGGTAACGGTACTCTATCTTCTTGCGTTGACGCTCGG
CAAGGGGCGTACCATGTCTCGTAATGAATTGAAGCTCTACCTCAAAGAGCTTAACGGTATTCCTGAAAAAGTGGAACGAA
TTCTCAAGCAGAATGACCTTATTCTGGAAATAGCTAAAAACTATAAAGATGCCGGAAATTTCCTCTACCTCGGGCGCGGG
TACAATTTCCCCGTAGCGCTTGAAGGGGCGTTGAAGCTCAAGGAGATTTCCTACATTCATGCCGAGGGGTATCCGGCTGC
AGAAATGAAGCACGGTCCTATTGCGCTTATTGACCAGGATATGCCGGTTATCTTTATCGCGACACGCGATAACTCGTATG
CCAAAGTATTGAGCAACATCGAGGAGGTCAGAAGTCGCAAGGGCAAGGTGATCGCTATTGCCAATCATGGCGATGACGAA
ATCGGCAGGCTTGCCGATCATGTTATTTATATTCCTCCTGCATCAGCTCCGGTAACCCCGCTGCTCTCAGTAATCCCCTT
ACAACTGCTTTCTTATCACATCGCGACGCTGAGGGGCTGCAATGTTGACCGTCCGAGAAACCTCGCTAAATCGGTAACGG
TTGAGTGA

Upstream 100 bases:

>100_bases
GGACTCAGTGAGCCGGAAAGCGGAGGCGCTTCATGATGAGATGCTGAAAATTTTTTGACAGCTGCCGGCGCTTTTTCTCT
GTTCAAATAAACTAGTGTTC

Downstream 100 bases:

>100_bases
TTGGACTGGGAAAGTCAAAAGGCAAAAGTAAAAAAGCGCATACGTTTGATAGCTGCTGAGCTGGTTGGGATTGTCGTGCC
GCTTCGTGAAACAGTTGTTC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MCGIVGYIGHRDAAGLLLNGLRRLEYRGYDSAGIAVLNGGLKMFKQKGSVDELRRSLHDAGNPLNGATIGIGHTRWATHG
DPSDRNAHPHVSSDGRIALIHNGIIENYPAIKKELISKGVHFSSDTDSEVLVHLIESIWSDNPGMALEAAVRSALYHVEG
AYGLCVISEREPDSIVVARKGSPLVIGIGEGEYYIASDAAPIVEHTKKVVYLADGEMAVVTRNDGFAIKTIENIAREKHV
SELEFELAEIEKGGFEHFMLKEIFEQPKVLQDVMRGRVRLDEGQVRLGGIEDYLDRLKLSSRVIICACGTSWHAGLIGEY
LIEEFARIPVEVDYASEFRYRNPVITRDDVVIVISQSGETADTLAALRLAREKGALVMGICNVVGSTIARETLCGIYTHA
GPEVGVASTKAFTAQVTVLYLLALTLGKGRTMSRNELKLYLKELNGIPEKVERILKQNDLILEIAKNYKDAGNFLYLGRG
YNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDQDMPVIFIATRDNSYAKVLSNIEEVRSRKGKVIAIANHGDDE
IGRLADHVIYIPPASAPVTPLLSVIPLQLLSYHIATLRGCNVDRPRNLAKSVTVE

Sequences:

