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The map label for this gene is cfxE

Identifier: 189026168

GI number: 189026168

Start: 1028473

End: 1029129

Strand: Reverse

Name: cfxE

Synonym: TPASS_0945

Alternate gene names: 189026168

Gene position: 1029129-1028473 (Counterclockwise)

Preceding gene: 189026170

Following gene: 189026167

Centisome position: 90.32

GC content: 54.34

Gene sequence:

>657_bases
ATGGAGCGGTCTTTTACATTGGCACCTTCACTATTAAGTGCAGATTTCTCTGCGCTCGATAGGGCGCTGGTGTATTTGGA
AGCGCACGGCGCACAGTGGGTGCACCTGGATGTTATGGATGGGCACTTTGTGCCAAACCTGACGTTTGGTGCTCCGGTGC
TGCGTTGTTTGCGTAGCAAAACGCACCTGCCGTTTGATGTTCACCTGATGGTCAGTAGGCCTGCCGACCTCATTGAGGAT
TTTGTGCAGGCGGGCGCGGACTTCTTAACTTTTCACATAGAGGCGGAGGTGCATGCACACCGGCTTATCCATGCCATTCG
TGGTCGGGGAGTGAAGGTGGGTATTAGCCTCGTGCCGTCTACTCCTGTTGCTGCGCTCAGTGAAGTGCTGCCCTTCGTGG
ACCTAGTGCTGGTAATGACGGTTAATCCTGGTTTTAGCGGACAGCAGATGATTGCCCATTGCCTTTCTAAAGTGTCAGCA
CTTGTGCAGATGCGCACCGAACGGGGGTATTCGTACATGATCTCGGTTGATGGGGGCATCGACTGTCGCACGTTGCCGCA
GGCGCTTGACGCTGGTGCGGATGTGATAGTGTCAGGCTCTGCTTTTTTTTCCGGTACCTTGAGGTCTCTTCTCTGCAAGG
ACAGCTCAGGGGCGTAA

Upstream 100 bases:

>100_bases
AAATAAAACAGGATAAGCAGGACACTGTCTTGAATGTTTGGGGTTGTTCACGCCAGTATCCATATTTACAGGTGCTCGAT
TTGTTTGCTAGCATGGACCT

Downstream 100 bases:

>100_bases
GGTGTTCAGGTGTAAGGAGACCCTGTCGCTCATAGGGTACTAGAGCGCTTGTTTTTCTGCGGGGATACTGCTTCTTGCTA
TGCATAGGGGTTAGTTTTTG

Product: ribulose-phosphate 3-epimerase

Products: NA

Alternate protein names: Pentose-5-phosphate 3-epimerase; PPE; R5P3E

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLPFDVHLMVSRPADLIED
FVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSA
LVQMRTERGYSYMISVDGGIDCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA

Sequences:

>Translated_218_residues
MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLPFDVHLMVSRPADLIED
FVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSA
LVQMRTERGYSYMISVDGGIDCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA
>Mature_218_residues
MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLPFDVHLMVSRPADLIED
FVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSA
LVQMRTERGYSYMISVDGGIDCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA

Specific function: Unknown

COG id: COG0036

COG function: function code G; Pentose-5-phosphate-3-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribulose-phosphate 3-epimerase family

Homologues:

Organism=Homo sapiens, GI40385883, Length=205, Percent_Identity=41.9512195121951, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI219879828, Length=205, Percent_Identity=40, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI24307923, Length=155, Percent_Identity=36.7741935483871, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1789788, Length=204, Percent_Identity=42.6470588235294, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1790523, Length=196, Percent_Identity=40.3061224489796, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1790754, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552948, Length=211, Percent_Identity=42.654028436019, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322341, Length=211, Percent_Identity=39.3364928909953, Blast_Score=158, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24586301, Length=209, Percent_Identity=40.6698564593301, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPE_TREPA (O66107)

Other databases:

- EMBL:   U97573
- EMBL:   AE000520
- PIR:   G71260
- RefSeq:   NP_219381.1
- ProteinModelPortal:   O66107
- SMR:   O66107
- IntAct:   O66107
- MINT:   MINT-6481130
- GeneID:   2611488
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0945
- NMPDR:   fig|243276.1.peg.939
- TIGR:   TP_0945
- HOGENOM:   HBG571751
- OMA:   KHIHGAL
- ProtClustDB:   CLSK218939
- BioCyc:   TPAL243276:TP_0945-MONOMER
- BRENDA:   5.1.3.1
- InterPro:   IPR013785
- InterPro:   IPR000056
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR11749
- PIRSF:   PIRSF001461
- TIGRFAMs:   TIGR01163

Pfam domain/function: PF00834 Ribul_P_3_epim; SSF51366 RibP_bind_barrel

EC number: =5.1.3.1

Molecular weight: Translated: 23514; Mature: 23514

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01085 RIBUL_P_3_EPIMER_1; PS01086 RIBUL_P_3_EPIMER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSK
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHC
THLPFDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPS
CCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEEEECCC
TPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYSYMISVDGGI
CHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA
CHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSK
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHC
THLPFDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPS
CCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEEEECCC
TPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYSYMISVDGGI
CHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA
CHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876