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The map label for this gene is aslA [H]

Identifier: 189352168

GI number: 189352168

Start: 199882

End: 201831

Strand: Direct

Name: aslA [H]

Synonym: BMULJ_03386

Alternate gene names: 189352168

Gene position: 199882-201831 (Clockwise)

Preceding gene: 189352165

Following gene: 189352169

Centisome position: 8.08

GC content: 67.44

Gene sequence:

>1950_bases
ATGAGCATGTCCGCGTCACGTTCGGTCCCGTTCCGTCTTCGCGTCGTATGCGCGATCGCCGCCGGTGCGCTGTCGCTCGC
GTCGTGCGGCGGCGTCGACGGCAACCCGCCTCCGCAGGCCGACGCGACGCCATCGGCGAAGCGCCCGAACATCCTCTACA
TCATGGCCGACGATCTCGGCTATTCCGACATCCACGCGTTCGGCGGCGAGATCAACACGCCGAACCTCGACGCGCTCGTC
GCGTCGGGCCGCATCCTGTCGAACCACCATACGGGCACCGTATGCGCGATCACGCGCGCGATGCTGATTTCGGGCACGGA
TCACCATCTCGTCGGCGAAGGCACGATGGGCGTGCCGACCGACGAGCGGCGCGGGCTGCCGGGCTACGAGGGCTATCTGA
ACGATCGCGCGCTGTCGTTCGCGCAGCTGCTGAAGGATGCCGGCTATCACACGTATATCGCGGGCAAGTGGCACATCGGC
TCGGGCATCGTCGGCAGCGCGACGGGCAGCGGGCAGACGCCCGATCAATGGGGCTTCGAGCGCAGCTACGTGCTGCTCGG
CGGCGCGGCGACGAACCACTTCGCGCACGAGCCGGCCGGCTCGTCGAACTACACGGAGGACGGCCGCTACGTGCAGCCGG
GCCAGCCCGGGCAGCCGGGCGGCACGGGCGGCAATCCGGCGGTGTTCTATTCGACGAATTTCTATACGCAGAAGCTGATC
CAGTACATCGATTCGAATCACAGCGACGGCAAGCCGTTCTTCGCCTATGCGGCATACACGTCGCCACACTGGCCGCTGCA
GGTGCCCGATCCGTGGCTGCACAAGTACGCGGGCGTCTACGACGCCGGCTACGATGCGATCCGCAACGCGCGAATCGCGC
GGCAGAAGGCGCTCGGCCTGATTCCGGCCGACTTCAAGCCGTTCGACGGATTGCCCGAGACGACGGTTGCGTCGCCAGCG
ACGGCGAACGACGGCACCGCCAACGCGAAATACGTCAGCGCCGTGCATTCGGCGGCCGACGGCTACCGCGACTACGGCGC
GGGCAAGGTCGACAAGCTGTGGTCGAGCCTGAGCCCGGCCGAACGCAAGGCGCAGGCGCGCTACATGGAGATCTACGCGG
GGATGGTCGAGAACCTCGACTACAACATCGGCCTGCTGATCCAGCACCTGAAGGACATCGGCGAATACGACAACACGTTC
ATCATGTTCCAGTCGGACAACGGCGCGGAAGGCTGGCCGATCGATTCGGGCGCGGACCCGACCGCGACCGATACCGCGAA
CGCGCAGGAACCGACCTATTCGGCGCTCGGCACCGACAACGGCAAGCAGAACGCGCAGCGGCTGCAGTACGGGCTGCGCT
GGGCCGAGGTGAGCGCGACGCCGTTCCGGCTCACGAAGGGCTATTCGGCCGAAGGCGGCGTGTCGACGCCGACGATCGTT
CATCTGCCGGGCCAGACGCAGCAGCTGCCGACGCTGCGCGCGTTCACGCACGTGACCGACAACACGGCGACGTTCCTCGC
GGTAGCGGGCGTGACGCCGCCGTCGCAGCCGGCGCCGCCGCTGATCAACACGCTGACGGGCGTCGATCAGAACAAGGGCA
AGGTCGTATACGGCAACCGCTACGTCTATCCCGTCACCGGCCAGTCGCTGCTGCCGGTGCTGACCGGCGCCGCGAACGGC
GAAGTGCACACCGCGCCGTTCGGCGACGAAGCCTACGGCCGCGCGTATCTGCGCAGTGCCGACGGCCGCTGGAAAGCGTT
GTGGACGGAGCCGCCGCTCGGGCCGCTCGACGGTCACTGGCAGCTGTACGACCTCACGACGGACCGCGGCGAGACGATCG
ACGTGTCCGCGCAGAATCCGTCGGTGGTCAGCACGCTGATCGATCAGTGGAAGGCGTACATGAGCAACGTCGGCGGCGTC
GAGCCGCTGCGTCCGCGCGGCTACTACTGA

Upstream 100 bases:

>100_bases
ATCCCGATATTCCGCCTGCCTGTTAGCTTGTGACGATTTCGACTTTGGACCCCGCGTGCCGGACGCTACCATCGCCGCTC
CGTCCCTCAGGTGATAAAGC

Downstream 100 bases:

>100_bases
GGATTCGGCGATGCGGTTCTGGACGATCGGCGCGGCGCTCGCGGCCGCACTGTTCGGCGCGGCGTTCGCGGCCGGCTATA
CGCACGGGCCGGCGGCGCCG

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSMSASRSVPFRLRVVCAIAAGALSLASCGGVDGNPPPQADATPSAKRPNILYIMADDLGYSDIHAFGGEINTPNLDALV
ASGRILSNHHTGTVCAITRAMLISGTDHHLVGEGTMGVPTDERRGLPGYEGYLNDRALSFAQLLKDAGYHTYIAGKWHIG
SGIVGSATGSGQTPDQWGFERSYVLLGGAATNHFAHEPAGSSNYTEDGRYVQPGQPGQPGGTGGNPAVFYSTNFYTQKLI
QYIDSNHSDGKPFFAYAAYTSPHWPLQVPDPWLHKYAGVYDAGYDAIRNARIARQKALGLIPADFKPFDGLPETTVASPA
TANDGTANAKYVSAVHSAADGYRDYGAGKVDKLWSSLSPAERKAQARYMEIYAGMVENLDYNIGLLIQHLKDIGEYDNTF
IMFQSDNGAEGWPIDSGADPTATDTANAQEPTYSALGTDNGKQNAQRLQYGLRWAEVSATPFRLTKGYSAEGGVSTPTIV
HLPGQTQQLPTLRAFTHVTDNTATFLAVAGVTPPSQPAPPLINTLTGVDQNKGKVVYGNRYVYPVTGQSLLPVLTGAANG
EVHTAPFGDEAYGRAYLRSADGRWKALWTEPPLGPLDGHWQLYDLTTDRGETIDVSAQNPSVVSTLIDQWKAYMSNVGGV
EPLRPRGYY

Sequences:

>Translated_649_residues
MSMSASRSVPFRLRVVCAIAAGALSLASCGGVDGNPPPQADATPSAKRPNILYIMADDLGYSDIHAFGGEINTPNLDALV
ASGRILSNHHTGTVCAITRAMLISGTDHHLVGEGTMGVPTDERRGLPGYEGYLNDRALSFAQLLKDAGYHTYIAGKWHIG
SGIVGSATGSGQTPDQWGFERSYVLLGGAATNHFAHEPAGSSNYTEDGRYVQPGQPGQPGGTGGNPAVFYSTNFYTQKLI
QYIDSNHSDGKPFFAYAAYTSPHWPLQVPDPWLHKYAGVYDAGYDAIRNARIARQKALGLIPADFKPFDGLPETTVASPA
TANDGTANAKYVSAVHSAADGYRDYGAGKVDKLWSSLSPAERKAQARYMEIYAGMVENLDYNIGLLIQHLKDIGEYDNTF
IMFQSDNGAEGWPIDSGADPTATDTANAQEPTYSALGTDNGKQNAQRLQYGLRWAEVSATPFRLTKGYSAEGGVSTPTIV
HLPGQTQQLPTLRAFTHVTDNTATFLAVAGVTPPSQPAPPLINTLTGVDQNKGKVVYGNRYVYPVTGQSLLPVLTGAANG
EVHTAPFGDEAYGRAYLRSADGRWKALWTEPPLGPLDGHWQLYDLTTDRGETIDVSAQNPSVVSTLIDQWKAYMSNVGGV
EPLRPRGYY
>Mature_648_residues
SMSASRSVPFRLRVVCAIAAGALSLASCGGVDGNPPPQADATPSAKRPNILYIMADDLGYSDIHAFGGEINTPNLDALVA
SGRILSNHHTGTVCAITRAMLISGTDHHLVGEGTMGVPTDERRGLPGYEGYLNDRALSFAQLLKDAGYHTYIAGKWHIGS
GIVGSATGSGQTPDQWGFERSYVLLGGAATNHFAHEPAGSSNYTEDGRYVQPGQPGQPGGTGGNPAVFYSTNFYTQKLIQ
YIDSNHSDGKPFFAYAAYTSPHWPLQVPDPWLHKYAGVYDAGYDAIRNARIARQKALGLIPADFKPFDGLPETTVASPAT
ANDGTANAKYVSAVHSAADGYRDYGAGKVDKLWSSLSPAERKAQARYMEIYAGMVENLDYNIGLLIQHLKDIGEYDNTFI
MFQSDNGAEGWPIDSGADPTATDTANAQEPTYSALGTDNGKQNAQRLQYGLRWAEVSATPFRLTKGYSAEGGVSTPTIVH
LPGQTQQLPTLRAFTHVTDNTATFLAVAGVTPPSQPAPPLINTLTGVDQNKGKVVYGNRYVYPVTGQSLLPVLTGAANGE
VHTAPFGDEAYGRAYLRSADGRWKALWTEPPLGPLDGHWQLYDLTTDRGETIDVSAQNPSVVSTLIDQWKAYMSNVGGVE
PLRPRGYY