>Translated_615_residues
MCGIVGYIGHRDAAGLLLNGLRRLEYRGYDSAGIAVLNGGLKMFKQKGSVDELRRSLHDAGNPLNGATIGIGHTRWATHG
DPSDRNAHPHVSSDGRIALIHNGIIENYPAIKKELISKGVHFSSDTDSEVLVHLIESIWSDNPGMALEAAVRSALYHVEG
AYGLCVISEREPDSIVVARKGSPLVIGIGEGEYYIASDAAPIVEHTKKVVYLADGEMAVVTRNDGFAIKTIENIAREKHV
SELEFELAEIEKGGFEHFMLKEIFEQPKVLQDVMRGRVRLDEGQVRLGGIEDYLDRLKLSSRVIICACGTSWHAGLIGEY
LIEEFARIPVEVDYASEFRYRNPVITRDDVVIVISQSGETADTLAALRLAREKGALVMGICNVVGSTIARETLCGIYTHA
GPEVGVASTKAFTAQVTVLYLLALTLGKGRTMSRNELKLYLKELNGIPEKVERILKQNDLILEIAKNYKDAGNFLYLGRG
YNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDQDMPVIFIATRDNSYAKVLSNIEEVRSRKGKVIAIANHGDDE
IGRLADHVIYIPPASAPVTPLLSVIPLQLLSYHIATLRGCNVDRPRNLAKSVTVE
>Mature_615_residues
MCGIVGYIGHRDAAGLLLNGLRRLEYRGYDSAGIAVLNGGLKMFKQKGSVDELRRSLHDAGNPLNGATIGIGHTRWATHG
DPSDRNAHPHVSSDGRIALIHNGIIENYPAIKKELISKGVHFSSDTDSEVLVHLIESIWSDNPGMALEAAVRSALYHVEG
AYGLCVISEREPDSIVVARKGSPLVIGIGEGEYYIASDAAPIVEHTKKVVYLADGEMAVVTRNDGFAIKTIENIAREKHV
SELEFELAEIEKGGFEHFMLKEIFEQPKVLQDVMRGRVRLDEGQVRLGGIEDYLDRLKLSSRVIICACGTSWHAGLIGEY
LIEEFARIPVEVDYASEFRYRNPVITRDDVVIVISQSGETADTLAALRLAREKGALVMGICNVVGSTIARETLCGIYTHA
GPEVGVASTKAFTAQVTVLYLLALTLGKGRTMSRNELKLYLKELNGIPEKVERILKQNDLILEIAKNYKDAGNFLYLGRG
YNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDQDMPVIFIATRDNSYAKVLSNIEEVRSRKGKVIAIANHGDDE
IGRLADHVIYIPPASAPVTPLLSVIPLQLLSYHIATLRGCNVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=40.3508771929825, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=39.4736842105263, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI29570798, Length=205, Percent_Identity=29.7560975609756, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790167, Length=621, Percent_Identity=45.8937198067633, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788651, Length=224, Percent_Identity=31.6964285714286, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=713, Percent_Identity=37.1669004207574, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=48.2758620689655, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=48.2758620689655, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322745, Length=446, Percent_Identity=42.8251121076233, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=38.0510440835267, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.5365853658537, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=41.4598540145985, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI28573187, Length=144, Percent_Identity=32.6388888888889, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67401; Mature: 67401

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGHRDAAGLLLNGLRRLEYRGYDSAGIAVLNGGLKMFKQKGSVDELRRSLHDA
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHC
GNPLNGATIGIGHTRWATHGDPSDRNAHPHVSSDGRIALIHNGIIENYPAIKKELISKGV
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCHHHHHHHHHCCC
HFSSDTDSEVLVHLIESIWSDNPGMALEAAVRSALYHVEGAYGLCVISEREPDSIVVARK
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEC
GSPLVIGIGEGEYYIASDAAPIVEHTKKVVYLADGEMAVVTRNDGFAIKTIENIAREKHV
CCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEECCCCEEEHHHHHHHHHHHH
SELEFELAEIEKGGFEHFMLKEIFEQPKVLQDVMRGRVRLDEGQVRLGGIEDYLDRLKLS
HHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCEEECCCCEEECCHHHHHHHHHCC
SRVIICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRNPVITRDDVVIVISQSGET
CCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCCCCCCEEEEEECCCCH
ADTLAALRLAREKGALVMGICNVVGSTIARETLCGIYTHAGPEVGVASTKAFTAQVTVLY
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LLALTLGKGRTMSRNELKLYLKELNGIPEKVERILKQNDLILEIAKNYKDAGNFLYLGRG
HHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHCCCCCCCEEEEECC
YNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDQDMPVIFIATRDNSYAKVLSNI
CCCCEEECCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHH
EEVRSRKGKVIAIANHGDDEIGRLADHVIYIPPASAPVTPLLSVIPLQLLSYHIATLRGC
HHHHHCCCCEEEEECCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NVDRPRNLAKSVTVE
CCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGHRDAAGLLLNGLRRLEYRGYDSAGIAVLNGGLKMFKQKGSVDELRRSLHDA
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHC
GNPLNGATIGIGHTRWATHGDPSDRNAHPHVSSDGRIALIHNGIIENYPAIKKELISKGV
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCHHHHHHHHHCCC
HFSSDTDSEVLVHLIESIWSDNPGMALEAAVRSALYHVEGAYGLCVISEREPDSIVVARK
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEC
GSPLVIGIGEGEYYIASDAAPIVEHTKKVVYLADGEMAVVTRNDGFAIKTIENIAREKHV
CCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEECCCCEEEHHHHHHHHHHHH
SELEFELAEIEKGGFEHFMLKEIFEQPKVLQDVMRGRVRLDEGQVRLGGIEDYLDRLKLS
HHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCEEECCCCEEECCHHHHHHHHHCC
SRVIICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRNPVITRDDVVIVISQSGET
CCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCCCCCCEEEEEECCCCH
ADTLAALRLAREKGALVMGICNVVGSTIARETLCGIYTHAGPEVGVASTKAFTAQVTVLY
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LLALTLGKGRTMSRNELKLYLKELNGIPEKVERILKQNDLILEIAKNYKDAGNFLYLGRG
HHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHCCCCCCCEEEEECC
YNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDQDMPVIFIATRDNSYAKVLSNI
CCCCEEECCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHH
EEVRSRKGKVIAIANHGDDEIGRLADHVIYIPPASAPVTPLLSVIPLQLLSYHIATLRGC
HHHHHCCCCEEEEECCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
NVDRPRNLAKSVTVE
CCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]