BacMap

Definition	Treponema pallidum subsp. pallidum SS14, complete genome.
Accession	NC_010741
Length	1,139,457

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The map label for this gene is cyp

Identifier: 189026170

GI number: 189026170

Start: 1029994

End: 1030641

Strand: Reverse

Name: cyp

Synonym: TPASS_0947

Alternate gene names: 189026170

Gene position: 1030641-1029994 (Counterclockwise)

Preceding gene: 189026171

Following gene: 189026168

Centisome position: 90.45

GC content: 52.47

Gene sequence:

>648_bases
ATGAATACGCAGGTGTGGCGCGTCTGTGTGGGGGTGATGTTGTTCTGCTTCGTTGGCAGGATCGGGTGTGCGGAGGAAAA
AATGGTACGCGAGGAAGGGTTGGCGGTCGCTGACGGTATATATGCGGTAATGGAAACAAATCGGGGAACGATTGTTCTCT
CGCTTTTTTTTGAAAAGGCGCCGCTTACGGTGTGTAATTTTGTGGGGTTAGCAGAGGGAACGTTGGCGGTGTGCAAGGGT
CGTCCTTTTTATCAGGGGTTAACGTTTCACCGTGTTATCAAAGATTTTATGATCCAGGGGGGAGACCCGCAGGGAAATGG
GACGGGAGGTCCTGGCTATCAATTCCCCGATGAATGTGATCCTGCGTTGCGACACGACAGCCCAGGAGTGTTGTCAATGG
CGAATGCAGGACCAGGAACGAACGGTTCGCAGTTTTTTATTACCCACGTGGCTACGCCGTGGTTGGATGGAAAGCATACC
GTGTTTGGCAAAGTCGTTGAGGGTATGGAAGTGGTGCATGCAATTATAGCGGGAGATACGATTCGCTCACTCAAAATAGT
GCGCCGTGGTGCGGCAGCGAAGCGTTTTGTCTGCGATCAGGCGCAGTTCGACCAGCTGCGAAAACGGGTATCCGCAGCGT
CCAAATAA

Upstream 100 bases:

>100_bases
TTATTCATACAACGCTGCATGGGATCAGTGGGGTAGAGACCAGAAGTGAGGGGGAAGGGCTTTACAAGCAGGTGCGGGTG
TGTCACACCGGGGGTGCGAT

Downstream 100 bases:

>100_bases
TGGGCATGCCGTTTGTATGTTCTCCTCTCTGCTGTGCTCCTGTGTCACTGGGGAGGCGCTGCGCAGGGTGTGTGTATGGC
AACGAGGTGCCGTGCTTCGT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-binding

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKAPLTVCNFVGLAEGTLAVCKG
RPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECDPALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHT
VFGKVVEGMEVVHAIIAGDTIRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK

Sequences:

>Translated_215_residues
MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKAPLTVCNFVGLAEGTLAVCKG
RPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECDPALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHT
VFGKVVEGMEVVHAIIAGDTIRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK
>Mature_215_residues
MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKAPLTVCNFVGLAEGTLAVCKG
RPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECDPALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHT
VFGKVVEGMEVVHAIIAGDTIRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain

Homologues:

