Definition Treponema pallidum subsp. pallidum SS14, complete genome.
Accession NC_010741
Length 1,139,457

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The map label for this gene is nrdA

Identifier: 189026231

GI number: 189026231

Start: 1099436

End: 1101973

Strand: Reverse

Name: nrdA

Synonym: TPASS_1008

Alternate gene names: 189026231

Gene position: 1101973-1099436 (Counterclockwise)

Preceding gene: 189026232

Following gene: 189026230

Centisome position: 96.71

GC content: 47.64

Gene sequence:

>2538_bases
ATGCATATCATCAAGCGAAATGGCGAACCGCAACCTTACATGCGCGAGAAAATAATTGTTGCTATCAGTGCTGCTTTTAG
AAGTGTCCAGAATCCTCTTGCTCCTGAAGTTCCTGCTATCATCACAGATCTTGCCGCGGAGGTTGAGCGACAGCTTTTTG
AGATGAACCGTGCGGGCGTTCCTGTTCACGTGGAAAAGATTCAGGACTTTGTCGAAAAGACTCTTACCAAATACAATCAC
AGCGATGAAGTGAAGAGTTTTATCCTGTACCGTGACGATCGCACAAAAAAGCGTATTGCAAGAGAACAGATTGCGTGCTG
TTTTACTGACTCTTCAGTGCTCGGTGTACTGAAAGAAATCCAACAAGACTTTCCGTTTCCTGAGTACAGTCTCGATGCAC
TCGCCAGTAAGTTCCTGCTCTTTAAAAAAGAAGTTACGGACGAGCGTCGGAGTATGCAACTGCTTATTAAGGCAGCGGTG
GAACTGACTGCCCAAGAGGCTCCCCAGTGGGAGCTTATTGCTGCGCGCTTGCTTATGCTCGACTTTTCACTCGCGCTAGG
AACATCTTTGGAAAAGTTAAATATTCACTCCTTCTACGAGAAAATAACTTATCTTGAAGAGGCCGGTCTATATGGGGTGT
ACATCCGCACGCACTATAGTCGGGCAGAAATTGAGGAAGCTGCCACGTATCTTGAGTGTAGTCGCGATAAATTGTTTACG
TACAGCAGTCTGGATATGATTCTGCGTCGCTATGTGATCAGAACGCGTGCGCATGTACCTCTTGAAACTCCTCAGGAGAT
GTTTCTCGGTATTGCACTGCATCTAGCGATGAATGAAACCCAAGATCGTATGCAATGGGTAAAACGCTTTTATACAGTCC
TCAGCAAGTTGCAGGTTACGGTCGCAACACCTACGCTTTCAAACGCGCGCAAACCTTTTCATCAACTTTCCTCGTGTTTC
GTTGATACGGTGCCAGATTCGCTCGACGGTATCTACCGCAGCATCGACAATTTTTCCCAGGTATCTAAGTTTGGGGGAGG
GATGGGGCTGTACTTTGGAAAAGTGCGTGCGGTAGGCGCTCCCATTCGGGGGTTCCAGGGTGCTGCAGGTGGTATTCTCC
GTTGGATTAAGCTCGCCAATGATACTGCAGTTGCAGTAGATCAACTAGGAGTACGCCAAGGCTCGGTGGCAGTGTATTTG
GATGTATGGCACAAGGATATTCCGGAATTTTTGCAATTACGGACTAATAATGGGGATGACCGCATGAAAGCACATGACGT
ATTTCCTGCGGTCTGTTATCCAGATTTGTTCTGGAAGACAGTACGCGATAATTTGGGGGCGTCGTGGTATTTAATGTGTC
CGCATGAGATTCTTACGGTGAAAGGCTATGCTTTGGAGGATTTTTATGCGGAGGAATGGGAGAAGCGCTACTGGGATTGT
GTAAAGGATGCGCGTATCTCTAAGAGGACCATTCCGATTAAGGAGTTGGTGCGCTTGGTGCTAAAATCTGTGGTGGAAAC
CGGTACTCCCTTTGCGTTTTACCGAGATCATGCAAACCGTGCAAATCCCAATGGGCATCGGGGAATTATTTACTGTTCTA
ATTTGTGTACTGAAATTGCGCAGAACATGAGCGCTATTAATTTAGTAAGCGTAAAAATCACCGAGGTTGATGGACAAAAG
GTAGTGGTGCAGACAACGCGGCCGGGGGATTTTGTTGTATGTAACCTCGCGTCGTTGGTGCTGAGCAATATTGACCTTTC
AGATGATAAGGAGTTGCGCGAGGTAGTGCGTGTGGCGGTACGTGCATTAGACAACGTGATCGATTTGACATATTATCCGG
TTCCCTATGCACAGGTAACCAATGCGTATTATCGTGCTATTGGTTTAGGTGTTTCAGGCTACCATCACGTGCTTGCCCAG
CAAGGAATCGATTGGGAAAGTGATGAACATCTTGCATTTGCGGACAGAATATTTGAGCGCATTAACCGTGCCGCAATTGA
AGCGAGTATGACAATCGCGCGCGAGAAGGGTGCGTATGGGTGTTTCACTGGGAGCGATTGGTGTACCGGTGCGTATTTTC
GCAAACGCGGCTATGTCTCTGAAGACTGGCAACGTTTGCAGCGTGAGGTAGCAACACATGGGATGCGCAACGGTTACTTA
CTTGCAGTCGCGCCAACTAGTTCTACGTCTATCATTGCAGGGACCACTGCGGGTGTAGATCCTATTATGAAGCAGTATTT
CCTCGAGGAAAAGAAAGGCATGCTAATGCCACGCGTAGCTCCTTCTCTTTCGCAGAAGACCTGTCCACTGTATAAAAGTG
CACACGCAGTGGAGCAGCGTTGGAGTATCCGTGCTGCGGGTCTGCGGCAACGACATATTGACCAGGCACAGTCAGTGAAT
CTGTACATTACAACGGACTTTACACTGAAGCAGGTTCTAGATTTGTACGTGTATGCGTGGGAAGTAGGAATGAAGTCACT
ATACTACGTACGAAGCCAGTCGCTCGAAATAGATTTGTGTGGGTATTGTGCCTCGTAG