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI38569407, Length=292, Percent_Identity=30.4794520547945, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI38569405, Length=285, Percent_Identity=30.8771929824561, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI109389362, Length=245, Percent_Identity=29.7959183673469, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI59797060, Length=262, Percent_Identity=27.8625954198473, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI53831991, Length=400, Percent_Identity=25, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI157266309, Length=168, Percent_Identity=35.1190476190476, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790112, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=304, Percent_Identity=27.9605263157895, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI115533418, Length=289, Percent_Identity=27.681660899654, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559078, Length=142, Percent_Identity=34.5070422535211, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363223, Length=241, Percent_Identity=30.2904564315353, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24666175, Length=273, Percent_Identity=26.3736263736264, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666109, Length=252, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281366397, Length=146, Percent_Identity=36.3013698630137, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366395, Length=146, Percent_Identity=36.3013698630137, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666163, Length=146, Percent_Identity=36.3013698630137, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 69564; Mature: 69433

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSASRSVPFRLRVVCAIAAGALSLASCGGVDGNPPPQADATPSAKRPNILYIMADDLG
CCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
YSDIHAFGGEINTPNLDALVASGRILSNHHTGTVCAITRAMLISGTDHHLVGEGTMGVPT
CHHHHHCCCCCCCCCHHHEEECCEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCC
DERRGLPGYEGYLNDRALSFAQLLKDAGYHTYIAGKWHIGSGIVGSATGSGQTPDQWGFE
HHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCEEECCCCCCCCCHHCCCC
RSYVLLGGAATNHFAHEPAGSSNYTEDGRYVQPGQPGQPGGTGGNPAVFYSTNFYTQKLI
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEECCHHHHHHH
QYIDSNHSDGKPFFAYAAYTSPHWPLQVPDPWLHKYAGVYDAGYDAIRNARIARQKALGL
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHCCC
IPADFKPFDGLPETTVASPATANDGTANAKYVSAVHSAADGYRDYGAGKVDKLWSSLSPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHCCHH
ERKAQARYMEIYAGMVENLDYNIGLLIQHLKDIGEYDNTFIMFQSDNGAEGWPIDSGADP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
TATDTANAQEPTYSALGTDNGKQNAQRLQYGLRWAEVSATPFRLTKGYSAEGGVSTPTIV
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCCCEEE
HLPGQTQQLPTLRAFTHVTDNTATFLAVAGVTPPSQPAPPLINTLTGVDQNKGKVVYGNR
ECCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCEEEECCE
YVYPVTGQSLLPVLTGAANGEVHTAPFGDEAYGRAYLRSADGRWKALWTEPPLGPLDGHW
EEEEECCCCHHHHHCCCCCCCEEECCCCCHHHCHHHEECCCCCEEEEECCCCCCCCCCCE
QLYDLTTDRGETIDVSAQNPSVVSTLIDQWKAYMSNVGGVEPLRPRGYY
EEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SMSASRSVPFRLRVVCAIAAGALSLASCGGVDGNPPPQADATPSAKRPNILYIMADDLG
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
YSDIHAFGGEINTPNLDALVASGRILSNHHTGTVCAITRAMLISGTDHHLVGEGTMGVPT
CHHHHHCCCCCCCCCHHHEEECCEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCC
DERRGLPGYEGYLNDRALSFAQLLKDAGYHTYIAGKWHIGSGIVGSATGSGQTPDQWGFE
HHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCEEECCCCCCCCCHHCCCC
RSYVLLGGAATNHFAHEPAGSSNYTEDGRYVQPGQPGQPGGTGGNPAVFYSTNFYTQKLI
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEECCHHHHHHH
QYIDSNHSDGKPFFAYAAYTSPHWPLQVPDPWLHKYAGVYDAGYDAIRNARIARQKALGL
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCHHHCCHHHHHHHHHHHHHHCCC
IPADFKPFDGLPETTVASPATANDGTANAKYVSAVHSAADGYRDYGAGKVDKLWSSLSPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHCCHH
ERKAQARYMEIYAGMVENLDYNIGLLIQHLKDIGEYDNTFIMFQSDNGAEGWPIDSGADP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
TATDTANAQEPTYSALGTDNGKQNAQRLQYGLRWAEVSATPFRLTKGYSAEGGVSTPTIV
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCCCEEE
HLPGQTQQLPTLRAFTHVTDNTATFLAVAGVTPPSQPAPPLINTLTGVDQNKGKVVYGNR
ECCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCEEEECCE
YVYPVTGQSLLPVLTGAANGEVHTAPFGDEAYGRAYLRSADGRWKALWTEPPLGPLDGHW
EEEEECCCCHHHHHCCCCCCCEEECCCCCHHHCHHHEECCCCCEEEEECCCCCCCCCCCE
QLYDLTTDRGETIDVSAQNPSVVSTLIDQWKAYMSNVGGVEPLRPRGYY
EEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]