Organism=Homo sapiens, GI7706339, Length=135, Percent_Identity=52.5925925925926, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI24308049, Length=162, Percent_Identity=50.6172839506173, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4758950, Length=180, Percent_Identity=46.6666666666667, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI4505991, Length=175, Percent_Identity=47.4285714285714, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI10863927, Length=131, Percent_Identity=51.9083969465649, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI5031987, Length=131, Percent_Identity=54.1984732824427, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI19557636, Length=136, Percent_Identity=47.0588235294118, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4826932, Length=134, Percent_Identity=51.4925373134328, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI6631100, Length=182, Percent_Identity=42.3076923076923, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI310129267, Length=138, Percent_Identity=48.5507246376812, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI310120620, Length=138, Percent_Identity=48.5507246376812, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI42560244, Length=134, Percent_Identity=49.2537313432836, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI5454154, Length=135, Percent_Identity=51.1111111111111, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI310110104, Length=138, Percent_Identity=47.8260869565217, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI303305009, Length=140, Percent_Identity=47.1428571428571, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI256017253, Length=130, Percent_Identity=48.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI221139811, Length=130, Percent_Identity=48.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI256017251, Length=130, Percent_Identity=48.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310127646, Length=138, Percent_Identity=47.1014492753623, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI310114371, Length=138, Percent_Identity=47.1014492753623, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI310119221, Length=138, Percent_Identity=47.1014492753623, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI5174637, Length=133, Percent_Identity=49.6240601503759, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI45439316, Length=131, Percent_Identity=49.618320610687, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI178057341, Length=131, Percent_Identity=47.3282442748092, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169164185, Length=131, Percent_Identity=48.0916030534351, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169163623, Length=131, Percent_Identity=48.0916030534351, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI209417936, Length=131, Percent_Identity=47.3282442748092, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI30102944, Length=131, Percent_Identity=47.3282442748092, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI219842199, Length=131, Percent_Identity=47.3282442748092, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169163387, Length=131, Percent_Identity=48.0916030534351, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI22547212, Length=138, Percent_Identity=47.1014492753623, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI7657473, Length=138, Percent_Identity=47.1014492753623, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI22547215, Length=138, Percent_Identity=47.1014492753623, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI310132444, Length=131, Percent_Identity=45.8015267175573, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI310113152, Length=131, Percent_Identity=45.8015267175573, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI20911035, Length=144, Percent_Identity=38.8888888888889, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI310127745, Length=157, Percent_Identity=40.7643312101911, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI310119290, Length=157, Percent_Identity=40.7643312101911, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI150418007, Length=131, Percent_Identity=45.8015267175573, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI310114540, Length=129, Percent_Identity=45.7364341085271, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI64276486, Length=127, Percent_Identity=40.9448818897638, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI169214050, Length=131, Percent_Identity=44.2748091603053, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI239751853, Length=131, Percent_Identity=44.2748091603053, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI113428306, Length=131, Percent_Identity=44.2748091603053, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI27735045, Length=133, Percent_Identity=38.3458646616541, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI14277126, Length=81, Percent_Identity=48.1481481481481, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI289803023, Length=159, Percent_Identity=31.4465408805031, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1789763, Length=142, Percent_Identity=38.7323943661972, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786736, Length=151, Percent_Identity=37.0860927152318, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=135, Percent_Identity=52.5925925925926, Blast_Score=139, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17559074, Length=133, Percent_Identity=54.8872180451128, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17506311, Length=138, Percent_Identity=53.6231884057971, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17566266, Length=133, Percent_Identity=54.1353383458647, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17506307, Length=151, Percent_Identity=52.9801324503311, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17552780, Length=152, Percent_Identity=53.9473684210526, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551282, Length=132, Percent_Identity=56.8181818181818, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551284, Length=132, Percent_Identity=56.8181818181818, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17565860, Length=140, Percent_Identity=49.2857142857143, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17552782, Length=133, Percent_Identity=52.6315789473684, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71980590, Length=136, Percent_Identity=44.8529411764706, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=136, Percent_Identity=44.8529411764706, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17552784, Length=134, Percent_Identity=48.5074626865672, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17539498, Length=132, Percent_Identity=50.7575757575758, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17532643, Length=131, Percent_Identity=51.1450381679389, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17532641, Length=143, Percent_Identity=42.6573426573427, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=43.4108527131783, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32563659, Length=160, Percent_Identity=33.125, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115533296, Length=138, Percent_Identity=38.4057971014493, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=131, Percent_Identity=53.4351145038168, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323246, Length=136, Percent_Identity=50.7352941176471, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323562, Length=138, Percent_Identity=51.4492753623188, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321848, Length=172, Percent_Identity=41.8604651162791, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320510, Length=132, Percent_Identity=50.7575757575758, Blast_Score=111, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322492, Length=157, Percent_Identity=40.1273885350318, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17986117, Length=138, Percent_Identity=51.4492753623188, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=51.25, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922376, Length=139, Percent_Identity=45.3237410071942, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45549139, Length=131, Percent_Identity=53.4351145038168, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130249, Length=131, Percent_Identity=52.6717557251908, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24650807, Length=134, Percent_Identity=48.5074626865672, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24664125, Length=131, Percent_Identity=51.9083969465649, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357783, Length=131, Percent_Identity=51.9083969465649, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136360, Length=159, Percent_Identity=47.7987421383648, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24586038, Length=139, Percent_Identity=49.6402877697842, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17647301, Length=131, Percent_Identity=48.0916030534351, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357249, Length=146, Percent_Identity=39.7260273972603, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652460, Length=136, Percent_Identity=38.2352941176471, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355677, Length=160, Percent_Identity=36.25, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24661775, Length=130, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355237, Length=130, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24661771, Length=130, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPIB_TREPA (O66105)

Other databases:

- EMBL:   U97573
- EMBL:   AE000520
- PIR:   A71261
- RefSeq:   NP_219383.1
- ProteinModelPortal:   O66105
- SMR:   O66105
- IntAct:   O66105
- GeneID:   2611518
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0947
- NMPDR:   fig|243276.1.peg.941
- TIGR:   TP_0947
- HOGENOM:   HBG610621
- OMA:   SISMAHA
- ProtClustDB:   CLSK2300340
- BioCyc:   TPAL243276:TP_0947-MONOMER
- BRENDA:   5.2.1.8
- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130
- Gene3D:   G3DSA:2.40.100.10
- PRINTS:   PR00153

Pfam domain/function: PF00160 Pro_isomerase; SSF50891 CSA_PPIase

EC number: =5.2.1.8

Molecular weight: Translated: 23272; Mature: 23272

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00170 CSA_PPIASE_1; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKA
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEEEEECCCCEEEEEEEECCC
PLTVCNFVGLAEGTLAVCKGRPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECD
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHTVFGKVVEGMEVVHAIIAGDT
HHHCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
IRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK
HHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKA
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEEEEECCCCEEEEEEEECCC
PLTVCNFVGLAEGTLAVCKGRPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECD
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHTVFGKVVEGMEVVHAIIAGDT
HHHCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
IRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK
HHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876