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The map label for this gene is thyX

Identifier: 189026230

GI number: 189026230

Start: 1098476

End: 1099393

Strand: Reverse

Name: thyX

Synonym: TPASS_1007

Alternate gene names: 189026230

Gene position: 1099393-1098476 (Counterclockwise)

Preceding gene: 189026231

Following gene: 189026229

Centisome position: 96.48

GC content: 52.18

Gene sequence:

>918_bases
GTGACGTTGCGTACGCTTCAAGCCGGTGTGGCGGTCAGTATCGCTCTGGATCGTGTGTGCTTTTTCTGTTATAACGGGGC
GGTGGCACACTGTGTAGTAGAAGCTGCCGAAGATATTTTGGACCGGCGTTTTTCTGTATTGGATAAGGGTTTCGTGCGTT
TGATAGATTACCTGGGAGGGGATGCACGCATTGTGCAGGCAGCGCGTGTTTCTTACGGTGCGGGGACTAGGACTGCGCGT
GACGATGCGGCGCTTATCGATTTTCTTTTACGCAATAAGCATACGTCTCCTTTTGAGCAGGTGGTCCTTACCTTCCATGT
ACGTGCACCGATTTTTGTCGCGCGTCAGTGGATGCGGCATCGCACTGCTCGCATCAGTGAGGTGTCTAGTCGTTATTCGC
TTCTTAGTCATGACTGTTATGTTCCGCAGGAAACTTCAGTTGCAGTTCAGTCCACGCGTAACAAGCAGGGCCGCGCGTCC
GAAGGTATCTCTCCTGAACAGCAGCAGGAAGTGCGGGCAGCGTTTGAAGCTCAGCAGAAAGCGGCGTGTGCCGCTTACGA
CGCATTGATTCAAAAGAACATCGCGCGGGAGCTAGCGCGTATTAACGTGCCGCTTTCGCTTTACACCGAGTGGTATTGGC
AGATTGATTTACACAATCTTTTTCATTTTTTGCGTTTACGTGCGAGCGCTCATGCGCAAGCAGAGATTCGTGCGTATGCA
GAGGTAATCATTGAAATTACCCGTGCAGTTGCGCCGTGCGCTACCGCCTCTTTTGAAAATCATGAAAAAGATGGGGTGCA
GTTTTCAGGGCGGGAGTTTGCTGCGCTTAAGGCCTTACTGGCTGGAGAGGGTCTCTCCCTTGAGGGGAAGGAACGTGCGC
GCTTTGAAGAAAAATTACGCTCTGGCCTGCAGCAGTAG

Upstream 100 bases:

>100_bases
ATACTACGTACGAAGCCAGTCGCTCGAAATAGATTTGTGTGGGTATTGTGCCTCGTAGGAGCGTGCTTGCATAACACTGT
CCACTGTGTAGGCTTTCTTT

Downstream 100 bases:

>100_bases
AAGTCTATAGTGCGCTCGTCTGTGTGAGCAGCAAGAGTATTGCCTTTCTGTGTCTTAAAAAGGTGAATGTGGTCATAGGT
ATGCTGATGAAAAGGAGAGC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGGDARIVQAARVSYGAGTRTAR
DDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRHRTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRAS
EGISPEQQQEVRAAFEAQQKAACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYA
EVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLRSGLQQ

Sequences:

>Translated_305_residues
MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGGDARIVQAARVSYGAGTRTAR
DDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRHRTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRAS
EGISPEQQQEVRAAFEAQQKAACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYA
EVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLRSGLQQ
>Mature_304_residues
TLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGGDARIVQAARVSYGAGTRTARD
DAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRHRTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRASE
GISPEQQQEVRAAFEAQQKAACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYAE
VIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLRSGLQQ

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_TREPA (O83971)

Other databases:

- EMBL:   AE000520
- PIR:   A71255
- RefSeq:   NP_219444.1
- ProteinModelPortal:   O83971
- SMR:   O83971
- IntAct:   O83971
- GeneID:   2610808
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1007
- NMPDR:   fig|243276.1.peg.1002
- TIGR:   TP_1007
- HOGENOM:   HBG353106
- OMA:   LPIFVAR
- ProtClustDB:   PRK00847
- BioCyc:   TPAL243276:TP_1007-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 34186; Mature: 34055

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGG
CCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DARIVQAARVSYGAGTRTARDDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRH
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHH
RTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRASEGISPEQQQEVRAAFEAQQK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGLQQ
HHCCC
>Mature Secondary Structure 
TLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGG
CCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DARIVQAARVSYGAGTRTARDDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRH
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHH
RTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRASEGISPEQQQEVRAAFEAQQK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGLQQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876