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The map label for this gene is fklB [H]

Identifier: 189026086

GI number: 189026086

Start: 940866

End: 941660

Strand: Reverse

Name: fklB [H]

Synonym: TPASS_0862

Alternate gene names: 189026086

Gene position: 941660-940866 (Counterclockwise)

Preceding gene: 189026088

Following gene: 189026085

Centisome position: 82.64

GC content: 54.09

Gene sequence:

>795_bases
GTGATTTTGAAAAAAGAAGCTGCAGGGGTGTGTTCTTTCGCGCTTCTGCTCCTTGCGGGTATGAGTATTTTTTCCTGTCG
GAAGGGTGCTGAGGGGGTGTCCTCTGCCGGGGAGGCTGCGGATAAGAAGGCGCTGACTGCTGATCAGCTCGATCCGCGAA
AGGTGCAGGAGCAGGAGCGGCAGAAGACGCCGCTTTCAAAGAAGAGTGTGGGGTATGCCTTTGGGGTTCTCATGGGGGTG
ACGCTGCAGGATTCGAAGTTAGACGTTGACCTGGGTCAGGTGTGGAAGGGTCTAAAGAAGACAGTCAGTGCAGACAAGGA
TAAGCAGGCACTTGCGGATGCGCAGGACGTGCTACAGCGTGCGTTCGAGGCATATCGGCAAAAAGAGGTAGAGAAGAATT
CGCAGGAGGCAAAGGCCTTTCTTGAAGAGAATGCGAAGAAGCCAGGTGTGCAGGTAACTTCCTCTGGGTTGCAGTACGAG
GTGGTAAAGGCTGCAGATGGTCCAAAGCCGCAGGGCGGTCAGAGGGTGCGCACTCAGTACAAGGGGACGCTGCTTGATGG
AACGGTGTTTGATGCCTCTCGAGATAAGCCTGCGGAGTTTCCGGTGGATGGTATGGTGCCTGGGGTATCTGAGGGCTTAA
AGCTGATGCCGGTGGGTTCTACCTATCGGTTTTATGTGCCTTCTTCCTTGGGGTATGGGGAGCGTGGTATCGAGGGGGTT
ATCCCTCCAGGTGCGCTCCTAGTTTTTGAGATAGAGTTACAGGAAATACTCCCAGATTCAGCTTCGAAAAAGTGA

Upstream 100 bases:

>100_bases
AAGGAAGGATCGGGGCATTAGCTATCTCCTTGACGTGTGAAGTACGGATGGGGTAGGCTGGTCGCCTCGGGGCGGCGCGG
ATGAGCGCGCAAAAGGAGCG

Downstream 100 bases:

>100_bases
GCGATGTGCAGCAAGGCAACGGATGGGCATGGGATCGCCTGTGACCTGTGGGTTACCTTGCTCGTTCGTCGGGTCTCCCC
TTGGGGGAGGTGGTGAGTCT

Product: peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQERQKTPLSKKSVGYAFGVLMGV
TLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQRAFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYE
VVKAADGPKPQGGQRVRTQYKGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGV
IPPGALLVFEIELQEILPDSASKK

Sequences:

>Translated_264_residues
MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQERQKTPLSKKSVGYAFGVLMGV
TLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQRAFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYE
VVKAADGPKPQGGQRVRTQYKGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGV
IPPGALLVFEIELQEILPDSASKK
>Mature_264_residues
MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQERQKTPLSKKSVGYAFGVLMGV
TLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQRAFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYE
VVKAADGPKPQGGQRVRTQYKGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGV
IPPGALLVFEIELQEILPDSASKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI33469985, Length=96, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=196, Percent_Identity=42.3469387755102, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789745, Length=207, Percent_Identity=36.7149758454106, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=39.622641509434, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=38, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=93, Percent_Identity=45.1612903225806, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=38.6792452830189, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28416; Mature: 28416

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQER
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QKTPLSKKSVGYAFGVLMGVTLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQR
HHCCCCHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYEVVKAADGPKPQGGQRVRTQY
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCCCHHHHHHH
KGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGV
CCEEECCEEECCCCCCCCCCCCCCCCCCHHCCCEEEECCCEEEEECCCCCCCCCCCCCCC
IPPGALLVFEIELQEILPDSASKK
CCCCEEEEEEEEHHHHCCCCCCCC
>Mature Secondary Structure
MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQER
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QKTPLSKKSVGYAFGVLMGVTLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQR
HHCCCCHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYEVVKAADGPKPQGGQRVRTQY
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCCCHHHHHHH
KGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGV
CCEEECCEEECCCCCCCCCCCCCCCCCCHHCCCEEEECCCEEEEECCCCCCCCCCCCCCC
IPPGALLVFEIELQEILPDSASKK
CCCCEEEEEEEEHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]