Upstream 100 bases:

>100_bases
TCTGTGGGGGAAGCGTAAAGAACGAGTCTAGGAGTGGAAGCGAGAACTCTTACCCAAATGTTATTTTTGGCCCATAATCC
GCGTTCGGACGGAGAGATAT

Downstream 100 bases:

>100_bases
GAGCGTGCTTGCATAACACTGTCCACTGTGTAGGCTTTCTTTGTGACGTTGCGTACGCTTCAAGCCGGTGTGGCGGTCAG
TATCGCTCTGGATCGTGTGT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase

Number of amino acids: Translated: 845; Mature: 845

Protein sequence:

>845_residues
MHIIKRNGEPQPYMREKIIVAISAAFRSVQNPLAPEVPAIITDLAAEVERQLFEMNRAGVPVHVEKIQDFVEKTLTKYNH
SDEVKSFILYRDDRTKKRIAREQIACCFTDSSVLGVLKEIQQDFPFPEYSLDALASKFLLFKKEVTDERRSMQLLIKAAV
ELTAQEAPQWELIAARLLMLDFSLALGTSLEKLNIHSFYEKITYLEEAGLYGVYIRTHYSRAEIEEAATYLECSRDKLFT
YSSLDMILRRYVIRTRAHVPLETPQEMFLGIALHLAMNETQDRMQWVKRFYTVLSKLQVTVATPTLSNARKPFHQLSSCF
VDTVPDSLDGIYRSIDNFSQVSKFGGGMGLYFGKVRAVGAPIRGFQGAAGGILRWIKLANDTAVAVDQLGVRQGSVAVYL
DVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKTVRDNLGASWYLMCPHEILTVKGYALEDFYAEEWEKRYWDC
VKDARISKRTIPIKELVRLVLKSVVETGTPFAFYRDHANRANPNGHRGIIYCSNLCTEIAQNMSAINLVSVKITEVDGQK
VVVQTTRPGDFVVCNLASLVLSNIDLSDDKELREVVRVAVRALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLAQ
QGIDWESDEHLAFADRIFERINRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYVSEDWQRLQREVATHGMRNGYL
LAVAPTSSTSIIAGTTAGVDPIMKQYFLEEKKGMLMPRVAPSLSQKTCPLYKSAHAVEQRWSIRAAGLRQRHIDQAQSVN
LYITTDFTLKQVLDLYVYAWEVGMKSLYYVRSQSLEIDLCGYCAS

Sequences:

>Translated_845_residues
MHIIKRNGEPQPYMREKIIVAISAAFRSVQNPLAPEVPAIITDLAAEVERQLFEMNRAGVPVHVEKIQDFVEKTLTKYNH
SDEVKSFILYRDDRTKKRIAREQIACCFTDSSVLGVLKEIQQDFPFPEYSLDALASKFLLFKKEVTDERRSMQLLIKAAV
ELTAQEAPQWELIAARLLMLDFSLALGTSLEKLNIHSFYEKITYLEEAGLYGVYIRTHYSRAEIEEAATYLECSRDKLFT
YSSLDMILRRYVIRTRAHVPLETPQEMFLGIALHLAMNETQDRMQWVKRFYTVLSKLQVTVATPTLSNARKPFHQLSSCF
VDTVPDSLDGIYRSIDNFSQVSKFGGGMGLYFGKVRAVGAPIRGFQGAAGGILRWIKLANDTAVAVDQLGVRQGSVAVYL
DVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKTVRDNLGASWYLMCPHEILTVKGYALEDFYAEEWEKRYWDC
VKDARISKRTIPIKELVRLVLKSVVETGTPFAFYRDHANRANPNGHRGIIYCSNLCTEIAQNMSAINLVSVKITEVDGQK
VVVQTTRPGDFVVCNLASLVLSNIDLSDDKELREVVRVAVRALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLAQ
QGIDWESDEHLAFADRIFERINRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYVSEDWQRLQREVATHGMRNGYL
LAVAPTSSTSIIAGTTAGVDPIMKQYFLEEKKGMLMPRVAPSLSQKTCPLYKSAHAVEQRWSIRAAGLRQRHIDQAQSVN
LYITTDFTLKQVLDLYVYAWEVGMKSLYYVRSQSLEIDLCGYCAS
>Mature_845_residues
MHIIKRNGEPQPYMREKIIVAISAAFRSVQNPLAPEVPAIITDLAAEVERQLFEMNRAGVPVHVEKIQDFVEKTLTKYNH
SDEVKSFILYRDDRTKKRIAREQIACCFTDSSVLGVLKEIQQDFPFPEYSLDALASKFLLFKKEVTDERRSMQLLIKAAV
ELTAQEAPQWELIAARLLMLDFSLALGTSLEKLNIHSFYEKITYLEEAGLYGVYIRTHYSRAEIEEAATYLECSRDKLFT
YSSLDMILRRYVIRTRAHVPLETPQEMFLGIALHLAMNETQDRMQWVKRFYTVLSKLQVTVATPTLSNARKPFHQLSSCF
VDTVPDSLDGIYRSIDNFSQVSKFGGGMGLYFGKVRAVGAPIRGFQGAAGGILRWIKLANDTAVAVDQLGVRQGSVAVYL
DVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKTVRDNLGASWYLMCPHEILTVKGYALEDFYAEEWEKRYWDC
VKDARISKRTIPIKELVRLVLKSVVETGTPFAFYRDHANRANPNGHRGIIYCSNLCTEIAQNMSAINLVSVKITEVDGQK
VVVQTTRPGDFVVCNLASLVLSNIDLSDDKELREVVRVAVRALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLAQ
QGIDWESDEHLAFADRIFERINRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYVSEDWQRLQREVATHGMRNGYL
LAVAPTSSTSIIAGTTAGVDPIMKQYFLEEKKGMLMPRVAPSLSQKTCPLYKSAHAVEQRWSIRAAGLRQRHIDQAQSVN
LYITTDFTLKQVLDLYVYAWEVGMKSLYYVRSQSLEIDLCGYCAS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Homo sapiens, GI4506749, Length=645, Percent_Identity=32.4031007751938, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI1789030, Length=681, Percent_Identity=29.0748898678414, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI2367133, Length=706, Percent_Identity=26.3456090651558, Blast_Score=251, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17555242, Length=729, Percent_Identity=29.9039780521262, Blast_Score=304, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320914, Length=650, Percent_Identity=31.6923076923077, Blast_Score=312, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322123, Length=650, Percent_Identity=30.6153846153846, Blast_Score=310, Evalue=6e-85,
Organism=Drosophila melanogaster, GI17352481, Length=732, Percent_Identity=29.0983606557377, Blast_Score=306, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIR1_TREPA (O83972)

Other databases:

- EMBL:   AE000520
- PIR:   B71255
- RefSeq:   NP_219445.1
- ProteinModelPortal:   O83972
- SMR:   O83972
- IntAct:   O83972
- GeneID:   2610819
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1008
- NMPDR:   fig|243276.1.peg.1003
- TIGR:   TP_1008
- HOGENOM:   HBG296647
- OMA:   KANGMRN
- ProtClustDB:   PRK12364
- BioCyc:   TPAL243276:TP_1008-MONOMER
- BRENDA:   1.17.4.1
- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- PANTHER:   PTHR11573
- PRINTS:   PR01183
- TIGRFAMs:   TIGR02506

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; SSF48168 Ribonucleo_red_N

EC number: =1.17.4.1

Molecular weight: Translated: 95988; Mature: 95988

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS51161 ATP_CONE; PS00089 RIBORED_LARGE

Important sites: ACT_SITE 534-534 ACT_SITE 536-536 ACT_SITE 538-538 BINDING 303-303 BINDING 347-347

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MHIIKRNGEPQPYMREKIIVAISAAFRSVQNPLAPEVPAIITDLAAEVERQLFEMNRAGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PVHVEKIQDFVEKTLTKYNHSDEVKSFILYRDDRTKKRIAREQIACCFTDSSVLGVLKEI
CEEHHHHHHHHHHHHHHCCCCHHHHHEEEECCCCHHHHHHHHHHHHEECCHHHHHHHHHH
QQDFPFPEYSLDALASKFLLFKKEVTDERRSMQLLIKAAVELTAQEAPQWELIAARLLML
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DFSLALGTSLEKLNIHSFYEKITYLEEAGLYGVYIRTHYSRAEIEEAATYLECSRDKLFT
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEE
YSSLDMILRRYVIRTRAHVPLETPQEMFLGIALHLAMNETQDRMQWVKRFYTVLSKLQVT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEE
VATPTLSNARKPFHQLSSCFVDTVPDSLDGIYRSIDNFSQVSKFGGGMGLYFGKVRAVGA
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
PIRGFQGAAGGILRWIKLANDTAVAVDQLGVRQGSVAVYLDVWHKDIPEFLQLRTNNGDD
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEHHHHCHHHHHHHHCCCCCC
RMKAHDVFPAVCYPDLFWKTVRDNLGASWYLMCPHEILTVKGYALEDFYAEEWEKRYWDC
CHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHEEECCCHHHHHHHHHHHHHHHHH
VKDARISKRTIPIKELVRLVLKSVVETGTPFAFYRDHANRANPNGHRGIIYCSNLCTEIA
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
QNMSAINLVSVKITEVDGQKVVVQTTRPGDFVVCNLASLVLSNIDLSDDKELREVVRVAV
HCCCCEEEEEEEEEEECCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHH
RALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLAQQGIDWESDEHLAFADRIFER
HHHHHHHHCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
INRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYVSEDWQRLQREVATHGMRNGYL
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEE
LAVAPTSSTSIIAGTTAGVDPIMKQYFLEEKKGMLMPRVAPSLSQKTCPLYKSAHAVEQR
EEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WSIRAAGLRQRHIDQAQSVNLYITTDFTLKQVLDLYVYAWEVGMKSLYYVRSQSLEIDLC
HHHHHHHHHHHHCCHHHCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
GYCAS
CCCCC
>Mature Secondary Structure
MHIIKRNGEPQPYMREKIIVAISAAFRSVQNPLAPEVPAIITDLAAEVERQLFEMNRAGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PVHVEKIQDFVEKTLTKYNHSDEVKSFILYRDDRTKKRIAREQIACCFTDSSVLGVLKEI
CEEHHHHHHHHHHHHHHCCCCHHHHHEEEECCCCHHHHHHHHHHHHEECCHHHHHHHHHH
QQDFPFPEYSLDALASKFLLFKKEVTDERRSMQLLIKAAVELTAQEAPQWELIAARLLML
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DFSLALGTSLEKLNIHSFYEKITYLEEAGLYGVYIRTHYSRAEIEEAATYLECSRDKLFT
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEE
YSSLDMILRRYVIRTRAHVPLETPQEMFLGIALHLAMNETQDRMQWVKRFYTVLSKLQVT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEE
VATPTLSNARKPFHQLSSCFVDTVPDSLDGIYRSIDNFSQVSKFGGGMGLYFGKVRAVGA
EECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
PIRGFQGAAGGILRWIKLANDTAVAVDQLGVRQGSVAVYLDVWHKDIPEFLQLRTNNGDD
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEHHHHCHHHHHHHHCCCCCC
RMKAHDVFPAVCYPDLFWKTVRDNLGASWYLMCPHEILTVKGYALEDFYAEEWEKRYWDC
CHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHEEECCCHHHHHHHHHHHHHHHHH
VKDARISKRTIPIKELVRLVLKSVVETGTPFAFYRDHANRANPNGHRGIIYCSNLCTEIA
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
QNMSAINLVSVKITEVDGQKVVVQTTRPGDFVVCNLASLVLSNIDLSDDKELREVVRVAV
HCCCCEEEEEEEEEEECCCEEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHH
RALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLAQQGIDWESDEHLAFADRIFER
HHHHHHHHCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
INRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYVSEDWQRLQREVATHGMRNGYL
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEE
LAVAPTSSTSIIAGTTAGVDPIMKQYFLEEKKGMLMPRVAPSLSQKTCPLYKSAHAVEQR
EEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WSIRAAGLRQRHIDQAQSVNLYITTDFTLKQVLDLYVYAWEVGMKSLYYVRSQSLEIDLC
HHHHHHHHHHHHCCHHHCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
GYCAS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876